The Wnt signaling pathway and mitotic regulators in the initiation and evolution of mantle cell lymphoma: Gene expression analysis

International Journal of Oncology

Volumn 43, Issue 2, 2013, Pages 457-468

  Kimura, Yoshizo ^a   Arakawa, Fumiko ^a   Kiyasu, Junichi ^a   Miyoshi, Hiroaki ^a   Yoshida, Maki ^a   Ichikawa, Ayako ^a   Niino, Daisuke ^a   Sugita, Yasuo ^a   Okamura, Takashi ^a   Doi, Atushi ^b   Yasuda, Kaori ^b   Tashiro, Kosuke ^b   Kuhara, Satoru ^b   Ohshima, Koichi ^a  

^a KURUME UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b KYUSHU UNIVERSITY   (Japan)

Author keywords

cDNA microarray analysis; Initiation; Laser microdissection; Mantle cell lymphoma; Mitotic regulator; Transformation; Wnt signaling pathway

Indexed keywords

BETA CATENIN; BIRC5 PROTEIN; CELL PROTEIN; COMPLEMENTARY DNA; CYCLIN DEPENDENT KINASE 1; FOXM1 PROTEIN; PROTEIN P53; UNCLASSIFIED DRUG; WNT3 PROTEIN;

ADULT; AGED; ARTICLE; B LYMPHOCYTE; CANCER CLASSIFICATION; CANCER GRADING; CELL CYCLE PROGRESSION; CONTROLLED STUDY; FEMALE; G2 PHASE CELL CYCLE CHECKPOINT; GENE EXPRESSION; GENE IDENTIFICATION; GENETIC ANALYSIS; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LASER MICRODISSECTION; MAJOR CLINICAL STUDY; MALE; MANTLE CELL LYMPHOMA; MICROARRAY ANALYSIS; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; WNT SIGNALING PATHWAY;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; B-LYMPHOCYTES; CYCLIN B; FEMALE; FORKHEAD TRANSCRIPTION FACTORS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; INHIBITOR OF APOPTOSIS PROTEINS; LYMPHOMA, MANTLE-CELL; MALE; MIDDLE AGED; TUMOR SUPPRESSOR PROTEIN P53; WNT SIGNALING PATHWAY; WNT3 PROTEIN;

EID: 84879615395     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo.2013.1982     Document Type: Article

References (43)

1. Kimura Y, Sato K, Arakawa F, et al: Mantle cell lymphoma shows three morphological evolutions of classical, intermediate, and aggressive forms, which occur in parallel with increased labeling index of cyclin D1 and Ki-67. Cancer Sci 101: 806-814, 2010.
2. Kaleem Z, Wakoff AR, Smith RP and Hess JL: Blastic transformation of mantle cell lymphoma. Arch Pathol Lab Med 120: 577-580, 1996. (Pubitemid 26193333)
3. Bodrug SE, Warner BJ, Bath ML, Lindeman GJ, Harris AW and Adams JM: Cyclin D1 transgene impedes lymphocyte maturation and collaborates in lymphomagenesis with the myc gene. EMBO J 13: 2124-2130, 1994. (Pubitemid 24139725)
4. Hirt C, Schuler F, Dolken L, Schmidt CA and Dolken G: Low prevalence of circulating t(11;14)(q13;q32)-positive cells in the peripheral blood of healthy individuals as detected by real-time quantitative PCR. Blood 104: 904-905, 2004. (Pubitemid 38970591)
5. De Vos S, Krug U, Hofmann WK, et al: Cell cycle alterations in the blastoid variant of mantle cell lymphoma (MCL-BV) as detected by gene expression profiling of mantle cell lymphoma (MCL) and MCL-BV. Diagn Mol Pathol 12: 35-43, 2003. (Pubitemid 36255268)
6. Rizzatti EG, Falcao RP, Panepucci RA, et al: Gene expression profiling of mantle cell lymphoma cells reveals aberrant expression of genes from the PI3K-AKT, WNT and TGFbeta signalling pathways. Br J Haematol 130: 516-526, 2005. (Pubitemid 43899754)
7. Martinez N, Camacho FI, Algara P, et al: The molecular signature of mantle cell lymphoma reveals multiple signals favoring cell survival. Cancer Res 63: 8226-8232, 2003. (Pubitemid 37549472)
8. Bolstad BM, Irizarry RA, Astrand M and Speed TP: A comparison of normalization methods for high density oligonucleotide array data based on variance and bias. Bioinformatics 19: 185-193, 2003. (Pubitemid 36181903)
9. Gentleman RC, Carey VJ, Bates DM, et al: Bioconductor: open software development for computational biology and bioinformatics. Genome Biol 5: R80, 2004.
10. Smyth GK, Michaud J and Scott HS: Use of within-array replicate spots for assessing differential expression in microarray experiments. Bioinformatics 21: 2067-2075, 2005. (Pubitemid 40668046)
11. Quackenbush J: Microarray data normalization and transformation. Nat Genet 32 (Suppl): 496-501, 2002.
12. Saeed AI, Sharov V, White J, et al: TM4: a free, open-source system for microarray data management and analysis. Biotechniques 34: 374-378, 2003. (Pubitemid 36184095)
13. Aguilera O, Munoz A, Esteller M and Fraga MF: Epigenetic alterations of the Wnt/beta-catenin pathway in human disease. Endocr Metab Immune Disord Drug Targets 7: 13-21, 2007. (Pubitemid 46380414)
14. Daugherty RL and Gottardi CJ: Phospho-regulation of beta-catenin adhesion and signaling functions. Physiology (Bethesda) 22: 303-309, 2007.
15. Fang D, Hawke D, Zheng Y, et al: Phosphorylation of beta-catenin by AKT promotes beta-catenin transcriptional activity. J Biol Chem 282: 11221-11229, 2007. (Pubitemid 47100795)
16. Massague J: G1 cell-cycle control and cancer. Nature 432: 298-306, 2004.
17. Rosenwald A, Wright G, Wiestner A, et al: The proliferation gene expression signature is a quantitative integrator of oncogenic events that predicts survival in mantle cell lymphoma. Cancer Cell 3: 185-197, 2003. (Pubitemid 37443390)
18. Sander B, Flygare J, Porwit-Macdonald A, et al: Mantle cell lymphomas with low levels of cyclin D1 long mRNA transcripts are highly proliferative and can be discriminated by elevated cyclin A2 and cyclin B1. Int J Cancer 117: 418-430, 2005. (Pubitemid 41429565)
19. Perez de Castro I, de Carcer G and Malumbres M: A census of mitotic cancer genes: new insights into tumor cell biology and cancer therapy. Carcinogenesis 28: 899-912, 2007. (Pubitemid 47072171)
20. Blenk S, Engelmann JC, Pinkert S, et al: Explorative data analysis of MCL reveals gene expression networks implicated in survival and prognosis supported by explorative CGH analysis. BMC Cancer 8: 106, 2008.
21. Hui D, Reiman T, Hanson J, et al: Immunohistochemical detection of cdc2 is useful in predicting survival in patients with mantle cell lymphoma. Mod Pathol 18: 1223-1231, 2005. (Pubitemid 43079922)
22. Schimmer AD: Inhibitor of apoptosis proteins: translating basic knowledge into clinical practice. Cancer Res 64: 7183-7190, 2004.
23. Mita AC, Mita MM, Nawrocki ST and Giles FJ: Survivin: key regulator of mitosis and apoptosis and novel target for cancer therapeutics. Clin Cancer Res 14: 5000-5005, 2008.
24. Martinez A, Bellosillo B, Bosch F, et al: Nuclear survivin expression in mantle cell lymphoma is associated with cell proliferation and survival. Am J Pathol 164: 501-510, 2004. (Pubitemid 38364666)
25. Wierstra I and Alves J: FOXM1, a typical proliferation-associated transcription factor. Biol Chem 388: 1257-1274, 2007. (Pubitemid 350135573)
26. Liu M, Dai B, Kang SH, et al: FoxM1B is overexpressed in human glioblastomas and critically regulates the tumorigenicity of glioma cells. Cancer Res 66: 3593-3602, 2006.
27. Kalin TV, Wang IC, Ackerson TJ, et al: Increased levels of the FoxM1 transcription factor accelerate development and progression of prostate carcinomas in both TRAMP and LADY transgenic mice. Cancer Res 66: 1712-1720, 2006. (Pubitemid 43259956)
28. Ott G, Kalla J, Ott MM, et al: Blastoid variants of mantle cell lymphoma: frequent bcl-1 rearrangements at the major translocation cluster region and tetraploid chromosome clones. Blood 89: 1421-1429, 1997. (Pubitemid 27080007)
29. Pinyol M, Hernandez L, Cazorla M, et al: Deletions and loss of expression of p16INK4a and p21Waf1 genes are associated with aggressive variants of mantle cell lymphomas. Blood 89: 272-280, 1997. (Pubitemid 26428202)
30. Hernandez L, Fest T, Cazorla M, et al: p53 gene mutations and protein overexpression are associated with aggressive variants of mantle cell lymphomas. Blood 87: 3351-3359, 1996. (Pubitemid 26115366)
31. Greiner TC, Moynihan MJ, Chan WC, et al: p53 mutations in mantle cell lymphoma are associated with variant cytology and predict a poor prognosis. Blood 87: 4302-4310, 1996. (Pubitemid 26152272)
32. Bentz M, Plesch A, Bullinger L, et al: t(11;14)-positive mantle cell lymphomas exhibit complex karyotypes and share similarities with B-cell chronic lymphocytic leukemia. Genes Chromosomes Cancer 27: 285-294, 2000. (Pubitemid 30067458)
33. Monni O, Oinonen R, Elonen E, et al: Gain of 3q and deletion of 11q22 are frequent aberrations in mantle cell lymphoma. Genes Chromosomes Cancer 21: 298-307, 1998. (Pubitemid 28165037)
34. Stilgenbauer S, Winkler D, Ott G, et al: Molecular characterization of 11q deletions points to a pathogenic role of the ATM gene in mantle cell lymphoma. Blood 94: 3262-3264, 1999. (Pubitemid 29512737)
35. Soong R, Robbins PD, Dix BR, et al: Concordance between p53 protein overexpression and gene mutation in a large series of common human carcinomas. Hum Pathol 27: 1050-1055, 1996. (Pubitemid 26347060)
36. Vogelstein B, Fearon ER, Hamilton SR, et al: Genetic alterations during colorectal-tumor development. N Engl J Med 319: 525-532, 1988.
37. Reya T, O'Riordan M, Okamura R, et al: Wnt signaling regulates B lymphocyte proliferation through a LEF-1 dependent mechanism. Immunity 13: 15-24, 2000.
38. Staal FJ and Sen JM: The canonical Wnt signaling pathway plays an important role in lymphopoiesis and hematopoiesis. Eur J Immunol 38: 1788-1794, 2008.
39. Ge X and Wang X: Role of Wnt canonical pathway in hematological malignancies. J Hematol Oncol 3: 33, 2010.
40. Gelebart P, Anand M, Armanious H, et al: Constitutive activation of the Wnt canonical pathway in mantle cell lymphoma. Blood 112: 5171-5179, 2008.
41. Lako M, Lindsay S, Lincoln J, Cairns PM, Armstrong L and Hole N: Characterisation of Wnt gene expression during the differentiation of murine embryonic stem cells in vitro: role of Wnt3 in enhancing haematopoietic differentiation. Mech Dev 103: 49-59, 2001. (Pubitemid 32457906)
42. Lu D, Zhao Y, Tawatao R, et al: Activation of the Wnt signaling pathway in chronic lymphocytic leukemia. Proc Natl Acad Sci USA 101: 3118-3123, 2004. (Pubitemid 38327744)
43. Rosenwald A, Alizadeh AA, Widhopf G, et al: Relation of gene expression phenotype to immunoglobulin mutation genotype in B cell chronic lymphocytic leukemia. J Exp Med 194: 1639-1647, 2001. (Pubitemid 33126814)