Identification of steroid sensitive responders versus non-responders in the treatment of keloid disease

Archives of Dermatological Research

Volumn 305, Issue 5, 2013, Pages 423-432

  Ud Din, Sara ^a,b   Bowring, Alison ^a,b   Derbyshire, Barbara ^b   Morris, Julie ^b   Bayat, Ardeshir ^a,b  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b MANCHESTER UNIVERSITY NHS FOUNDATION TRUST   (United Kingdom)

Author keywords

Hypertrophic scars; Keloid disease; Non responders; Raised dermal scarring; Responders; Steroid injection; Steroid sensitivity; Triamcinolone acetonide

Indexed keywords

TRIAMCINOLONE ACETONIDE;

ADOLESCENT; ADULT; AGED; ARTICLE; CHILD; CORRELATION ANALYSIS; DRUG EFFICACY; FEMALE; FOLLOW UP; HUMAN; KELOID; MAJOR CLINICAL STUDY; MALE; PATIENT CODING; PRIORITY JOURNAL; RECURRENT DISEASE; SCHOOL CHILD; STATISTICAL ANALYSIS; TREATMENT OUTCOME;

ADOLESCENT; ADRENAL CORTEX HORMONES; ADULT; AGED; CHI-SQUARE DISTRIBUTION; CHILD; DRUG RESISTANCE; FEMALE; HUMANS; INJECTIONS, INTRALESIONAL; KELOID; MALE; MIDDLE AGED; REMISSION INDUCTION; SEVERITY OF ILLNESS INDEX; SKIN; TIME FACTORS; TREATMENT OUTCOME; TRIAMCINOLONE ACETONIDE; YOUNG ADULT;

EID: 84879555016     PISSN: 03403696     EISSN: 1432069X     Source Type: Journal    
DOI: 10.1007/s00403-013-1328-7     Document Type: Article

References (52)

1. Ardehali B, Nouraei SA, Van Dam H, Dex E, Wood S, Nduka C (2007) Objective assessment of keloid scars with three-dimensional imaging: quantifying response to intralesional steroid therapy. Plast Reconstr Surg 119:556-561
2. Asilian A, Darougheh A, Shariati F (2006) New combination of triamcinolone, 5-fluorouracil, and pulsed-dye laser for treatment of keloid and hypertrophic scars. Dermatol Surg 32:907-915
3. Atiyeh BS (2007) Nonsurgical management of hypertrophic scars: evidence-based therapies, standard practices and emerging methods. Aesthet Plast Surg 31:468-492
4. Bayat A, McGrouther D, Ferguson M (2003) Skin scarring. BMJ 326:88-92
5. Beausang E, Floyd H, Dunn KW, Orton CI, Ferguson MW (1998) A new quantitative scale for clinical scar assessment. Plast Reconstr Surg 102:1954-1961
6. Beranak JT (1997) Silicone gel sheeting for the management of hypertrophic and keloids scars: the mechanism of its action. Dermatol Surg 23:401-405
7. Berman B, Flores F (1999) Comparison of a silicone gel-filled cushion and silicone gel sheeting for the treatment of hypertrophic or keloid scars. Dermatol Surg 25:484-486
8. Boutli-Kasapidou F, Tsakiri A, Anagnostou E, Mourellou O (2005) Hypertrophic and keloidal scars: an approach to polytherapy. Int J Dermatol 44:324-327
9. Boyadjiev C, Popchristova E, Mazgalova J (1995) Histomorphologic changes in keloids treated with Kenacort. J Trauma 38:299-302
10. Brent B (1978) The role of pressure therapy in management of earlobe keloids: preliminary report of a controlled study. Ann Plast Sur 1:579-581
11. Brown BC, McKenna SP, Siddhi K, McGrouther DA, Bayat A (2008) The hidden cost of skin scars: quality of life after skin scarring. J Plast Reconstr Aesthet Surg 61:1049-1058
12. Brown BC, McKenna SP, Solomon M, Wilburn J, McGrouther DA, Bayat A (2010) The patient-reported impact of scars measure: development and validation. Plast Reconstr Surg 125:1439-1449
13. Brown BC, Moss TP, McGrouther DA, Bayat A (2010) Skin scar preconceptions must be challenged: importance of self-perception in skin scarring. J Plast Reconstr Aesthet Surg 63:1022-1029
14. Conejo-Mir JS, Corbi R, Linares R (1998) Carbon dioxide laser ablation associated with interferon alfa-2b injection reduces the recurrence of keloids. J Am Acad Dermatol 39:1039-1040
15. Converse JM, Stallings JO (1972) Eradication of large auricular keloids by excision, skin grafting, and intradermal injection of triamcinolone acetonide solution. Case report. Plast Reconstr Surg 49:461-463
16. Cruz NI, Korchin L (1994) Inhibition of human keloid fibroblast growth by isotretinoin and triamcinolone acetonide in vitro. Ann Plast Surg 33:401-405
17. Darougheh A, Asilian A, Shariati F (2007) Intralesional triamcinolone alone or in combination with 5-fluorouracil for the treatment of keloid and hypertrophic scars. Clin Exp Dermatol 34:219-223
18. Darzi MA, Chowdri NA, Kaul SK, Khan M (1992) Evaluation of various methods of treating keloids and hypertrophics scars: a 10-year follow-up study. Br J Plast Surg 45:374-379
19. Donkor P (2007) Head and neck keloid: treatment by core excision and delayed intralesional injection of steroid. J Oral Maxillofac Surg 65:1292-1296
20. Fitzpatrick RE (1999) Treatment of inflamed hypertrophic scars using intralesional 5FU. Dermatol Surg 25:224-232
21. Gangemi EN, Gregori D, Berchialla P et al (2008) Epidemiology and risk factors for pathologic scarring after burn wounds. Arch Facial Plast Surg 10:93-102
22. Hollywood KA, Maatje M, Shadi IT, Henderson A, McGrouther DA (2010) Phenotypic profiling of keloid scars using FT-IR microspectroscopy reveals a unique spectral signature. Arch Dermatol Res 302:705-715
23. Iqbal SA, Sidgwick GP, Bayat A (2012) Identification of fibrocytes from mesenchymal stem cells in keloid tissue: a potential source of abnormal fibroblasts in keloid scarring. Arch Dermatol Res 304:665-671
24. Jalali M, Bayat (2007) Current use of steroids in management of abnormal raised skin scars. Surgeon 5:175-180
25. Kill J (1977) Keloids treated with topical injections of triamcinolone acetonide (kenalog): immediate and long-term results. Scand J Plast Reconstr Surg 11:169-172
26. Koc E, Arca E, Surucu B, Kurumlu Z (2008) An open, randomized, controlled, comparative study of the combined effect of intralesional triamcinolone acetonide and onion extract gel and intralesional triamcinolone acetonide alone in the treatment of hypertrophic scars and keloids. Dermatol Surg 34:1507-1514
27. Krusche T, Worret WI (1995) Mechanical properties of keloids in vivo during treatment with intralesional triamcinolone acetonide. Arch Dermatol Res 287:289-293
28. Larrabee WF, East CA, Jaffe HS, Stephensen C, Peterson KE (1990) Intralesional interferon gamma treatment for keloids and hypertrophic scars. Arch Otolaryngol Head Neck Surg 116:1159-1162
29. Layton AM, Yip J, Cunliffe WJ (1994) A comparison of intralesional triamcinolone and cryosurgery in the treatment of acne keloids. Br J Dermatol 130:498-501
30. Lee Y, Minn KW, Baek RM, Hong JJ (2001) A new surgical treatment of keloid: keloid core excision. Ann Plast Surg 46:135-140
31. Leventhal D, Furr M, Reiter D (2006) Treatment of keloids and hypertrophic scars. Arch Facial Plast Surg 8:362-368
32. Low SQ, Moy RL (1992) Scar war strategies. Target collagen. J Dermatol Surg Oncol 18:981-986
33. Manuskiatti W, Fitzpatrick RE (2002) Treatment response of keloidal and hypertrophic sternotomy scars. Comparison among intralesional corticosteroid, 5-fluorouracil, and 585 nm flashlamp-pumped pulsed dye laser treatments. Arch Dermatol 138:1149-1155
34. McCoy BJ, Diegelmann RF, Cohen IK (1980) In vitro inhibition of cell growth, collagen synthesis, and prolyl hydroxylase activity by triamcinolone acetonide. Proc Soc Exp Biol Med 163:216-222
35. Mustoe TA, Cooter RD, Gold MH et al (2002) International clinical recommendations on scar management. Plast Reconstr Surg 110:560-571
36. Nedelec B, Shankowsky H, Tredget E (2000) Rating the resolving hypertrophic scar: comparison of the Vancouver Scar Scale and scar volume. J Burn Care Rehabil 21:205
37. Ragoowansi R, Cornes PGS, Glees JP, Powell BW, Moss AL (2001) Ear-lobe keloids: treatment by a protocol of surgical excision and immediate postoperative adjuvant radiotherapy. Br J Plast Surg 54:504-508
38. Rahban S, Garner W (2003) Fibroproliferative scars. Clin Plast Surg 30:77-89
39. Reed BR, Clark RA (1985) Cutaneous tissue repair: practical implications of current knowledge, II. J Am Acad Dermatol 13:919-941
40. Robles D, Moore E, Draznin M, Berg D (2007) Keloids: patho-physiology and management. Dermatol Online J 13:9
41. Roques C, Teot L (2008) The use of corticosteroids to treat keloids: a review. Int J Low Extrem Wounds 7:137-145
42. Sadeghinia A, Sadeghinia S (2012) Comparison of the efficacy of intralesional triamcinolone acetonide and 5-fluorouracil tattooing for the treatment of keloids. Dermatol Surg 38:104-109
43. Salvarani C, Cantini F, Olivieri I, Barozzi L, Macchioni L, Boiardi L, Niccoli L, Padula A, Pulsatelli L, Meliconi R (2000) Corticosteroid injections in polymyalgia rheumatica: a double-blind, prospective, randomized, placebo controlled study. J Rheumatol 27:1470-1476
44. Seifert O, Mrowietz U (2009) Keloid scarring: bench and bedside. Arch Dermatol Res 301:259-272
45. Shih B, Bayat A (2010) Genetics of keloid scarring. Arch Dermatol Res 302:319-339
46. Shih B, Bayat A (2012) Comparative genomic hybridisation analysis of keloid tissue in Caucasians suggests possible involvement of HLA-DRB5 in disease pathogenesis. Arch Dermatol Res 304:241-249
47. Singer AJ, Clark RA (1999) Cutaneous wound healing. N Engl J Med 341:738-746
48. Sund B (2000) New developments in wound care. PJB Publications, London
49. Syed F, Bayat A (2013) Superior effect of combination vs. single steroid therapy in keloid disease: a comparative in vitro analysis of glucocorticoids. Wound Repair Regen 21:88-102
50. van Zuijlen P, Angeles A, Kreis R, Bos KE, Middlekoop E (2002) Scar assessment tools: implications for current research. Plast Reconstr Surg 109:1108
51. Wu WS, Wang FS, Yang KD, Huang CC, Kuo YR (2006) Dexamethasone induction of keloid regression through effective suppression of VEGF expression and keloid fibroblast proliferation. J Invest Dermatol 126:1264-1271
52. Yosipovitch G, Widijanti Sugeng M, Goon A, Chan YH, Goh CL (2001) A comparison of the combined effect of cryotherapy and corticosteroid injections versus corticosteroids and cryotherapy alone on keloids: a controlled study. J Dermatol Treat 12:87-90