Impaired EphA4 signaling leads to congenital hydronephrosis, renal injury, and hypertension

American Journal of Physiology - Renal Physiology

Volumn 305, Issue 1, 2013, Pages

  Sällström, Johan ^a,b   Peuckert, Christiane ^a   Gao, Xiang ^a   Larsson, Erik ^a   Nilsson, Anders ^a   Jensen, Boye L ^c   Onozato, Maristela L ^d   Persson, A Erik G ^a   Kullander, Klas ^a   Carlström, Mattias ^a,b  

^a UPPSALA UNIVERSITY   (Sweden)

^b KAROLINSKA INSTITUTE   (Sweden)

^c UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^d MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Ephrin; Gene modified mice; Human disorder; Receptor; Ureteral obstruction

Indexed keywords

ENHANCED GREEN FLUORESCENT PROTEIN; EPHRIN RECEPTOR A4;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD PRESSURE MEASUREMENT; CONTROLLED STUDY; GLOMERULUS FILTRATION; GLOMERULUS FILTRATION RATE; HYDRONEPHROSIS; HYPERTENSION; KIDNEY BLOOD FLOW; KIDNEY INJURY; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; URETER OBSTRUCTION;

EID: 84879572841     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.00694.2012     Document Type: Article

References (35)

1. Amar AD. Congenital hydronephrosis of lower segment in duplex kidney. Urology 7: 480-485, 1976.
2. Bartram MP, Hohne M, Dafinger C, Volker LA, Albersmeyer M, Heiss J, Gobel H, Bronneke H, Burst V, Liebau MC, Benzing T, Schermer B, Muller RU. Conditional loss of kidney microRNAs results in congenital anomalies of the kidney and urinary tract (CAKUT). J Mol Med (Berl) 2013 Jan 24 [Epub ahead of print].
3. Bolger PM, Eisner GM, Shea PT, Ramwell PW, Slotkoff LM. Effects of PGD2 on canine renal function. Nature 267: 628-630, 1977.
4. Carlstrom M. Causal link between neonatal hydronephrosis and later development of hypertension. Clin Exp Pharmacol Physiol 37: e14-23, 2010.
5. Carlstrom M, Brown RD, Edlund J, Sallstrom J, Larsson E, Teerlink T, Palm F, Wahlin N, Persson AE. Role of nitric oxide deficiency in the development of hypertension in hydronephrotic animals. Am J Physiol Renal Physiol 294: F362-F370, 2008.
6. Carlstrom M, Brown RD, Sallstrom J, Larsson E, Zilmer M, Zabihi S, Eriksson UJ, Persson AE. SOD1 deficiency causes salt sensitivity and aggravates hypertension in hydronephrosis. Am J Physiol Regul Integr Comp Physiol 297: R82-R92, 2009.
7. Carlstrom M, Lai EY, Steege A, Sendeski M, Ma Z, Zabihi S, Eriksson UJ, Patzak A, Persson AE. Nitric oxide deficiency and increased adenosine response of afferent arterioles in hydronephrotic mice with hypertension. Hypertension 51: 1386-1392, 2008.
8. Carlstrom M, Sallstrom J, Skott O, Larsson E, Wahlin N, Persson AE. Hydronephrosis causes salt-sensitive hypertension and impaired renal concentrating ability in mice. Acta Physiol (Oxf) 189: 293-301, 2007.
9. Carlstrom M, Wahlin N, Sallstrom J, Skott O, Brown R, Persson AE. Hydronephrosis causes salt-sensitive hypertension in rats. J Hypertens 24: 1437-1443, 2006.
10. 1 receptor blockade by candesartan on arterial pressure and renal function in rats. Am J Physiol Renal Physiol 274: F940-F945, 1998.
11. Chertin B, Puri P. Familial vesicoureteral reflux. J Urol 169: 1804-1808, 2003.
12. Chevalier R. Molecular and cellular pathophysiology of obstructive nephropathy. Pediatr Nephrol 13: 612-619, 1999.
13. Dahmann C, Oates AC, Brand M. Boundary formation and maintenance in tissue development. Nat Rev Genet 12: 43-55, 2011.
14. de Waard D, Dik P, Lilien MR, Kok ET, de Jong TP. Hypertension is an indication for surgery in children with ureteropelvic junction obstruction. J Urol 179: 1976-1978; discussion 1978-1979, 2008.
15. Dhillon HK. Prenatally diagnosed hydronephrosis: the Great Ormond Street experience. Br J Urol 81, Suppl 2: 39-44, 1998.
16. Feather SA, Malcolm S, Woolf AS, Wright V, Blaydon D, Reid CJ, Flinter FA, Proesmans W, Devriendt K, Carter J, Warwicker P, Goodship TH, Goodship JA. Primary, nonsyndromic vesicoureteric reflux and its nephropathy is genetically heterogeneous, with a locus on chromosome 1. Am J Hum Genet 66: 1420-1425, 2000.
17. Grunwald IC, Korte M, Adelmann G, Plueck A, Kullander K, Adams RH, Frotscher M, Bonhoeffer T, Klein R. Hippocampal plasticity requires postsynaptic ephrinBs. Nat Neurosci 7: 33-40, 2004.
18. Kawada N, Imai E, Karber A, Welch WJ, Wilcox CS. A mouse model of angiotensin II slow pressor response: role of oxidative stress. J Am Soc Nephrol 13: 2860-2868, 2002.
19. Liapis H. Biology of congenital obstructive nephropathy. Nephron Exp Nephrol 93: e87-91, 2003.
20. Lifland JH. Ureteropelvic obstruction of duplex kidney. Urology 6: 603-604, 1975.
21. Livera LN, Brookfield DS, Egginton JA, Hawnaur JM. Antenatal ultrasonography to detect fetal renal abnormalities: a prospective screening programme. BMJ 298: 1421-1423, 1989.
22. Lykkegard S, Poulsen K. Ultramicroassay for plasma renin concentration in the rat using the antibody-trapping technique. Anal Biochem 75: 250-259, 1976.
23. Morsing P, Stenberg A, Wahlin N, Persson AE. Tubuloglomerular feedback in rats with chronic partial bilateral ureteral obstruction. Renal Physiol Biochem 18: 27-34, 1995.
24. Nakai H, Asanuma H, Shishido S, Kitahara S, Yasuda K. Changing concepts in urological management of the congenital anomalies of kidney and urinary tract, CAKUT. Pediatr Int 45: 634-641, 2003.
25. Nusbacher N, Bryk D. Hydronephrosis of the lower pole of the duplex kidney: another renal pseudotumor. AJR Am J Roentgenol 130: 967-969, 1978.
26. Ogita H, Kunimoto S, Kamioka Y, Sawa H, Masuda M, Mochizuki N. EphA4-mediated Rho activation via Vsm-RhoGEF expressed specifically in vascular smooth muscle cells. Circ Res 93: 23-31, 2003.
27. Pasquale EB. Eph-ephrin bidirectional signaling in physiology and disease. Cell 133: 38-52, 2008.
28. Pitulescu ME, Adams RH. Eph/ephrin molecules-a hub for signaling and endocytosis. Genes Dev 24: 2480-2492, 2010.
29. Podevin G, Mandelbrot L, Vuillard E, Oury JF, Aigrain Y. Outcome of urological abnormalities prenatally diagnosed by ultrasound. Fetal Diagn Ther 11: 181-190, 1996.
30. Sallstrom J, Friden M. Simultaneous determination of renal plasma flow and glomerular filtration rate in conscious mice using dual bolus injection. J Pharmacol Toxicol Methods 67: 187-193, 2013.
31. Schlussel R, Retik A. Ectopic ureter, ureterocele, and other anomalies of the ureter. In: Campbell-Walsh Urology, edited by Wein A. Philadelphia, PA: Saunders, 2007, p. 3393-3413.
32. Sekine T, Miyazaki H, Endou H. Molecular physiology of renal organic anion transporters. Am J Physiol Renal Physiol 290: F251-F261, 2006.
33. Thomas DF. Fetal uropathy. Br J Urol 66: 225-231, 1990.
34. Ulman I, Jayanthi VR, Koff SA. The long-term followup of newborns with severe unilateral hydronephrosis initially treated nonoperatively. J Urol 164: 1101-1105, 2000.
35. Wiesel A, Queisser-Luft A, Clementi M, Bianca S, Stoll C. Prenatal detection of congenital renal malformations by fetal ultrasonographic examination: an analysis of 709,030 births in 12 European countries. Eur J Med Genet 48: 131-144, 2005.