Crystal structure of a Trimeresurus mucrosquamatus venom metalloproteinase providing new insights into the inhibition by endogenous tripeptide inhibitors

Toxicon

Volumn 71, Issue , 2013, Pages 140-146

  Chou, Tsung Lin ^a   Wu, Cheng Heng ^b   Huang, Kai Fa ^b,c   Wang, Andrew H J ^a,b,c  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^b INSTITUTE OF BIOLOGICAL CHEMISTRY   (Taiwan)

^c ACADEMIA SINICA   (Taiwan)

Author keywords

S1' substrate binding pocket; Snake venom metalloproteinase; Trimeresurus mucrosquamatus; Tripeptide inhibitor

Indexed keywords

DISULFIDE; METALLOPROTEINASE; PROTEIN INHIBITOR; PROTEIN TM 1; SNAKE VENOM; TRIPEPTIDE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; CRYSTAL STRUCTURE; DISULFIDE BOND; ENZYME ACTIVE SITE; ENZYME INHIBITION; ENZYME SPECIFICITY; ENZYME STABILITY; ENZYME STRUCTURE; ENZYME SUBSTRATE COMPLEX; HYDROPHOBICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; SNAKE; TRIMERESURUS MUCROSQUAMATUS;

S1′ SUBSTRATE-BINDING POCKET; SNAKE-VENOM METALLOPROTEINASE; TRIMERESURUS MUCROSQUAMATUS; TRIPEPTIDE INHIBITOR;

AMINO ACID SEQUENCE; ANIMALS; CATALYTIC DOMAIN; CROTALID VENOMS; CRYSTALLIZATION; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; METALLOPROTEASES; MOLECULAR SEQUENCE DATA; PIPERAZINES; PROTEASE INHIBITORS; PROTEIN CONFORMATION; STRUCTURE-ACTIVITY RELATIONSHIP; VIPERIDAE;

PROTOBOTHROPS MUCROSQUAMATUS;

EID: 84879562387     PISSN: 00410101     EISSN: 18793150     Source Type: Journal    
DOI: 10.1016/j.toxicon.2013.05.009     Document Type: Article

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