A short-term n-3 DPA supplementation study in humans

European Journal of Nutrition

Volumn 52, Issue 3, 2013, Pages 895-904

  Miller, Eliza ^a   Kaur, Gunveen ^b   Larsen, Amy ^a   Loh, Su Peng ^c   Linderborg, Kaisa ^d   Weisinger, Harrison S ^a   Turchini, Giovanni M ^e   Cameron Smith, David ^f   Sinclair, Andrew J ^a  

^a DEAKIN UNIVERSITY   (Australia)

^b VICTORIA UNIVERSITY   (Australia)

^c UNIVERSITY PUTRA MALAYSIA   (Malaysia)

^d UNIVERSITY OF TURKU   (Finland)

^e DEAKIN UNIVERSITY   (Australia)

^f UNIVERSITY OF AUCKLAND   (New Zealand)

Author keywords

Docosahexaenoic acid (DHA); Docosapentaenoic acid (DPA); Eicosapentaenoic acid (EPA); Fatty acid metabolism; n 3 Polyunsaturated fatty acids (PUFA)

Indexed keywords

CHOLESTEROL ESTER; DOCOSAHEXAENOIC ACID; DOCOSAPENTAENOIC ACID; ICOSAPENTAENOIC ACID; OLIVE OIL; PHOSPHOLIPID; TRIACYLGLYCEROL;

ADULT; ARTICLE; CLINICAL EFFECTIVENESS; CONTROLLED STUDY; CROSSOVER PROCEDURE; DIET SUPPLEMENTATION; DOUBLE BLIND PROCEDURE; ERYTHROCYTE LEVEL; FATTY ACID ANALYSIS; FEMALE; HUMAN; HUMAN EXPERIMENT; LIPID COMPOSITION; NORMAL HUMAN; NUTRITIONAL ASSESSMENT; NUTRITIONAL HEALTH; PHOSPHOLIPID BLOOD LEVEL; RANDOMIZED CONTROLLED TRIAL; STEADY STATE; TREATMENT DURATION; TRIACYLGLYCEROL BLOOD LEVEL;

ADULT; CHOLESTEROL ESTERS; CROSS-OVER STUDIES; DIARRHEA; DIETARY SUPPLEMENTS; DOCOSAHEXAENOIC ACIDS; DOUBLE-BLIND METHOD; EICOSAPENTAENOIC ACID; ERYTHROCYTES; FATTY ACIDS, UNSATURATED; FEMALE; FOOD PREFERENCES; HUMANS; PHOSPHOLIPIDS; TRIGLYCERIDES; VICTORIA; YOUNG ADULT;

EID: 84879555564     PISSN: 14366207     EISSN: 14366215     Source Type: Journal    
DOI: 10.1007/s00394-012-0396-3     Document Type: Article

References (49)

1. Saravanan P, Davidson NC, Schmidt EB, Calder PC (2010) Cardiovascular effects of marine omega-3 fatty acids. Lancet 376(9740):540-550
2. Calder PC, Yaqoob P (2010) Omega-3 (n-3) fatty acids, cardiovascular disease and stability of atherosclerotic plaques. Cell Mol Biol (Noisy-le-grand) 56(1):28-37
3. Mann NJ, Johnson LG, Warrick GE, Sinclair AJ (1995) The arachidonic acid content of the Australian diet is lower than previously estimated. J Nutr 125(10):2528-2535
4. Or-Rashid MM, Odongo NE, Wright TC, McBride BW (2009) Fatty acid profile of bovine milk naturally enhanced with docosahexaenoic acid. J Agric Food Chem 57(4):1366-1371
5. Howe P, Meyer B, Record S, Baghurst K (2006) Dietary intake of long-chain omega-3 polyunsaturated fatty acids: contribution of meat sources. Nutrition 22(1):47-53
6. Akiba S, Murata T, Kitatani K, Sato T (2000) Involvement of lipoxygenase pathway in docosapentaenoic acid-induced inhibition of platelet aggregation. Biological Pharmacol 23(11):1293-1297
7. Kaur G, Sinclair AJ, Cameron-Smith D, Barr DP, Molero-Navajas JC, Konstantopoulos N (2011) Docosapentaenoic acid (22:5n-3) down-regulates the expression of genes involved in fat synthesis in liver cells. Prostaglandins Leukot Essent Fatty Acids 85(3-4):155-161
8. Yoshida H, Mawatari M, Ikeda I, Imaizumi K, Seto A, Tsuji H (1999) Effect of dietary seal and fish oils on triacylglycerol metabolism in rats. J Nutr Sci Vitaminol 45(4):411-421
9. Akiba S, Murata T, Kitatani K, Sato T (2000) Involvement of lipoxygenase pathway in docosapentaenoic acid-induced inhibition of platelet aggregation. Biol Pharm Bull 23(11):1293-1297
10. Phang M, Garg ML, Sinclair AJ (2009) Inhibition of platelet aggregation by omega-3 polyunsaturated fatty acids is gender specific-redefining platelet response to fish oils. Prostaglandins Leukot Essent Fatty Acids 81(1):35-40
11. Gotoh N, Nagao K, Onoda S, Shirouchi B, Furuya K, Nagai T et al (2009) Effects of three different highly purified n-3 series highly unsaturated fatty acids on lipid metabolism in C57BL/KsJ-db/db mice. J Agric Food Chem 57(22):11047-11054
12. Pawar A, Jump DB (2003) Unsaturated fatty acid regulation of peroxisome proliferator-activated receptor alpha activity in rat primary hepatocytes. J Biol Chem 278(38):35931-35939
13. Kishida E, Tajiri M, Masuzawa Y (2006) Docosahexaenoic acid enrichment can reduce L929 cell necrosis induced by tumour necrosis factor. Biochim Biophys Acta 1761(4):454-462
14. Holub BJ, Swidinsky P, Park E (2011) Oral docosapentaenoic acid (22:5n-3) is differentially incorporated into phospholipid pools and differentially metabolized to eicosapentaenoic acid in tissues from young rats. Lipids [Research Support, Non-US Gov't] 46(5):399-407
15. Kaur G, Begg DP, Barr D, Garg M, Cameron-Smith D, Sinclair AJ (2010) Short-term docosapentaenoic acid (22:5 n-3) supplementation increases tissue docosapentaenoic acid, DHA and EPA concentrations in rats. Br J Nutr [Research Support, Non-US Gov't] 103(1):32-37
16. Meyer B, Mann N (2009) Comparison of seal oil to tuna oil on plasma lipid levels and blood pressure in hypertriglyceridaemic subjects. Lipids 44(9):827-835
17. Sullivan B, Brown J, Williams P, Meyer B (2008) Dietary validation of a new food frequency questionnaire that estimates long-chain omega-3 polyunsaturated fatty acids. Br J Nutr 99:660-666
18. Sullivan B, Williams P, Meyer B (2006) Biomarker validation of a new food frequency questionnaire that estimates long-chain omega-3 polyunsaturated fatty acids. Lipids 41:845-850
19. Swierk M, Williams P, Meyer B, Wilcox J, Russel K (2011) Validation of an Australian electronic food frequency questionnaire to measure polyunsaturated fatty acid intake. Nutrition 6:641-646
20. Sinclair A, O'Dea K, Dunstan G, Ireland P, Niall M (1987) Effects on plasma lipids and fatty acid composition of very low fat diets enriched with fish or kangaroo meat. Lipids 22:523-529
21. Ackman RG (2002) The gas chomatograph in practical analyses of common and uncommon fatty acids for the 21st century. Anal Chim Acta 465(1-2):175-192
22. Folch J, Lees M, Sloane-Stanley GH (1957) Methods for the isolation and purification of total lipids from animal tissue. J Biol Chem 226:497-509
23. Armstrong JM, Metherel AH, Stark KD (2008) Direct microwave transesterification of fingertip prick blood samples for fatty acid determinations. Lipids 43(2):187-196
24. Popovic T, Borozan S, Arsic A, Martacic JD, Vucic V, Trbovic A et al (2011) Fish oil supplementation improved liver phospholipids fatty acid composition and parameters of oxidative stress in male wistar rats. J Anim Physiol Anim Nutr. doi: 10.1111/j.1439-0396.2011.01216.x
25. Abeywardena MY, Patten GS (2011) Role of ω3 long-chain polyunsaturated fatty acids in reducing cardio-metabolic risk factors. Endocr Metab Immune Disord Drug Targets 11(3):232-246. ISSN: 2212-3873
26. Westphal S, Orth M, Ambrosch A, Osmundsen K, Luley C (2000) Postprandial chylomicrons and VLDLs in severe hypertriacylglycerolemia are lowered more effectively than are chylomicron remnants after treatment with n-3 fatty acids. Am J Clin Nutr 71(4):914-920
27. Roche HM, Gibney MJ (2000) Effect of long-chain n-3 polyunsaturated fatty acids on fasting and postprandial triacylglycerol metabolism. Am J Clin Nutr 71(1 Suppl):232S-237S
28. Fox JC, Hay RV (1992) Eicosapentaenoic acid inhibits cell growth and triacylglycerol secretion in McA-RH7777 rat hepatoma cultures. Biochem J 286(Pt 1):305-312
29. Benner KG, Sasaki A, Gowen DR, Weaver A, Connor WE (1990) The differential effect of eicosapentaenoic acid and oleic acid on lipid synthesis and VLDL secretion in rabbit hepatocytes. Lipids 25(9):534-540
30. Chen HW, Lii CK, Ko JJ, Wang ST, Hsu JD (1996) Regulatory effects of dietary n-3 and n-6 lipids on plasma and hepatic lipid levels, liver cell number and microsomal protein content in spontaneously hypertensive rats. Prostaglandins Leukot Essent Fatty Acids 55(5):329-335
31. Willumsen N, Skorve J, Hexeberg S, Rustan AC, Berge RK (1993) The hypotriglyceridemic effect of eicosapentaenoic acid in rats is reflected in increased mitochondrial fatty acid oxidation followed by diminished lipogenesis. Lipids 28(8):683-690
32. Skulas-Ray AC, Kris-Etherton PM, Harris WS, vanden Heuvel JP, Wagner PR, West SG (2011) Dose-response effects of omega-3 fatty acids on triglycerides, inflammation, and endothelial function in healthy persons with moderate hypertriglyceridemia. Am J Clin Nutr 93(2):243-252
33. Oya J, Nakagami T, Sasaki S, Jimba S, Murakami K, Kasahara T et al (2010) Intake of n-3 polyunsaturated fatty acids and non-alcoholic fatty liver disease: a cross-sectional study in Japanese men and women. Eur J Clin Nutr 64(10):1179-1185
34. Hodge J, Sanders K, Sinclair AJ (1993) Differential utilization of eicosapentaenoic acid and docosahexaenoic acid in human plasma. Lipids 28(6):525-531
35. Yep YL, Li D, Mann NJ, Bode O, Sinclair AJ (2002) Bread enriched with microencapsulated tuna oil increases plasma docosahexaenoic acid and total omega-3 fatty acids in humans. Asia Pac J Clin Nutr 11(4):285-291
36. Conquer JA, Cheryk LA, Chan E, Gentry PA, Holub BJ (1999) Effect of supplementation with dietary seal oil on selected cardiovascular risk factors and hemostatic variables in healthy male subjects. Thromb Res 96(3):239-250
37. Mori TA, Burke V, Puddey IB, Watts GF, O'Neal DN, Best JD et al (2000) Purified eicosapentaenoic and docosahexaenoic acids have differential effects on serum lipids and lipoproteins, LDL particle size, glucose, and insulin in mildly hyperlipidemic men. Am J Clin Nutr 71(5):1085-1094
38. Cao J, Schwichtenberg KA, Hanson NQ, Tsai MY (2006) Incorporation and clearance of omega-3 fatty acids in erythrocyte membranes and plasma phospholipids. Clin Chem [Randomized Controlled Trial] 52(12):2265-2272
39. Zuijdgeest-van Leeuwen SD, Dagnelie PC, Rietveld T, van den Berg JW, Wilson JH (1999) Incorporation and washout of orally administered n-3 fatty acid ethyl esters in different plasma lipid fractions. Br J Nutr 82(6):481-488
40. Christensen E, Woldseth B, Hagve TA, Poll-The BT, Wanders RJ, Sprecher H et al (1993) Peroxisomal beta-oxidation of polyunsaturated long chain fatty acids in human fibroblasts. The polyunsaturated and the saturated long chain fatty acids are retroconverted by the same acyl-CoA oxidase. Scand J Clin Lab Invest Suppl 215:61-74
41. Stoffel W, Eker A, Assad H, Sprecher H (1970) Enzymatic studies on the mechanism of the retroconversion of C22-polyenoic fatty acids to their C20-homologues. Hoppe Seylers Z Physiol Chem 351(12):1545-1554
42. Achard F, Benistant C, Lagarde M (1995) Interconversions and distinct metabolic fate of eicosapentaenoic, docosapentaenoic and docosahexaenoic acids in bovine aortic endothelial cells. Biochim Biophys Acta 1255(3):260-266
43. Rosenthal MD, Garcia MC, Jones MR, Sprecher H (1991) Retroconversion and delta 4 desaturation of docosatetraenoate (22:4(n-6)) and docosapentaenoate (22:5(n-3)) by human cells in culture. Biochim Biophys Acta 1083(1):29-36
44. Katan MB, Deslypere JP, van Birgelen AP, Penders M, Zegwaard M (1997) Kinetics of the incorporation of dietary fatty acids into serum cholesteryl esters, erythrocyte membranes, and adipose tissue: an 18-month controlled study. J Lipid Res 38(10):2012-2022
45. Krul ES, Lemke SL, Mukherjea R, Taylor ML, Goldstein DA, Su H et al (2012) Effects of duration of treatment and dosage of eicosapentaenoic acid and stearidonic acid on red blood cell eicosapentaenoic acid content. Prostaglandins Leukot Essent Fatty Acids 86(1-2):51-59
46. Meyer BJ, Lane AE, Mann NJ (2009) Comparison of seal oil to tuna oil on plasma lipid levels and blood pressure in hypertriglyceridaemic subjects. Lipids 44(9):827-835
47. Brown AJ, Pang E, Roberts DC (1991) Erythrocyte eicosapentaenoic acid versus docosahexaenoic acid as a marker for fish and fish oil consumption. Prostaglandins Leukot Essent Fatty Acids 44(2):103-106
48. Brown AJ, Pang E, Roberts DC (1991) Persistent changes in the fatty acid composition of erythrocyte membranes after moderate intake of n-3 polyunsaturated fatty acids: study design implications. Am J Clin Nutr 54(4):668-673
49. Cartwright IJ, Pockley AG, Galloway JH, Greaves M, Preston FE (1985) The effects of dietary omega-3 polyunsaturated fatty acids on erythrocyte membrane phospholipids, erythrocyte deformability and blood viscosity in healthy volunteers. Atherosclerosis 55(3):267-281