-
2
-
-
33749168975
-
ACC/AHA/ESC 2006 guidelines for the management of patients with atrial fibrillation
-
Full text: A report of the American College of Cardiology/American Heart Association Task Force on practice guidelines and the European Society of Cardiology Committee for Practice Guidelines (Writing Committee to Revise the 2001 guidelines for the management of patients with atrial fibrillation) developed in collaboration with the European Heart Rhythm Association and the Heart Rhythm Society
-
Fuster V, Ryden LE, Cannom DS et al. ACC/AHA/ESC 2006 guidelines for the management of patients with atrial fibrillation: full text: a report of the American College of Cardiology/American Heart Association Task Force on practice guidelines and the European Society of Cardiology Committee for Practice Guidelines (Writing Committee to Revise the 2001 guidelines for the management of patients with atrial fibrillation) developed in collaboration with the European Heart Rhythm Association and the Heart Rhythm Society. Europace 2006 8 : 651 745.
-
(2006)
Europace
, vol.8
, pp. 651-745
-
-
Fuster, V.1
Ryden, L.E.2
Cannom, D.S.3
-
3
-
-
4644230820
-
The pharmacology and management of the vitamin K antagonists: The Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy
-
Ansell J, Hirsh J, Poller L, Bussey H, Jacobson A, Hylek E. The pharmacology and management of the vitamin K antagonists: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy. Chest 2004 126 : 2045 335.
-
(2004)
Chest
, vol.126
, pp. 2045-2335
-
-
Ansell, J.1
Hirsh, J.2
Poller, L.3
Bussey, H.4
Jacobson, A.5
Hylek, E.6
-
5
-
-
25844525489
-
Safety, pharmacodynamics, and pharmacokinetics of single doses of BAY59-7939, an oral, direct factor Xa inhibitor
-
Kubitza D, Becka M, Voith B, Zuehlsdorf M, Wensing G. Safety, pharmacodynamics, and pharmacokinetics of single doses of BAY59-7939, an oral, direct factor Xa inhibitor. Clin Pharmacol Ther 2005 78 : 412 21.
-
(2005)
Clin Pharmacol Ther
, vol.78
, pp. 412-421
-
-
Kubitza, D.1
Becka, M.2
Voith, B.3
Zuehlsdorf, M.4
Wensing, G.5
-
6
-
-
34547110933
-
The effect of extreme age, and gender, on the pharmacology and tolerability of rivaroxaban - An oral, direct factor Xa inhibitor
-
(Abstract 905).
-
Kubitza D, Becka M, Mueck W, Zuehlsdorf M. The effect of extreme age, and gender, on the pharmacology and tolerability of rivaroxaban - an oral, direct factor Xa inhibitor (Abstract 905). Blood 2006 107 : 108.
-
(2006)
Blood
, vol.107
, pp. 108
-
-
Kubitza, D.1
Becka, M.2
Mueck, W.3
Zuehlsdorf, M.4
-
7
-
-
22844442726
-
In vitro and in vivo studies of the novel antithrombotic agent BAY 59-7939 - An oral, direct factor Xa inhibitor
-
Perzborn E, Strassburger J, Wilmen A et al. In vitro and in vivo studies of the novel antithrombotic agent BAY 59-7939 - an oral, direct factor Xa inhibitor. J Thromb Haemost 2005 3 : 514 21.
-
(2005)
J Thromb Haemost
, vol.3
, pp. 514-521
-
-
Perzborn, E.1
Strassburger, J.2
Wilmen, A.3
-
8
-
-
45949099359
-
Rivaroxaban versus enoxaparin for thromboprophylaxis after hip arthroplasty
-
Eriksson BI, Borris LC, Friedman RJ et al. Rivaroxaban versus enoxaparin for thromboprophylaxis after hip arthroplasty. N Engl J Med 2008 358 : 2765 75.
-
(2008)
N Engl J Med
, vol.358
, pp. 2765-2775
-
-
Eriksson, B.I.1
Borris, L.C.2
Friedman, R.J.3
-
9
-
-
46049106502
-
Extended duration rivaroxaban versus short-term enoxaparin for the prevention of venous thromboembolism after total hip arthroplasty: A double-blind, randomised controlled study
-
Kakkar AK, Brenner B, Dahl OE et al. Extended duration rivaroxaban versus short-term enoxaparin for the prevention of venous thromboembolism after total hip arthroplasty: a double-blind, randomised controlled study. Lancet 2008 371 : 31 9.
-
(2008)
Lancet
, vol.371
, pp. 31-39
-
-
Kakkar, A.K.1
Brenner, B.2
Dahl, O.E.3
-
10
-
-
45949103416
-
Rivaroxaban versus enoxaparin for thromboprophylaxis after total knee arthroplasty
-
Lassen MR, Ageno W, Borris LC et al. Rivaroxaban versus enoxaparin for thromboprophylaxis after total knee arthroplasty. N Engl J Med 2008 358 : 2776 86.
-
(2008)
N Engl J Med
, vol.358
, pp. 2776-2786
-
-
Lassen, M.R.1
Ageno, W.2
Borris, L.C.3
-
11
-
-
34447317298
-
Treatment of proximal deep-vein thrombosis with the oral direct factor Xa inhibitor rivaroxaban (BAY 59-7939): The ODIXa-DVT (Oral Direct Factor Xa Inhibitor BAY 59-7939 in patients with Acute Symptomatic Deep-Vein Thrombosis) study
-
Agnelli G, Gallus A, Goldhaber SZ et al. Treatment of proximal deep-vein thrombosis with the oral direct factor Xa inhibitor rivaroxaban (BAY 59-7939): the ODIXa-DVT (Oral Direct Factor Xa Inhibitor BAY 59-7939 in patients with Acute Symptomatic Deep-Vein Thrombosis) study. Circulation 2007 116 : 180 7.
-
(2007)
Circulation
, vol.116
, pp. 180-187
-
-
Agnelli, G.1
Gallus, A.2
Goldhaber, S.Z.3
-
12
-
-
53849123533
-
A dose-ranging study evaluating once-daily oral administration of the factor Xa inhibitor rivaroxaban in the treatment of patients with acute symptomatic deep vein thrombosis: The Einstein-DVT Dose-Ranging Study
-
on behalf of the Einstein-DVT Dose-Ranging Study Investigators.
-
Buller HR, Lensing AWA, Prins MH et al., on behalf of the Einstein-DVT Dose-Ranging Study Investigators. A dose-ranging study evaluating once-daily oral administration of the factor Xa inhibitor rivaroxaban in the treatment of patients with acute symptomatic deep vein thrombosis: the Einstein-DVT Dose-Ranging Study. Blood 2008 112 : 2242 7.
-
(2008)
Blood
, vol.112
, pp. 2242-2247
-
-
Buller, H.R.1
Lensing, A.W.A.2
Prins, M.H.3
-
13
-
-
36348964994
-
Preclinical pharmacokinetic and metabolism of apixaban, a potent and selective Factor Xa inhibitor
-
Abstract 901)
-
He K, He B, Grace JE et al. Preclinical pharmacokinetic and metabolism of apixaban, a potent and selective Factor Xa inhibitor (Abstract 901) Blood 2006 107 : 108.
-
(2006)
Blood
, vol.107
, pp. 108
-
-
He, K.1
He, B.2
Grace, J.E.3
-
14
-
-
36348978071
-
The efficacy and safety of apixaban, an oral, direct factor Xa inhibitor, as thromboprophylaxis in patients following total knee replacement
-
Lassen MR, Davidson BL, Gallus A, Pineo G, Ansell J, Deitchman D. The efficacy and safety of apixaban, an oral, direct factor Xa inhibitor, as thromboprophylaxis in patients following total knee replacement. J Thromb Haemost 2007 5 : 2368 75.
-
(2007)
J Thromb Haemost
, vol.5
, pp. 2368-2375
-
-
Lassen, M.R.1
Davidson, B.L.2
Gallus, A.3
Pineo, G.4
Ansell, J.5
Deitchman, D.6
-
15
-
-
47649098524
-
Efficacy and safety of the oral direct factor Xa inhibitor apixaban for symptomatic deep vein thrombosis. the Botticelli DVT dose-ranging study
-
Botticelli Investigators, Writing Committee.
-
Buller H, Deitchman D, Prins M, Segers A, Botticelli Investigators, Writing Committee. Efficacy and safety of the oral direct factor Xa inhibitor apixaban for symptomatic deep vein thrombosis. The Botticelli DVT dose-ranging study. J Thromb Haemost 2008 6 : 1313 8.
-
(2008)
J Thromb Haemost
, vol.6
, pp. 1313-1318
-
-
Buller, H.1
Deitchman, D.2
Prins, M.3
Segers, A.4
-
16
-
-
62549137247
-
-
Bristol-Myers Squibb and Pfizer. (press release), 26 August 2008. (accessed December 2008).
-
Bristol-Myers Squibb and Pfizer. Bristol-Myers Squibb and Pfizer provide update on apixaban clinical development program (press release), 26 August 2008. http://www.prdomain.com/companies/P/Pfizer/newsreleases/20089361638.htm (accessed December 2008).
-
Bristol-Myers Squibb and Pfizer Provide Update on Apixaban Clinical Development Program
-
-
-
17
-
-
62549137247
-
-
Bristol-Myers Squibb and Pfizer. (press release), 26 August 2008. (accessed December 2008).
-
Bristol-Myers Squibb and Pfizer. Bristol-Myers Squibb and Pfizer provide update on apixaban clinical development program (press release), 26 August 2008. http://www.pfizer.com/news/press-releases/pfizer-press-releases.jsp?rssUrl= http://mediaroom.pfizer.com/portal/site/pfizer/index.jsp?ndmViewId= news-view&ndmConfigId=1010794&newsId=20080826006372&newsLang=en (accessed December 2008).
-
Bristol-Myers Squibb and Pfizer Provide Update on Apixaban Clinical Development Program
-
-
-
18
-
-
34249337290
-
Biochemical and pharmacological profiles of YM150, an oral direct Factor Xa inhibitor
-
(Abstract 911).
-
Iwatsuki Y, Shigenaga T, Moritani Y et al. Biochemical and pharmacological profiles of YM150, an oral direct Factor Xa inhibitor (Abstract 911). Blood 2006 107 : 108.
-
(2006)
Blood
, vol.107
, pp. 108
-
-
Iwatsuki, Y.1
Shigenaga, T.2
Moritani, Y.3
-
19
-
-
34447639584
-
A dose escalation study of YM150, an oral direct factor Xa inhibitor, in the prevention of venous thromboembolism in elective primary hip replacement surgery
-
Eriksson BI, Turpie AG, Lassen MR et al. A dose escalation study of YM150, an oral direct factor Xa inhibitor, in the prevention of venous thromboembolism in elective primary hip replacement surgery. J Thromb Haemost 2007 5 : 1660 5.
-
(2007)
J Thromb Haemost
, vol.5
, pp. 1660-1665
-
-
Eriksson, B.I.1
Turpie, A.G.2
Lassen, M.R.3
-
20
-
-
34147141000
-
A phase II study of the oral factor Xa inhibitor LY517717 for the prevention of venous thromboembolism after hip or knee replacement
-
Agnelli G, Haas S, Ginsberg JS, Krueger KA, Dmitrienko A, Brandt JT. A phase II study of the oral factor Xa inhibitor LY517717 for the prevention of venous thromboembolism after hip or knee replacement. J Thromb Haemost 2007 5 : 746 53.
-
(2007)
J Thromb Haemost
, vol.5
, pp. 746-753
-
-
Agnelli, G.1
Haas, S.2
Ginsberg, J.S.3
Krueger, K.A.4
Dmitrienko, A.5
Brandt, J.T.6
-
21
-
-
33745757105
-
A phase-1 study to assess the antithrombotic properties of DU-176b: An orally active direct factor-Xa inhibitor
-
(Abstract 908-161).
-
Zafar MU, Gaztanga J, Velez M et al. A phase-1 study to assess the antithrombotic properties of DU-176b: an orally active direct factor-Xa inhibitor (Abstract 908-161). J Am Coll Cardiol 2006 47 : 288A.
-
(2006)
J Am Coll Cardiol
, vol.47
-
-
Zafar, M.U.1
Gaztanga, J.2
Velez, M.3
-
22
-
-
4644349854
-
Oral direct thrombin inhibition: An effective and novel approach for venous thromboembolism
-
Haas S. Oral direct thrombin inhibition: an effective and novel approach for venous thromboembolism. Drugs 2004 64 : 7 16.
-
(2004)
Drugs
, vol.64
, pp. 7-16
-
-
Haas, S.1
-
24
-
-
13444278653
-
Ximelagatran vs low-molecular-weight heparin and warfarin for the treatment of deep vein thrombosis: A randomized trial
-
Fiessinger JN, Huisman MV, Davidson BL et al. Ximelagatran vs low-molecular-weight heparin and warfarin for the treatment of deep vein thrombosis: a randomized trial. JAMA 2005 293 : 681 9.
-
(2005)
JAMA
, vol.293
, pp. 681-689
-
-
Fiessinger, J.N.1
Huisman, M.V.2
Davidson, B.L.3
-
25
-
-
0038185371
-
Ximelagatran versus warfarin for stroke prevention in patients with nonvalvular atrial fibrillation. SPORTIF II: A dose-guiding, tolerability and safety study
-
SPORTIF II Investigators.
-
Petersen P, Grind M, Adler J, SPORTIF II Investigators. Ximelagatran versus warfarin for stroke prevention in patients with nonvalvular atrial fibrillation. SPORTIF II: a dose-guiding, tolerability and safety study. J Am Coll Cardiol 2003 41 : 1445 51.
-
(2003)
J Am Coll Cardiol
, vol.41
, pp. 1445-1451
-
-
Petersen, P.1
Grind, M.2
Adler, J.3
-
26
-
-
0345414673
-
Executive Steering Committee on behalf of the SPORTIF III Investigators. Stroke prevention with the oral direct thrombin inhibitor ximelagatran compared with warfarin in patients with non-valvular atrial fibrillation (SPORTIF III): Randomized controlled trial
-
Olsson S. Executive Steering Committee on behalf of the SPORTIF III Investigators. Stroke prevention with the oral direct thrombin inhibitor ximelagatran compared with warfarin in patients with non-valvular atrial fibrillation (SPORTIF III): randomized controlled trial. Lancet 2003 362 : 1691 8.
-
(2003)
Lancet
, vol.362
, pp. 1691-1698
-
-
Olsson, S.1
-
27
-
-
13444309949
-
Ximelagatran versus warfarin for stroke prevention in patients with nonvalvular atrial fibrillation
-
SPORTIF Executive Committee for the SPORTIF V Investigators.
-
SPORTIF Executive Committee for the SPORTIF V Investigators. Ximelagatran versus warfarin for stroke prevention in patients with nonvalvular atrial fibrillation. JAMA 2005 293 : 690 8.
-
(2005)
JAMA
, vol.293
, pp. 690-698
-
-
-
28
-
-
0041829444
-
ESTEEM Investigators Oral ximelagatran for secondary prophylaxis after myocardial infarction: The ESTEEM randomized controlled trial
-
Wallentin L, Wilcox RG, Weaver WD et al. ESTEEM Investigators Oral ximelagatran for secondary prophylaxis after myocardial infarction: the ESTEEM randomized controlled trial. Lancet 2003 362 : 789 97.
-
(2003)
Lancet
, vol.362
, pp. 789-797
-
-
Wallentin, L.1
Wilcox, R.G.2
Weaver, W.D.3
-
30
-
-
57849143295
-
Safety assessment of new antithrombotic agents: Lessons from the EXTEND study on ximelagatran
-
Agnelli G, Eriksson BI, Cohen AT et al. Safety assessment of new antithrombotic agents: lessons from the EXTEND study on ximelagatran. Thromb Res 2009 123 : 488 97.
-
(2009)
Thromb Res
, vol.123
, pp. 488-497
-
-
Agnelli, G.1
Eriksson, B.I.2
Cohen, A.T.3
-
31
-
-
62549123947
-
-
(accessed December 2008).
-
AstraZeneca provide update on Ximelagatran. http://www. astrazenecaclinicaltrials.com/article/528850.aspx (accessed December 2008).
-
AstraZeneca Provide Update on Ximelagatran
-
-
-
32
-
-
27144511749
-
Ximelagatran for the secondary prevention of venous thromboembolism: A complementary follow-up analysis of the THRIVE III Study
-
Schulman S, Lundstrom T, Walander K, Billing Clason S, Eriksson H. Ximelagatran for the secondary prevention of venous thromboembolism: a complementary follow-up analysis of the THRIVE III Study. Thromb Haemost 2005 94 : 820 4.
-
(2005)
Thromb Haemost
, vol.94
, pp. 820-824
-
-
Schulman, S.1
Lundstrom, T.2
Walander, K.3
Billing Clason, S.4
Eriksson, H.5
-
33
-
-
34548031359
-
The pharmacokinetics, pharmacodynamics and tolerability of dabigatran etexilate, a new oral direct thrombin inhibitor, in healthy male subjects
-
Stangier J, Rathgen K, Stahle H, Gansser D, Roth W. The pharmacokinetics, pharmacodynamics and tolerability of dabigatran etexilate, a new oral direct thrombin inhibitor, in healthy male subjects. Br J Clin Pharmacol 2007 64 : 292 303.
-
(2007)
Br J Clin Pharmacol
, vol.64
, pp. 292-303
-
-
Stangier, J.1
Rathgen, K.2
Stahle, H.3
Gansser, D.4
Roth, W.5
-
34
-
-
13244266944
-
Dose escalating safety study of a new oral direct thrombin inhibitor, dabigatran etexilate, in patients undergoing total hip replacement: BISTRO i
-
Eriksson BI, Dahl OE, Ahnfelt L et al. Dose escalating safety study of a new oral direct thrombin inhibitor, dabigatran etexilate, in patients undergoing total hip replacement: BISTRO I. J Thromb Haemost 2004 2 : 1573 80.
-
(2004)
J Thromb Haemost
, vol.2
, pp. 1573-1580
-
-
Eriksson, B.I.1
Dahl, O.E.2
Ahnfelt, L.3
-
35
-
-
0035133938
-
Sixth ACCP Consensus Conference on Antithrombotic therapy. Prevention of venous thromboembolism
-
Geerts WH, Heit JA, Clagett GP et al. Sixth ACCP Consensus Conference on Antithrombotic therapy. Prevention of venous thromboembolism. Chest 2001 119 : 132S 75S.
-
(2001)
Chest
, vol.119
, pp. 132-175
-
-
Geerts, W.H.1
Heit, J.A.2
Clagett, G.P.3
-
36
-
-
17644409026
-
A new oral direct thrombin inhibitor, dabigatran etexilate, compared with enoxaparin for prevention of thromboembolic events following total hip or knee replacement: The BISTRO II randomized trial
-
Erisksson BI, Dahl OE, Buller HR et al. A new oral direct thrombin inhibitor, dabigatran etexilate, compared with enoxaparin for prevention of thromboembolic events following total hip or knee replacement: the BISTRO II randomized trial. J Thromb Haemost 2005 3 : 103 11.
-
(2005)
J Thromb Haemost
, vol.3
, pp. 103-111
-
-
Erisksson, B.I.1
Dahl, O.E.2
Buller, H.R.3
-
37
-
-
35348879239
-
Dabigatran with or without concomitant aspirin compared with warfarin alone in patients with nonvalvular atrial fibrillation (PETRO Study)
-
Ezekowitz MD, Reilly PA, Nehmiz G et al. Dabigatran with or without concomitant aspirin compared with warfarin alone in patients with nonvalvular atrial fibrillation (PETRO Study). Am J Cardiol 2007 100 : 1419 26.
-
(2007)
Am J Cardiol
, vol.100
, pp. 1419-1426
-
-
Ezekowitz, M.D.1
Reilly, P.A.2
Nehmiz, G.3
-
38
-
-
34548575058
-
Dabigatran etexilate versus enoxaparin for prevention of venous thromboembolism after total hip replacement: A randomized, double-blind, non-inferiority trial
-
Eriksson BI, Dahl OE, Rosencher N et al. Dabigatran etexilate versus enoxaparin for prevention of venous thromboembolism after total hip replacement: a randomized, double-blind, non-inferiority trial. Lancet 2007 370 : 949 56.
-
(2007)
Lancet
, vol.370
, pp. 949-956
-
-
Eriksson, B.I.1
Dahl, O.E.2
Rosencher, N.3
-
39
-
-
35449007749
-
Oral dabigatran etexilate vs. subcutaneous enoxaparin for the prevention of venous thromboembolism after total knee replacement: The RE-MODEL randomized trial
-
Eriksson BI, Dahl OE, Rosencher N et al. Oral dabigatran etexilate vs. subcutaneous enoxaparin for the prevention of venous thromboembolism after total knee replacement: the RE-MODEL randomized trial. J Thromb Haemost 2007 5 : 2178 85.
-
(2007)
J Thromb Haemost
, vol.5
, pp. 2178-2185
-
-
Eriksson, B.I.1
Dahl, O.E.2
Rosencher, N.3
-
40
-
-
57649123692
-
The oral thrombin inhibitor dabigatran etexilate vs the North American enoxaparin regimen for the prevention of venous thromboembolism after knee arthroplasty surgery
-
The RE-MOBILIZE Writing Committee.
-
The RE-MOBILIZE Writing Committee. The oral thrombin inhibitor dabigatran etexilate vs the North American enoxaparin regimen for the prevention of venous thromboembolism after knee arthroplasty surgery. J Arthroplasty 2009 24 : 1 9.
-
(2009)
J Arthroplasty
, vol.24
, pp. 1-9
-
-
-
41
-
-
62549148456
-
-
ClinicalTrials.gov Identifier: NCT00808067. (accessed December 2008).
-
ClinicalTrials.gov Identifier: NCT00808067. http://clinicaltrials.gov/ ct2/show/NCT00808067 (accessed December 2008).
-
-
-
|