Sources of pain in osteoarthritis: Implications for therapy

International Journal of Clinical Rheumatology

Volumn 8, Issue 3, 2013, Pages 335-345

  Jones, Graeme ^a  

^a UNIVERSITY OF TASMANIA   (Australia)

Author keywords

epidemiology; osteoarthritis; pain; therapy

Indexed keywords

ARTHRALGIA; BONE MARROW DISEASE; BONE RADIOGRAPHY; CHONDROPATHY; CLINICAL FEATURE; DISEASE ASSOCIATION; FOOT DISEASE; HAND OSTEOARTHRITIS; HIP OSTEOARTHRITIS; HUMAN; JOINT EFFUSION; JOINT PROSTHESIS; KNEE MENISCUS RUPTURE; KNEE OSTEOARTHRITIS; KNEE PAIN; MUSCLE STRENGTH; MUSCLE WEAKNESS; NUCLEAR MAGNETIC RESONANCE IMAGING; OBESITY; OSTEOARTHRITIS; OUTCOME ASSESSMENT; PATHOPHYSIOLOGY; PHYSICAL DISABILITY; PRIORITY JOURNAL; PUBLIC HEALTH PROBLEM; QUALITY OF LIFE; REVIEW; SPINE DISEASE; SYNOVITIS; WEATHER; WESTERN ONTARIO AND MCMASTER UNIVERSITIES OSTEOARTHRITIS INDEX;

EID: 84879633828     PISSN: 17584272     EISSN: 17584280     Source Type: Journal    
DOI: 10.2217/ijr.13.19     Document Type: Review

References (68)

1. Felson DT. Clinical practice. Osteoarthritis of the knee. N. Engl. J. Med. 354, 841-848 (2006).
2. Laslett LL, Quinn S, Winzenberg T, Sanderson K, Cicuttini FM, Jones G. A prospective study of the impact of musculoskeletal pain and radiographic osteoarthritis on health related quality of life in community dwelling older people. BMC Musculoskelet. Disord. 13, 168 (2012).
3. Sharma L, Kapoor D, Issa S. Epidemiology of osteoarthritis: an update. Curr. Opin. Rheumatol. 18, 147-156 (2006). (Pubitemid 43740387)
4. Jones G, Ding C, Scott F, Glisson M, Cicuttini F. Early radiographic osteoarthritis is associated with substantial changes in cartilage volume and tibial bone surface area in both males and females. Osteoarthritis Cartilage 12, 169-174 (2004). (Pubitemid 38181124)
5. Hunter DJ, Arden N, Conaghan PG et al.; OARSI OA Imaging Working Group. Definition of osteoarthritis on MRI: results of a Delphi exercise. Osteoarthritis Cartilage 19, 963-969 (2011).
6. Guermazi A, Niu J, Hayashi D et al. Prevalence of abnormalities in knees detected by MRI in adults without knee osteoarthritis: population based observational study (Framingham Osteoarthritis Study). BMJ 345, e5339 (2012).
7. Bedson J, Croft PR. The discordance between clinical and radiographic knee osteoarthritis: a systematic search and summary of the literature. BMC Musculoskelet. Disord. 9, 116 (2008).
8. Zhai G, Blizzard L, Srikanth V et al. Correlates of knee pain in older adults: Tasmanian Older Adult Cohort Study. Arthritis Rheum. 55, 264-271 (2006).
9. Javaid MK, Kiran A, Guermazi A et al. Individual magnetic resonance imaging and radiographic features of knee osteoarthritis in subjects with unilateral knee pain: the health, aging, and body composition study. Arthritis Rheum. 64, 3246-3255 (2012).
10. Ding C, Cicuttini F, Jones G. Tibial subchondral bone size and knee cartilage defects: relevance to knee osteoarthritis. Osteoarthritis Cartilage 15, 479-486 (2007). (Pubitemid 46667721)
11. Felson DT, Chaisson CE, Hill CL et al. The association of bone marrow lesions with pain in knee osteoarthritis. Ann. Intern. Med. 134, 541-549 (2001). (Pubitemid 32245315)
12. Dore D, Quinn S, Ding C et al. Natural history and clinical significance of MRI-detected bone marrow lesions at the knee: a prospective study in community dwelling older adults. Arthritis Res. Ther. 12, R223 (2010).
13. Felson DT, Niu J, Guermazi A et al. Correlation of the development of knee pain with enlarging bone marrow lesions on magnetic resonance imaging. Arthritis Rheum. 56, 2986-2992 (2007). (Pubitemid 47502745)
14. Davies-Tuck ML, Wluka AE, Wang Y, English DR, Giles GG, Cicuttini F. The natural history of bone marrow lesions in community-based adults with no clinical knee osteoarthritis. Ann. Rheum. Dis. 68, 904-908 (2009).
15. Lo GH, McAlindon TE, Niu J et al. Bone marrow lesions and joint effusion are strongly and independently associated with weight-bearing pain in knee osteoarthritis: data from the osteoarthritis initiative. Osteoarthritis Cartilage 17, 1562-1569 (2009).
16. Kornaat PR, Kloppenburg M, Sharma R et al. Bone marrow edema-like lesions change in volume in the majority of patients with osteoarthritis; associations with clinical features. Eur. Radiol. 17, 3073-3078 (2007). (Pubitemid 350142331)
17. Phan CM, Link TM, Blumenkrantz G et al. MR imaging findings in the follow-up of patients with different stages of knee osteoarthritis and the correlation with clinical symptoms. Eur. Radiol. 16, 608-618 (2006). (Pubitemid 44149373)
18. Zhang Y, Nevitt M, Niu J et al. Fluctuation of knee pain and changes in bone marrow lesions, effusions, and synovitis on magnetic resonance imaging. Arthritis Rheum. 63, 691-699 (2011).
19. Laslett LL, Doré D, Quinn S et al. Zoledronic acid reduces knee pain and bone marrow lesions over one year: a randomised controlled trial. Ann. Rheum. Dis. 71, 1322-1328 (2012).
20. Wildi LM, Raynauld JP, Martel-Pelletier J et al. Chondroitin sulphate reduces both cartilage volume loss and bone marrow lesions in knee osteoarthritis patients starting as early as 6 months after initiation of therapy: a randomised, double-blind, placebo-controlled pilot study using MRI. Ann. Rheum. Dis. 70, 982-989 (2011).
21. Sowers MF, Hayes C, Jamadar D et al. Magnetic resonance-detected subchondral bone marrow and cartilage defect characteristics associated with pain and X-ray-defined knee osteoarthritis. Osteoarthritis Cartilage 11, 387-393 (2003). (Pubitemid 36722652)
22. Zhai G, Cicuttini F, Ding C, Scott F, Garnero P, Jones G. Correlates of knee pain in younger subjects. Clin. Rheumatol. 26, 75-80 (2006).
23. Torres L, Dunlop DD, Peterfy C et al. The relationship between specific tissue lesions and pain severity in persons with knee osteoarthritis. Osteoarthritis Cartilage 14, 1033-1040 (2006). (Pubitemid 44321374)
24. Link TM, Steinbach LS, Ghosh S et al. Osteoarthritis: MR imaging findings in different stages of disease and correlation with clinical findings. Radiology 226, 373-381 (2003). (Pubitemid 36313421)
25. Sowers M, Karvonen-Gutierrez CA, Jacobson JA, Jiang Y, Yosef M. Associations of anatomical measures from MRI with radiographically defined knee osteoarthritis score, pain, and physical functioning. J. Bone Joint Surg. Am. 93, 241-251 (2011).
26. Fortier LA, Nixon AJ. Distributional changes in substance P nociceptive fiber patterns in naturally osteoarthritic articulations. J. Rheumatol. 24, 524-530 (1997). (Pubitemid 27153419)
27. Amin AR, Attur M, Patel RN et al. Superinduction of cyclooxygenase-2 activity in human osteoarthritis-affected cartilage. Influence of nitric oxide. J. Clin. Invest. 99, 1231-1237 (1997). (Pubitemid 27142759)
28. Englund M, Niu J, Guermazi A et al. Effect of meniscal damage on the development of frequent knee pain, aching, or stiffness. Arthritis Rheum. 56, 4048-4054 (2007). (Pubitemid 350262332)
29. Ding C, Martel-Pelletier J, Pelletier J-P et al. Is meniscal tear an osteoarthritis risk factor? A cross-sectional study of associations between meniscal tear and knee structure, radiographic changes and symptoms in a largely non-osteoarthritic cohort. J. Rheumatol. 34, 776-784 (2007). (Pubitemid 46641385)
30. Hill CL, Hunter DJ, Niu J et al. Synovitis detected on magnetic resonance imaging and its relation to pain and cartilage loss in knee osteoarthritis. Ann. Rheum. Dis. 66, 1599-1603 (2007). (Pubitemid 350205447)
31. Stannus O, Jones G, Cicuttini F et al. Associations between serum levels of inflammatory markers and change in knee pain over 5 years in older adults: a prospective cohort study. Ann. Rheum. Dis. 72(4), 535-540 (2013).
32. Smith MD, Wetherall M, Darby T et al. A randomized placebo-controlled trial of arthroscopic lavage versus lavage plus intra-articular corticosteroids in the management of symptomatic osteoarthritis of the knee. Rheumatology 42, 1477-1485 (2003). (Pubitemid 37508921)
33. Maksymowych WP, Russell AS, Chiu P et al. Targeting tumour necrosis factor alleviates signs and symptoms of inflammatory osteoarthritis of the knee. Arthritis Res. Ther. 14, R206 (2012).
34. Zhang W, Nuki G, Moskowitz RW et al. OARSI recommendations for the management of hip and knee osteoarthritis: part III: changes in evidence following systematic cumulative update of research published through January 2009. Osteoarthritis Cartilage 18, 476-499 (2010).
35. Soni A, Kiran A, Hart DJ et al. Prevalence of reported knee pain over twelve years in a community-based cohort. Arthritis Rheum. 64, 1145-1152 (2012).
36. Thompson LR, Boudreau R, Newman AB et al. The association of osteoarthritis risk factors with localized, regional and diffuse knee pain. Osteoarthritis Cartilage 18, 1244-1249 (2010).
37. Nguyen US, Zhang Y, Zhu Y, Niu J, Zhang B, Felson DT. Increasing prevalence of knee pain and symptomatic knee osteoarthritis: survey and cohort data. Ann. Intern. Med. 155, 725-732 (2011).
38. Gudbergsen H, Boesen M, Lohmander LS et al. Weight loss is effective for symptomatic relief in obese subjects with knee osteoarthritis independently of joint damage severity assessed by high-field MRI and radiography. Osteoarthritis Cartilage 20, 495-502 (2012).
39. Tanamas S, Wluka A, Berry P et al. Weight gain is associated with worsening of knee pain, stiffness, and function: a longitudinal study. Arthritis Care Res. 65, 34-43 (2012).
40. Amin S, Baker K, Niu J et al. Quadriceps strength and the risk of cartilage loss and symptom progression in knee osteoarthritis. Arthritis Rheum. 60, 189-198 (2009).
41. Sattler M, Dannhauer T, Hudelmaier M et al. Side differences of thigh muscle cross-sectional areas and maximal isometric muscle force in bilateral knees with the same radiographic disease stage, but unilateral frequent pain-data from the osteoarthritis initiative. Osteoarthritis Cartilage 20, 532-540 (2012).
42. Edwards RR, Cahalan C, Mensing G, Smith M, Haythornthwaite JA. Pain, catastrophizing, and depression in the rheumatic diseases. Nat. Rev. Rheumatol. 7, 216-224 (2011).
43. Riddle DL, Kong X, Fitzgerald GK. Psychological health impact on 2-year changes in pain and function in persons with knee pain: data from the Osteoarthritis Initiative. Osteoarthritis Cartilage 19, 1095-1101 (2011).
44. Keefe FJ, Lefebvre JC, Egert JR, Affleck G, Sullivan MJ, Caldwell DS. The relationship of gender to pain, pain behavior, and disability in osteoarthritis patients: the role of catastrophizing. Pain 87, 325-334 (2000). (Pubitemid 30645881)
45. Somers TJ, Keefe FJ, Godiwala N, Hoyler GH. Psychosocial factors and the pain experience of osteoarthritis patients: new findings and new directions. Curr. Opin. Rheumatol. 21, 501-506 (2009).
46. White DK, Keysor JJ, Neogi T et al. When it hurts, a positive attitude may help: association of positive affect with daily walking in knee osteoarthritis. Results from a multicenter longitudinal cohort study. Arthritis Care Res. 64, 1312-1319 (2012).
47. Zhai G, Jones G, Ding C, Scott F, Cicuttini F. The genetic contribution to muscle strength, knee pain, cartilage volume, bone size and radiographic osteoarthritis: a sibpair Study. Arthritis Rheum. 50, 805-810 (2004). (Pubitemid 38326180)
48. Valdes AM, De Wilde G, Doherty SA et al. The Ile585Val TRPV1 variant is involved in risk of painful knee osteoarthritis. Ann. Rheum. Dis. 70, 1556-1561 (2011).
49. van Meurs JB, Uitterlinden AG, Stolk L et al. A functional polymorphism in the catechol-O-methyltransferase gene is associated with osteoarthritis- related pain. Arthritis Rheum. 60, 628-629 (2009).
50. Arendt-Nielsen L, Nie H, Laursen MB et al. Sensitization in patients with painful knee osteoarthritis. Pain 149, 573-581 (2010).
51. Malfait AM, Seymour AB, Gao F et al. A role for PACE4 in osteoarthritis pain: evidence from human genetic association and null mutant phenotype. Ann. Rheum. Dis. 71, 1042-1048 (2012).
52. Hochberg MC, Wohlreich M, Gaynor P, Hanna S, Risser R. Clinically relevant outcomes based on analysis of pooled data from 2 trials of duloxetine in patients with knee osteoarthritis. J. Rheumatol. 39, 352-358 (2012).
53. McAlindon T, Formica M, Schmid CH, Fletcher J. Changes in barometric pressure and ambient temperature influence osteoarthritis pain. Am. J. Med. 120, 429-434 (2007). (Pubitemid 46627442)
54. Jones G, Cooley H, Bellamy N. A cross-sectional study of the association between Heberden's nodes, radiographic osteoarthritis of the hands, grip strength, disability and pain. Osteoarthritis Cartilage 9, 606-611 (2001). (Pubitemid 32998380)
55. Marshall M, van der Windt D, Nicholls E, Myers H, Dziedzic K. Radiographic thumb osteoarthritis: frequency, patterns and associations with pain and clinical assessment findings in a community-dwelling population. Rheumatology (Oxford) 50, 735-739 (2011).
56. Nicholls EE, van der Windt DA, Jordan JL, Dziedzic KS, Thomas E. Factors associated with the severity and progression of self-reported hand pain and functional difficulty in community-dwelling older adults: a systematic review. Musculoskelet. Care 10, 51-62 (2012).
57. Haugen IK, Bøyesen P, Slatkowsky-Christensen B, Sesseng S, van der Heijde D, Kvien TK. Associations between MRI-defined synovitis, bone marrow lesions and structural features and measures of pain and physical function in hand osteoarthritis. Ann. Rheum. Dis. 71, 899-904 (2012).
58. Verbruggen G, Wittoek R, Vander Cruyssen B, Elewaut D. Tumour necrosis factor blockade for the treatment of erosive osteoarthritis of the interphalangeal finger joints: a double blind, randomised trial on structure modification. Ann. Rheum. Dis. 71, 891-898 (2012).
59. Jacobsen S, Sonne-Holm S, Søballe K, Gebuhr P, Lund B. Radiographic case definitions and prevalence of osteoarthrosis of the hip: a survey of 4151 subjects in the Osteoarthritis Substudy of the Copenhagen City Heart Study. Acta Orthop. Scand. 75, 713-720 (2004). (Pubitemid 40018801)
60. Birrell F, Lunt M, Macfarlane G, Silman A. Association between pain in the hip region and radiographic changes of osteoarthritis: results from a population-based study. Rheumatology (Oxford) 44, 337-341 (2005). (Pubitemid 40361290)
61. Pope DP, Hunt IM, Birrell FN, Silman AJ, Macfarlane GJ. Hip pain onset in relation to cumulative workplace and leisure time mechanical load: a population based case-control study. Ann. Rheum. Dis. 62, 322-326 (2003). (Pubitemid 36363437)
62. Gosvig KK, Jacobsen S, Sonne-Holm S, Gebuhr P. The prevalence of cam-type deformity of the hip joint: a survey of 4151 subjects of the Copenhagen Osteoarthritis Study. Acta Radiol. 49, 436-441 (2008). (Pubitemid 351598799)
63. Butterworth PA, Landorf KB, Smith SE, Menz HB. The association between body mass index and musculoskeletal foot disorders: a systematic review. Obes. Rev. 13, 630-642 (2012).
64. Tanamas S, Wluka A, Berry P et al. The relationship between obesity and foot pain is related to fat mass and fat distribution but not muscle mass. Arthritis Care Res. 64, 262-268 (2012).
65. Menz HB, Roddy E, Thomas E, Croft PR. Impact of hallux valgus severity on general and foot-specific health-related quality of life. Arthritis Care Res. 63, 396-404 (2011).
66. Muraki S, Oka H, Akune T et al. Prevalence of radiographic lumbar spondylosis and its association with low back pain in elderly subjects of population-based cohorts: the ROAD study. Ann. Rheum. Dis. 68, 1401-1406 (2009).
67. Jensen TS, Karppinen J, Sorensen JS, Niinimäki J, Leboeuf-Yde C. Vertebral endplate signal changes (Modic change): a systematic literature review of prevalence and association with non-specific low back pain. Eur. Spine J. 17, 1407-1422 (2008).
68. Cauley JA, Black D, Boonen S et al. Once-yearly zoledronic acid and days of disability, bed rest, and back pain: randomized, controlled HORIZON Pivotal Fracture Trial. J. Bone Miner. Res. 26, 984-992 (2011).