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1
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84862579572
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Emergence and evolution of the renin-angiotensin-aldosterone system
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This report presents a phylogenetic analysis of the evolution of the renin-angiotensin-aldosterone systems and notes that about 400 million years ago the pathway evolved in primitive chordates as the need for salt conservation and blood pressure maintenance arose
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• Milliez P, Girerd X, Plouin PF, et al. Emergence and evolution of the renin-angiotensin-aldosterone system. J Mol Med (Berl). 2012;90:495-508. This report presents a phylogenetic analysis of the evolution of the renin-angiotensin-aldosterone systems and notes that about 400 million years ago the pathway evolved in primitive chordates as the need for salt conservation and blood pressure maintenance arose.
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(2012)
J Mol Med (Berl)
, vol.90
, pp. 495-508
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Milliez, P.1
Girerd, X.2
Plouin, P.F.3
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2
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85047675273
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Evolution and the cardiac patient
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6352032 10.1093/cvr/17.8.437 1:STN:280:DyaL2c%2Fgt1Sltw%3D%3D
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Harris P. Evolution and the cardiac patient. Cardiovasc Res. 1983;17:437-45.
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(1983)
Cardiovasc Res
, vol.17
, pp. 437-445
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Harris, P.1
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3
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3042731163
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Serum aldosterone and the incidence of hypertension in nonhypertensive persons
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15229305 10.1056/NEJMoa033263 1:CAS:528:DC%2BD2cXltlOjsLY%3D
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Vasan RS, Evans JC, Larson MG, et al. Serum aldosterone and the incidence of hypertension in nonhypertensive persons. N Engl J Med. 2004;351:33-41.
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N Engl J Med
, vol.351
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Vasan, R.S.1
Evans, J.C.2
Larson, M.G.3
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4
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84856334802
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Acute and chronic regulation of aldosterone production
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21839803 10.1016/j.mce.2011.07.034 1:CAS:528:DC%2BC38Xhs1CqtLk%3D This report discusses the molecular mechanisms underlying the acute and chronic phases of aldosterone secretion in response to various physiological stimuli
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• Hattangady NG, Olala LO, Bollag WB, Rainey WE. Acute and chronic regulation of aldosterone production. Mol Cell Endocrinol. 2012;350:151-62. This report discusses the molecular mechanisms underlying the acute and chronic phases of aldosterone secretion in response to various physiological stimuli.
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(2012)
Mol Cell Endocrinol
, vol.350
, pp. 151-162
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Hattangady, N.G.1
Olala, L.O.2
Bollag, W.B.3
Rainey, W.E.4
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5
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84874229170
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Vascular actions of aldosterone
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23172373 10.1159/000345243 This is a comprehensive review of the multiple molecular mechanisms by which aldosterone impairs endothelial function
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•• Briet M, Schiffrin EL. Vascular actions of aldosterone. J Vasc Res. 2012;50:89-99. This is a comprehensive review of the multiple molecular mechanisms by which aldosterone impairs endothelial function.
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(2012)
J Vasc Res
, vol.50
, pp. 89-99
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Briet, M.1
Schiffrin, E.L.2
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6
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84859907412
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Mineralocorticoid receptor-associated hypertension and its organ damage: Clinical relevance for resistant hypertension
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This is a state-of-the-art review that discusses the pathogenesis of the two categories of mineralocorticoid-associated hypertension (with elevated and normal aldosterone levels) and disease mechanisms underlying this state
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•• Shibata H, Itoh H. Mineralocorticoid receptor-associated hypertension and its organ damage: clinical relevance for resistant hypertension. Am J Hypertens. 2012;25:514-23. This is a state-of-the-art review that discusses the pathogenesis of the two categories of mineralocorticoid- associated hypertension (with elevated and normal aldosterone levels) and disease mechanisms underlying this state.
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(2012)
Am J Hypertens
, vol.25
, pp. 514-523
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Shibata, H.1
Itoh, H.2
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7
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32544448025
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Prevalence and characteristics of the metabolic syndrome in primary Aldosteronism
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16291704 10.1210/jc.2005-1733 1:CAS:528:DC%2BD28XhsFKntLk%3D
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Fallo F, Veglio F, Bertello C, et al. Prevalence and characteristics of the metabolic syndrome in primary Aldosteronism. J Clin Endocrinol Metab. 2006;91:454-9.
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(2006)
J Clin Endocrinol Metab
, vol.91
, pp. 454-459
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Fallo, F.1
Veglio, F.2
Bertello, C.3
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8
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10744220710
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Human adipocytes secrete mineralocorticoid-releasing factors
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14614137 10.1073/pnas.2336140100 1:CAS:528:DC%2BD3sXpsFGiur4%3D
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Ehrhart-Bornstein M, Lamounier-Zepter V, Schraven A, et al. Human adipocytes secrete mineralocorticoid-releasing factors. Proc Natl Acad Sci. 2003;100:14211-6.
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(2003)
Proc Natl Acad Sci
, vol.100
, pp. 14211-14216
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Ehrhart-Bornstein, M.1
Lamounier-Zepter, V.2
Schraven, A.3
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9
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21044441652
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Clinical and genetic correlates of serum aldosterone in the community: The Framingham Heart Study
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15882548 10.1016/j.amjhyper.2004.12.005 1:CAS:528:DC%2BD2MXjvFelu7c%3D
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Kathiresan S, Larson MG, Benjamin EJ, et al. Clinical and genetic correlates of serum aldosterone in the community: the Framingham Heart Study. Am J Hypertens. 2005;18:657-65.
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(2005)
Am J Hypertens
, vol.18
, pp. 657-665
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Kathiresan, S.1
Larson, M.G.2
Benjamin, E.J.3
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10
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34047233709
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Clinical and genetic correlates of aldosterone-to-renin ratio and relations to blood pressure in a community sample
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17296870 10.1161/01.HYP.0000258554.87444.91 1:CAS:528: DC%2BD2sXivVamsbg%3D
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Newton-Cheh C, Guo CY, Gona P, et al. Clinical and genetic correlates of aldosterone-to-renin ratio and relations to blood pressure in a community sample. Hypertension. 2007;49:846-56.
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(2007)
Hypertension
, vol.49
, pp. 846-856
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Newton-Cheh, C.1
Guo, C.Y.2
Gona, P.3
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11
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17144421237
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Evidence for an increased rate of cardiovascular events in patients with primary aldosteronism
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15837256 10.1016/j.jacc.2005.01.015 1:CAS:528:DC%2BD2MXjtlagt70%3D
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Milliez P, Girerd X, Plouin PF, et al. Evidence for an increased rate of cardiovascular events in patients with primary aldosteronism. J Am Coll Cardiol. 2005;45:1243-8.
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(2005)
J Am Coll Cardiol
, vol.45
, pp. 1243-1248
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Milliez, P.1
Girerd, X.2
Plouin, P.F.3
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12
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84870240654
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Association of elevated plasma aldosterone-to-renin ratio with future cardiovascular events in patients with essential hypertension
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Among Japanese patients with hypertension followed up for up to 9 years, those with higher ARR (above the median) had a 2.7-fold greater risk of stroke, and addition of ARR to the Framingham risk score increased model performance as evaluated by discrimination index (the C-statistic)
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• Kisaka T, Ozono R, Ishida T, et al. Association of elevated plasma aldosterone-to-renin ratio with future cardiovascular events in patients with essential hypertension. J Hypertens. 2012;30:2322-30. Among Japanese patients with hypertension followed up for up to 9 years, those with higher ARR (above the median) had a 2.7-fold greater risk of stroke, and addition of ARR to the Framingham risk score increased model performance as evaluated by discrimination index (the C-statistic).
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(2012)
J Hypertens
, vol.30
, pp. 2322-2330
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Kisaka, T.1
Ozono, R.2
Ishida, T.3
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13
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0033310867
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Biochemical evidence of aldosterone overproduction and abnormal regulation in normotensive individuals with familial Hyperaldosteronism type i
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10566645 10.1210/jc.84.11.4031 1:CAS:528:DyaK1MXntlOqtbw%3D
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Stowasser M, Huggard PR, Rossetti TR, et al. Biochemical evidence of aldosterone overproduction and abnormal regulation in normotensive individuals with familial Hyperaldosteronism type I. J Clin Endocrinol Metab. 1999;84:4031-6.
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(1999)
J Clin Endocrinol Metab
, vol.84
, pp. 4031-4036
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Stowasser, M.1
Huggard, P.R.2
Rossetti, T.R.3
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14
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0034458423
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Severity of hypertension in familial Hyperaldosteronism type I: Relationship to gender and degree of biochemical disturbance
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10852446 10.1210/jc.85.6.2160 1:CAS:528:DC%2BD3cXlsVequrc%3D
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Stowasser M, Bachmann AW, Huggard PR, et al. Severity of hypertension in familial Hyperaldosteronism type I: relationship to gender and degree of biochemical disturbance. J Clin Endocrinol Metab. 2000;85:2160-6.
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J Clin Endocrinol Metab
, vol.85
, pp. 2160-2166
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Stowasser, M.1
Bachmann, A.W.2
Huggard, P.R.3
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15
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0029847663
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Inherited forms of mineralocorticoid hypertension
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8952579 10.1161/01.HYP.28.6.927 1:CAS:528:DyaK2sXisVSgsA%3D%3D
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White PC. Inherited forms of mineralocorticoid hypertension. Hypertension. 1996;28:927-36.
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(1996)
Hypertension
, vol.28
, pp. 927-936
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White, P.C.1
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16
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84866545065
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Primary aldosteronism: Evidence against a second epidemic
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This review highlights the limitations of the ARR as a sole diagnostic tool for making a diagnosis of primary hyperaldosteronism and discusses how referral bias inflates prevalence estimates of the condition among hypertensive patients in different settings (primary care clinic vs. hypertension clinic vs resistant hypertension)
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•• Kaplan NM. Primary aldosteronism: evidence against a second epidemic. J Hypertens. 2012;30:1899-902. This review highlights the limitations of the ARR as a sole diagnostic tool for making a diagnosis of primary hyperaldosteronism and discusses how referral bias inflates prevalence estimates of the condition among hypertensive patients in different settings (primary care clinic vs. hypertension clinic vs resistant hypertension).
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(2012)
J Hypertens
, vol.30
, pp. 1899-1902
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Kaplan, N.M.1
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17
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44649087034
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Aldosterone-to-renin ratio as a screening test for primary aldosteronism - The Dutch ARRAT Study
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18490805 1:STN:280:DC%2BD1czislCgsw%3D%3D
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Jansen PM, Boomsma F, van den Meiracker AH. Aldosterone-to-renin ratio as a screening test for primary aldosteronism - the Dutch ARRAT Study. Neth J Med. 2008;66:220-8.
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(2008)
Neth J Med
, vol.66
, pp. 220-228
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Jansen, P.M.1
Boomsma, F.2
Van Den Meiracker, A.H.3
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18
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84860917505
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Resistant hypertension and aldosterone: An update
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This report highlights the high prevalence of primary hyperaldosteronism in patients with resistant hypertension, discusses the good response to spironolactone treatment in these patients and highlights the association of hyperaldosteronism with obstructive sleep apnea
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•• Clark III D, Ahmed MI, Calhoun DA. Resistant hypertension and aldosterone: an update. Can J Cardiol. 2012;28:318-25. This report highlights the high prevalence of primary hyperaldosteronism in patients with resistant hypertension, discusses the good response to spironolactone treatment in these patients and highlights the association of hyperaldosteronism with obstructive sleep apnea.
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(2012)
Can J Cardiol
, vol.28
, pp. 318-325
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Clark Iii, D.1
Ahmed, M.I.2
Calhoun, D.A.3
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19
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0035941955
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Cautions over the current epidemic of primary aldosteronism
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11289366 10.1016/S0140-6736(00)04223-9 1:STN:280:DC%2BD3M7pvFGhsg%3D%3D
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Kaplan NM. Cautions over the current epidemic of primary aldosteronism. Lancet. 2001;357:953-4.
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(2001)
Lancet
, vol.357
, pp. 953-954
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Kaplan, N.M.1
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20
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84862749262
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Screening for primary aldosteronism in hypertensive subjects: Results from two German epidemiological studies
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This report elucidates how use of 3 different sets of diagnostic criteria (using a combination of high ARR, high serum aldosterone and reduced plasma renin concentrations) can result in widely varying prevalence estimates for primary hyperaldosteronism in hypertensive patients in the community
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•• Hannemann A, Bidlingmaier M, Friedrich N, et al. Screening for primary aldosteronism in hypertensive subjects: results from two German epidemiological studies. Eur J Endocrinol. 2012;167:7-15. This report elucidates how use of 3 different sets of diagnostic criteria (using a combination of high ARR, high serum aldosterone and reduced plasma renin concentrations) can result in widely varying prevalence estimates for primary hyperaldosteronism in hypertensive patients in the community.
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(2012)
Eur J Endocrinol
, vol.167
, pp. 7-15
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Hannemann, A.1
Bidlingmaier, M.2
Friedrich, N.3
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21
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51749083776
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Case detection, diagnosis, and treatment of patients with primary Aldosteronism: An endocrine society clinical practice guideline
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18552288 10.1210/jc.2008-0104 1:CAS:528:DC%2BD1cXhtFChurrI
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Funder JW, Carey RM, Fardella C, et al. Case detection, diagnosis, and treatment of patients with primary Aldosteronism: an endocrine society clinical practice guideline. J Clin Endocrinol Metab. 2008;93:3266-81.
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(2008)
J Clin Endocrinol Metab
, vol.93
, pp. 3266-3281
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Funder, J.W.1
Carey, R.M.2
Fardella, C.3
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22
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80054867841
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Higher aldosterone and lower N-terminal proatrial natriuretic peptide as biomarkers of salt sensitivity in the community
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This investigation demonstrates how the combination of higher salt intake, higher serum aldosterone and lower N-terminal proatrial natriuretic peptide concentrations can translate into a greater risk of developing hypertension prospectively among community-dwelling middle-aged adults
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• Lieb W, Pencina MJ, Jacques PF, et al. Higher aldosterone and lower N-terminal proatrial natriuretic peptide as biomarkers of salt sensitivity in the community. Eur J Cardiovasc Prev Rehabil. 2011;18:664-73. This investigation demonstrates how the combination of higher salt intake, higher serum aldosterone and lower N-terminal proatrial natriuretic peptide concentrations can translate into a greater risk of developing hypertension prospectively among community-dwelling middle-aged adults.
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(2011)
Eur J Cardiovasc Prev Rehabil
, vol.18
, pp. 664-673
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Lieb, W.1
Pencina, M.J.2
Jacques, P.F.3
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23
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84856822062
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Recent advancements in the treatment of resistant hypertension
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22314116 10.3810/pgm.2012.01.2519 This review discusses the importance of aldosterone excess and responsiveness to spironolactone treatment in patients with resistant hypertension
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•• Clark III D, Guichard JL, Calhoun DA, Ahmed MI. Recent advancements in the treatment of resistant hypertension. Postgrad Med. 2012;124:67-73. This review discusses the importance of aldosterone excess and responsiveness to spironolactone treatment in patients with resistant hypertension.
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(2012)
Postgrad Med
, vol.124
, pp. 67-73
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Clark Iii, D.1
Guichard, J.L.2
Calhoun, D.A.3
Ahmed, M.I.4
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