A randomized placebo-controlled trial of artroscopic lavage verus lavage plus intra-articular corticosteroids in the management of symptomatic osteoarthritis of the knee

Rheumatology

Volumn 42, Issue 12, 2003, Pages 1477-1485

  Smith, M D ^c   Wetherall, M ^c   Darby, T ^c   Esterman, A ^a   Slavotinek, J ^b   Roberts Thomson, P ^b   Coleman, M ^b   Ahern, Michael ^c  

^a FLINDERS UNIVERSITY   (Australia)

^b FLINDERS MEDICAL CENTRE   (Australia)

^c REPATRIATION GENERAL HOSPITAL   (Australia)

Author keywords

Intra artricular corticosteroids; Knee joint; Osteoarthritis; Randomised trial

Indexed keywords

ANALGESIC AGENT; CORTICOSTEROID; METHYLPREDNISOLONE; NONSTEROID ANTIINFLAMMATORY AGENT; PLACEBO; STEROID;

ADULT; AGED; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFICACY; DRUG RESPONSE; FEMALE; FUNCTIONAL ASSESSMENT; HUMAN; HUMAN TISSUE; INTERMETHOD COMPARISON; JOINT BIOPSY; JOINT EFFUSION; JOINT FUNCTION; JOINT STIFFNESS; KNEE ARTHROSCOPY; KNEE OSTEOARTHRITIS; KNEE PAIN; LAVAGE; MAJOR CLINICAL STUDY; MALE; OUTCOMES RESEARCH; PAIN ASSESSMENT; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RELAPSE; REST; RISK ASSESSMENT; SCORING SYSTEM; SIDE EFFECT; STATISTICAL SIGNIFICANCE; SYMPTOMATOLOGY; TIME; TREATMENT OUTCOME;

ADRENAL CORTEX HORMONES; AGED; ARTHROSCOPY; COMBINED MODALITY THERAPY; FEMALE; HUMANS; INJECTIONS, INTRA-ARTICULAR; IRRIGATION; MALE; METHYLPREDNISOLONE; MIDDLE AGED; OSTEOARTHRITIS, KNEE; PAIN MEASUREMENT; RANGE OF MOTION, ARTICULAR; RECURRENCE; SEVERITY OF ILLNESS INDEX; TREATMENT OUTCOME;

EID: 0344668705     PISSN: 14620324     EISSN: None     Source Type: Journal    
DOI: 10.1093/rheumatology/keg398     Document Type: Article

References (19)

1. Pelletier JP, Martel-Pelletier J, Abramson SB. Osteoarthritis, an inflammatory disease. Potential implication for the selection of new therapeutic targets. Arthritis Rheum 2001;44:1237-47.
2. Smith MD, Triantafillou S, Parker A, Youssef PP, Coleman M. Synovial membrane inflammation and cytokine production in patients with early osteoarthritis. J Rheumatol 1997;24:365-71.
3. Sharif M, Saxne T, Shepstone L et al. Relationship between serum cartilage oligomeric matrix protein levels and disease progression in osteoarthritis of the knee joint. Br J Rheumatol 1995;34:306-10.
4. Spector TD, Hart DJ, Nandra D et al. Low-level increases in serum C-reactive protein are present in early osteoarthritis of the knee and predict progressive disease. Arthritis Rheum 1997;40:723-7.
5. Goldberg RL, Huff JP, Lenz ME, Glickman P, Katz R, Thonar EJ. Elevated plasma levels of hyaluronate in patients with osteoarthritis and rheumatoid arthritis. Arthritis Rheum 1991;34:799-807.
6. Felson DT. The verdict favours nonsteroidal antiinflammatory drugs for treatment of osteoarthritis and a plea for more evidence on other treatments. Arthritis Rheum 2001;44:1477-80.
7. Pincus T, Koch GG, Sokka T et al. A randomised, double-blind crossover clinical trial of diclofenac plus misoprostol versus acetaminophen in patients with osteoarthritis of the hip or knee. Arthritis Rheum 2001; 44:1587-98.
8. Brandt KD, Bradley JD. Should the initial drug used to treat osteoarthritis pain be a nonsteroidal antiinflammatory drug? J Rheumatol 2001;28:467-73.
9. Creamer P. Intra-articular corticosteroid injections in osteoarthritis: Do they work and if so, how? Ann Rheum Dis 1997;56:634-6.
10. Ravaud P, Moulinier L, Giraudeau. B et al. Effects of joint lavage and steroid injection in patients with osteoarthritis of the knee. Results of a multicenter, randomised, controlled trial. Arthritis Rheum 1999; 42:475-82.
11. Bradley JD, Heilman DK, Katz BP, G'Sell P, Wallick JE, Brandt KD. Tidal irrigation as treatment for knee osteoarthritis. Arthritis Rheum 2002;46:100-8.
12. Altman R, Asch E, Bloch D et al. Development of criteria for the classification and reporting of osteoarthritis: classifications of osteoarthritis of the knee. Arthritis Rheum 1986;29:1039-49.
13. Young L, Katrib A, Cuello C et al. Effects of intraarticular glucocorticoids on macrophage infiltration and mediators of joint damage in osteoarthritis synovial membranes: findings in a double-blind, placebo-controlled study. Arthritis Rheum 2001;44: 343-50.
14. Brismar BH, Wredmark T, Movin T, Leandersson J, Svensson O. Observer reliability in the arthroscopic classification of osteoarthritis of the knee. J Bone Joint Surg Br 2002;84:42-7.
15. Dougados M, Ayral X, Listrat V et al. The SFA system for assessing articular cartilage lesions at arthroscopy of the knee. Arthroscopy 1994;10: 69-77.
16. Kellgren JH, Lawrence JS. Radiological assessment of osteoarthritis. Ann Rheum Dis 1957;16:494-501.
17. Jaccard J, Wan CK. LISREL approaches to interaction effects in multiple regression. Thousand Oaks (CA): Sage Publications, 1996.
18. Moseley JB, O'Malley K, Petersen NJ et al. A controlled trial of arthroscopic surgery for osteoarthritis of the knee. N Engl J Med 2002;347:81-7.
19. Kalunian KC, Moreland LW, Klashman DJ et al. Visually-guided irrigation in patients with early knee osteoarthritis: a multicentered randomized controlled trial. Osteoarthritis Cartilage 2000;8:412-8.