Imipramine reverses the depressive symptoms in sepsis survivor rats

Intensive Care Medicine

Volumn 33, Issue 12, 2007, Pages 2165-2167

  Tuon, Lisiane ^a   Comim, Clarissa M ^a   Antunes, Moises M ^a   Constantino, Larissa S ^a   Machado, Roberta A ^a   Izquierdo, Ivan ^b   Quevedo, João ^a   Dal Pizzol, Felipe ^a  

^a UNIVERSIDADE DO EXTREMO SUL CATARINENSE   (Brazil)

^b PONTIFICAL CATHOLIC UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

Author keywords

Cecal ligation and puncture; Depressive like symptoms; Rat; Sepsis; Survivors

Indexed keywords

CEFTRIAXONE; CLINDAMYCIN; IMIPRAMINE; SODIUM CHLORIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CECUM; CONTROLLED STUDY; CONVALESCENCE; DEPRESSION; EXPERIMENTAL LIGATION; FORCED SWIMMING TEST; IMMOBILIZATION; MALE; NONHUMAN; PERFORATION; PROSPECTIVE STUDY; RAT; SEPSIS; WISTAR RAT;

ANIMALS; ANTIDEPRESSIVE AGENTS, TRICYCLIC; BRAZIL; DEPRESSION; IMIPRAMINE; PROSPECTIVE STUDIES; RATS; SEPSIS; TREATMENT OUTCOME;

EID: 36448960521     PISSN: 03424642     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00134-007-0804-y     Document Type: Article

References (10)

1. Granja C, Dias C, Costa-Pereira A, Sarmento A (2004) Quality of life of survivors from severe sepsis and septic shock may be similar to that of others who survive critical illness. Crit Care Med 8:R91-R98
2. Ritter C, Andrades ME, Reinke A, Menna-Barreto S, Moreira JC, Dal-Pizzol F (2004) Treatment with N-acetylcysteine plus deferoxamine protects rats against oxidative stress and improves survival in sepsis. Crit Care Med 32:342-349
3. Barichello T, Martins MR, Reinke A, Feier G, Ritter C, Quevedo J, Dal-Pizzol F (2005) Cognitive impairment in sepsis survivors from cecal ligation and perforation. Crit Care Med 33:221-223
4. Ritter C, Andrades M, Frota Junior ML, Bonatto F, Pinho RA, Polydoro M, Klamt F, Pinheiro CT, Menna-Barreto SS, Moreira JC, Dal-Pizzol F (2003) Oxidative parameters and mortality in sepsis induced by cecal ligation and perforation. Intensive Care Med 29:1782-1789
5. Barichello T, Martins MR, Reinke A, Constantino LS, Machado RA, Reus GZ, Valvassori SS, Moreira JC, Quevedo J, Dal-Pizzol F (2007) Behavioural deficits in CLP-induced sepsis survivor rats. Braz J Med Biol Res 40:831-837
6. Porsolt RD (1979) Animal model of depression. Biomedicine 30:139-140
7. Viana A, Rego J-C, Poser GV, Ferraz A, Heckler AP, Costentin J, Kuze Rates SM (2005) The antidepressive-like effect of hypericum caprifoliatum Cham & Schlecht (Guttiferae) on forced swimming test results from an inhibition of neuronal monoamine uptake. Neuropharmacology 49:1042-1052
8. Vianna MR, Alonso M, Viola H, Quevedo J, de Paris F, Furman M, de Stein ML, Medina JH, Izquierdo I (2000) Role of hippocampal signaling pathways in long-term memory formation of a nonassociative learning task in the rat. Learn Mem 7:333-340
9. Cryan JF, Valentino RJ, Lucki I (2005) Assessing substrates underlying the behavioral effects of antidepressants using the modified rat forced swimming test. Neurosci Biobehav Rev 29:547-569
10. Gardier AM, Bourin M (2001) Appropriate use of 'knockout' mice as models of depression or models of testing the efficacy of antidepressants. Psychopharmacology (Berl) 153:393-394