Identification of fibrocytes from mesenchymal stem cells in keloid tissue: A potential source of abnormal fibroblasts in keloid scarring

Archives of Dermatological Research

Volumn 304, Issue 8, 2012, Pages 665-671

  Iqbal, S A ^a   Sidgwick, G P ^a   Bayat, A ^a,b  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b WYTHENSHAWE HOSPITAL   (United Kingdom)

Author keywords

CD34; Fibrocytes; Keloid disease; Keloid scarring; Mesenchymal stem cells; Raised dermal scarring

Indexed keywords

5' NUCLEOTIDASE; CALGRANULIN A; CALGRANULIN B; CD34 ANTIGEN; CD45RO ANTIGEN; COLLAGEN TYPE 1; ENDOGLIN; THY 1 ANTIGEN;

ADULT; AGED; ARTICLE; BONE MARROW CELL; CELL PROLIFERATION; CONTROLLED STUDY; FIBROBLAST; FIBROCYTE; FLUORESCENCE ACTIVATED CELL SORTING; HUMAN; HUMAN CELL; HUMAN TISSUE; HYBRID CELL; IMMUNOFLUORESCENCE; KELOID; MESENCHYMAL STEM CELL; PRIORITY JOURNAL; SKIN SCAR;

ADULT; AGED; BONE MARROW CELLS; CELL DIFFERENTIATION; CELL PROLIFERATION; CELLS, CULTURED; CICATRIX; CULTURE MEDIA, SERUM-FREE; FEMALE; HUMANS; KELOID; MALE; MESENCHYMAL STROMAL CELLS; MIDDLE AGED; REGENERATIVE MEDICINE; STEM CELL NICHE; YOUNG ADULT;

EID: 84867573201     PISSN: 03403696     EISSN: 1432069X     Source Type: Journal    
DOI: 10.1007/s00403-012-1225-5     Document Type: Article

References (18)

1. Barisic-Dujmovic T, Boban I, Clark SH (2010) Fibroblasts/myofibroblasts that participate in cutaneous wound healing are not derived from circulating progenitor cells. J Cell Physiol 222:703-712
2. Bucala R, Spiegel LA, Chesney J et al (1994) Circulating fibrocytes define a new leukocyte subpopulation that mediates tissue repair. Mol Med 1:71-81
3. Dienus K, Bayat A, Gilmore BF et al (2010) Increased expression of fibroblast activation protein-alpha in keloid fibroblasts: implications for development of a novel treatment option. Arch Dermatol Res 302:725-731
4. Dominici M, Le Blanc K, Mueller I et al (2006) Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy 8:315-317
5. Forbes SJ, Russo FP, Rey V et al (2004) A significant proportion of myofibroblasts are of bone marrow origin in human liver fibrosis. Gastroenterology 126:955-963
6. Iqbal SA, Manning C, Syed F et al (2011) Identification of mesenchymal stem cells in perinodular fat and skin in Dupuytren's disease: a potential source of myofibroblasts with implications for pathogenesis and therapy. Stem Cells Dev 21(4):609-622
7. Iqbal SA, Syed F, McGrouther DA et al (2010) Differential distribution of haematopoietic and nonhaematopoietic progenitor cells in intralesional and extralesional keloid: do keloid scars provide a niche for nonhaematopoietic mesenchymal stem cells? Br J Dermatol 162:1377-1383
8. James WD, Besanceney CD, Odom RB (1980) The ultrastructure of a keloid. J Am Acad Dermatol 3:50-57
9. Mori L, Bellini A, Stacey MA et al (2005) Fibrocytes contribute to the myofibroblast population in wounded skin and originate from the bone marrow. Exp Cell Res 304:81-90
10. Ogawa M, Larue AC, Drake CJ (2006) Hematopoietic origin of fibroblasts/myofibroblasts: its pathophysiologic implications. Blood 108:2893-2896
11. Pilling D, Buckley CD, Salmon M et al (2003) Inhibition of fibrocyte differentiation by serum amyloid P. J Immunol 171:5537-5546
12. Pilling D, Fan T, Huang D et al (2009) Identification of markers that distinguish monocyte-derived fibrocytes from monocytes, macrophages, and fibroblasts. PLoS One 4:e7475
13. Santucci M, Borgognoni L, Reali UM et al (2001) Keloids and hypertrophic scars of Caucasians show distinctive morphologic and immunophenotypic profiles. Virchows Arch 438:457-463
14. Shih B, Bayat A (2011) Comparative genomic hybridisation analysis of keloid tissue in Caucasians suggests possible involvement of HLA-DRB5 in disease pathogenesis. Arch Dermatol Res
15. Shih B, Bayat A (2010) Genetics of keloid scarring. Arch Dermatol Res 302:319-339
16. Shih B, Garside E, McGrouther DA et al (2010) Molecular dissection of abnormal wound healing processes resulting in keloid disease. Wound Repair Regen 18:139-153
17. Strieter RM, Keeley EC, Hughes MA et al (2009) The role of circulating mesenchymal progenitor cells (fibrocytes) in the pathogenesis of pulmonary fibrosis. J Leukoc Biol 86:1111-1118
18. Yang L, Scott PG, Dodd C et al (2005) Identification of fibrocytes in postburn hypertrophic scar. Wound Repair Regen 13:398-404