Effects of intermittent hypoxia on cognitive performance and quality of life in elderly adults: A pilot study

Gerontology

Volumn 59, Issue 4, 2013, Pages 316-323

  Schega, Lutz ^a   Peter, Beate ^a   Törpel, Alexander ^a   Mutschler, Harry ^a   Isermann, Berend ^a   Hamacher, Dennis ^a  

^a OTTO VON GUERICKE UNIVERSITY   (Germany)

Author keywords

Cognition; Elderly; Intermittent hypoxia; Quality of life

Indexed keywords

AGED; ARTICLE; CLINICAL ARTICLE; COGNITION; ENDURANCE; FEMALE; HUMAN; INTERMITTENT HYPOXIA; MALE; PHYSICAL ACTIVITY; PILOT STUDY; PRIORITY JOURNAL; QUALITY OF LIFE; SLEEP QUALITY; CONTROLLED STUDY; D2 TEST; ENDURANCE TRAINING; HEALTH PROGRAM; MENTAL PERFORMANCE; MINI MENTAL STATE EXAMINATION; NEUROPSYCHOLOGICAL TEST; NORMAL HUMAN; NUMBER COMBINATION TEST; PHYSICAL INACTIVITY; PITTSBURGH SLEEP QUALITY INDEX; RESISTANCE TRAINING; SHORT FORM 12;

AGED; AGING; ANOXIA; COGNITION; FEMALE; HUMANS; MALE; MIDDLE AGED; PHYSICAL ENDURANCE; PILOT PROJECTS; QUALITY OF LIFE; RESISTANCE TRAINING;

PLACEBO;

EID: 84879607668     PISSN: 0304324X     EISSN: 14230003     Source Type: Journal    
DOI: 10.1159/000350927     Document Type: Article

References (53)

1. Evans WJ: Effects of exercise on body composition and functional capacity of the elderly. J Gerontol A Biol Sci Med Sci 1995; 50: 147-150.
2. Fiatarone MA, Marks EC, Ryan ND, Meredith CN, Lipsitz LA, Evans WJ: High-intensity strength training in nonagenarians. Effects on skeletal muscle. JAMA 1990; 263: 3029-3034. (Pubitemid 20181606)
3. Fiatarone Singh MA: Exercise in the oldest old: some new insights and unanswered questions. J Am Geriatr Soc 2002; 50: 2089-2091. (Pubitemid 35462457)
4. Frontera WR, Meredith CN, O'Reilly KP, Knuttgen HG, Evans WJ: Strength conditioning in older men: skeletal muscle hypertrophy and improved function. J Appl Physiol 1988; 64: 1038-1044. (Pubitemid 18088522)
5. Hautier C, Bonnefoy M: Training for older adults. Ann Readapt Med Phys 2007; 50: 475-479, 469-474. (Pubitemid 46908844)
6. Hunter GR, McCarthy JP, Bamman MM: Effects of resistance training on older adults. Sports Med 2004; 34: 329-348. (Pubitemid 38680205)
7. Etnier JL, Salazar W, Landers DM, Petruzzello SJ, Han M, Nowell P: The influence of physical fitness and exercise upon cognitive functioning: a meta-analysis. J Sport Exer Psychol 1997; 19: 249-277.
8. Chang YK, Labban JD, Gapin JI, Etnier JL: The effects of acute exercise on cognitive performance: a meta-analysis. Brain Res 2012; 1453: 87-101.
9. Smith PJ, Blumenthal JA, Hoffman BM, Cooper H, Strauman TA, Welsh-Bohmer K, Browndyke JN, Sherwood A: Aerobic exercise and neurocognitive performance: a meta-analytic review of randomized controlled trials. Psychosom Med 2010; 72: 239-252.
10. Black JE, Isaacs KR, Anderson BJ, Alcantara AA, Greenough WT: Learning causes synaptogenesis, whereas motor activity causes angiogenesis, in cerebellar cortex of adult rats. Proc Natl Acad Sci USA 1990; 87: 5568-5572.
11. Neeper SA, Gomez-Pinilla F, Choi J, Cotman C: Exercise and brain neurotrophins. Nature 1995; 373: 109.
12. Kramer AF, Hahn S, Cohen NJ, Banich MT, McAuley E, Harrison CR, Chason J, Vakil E, Bardell L, Boileau RA, Colcombe A: Ageing, fitness and neurocognitive function. Nature 1999; 400: 418-419.
13. Lustig C, Shah P, Seidler R, Reuter-Lorenz PA: Aging, training, and the brain: a review and future directions. Neuropsychol Rev 2009; 19: 504-522.
14. Erickson KI, Voss MW, Prakash RS, Basak C, Szabo A, Chaddock L, Kim JS, Heo S, Alves H, White SM, Wojcicki TR, Mailey E, Vieira VJ, Martin SA, Pence BD, Woods JA, McAuley E, Kramer AF: Exercise training increases size of hippocampus and improves memory. Proc Natl Acad Sci USA 2011; 108: 3017-3022.
15. Seifert T, Brassard P, Wissenberg M, Rasmussen P, Nordby P, Stallknecht B, Adser H, Jakobsen AH, Pilegaard H, Nielsen HB, Secher NH: Endurance training enhances BDNF release from the human brain. Am J Physiol Regul Integr Comp Physiol 2010; 298:R372-R377.
16. Um HS, Kang EB, Koo JH, Kim HT, Jin L, Kim EJ, Yang CH, An GY, Cho IH, Cho JY: Treadmill exercise represses neuronal cell death in an aged transgenic mouse model of Alzheimer's disease. Neurosci Res 2011; 69: 161-173.
17. Zoladz JA, Pilc A: The effect of physical activity on the brain-derived neurotrophic factor: from animal to human studies. J Physiol Pharmacol 2010; 61: 533-541.
18. Knaepen K, Goekint M, Heyman EM, Meeusen R: Neuroplasticity exercise-induced response of peripheral brain-derived neurotrophic factor: a systematic review of experimental studies in human subjects. Sports Med 2010; 40: 765-801.
19. Gunstad J, Benitez A, Smith J, Glickman E, Spitznagel MB, Alexander T, Juvancic-Heltzel J, Murray L: Serum brain-derived neurotrophic factor is associated with cognitive function in healthy older adults. J Geriatr Psychiatry Neurol 2008; 21: 166-170.
20. Gomez-Pinilla F, Vaynman S, Ying Z: Brainderived neurotrophic factor functions as a metabotrophin to mediate the effects of exercise on cognition. Eur J Neurosci 2008; 28: 2278-2287.
21. Zhu XH, Yan HC, Zhang J, Qu HD, Qiu XS, Chen L, Li SJ, Cao X, Bean JC, Chen LH, Qin XH, Liu JH, Bai XC, Mei L, Gao TM: Intermittent hypoxia promotes hippocampal neurogenesis and produces antidepressantlike effects in adult rats. J Neurosci 2010; 30: 12653-12663.
22. Xie H, Leung KL, Chen L, Chan YS, Ng PC, Fok TF, Wing YK, Ke Y, Li AM, Yung WH: Brain-derived neurotrophic factor rescues and prevents chronic intermittent hypoxiainduced impairment of hippocampal longterm synaptic plasticity. Neurobiol Dis 2010; 40: 155-162.
23. Dreimuller N, Schlicht KF, Wagner S, Peetz D, Borysenko L, Hiemke C, Lieb K, Tadi? A: Early reactions of brain-derived neurotrophic factor in plasma and outcome to acute antidepressant treatment in patients with major depression. Neuropharmacology 2012; 62: 264-269.
24. Sipila S, Elorinne M, Alen M, Suominen H, Kovanen V: Effects of strength and endurance training on muscle fibre characteristics in elderly women. Clin Physiol 1997; 17: 459-474.
25. Acree LS, Longfors J, Fjeldstad AS, Fjeldstad C, Schank B, Nickel KJ, Montgomery PS, Gardner AW: Physical activity is related to quality of life in older adults. Health Qual Life Outcomes 2006; 4: 37.
26. Reid KJ, Baron KG, Lu B, Naylor E, Wolfe L, Zee PC: Aerobic exercise improves self-reported sleep and quality of life in older adults with insomnia. Sleep Med 2010; 11: 934-940.
27. Stewart KJ, Turner KL, Bacher AC, DeRegis JR, Sung J, Tayback M, Ouyang P: Are fitness, activity, and fatness associated with health-related quality of life and mood in older persons? J Cardiopulm Rehabil 2003; 23: 115-121. (Pubitemid 36378670)
28. Goekint M, De Pauw K, Roelands B, Njemini R, Bautmans I, Mets T, Meeusen R: Strength training does not influence serum brain-derived neurotrophic factor. Eur J Appl Physiol 2010; 110: 285-293.
29. Folstein MF, Folstein SE, McHugh PR: 'Mini mental state'. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975; 12: 189-198.
30. Brickenkamp R: Test: Testmaterial. Gottingen, Hogrefe, 1981.
31. Oswald WD, Roth E: Der Zahlen-Verbindungs-Test (ZVT): Handanweisung. Gottingen, Hogrefe, 1978.
32. Brahler E, Brickenkamp R: Brickenkamp-Handbuch Psychologischer und Padagogischer Tests. Gottingen, Hogrefe, 2002.
33. Brickenkamp R, Zillmer E: The d2 Test of Attention. Gottingen, Hogrefe & Huber, 1998.
34. Oswald WD: Psychometric tests and rating scales for gerontopsychological problems (in German). Z Gerontol 1979; 12: 341-350. (Pubitemid 9229049)
35. Lyons RA, Lo SV, Littlepage BN: Comparative health status of patients with 11 common illnesses in wales. J Epidemiol Community Health 1994; 48: 388-390. (Pubitemid 24271311)
36. Jenkinson C, Peto V, Coulter A: Measuring change over time: a comparison of results from a global single item of health status and the multi-dimensional SF-36 health status survey questionnaire in patients presenting with menorrhagia. Qual Life Res 1994; 3: 317-321. (Pubitemid 24358747)
37. Buysse DJ, Reynolds Iii CF, Monk TH, Berman SR, Kupfer DJ: The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research. Psychiatry Res 1989; 28: 193-213. (Pubitemid 19144991)
38. Beaudreau SA, Spira AP, Stewart A, Kezirian EJ, Lui LY, Ensrud K, Redline S, Ancoli-Israel S, Stone KL: Validation of the Pittsburgh Sleep Quality Index and the Epworth Sleepiness Scale in older black and white women. Sleep Med 2012; 13: 36-42.
39. Wagenhauser FJ, Spring H: Kraft: Theorie und Praxis. Stuttgart, Thieme, 1990.
40. Marschall F, Frohlich M: Testing the correlation between maximal strength and repetition maximum for deduced lower levels of intensity (in German). Dtsch Z Sportmed 1999; 50: 311-315.
41. Kleim JA, Cooper NR, VandenBerg PM: Exercise induces angiogenesis but does not alter movement representations within rat motor cortex. Brain Res 2002; 934: 1-6. (Pubitemid 34286562)
42. Gozal D, Kheirandish-Gozal L: Cardiovascular morbidity in obstructive sleep apnea: oxidative stress, inflammation, and much more. Am J Respir Crit Care Medicine 2008; 177: 369-375. (Pubitemid 351317579)
43. Row BW, Kheirandish L, Neville JJ, Gozal D: Impaired spatial learning and hyperactivity in developing rats exposed to intermittent hypoxia. Pediatr Res 2002; 52: 449-453. (Pubitemid 34920280)
44. Burtscher M, Mairer K, Wille M, Gatterer H, Ruedl G, Faulhaber M, Sumann G: Short-term exposure to hypoxia for work and leisure activities in health and disease: which level of hypoxia is safe? Sleep Breath 2012; 16: 435-442.
45. Rybnikova E, Vataeva L, Tyulkova E, Gluschenko T, Otellin V, Pelto-Huikko M, Samoilov MO: Mild hypoxia preconditioning pre vents impairment of passive avoidance learning and suppression of brain NGFI-A expression induced by severe hypoxia. Behav Brain Res 2005; 160: 107-114.
46. Levine BD: Intermittent hypoxic training: fact and fancy. High Alt Med Biol 2002; 3: 177-193.
47. Levine BD, Stray-Gundersen J: A practical approach to altitude training: where to live and train for optimal performance enhancement. Int J Sports Med 1992; 13(suppl 1): S209-S212.
48. Lu L, Dempsey J, Liu SY, Bossert JM, Shaham Y: A single infusion of brain-derived neurotrophic factor into the ventral tegmental area induces long-lasting potentiation of cocaine seeking after withdrawal. J Neurosci 2004; 24: 1604-1611. (Pubitemid 38240955)
49. Poo MM: Neurotrophins as synaptic modulators. Nat Rev Neurosci 2001; 2: 24-32.
50. Rose CR, Blum R, Kafitz KW, Kovalchuk Y, Konnerth A: From modulator to mediator: Rapid effects of BDNF on ion channels. Bioessays 2004; 26: 1185-1194. (Pubitemid 39536614)
51. Francomano A, Bonanno B, Fuca L, la Placa M, la Barbera D: The role of antidepressant treatments on cognitive deficits a review of recent literature. Clin Neuropsychiatry 2011; 8: 354-366.
52. Miller DI, Taler V, Davidson PSR, Messier C: Measuring the impact of exercise on cognitive aging: methodological issues. Neurobiol Aging 2012; 33: 622.e629-622.e643.
53. Silveira E, Taft C, Sundh V, Waern M, Palsson S, Steen B: Performance of the SF-36 health survey in screening for depressive and anxiety disorders in an elderly female Swedish population. Qual Life Res 2005; 14: 1263-1274. (Pubitemid 40895749)