Opioid analgesics in experimental sepsis: Effects on physiological, biochemical, and haemodynamic parameters

Fundamental and Clinical Pharmacology

Volumn 27, Issue 4, 2013, Pages 347-353

  Nardi, Geisson Marcos ^a   Bet, Angela Cristina ^b   Sordi, Regina ^b   Fernandes, Daniel ^c   Assreuy, Jamil ^b  

^a UNIVERSIDADE DO OESTE DE SANTA CATARINA   (Brazil)

^b FEDERAL UNIVERSITY OF SANTA CATARINA   (Brazil)

^c STATE UNIVERSITY OF PONTA GROSSA   (Brazil)

Author keywords

Analgesia; Cecal ligation and puncture; Fentanyl; Pain; Sepsis; Tramadol

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CREATININE; FENTANYL; INTERLEUKIN 1BETA; LACTIC ACID; MYELOPEROXIDASE; PHENYLEPHRINE; TRAMADOL; UREA;

ANALGESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD VESSEL REACTIVITY; BODY TEMPERATURE; BODY WEIGHT; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; FLUID INTAKE; FOOD INTAKE; HYPOTENSION; LEUKOCYTE; MEAN ARTERIAL PRESSURE; MORTALITY; NONHUMAN; PAIN; PRIORITY JOURNAL; RAT; SEPSIS;

ANALGESICS, OPIOID; ANIMALS; BIOCHEMICAL PHENOMENA; BODY TEMPERATURE; BODY WEIGHT; CARDIOVASCULAR SYSTEM; DISEASE MODELS, ANIMAL; EATING; FEMALE; FENTANYL; HEMODYNAMICS; RATS; SEPSIS; TRAMADOL; WATER;

EID: 84879554498     PISSN: 07673981     EISSN: 14728206     Source Type: Journal    
DOI: 10.1111/j.1472-8206.2012.01041.x     Document Type: Article

References (30)

1. Sessler C.N., Wilhelm W.Analgesia and sedation in the intensive care unit: an overview of the issues. Crit. Care (2008) 12 S1.
2. Epstein J., Breslow M.J.The stress response of critical illness. Crit. Care Clin. (1999) 15 17-33.
3. Fraser G.L., Prato B.S., Riker R.R. et al.Frequency, severity, and treatment of agitation in young versus elderly patients in the ICU. Pharmacotherapy (2000) 20 75-82.
4. Tipps L.B., Coplin W.M., Murry K.R. et al.Safety and feasibility of continuous infusion of remifentanyl in the neurosurgical intensive care unit. Neurosurgery (2000) 46 596-602.
5. Barichello T., Martins M.R., Reinke A. et al.Cognitive impairment in sepsis survivors from cecal ligation and perforation. Crit. Care Med. (2005) 33 221-223.
6. Tuon L., Comim C.M., Antunes M.M. et al.Imipramine reverses the depressive symptoms in sepsis survivor rats. Int. Care Med. (2007) 33 2165-2167.
7. Nakagawa N.K., Jukemura J., Aikawa P. et al. In vivo observation of mesenteric leukocyte-endothelial interactions after cecal ligation/puncture and surgical sepsis source control clinics. Shock (2007) 62 321-326.
8. Hubbard W., Choudhry M., Schwacha M.G. et al.Cecal ligation and puncture. Shock (2005) 24 52-57.
9. Trescot A.M., Datta S., Lee M. et al.Opioid pharmacology. Pain Physiol. (2008) 11 S133-S153.
10. Yao L., Kuai J., Liu X. et al.Pretreatment with fentanyl and propofol attenuates myocardial injury in rabbits with acute hemorrhagic shock. J. Surg. Res. (2009) 155 25-31.
11. Topcu I., Ekici N.Z., Isik R. et al.The effects of tramadol and fentanyl on gastrointestinal motility in septic rats. Anesth. Analg. (2006) 102 876-881.
12. Minneci P.C., Deans K.J., Hansen B. et al.A canine model of septic shock: balancing animal welfare and scientific relevance. Am. J. Physiol. Heart Circ. Physiol. (2007) 293 H2487-H2500.
13. Merx M.W., Liehn E.A., Graf J. et al.Statin treatment after onset of sepsis in a murine model improves survival. Circulation (2005) 112 117-124.
14. Wichterman K.A., Baue A.E., Chaudry I.H.Sepsis and septic shock: a review of laboratory models and a proposal. J. Surg. Res. (1980) 29 189-201.
15. Buras J.A., Holzmann B., Sitkovsky M.Animal models of sepsis: setting the stage. Nat. Rev. Drug Discov. (2005) 4 854-865.
16. Zelcer S., Kolesnikov Y., Kovalyshyn I. et al.Selective potentiation of opioid analgesia by nonsteroidal anti-inflammatory drugs. Brain Res. (2005) 1040 151-156.
17. Guneli E., Yavasoglu Nu K., Apaydin S. et al.Analysis of the antinociceptive effect of systemic administration of tramadol and dexmedetomidine combination on rat models of acute and neuropathic pain. Pharmacol. Biochem. Behav. (2007) 88 9-17.
18. Romero A., Miranda H.F., Puig M.M.Analysis of the opioid-opioid combinations according to the nociceptive stimulus in mice. Pharmacol. Res. (2010) 61 511-518.
19. Fernández-Dueñas V., Poveda R., Fernández A. et al.Fentanyl-trazodone-paracetamol triple drug combination: multimodal analgesia in a mouse model of visceral pain. Pharmacol. Biochem. Behav. (2011) 98 331-336.
20. Brooks H.F., Osabutey C.K., Moss R.F. et al.Caecal ligation and puncture in the rat mimics the pathophysiological changes in human sepsis and causes multi-organ dysfunction. Metab. Brain Dis. (2007) 22 353-373.
21. Hasselgren P.O.Pathways of muscle protein breakdown in injury and sepsis. Curr. Opin. Clin. Nutr. Metab. Care (1999) 2 155-160.
22. Bone R.C., Balk R.A., Cerra F.B. et al.Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine. Chest (1992) 101 1644-1655.
23. Carvalho M., Benjamim C., Santos F.Effect of mast cells depletion on the failure of neutrophil migration during sepsis. Eur. J. Pharmacol. (2005) 525 161-169.
24. Shih C.C., Chen S.J., Chen A. et al.Therapeutic effects of hypertonic saline on peritonitis-induced septic shock with multiple organ dysfunction syndrome in rats. Crit. Care Med. (2008) 36 1864-1872.
25. Fernandes D., Sordi R., Pacheco L.K. et al.Late, but not early, inhibition of soluble guanylate cyclase decreases mortality in a rat sepsis model. J. Pharmacol. Exp. Ther. (2009) 328 991-999.
26. Lam C., Tyml K., Martin C. et al.Microvascular perfusion is impaired in a rat model of normotensive sepsis. J. Clin. Invest. (1994) 94 2077-2083.
27. 2 extraction in sepsis. Am. J. Physiol. Heart Circ. Physiol. (2002) 282 H156-H164.
28. Abraham E., Singer M.Mechanisms of sepsis-induced organ dysfunction. Crit. Care Med. (2007) 35 2408-2416.
29. Molina P.E.Opioids and opiates: analgesia with cardiovascular, haemodynamic and immune implications in critical illness. J. Inter. Med. (2006) 259 138-154.
30. Hugunin K.M.S., Fry C., Shuster K. et al.Effects of tramadol and buprenorphine on selected immunologic factors in a cecal ligation and puncture model. Shock (2010) 34 250-260.