메뉴 건너뛰기




Volumn 63, Issue 4, 2009, Pages 630-641

Novel oral anticoagulants

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; ANTIDOTE; ANTITHROMBOCYTIC AGENT; APIXABAN; ATI 5923; AZD 0837; BETRIXABAN; BLOOD CLOTTING FACTOR 10A; BLOOD CLOTTING FACTOR 10A INHIBITOR; DABIGATRAN; DABIGATRAN ETEXILATE; DU 176B; ENOXAPARIN; FONDAPARINUX; IDRAPARINUX; KETOCONAZOLE; LOW MOLECULAR WEIGHT HEPARIN; MACROLIDE; MELAGATRAN; N [2 [4 (1 METHYL 4 PIPERIDINYL) 1 PIPERAZINYL] 2 OXO 1 PHENYLETHYL] 1H INDOLE 6 CARBOXAMIDE; PROTEINASE INHIBITOR; PROTON PUMP INHIBITOR; RECOMBINANT BLOOD CLOTTING FACTOR 7A; RIVAROXABAN; THROMBIN; THROMBIN INHIBITOR; UNCLASSIFIED DRUG; WARFARIN; XIMELAGATRAN; YM 150;

EID: 62549128155     PISSN: 13685031     EISSN: 17421241     Source Type: Journal    
DOI: 10.1111/j.1742-1241.2009.02011.x     Document Type: Review
Times cited : (31)

References (41)
  • 2
    • 33749168975 scopus 로고    scopus 로고
    • ACC/AHA/ESC 2006 guidelines for the management of patients with atrial fibrillation
    • Full text: A report of the American College of Cardiology/American Heart Association Task Force on practice guidelines and the European Society of Cardiology Committee for Practice Guidelines (Writing Committee to Revise the 2001 guidelines for the management of patients with atrial fibrillation) developed in collaboration with the European Heart Rhythm Association and the Heart Rhythm Society
    • Fuster V, Ryden LE, Cannom DS et al. ACC/AHA/ESC 2006 guidelines for the management of patients with atrial fibrillation: full text: a report of the American College of Cardiology/American Heart Association Task Force on practice guidelines and the European Society of Cardiology Committee for Practice Guidelines (Writing Committee to Revise the 2001 guidelines for the management of patients with atrial fibrillation) developed in collaboration with the European Heart Rhythm Association and the Heart Rhythm Society. Europace 2006 8 : 651 745.
    • (2006) Europace , vol.8 , pp. 651-745
    • Fuster, V.1    Ryden, L.E.2    Cannom, D.S.3
  • 3
    • 4644230820 scopus 로고    scopus 로고
    • The pharmacology and management of the vitamin K antagonists: The Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy
    • Ansell J, Hirsh J, Poller L, Bussey H, Jacobson A, Hylek E. The pharmacology and management of the vitamin K antagonists: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy. Chest 2004 126 : 2045 335.
    • (2004) Chest , vol.126 , pp. 2045-2335
    • Ansell, J.1    Hirsh, J.2    Poller, L.3    Bussey, H.4    Jacobson, A.5    Hylek, E.6
  • 5
    • 25844525489 scopus 로고    scopus 로고
    • Safety, pharmacodynamics, and pharmacokinetics of single doses of BAY59-7939, an oral, direct factor Xa inhibitor
    • Kubitza D, Becka M, Voith B, Zuehlsdorf M, Wensing G. Safety, pharmacodynamics, and pharmacokinetics of single doses of BAY59-7939, an oral, direct factor Xa inhibitor. Clin Pharmacol Ther 2005 78 : 412 21.
    • (2005) Clin Pharmacol Ther , vol.78 , pp. 412-421
    • Kubitza, D.1    Becka, M.2    Voith, B.3    Zuehlsdorf, M.4    Wensing, G.5
  • 6
    • 34547110933 scopus 로고    scopus 로고
    • The effect of extreme age, and gender, on the pharmacology and tolerability of rivaroxaban - An oral, direct factor Xa inhibitor
    • (Abstract 905).
    • Kubitza D, Becka M, Mueck W, Zuehlsdorf M. The effect of extreme age, and gender, on the pharmacology and tolerability of rivaroxaban - an oral, direct factor Xa inhibitor (Abstract 905). Blood 2006 107 : 108.
    • (2006) Blood , vol.107 , pp. 108
    • Kubitza, D.1    Becka, M.2    Mueck, W.3    Zuehlsdorf, M.4
  • 7
    • 22844442726 scopus 로고    scopus 로고
    • In vitro and in vivo studies of the novel antithrombotic agent BAY 59-7939 - An oral, direct factor Xa inhibitor
    • Perzborn E, Strassburger J, Wilmen A et al. In vitro and in vivo studies of the novel antithrombotic agent BAY 59-7939 - an oral, direct factor Xa inhibitor. J Thromb Haemost 2005 3 : 514 21.
    • (2005) J Thromb Haemost , vol.3 , pp. 514-521
    • Perzborn, E.1    Strassburger, J.2    Wilmen, A.3
  • 8
    • 45949099359 scopus 로고    scopus 로고
    • Rivaroxaban versus enoxaparin for thromboprophylaxis after hip arthroplasty
    • Eriksson BI, Borris LC, Friedman RJ et al. Rivaroxaban versus enoxaparin for thromboprophylaxis after hip arthroplasty. N Engl J Med 2008 358 : 2765 75.
    • (2008) N Engl J Med , vol.358 , pp. 2765-2775
    • Eriksson, B.I.1    Borris, L.C.2    Friedman, R.J.3
  • 9
    • 46049106502 scopus 로고    scopus 로고
    • Extended duration rivaroxaban versus short-term enoxaparin for the prevention of venous thromboembolism after total hip arthroplasty: A double-blind, randomised controlled study
    • Kakkar AK, Brenner B, Dahl OE et al. Extended duration rivaroxaban versus short-term enoxaparin for the prevention of venous thromboembolism after total hip arthroplasty: a double-blind, randomised controlled study. Lancet 2008 371 : 31 9.
    • (2008) Lancet , vol.371 , pp. 31-39
    • Kakkar, A.K.1    Brenner, B.2    Dahl, O.E.3
  • 10
    • 45949103416 scopus 로고    scopus 로고
    • Rivaroxaban versus enoxaparin for thromboprophylaxis after total knee arthroplasty
    • Lassen MR, Ageno W, Borris LC et al. Rivaroxaban versus enoxaparin for thromboprophylaxis after total knee arthroplasty. N Engl J Med 2008 358 : 2776 86.
    • (2008) N Engl J Med , vol.358 , pp. 2776-2786
    • Lassen, M.R.1    Ageno, W.2    Borris, L.C.3
  • 11
    • 34447317298 scopus 로고    scopus 로고
    • Treatment of proximal deep-vein thrombosis with the oral direct factor Xa inhibitor rivaroxaban (BAY 59-7939): The ODIXa-DVT (Oral Direct Factor Xa Inhibitor BAY 59-7939 in patients with Acute Symptomatic Deep-Vein Thrombosis) study
    • Agnelli G, Gallus A, Goldhaber SZ et al. Treatment of proximal deep-vein thrombosis with the oral direct factor Xa inhibitor rivaroxaban (BAY 59-7939): the ODIXa-DVT (Oral Direct Factor Xa Inhibitor BAY 59-7939 in patients with Acute Symptomatic Deep-Vein Thrombosis) study. Circulation 2007 116 : 180 7.
    • (2007) Circulation , vol.116 , pp. 180-187
    • Agnelli, G.1    Gallus, A.2    Goldhaber, S.Z.3
  • 12
    • 53849123533 scopus 로고    scopus 로고
    • A dose-ranging study evaluating once-daily oral administration of the factor Xa inhibitor rivaroxaban in the treatment of patients with acute symptomatic deep vein thrombosis: The Einstein-DVT Dose-Ranging Study
    • on behalf of the Einstein-DVT Dose-Ranging Study Investigators.
    • Buller HR, Lensing AWA, Prins MH et al., on behalf of the Einstein-DVT Dose-Ranging Study Investigators. A dose-ranging study evaluating once-daily oral administration of the factor Xa inhibitor rivaroxaban in the treatment of patients with acute symptomatic deep vein thrombosis: the Einstein-DVT Dose-Ranging Study. Blood 2008 112 : 2242 7.
    • (2008) Blood , vol.112 , pp. 2242-2247
    • Buller, H.R.1    Lensing, A.W.A.2    Prins, M.H.3
  • 13
    • 36348964994 scopus 로고    scopus 로고
    • Preclinical pharmacokinetic and metabolism of apixaban, a potent and selective Factor Xa inhibitor
    • Abstract 901)
    • He K, He B, Grace JE et al. Preclinical pharmacokinetic and metabolism of apixaban, a potent and selective Factor Xa inhibitor (Abstract 901) Blood 2006 107 : 108.
    • (2006) Blood , vol.107 , pp. 108
    • He, K.1    He, B.2    Grace, J.E.3
  • 14
    • 36348978071 scopus 로고    scopus 로고
    • The efficacy and safety of apixaban, an oral, direct factor Xa inhibitor, as thromboprophylaxis in patients following total knee replacement
    • Lassen MR, Davidson BL, Gallus A, Pineo G, Ansell J, Deitchman D. The efficacy and safety of apixaban, an oral, direct factor Xa inhibitor, as thromboprophylaxis in patients following total knee replacement. J Thromb Haemost 2007 5 : 2368 75.
    • (2007) J Thromb Haemost , vol.5 , pp. 2368-2375
    • Lassen, M.R.1    Davidson, B.L.2    Gallus, A.3    Pineo, G.4    Ansell, J.5    Deitchman, D.6
  • 15
    • 47649098524 scopus 로고    scopus 로고
    • Efficacy and safety of the oral direct factor Xa inhibitor apixaban for symptomatic deep vein thrombosis. the Botticelli DVT dose-ranging study
    • Botticelli Investigators, Writing Committee.
    • Buller H, Deitchman D, Prins M, Segers A, Botticelli Investigators, Writing Committee. Efficacy and safety of the oral direct factor Xa inhibitor apixaban for symptomatic deep vein thrombosis. The Botticelli DVT dose-ranging study. J Thromb Haemost 2008 6 : 1313 8.
    • (2008) J Thromb Haemost , vol.6 , pp. 1313-1318
    • Buller, H.1    Deitchman, D.2    Prins, M.3    Segers, A.4
  • 16
    • 62549137247 scopus 로고    scopus 로고
    • Bristol-Myers Squibb and Pfizer. (press release), 26 August 2008. (accessed December 2008).
    • Bristol-Myers Squibb and Pfizer. Bristol-Myers Squibb and Pfizer provide update on apixaban clinical development program (press release), 26 August 2008. http://www.prdomain.com/companies/P/Pfizer/newsreleases/20089361638.htm (accessed December 2008).
    • Bristol-Myers Squibb and Pfizer Provide Update on Apixaban Clinical Development Program
  • 17
    • 62549137247 scopus 로고    scopus 로고
    • Bristol-Myers Squibb and Pfizer. (press release), 26 August 2008. (accessed December 2008).
    • Bristol-Myers Squibb and Pfizer. Bristol-Myers Squibb and Pfizer provide update on apixaban clinical development program (press release), 26 August 2008. http://www.pfizer.com/news/press-releases/pfizer-press-releases.jsp?rssUrl= http://mediaroom.pfizer.com/portal/site/pfizer/index.jsp?ndmViewId= news-view&ndmConfigId=1010794&newsId=20080826006372&newsLang=en (accessed December 2008).
    • Bristol-Myers Squibb and Pfizer Provide Update on Apixaban Clinical Development Program
  • 18
    • 34249337290 scopus 로고    scopus 로고
    • Biochemical and pharmacological profiles of YM150, an oral direct Factor Xa inhibitor
    • (Abstract 911).
    • Iwatsuki Y, Shigenaga T, Moritani Y et al. Biochemical and pharmacological profiles of YM150, an oral direct Factor Xa inhibitor (Abstract 911). Blood 2006 107 : 108.
    • (2006) Blood , vol.107 , pp. 108
    • Iwatsuki, Y.1    Shigenaga, T.2    Moritani, Y.3
  • 19
    • 34447639584 scopus 로고    scopus 로고
    • A dose escalation study of YM150, an oral direct factor Xa inhibitor, in the prevention of venous thromboembolism in elective primary hip replacement surgery
    • Eriksson BI, Turpie AG, Lassen MR et al. A dose escalation study of YM150, an oral direct factor Xa inhibitor, in the prevention of venous thromboembolism in elective primary hip replacement surgery. J Thromb Haemost 2007 5 : 1660 5.
    • (2007) J Thromb Haemost , vol.5 , pp. 1660-1665
    • Eriksson, B.I.1    Turpie, A.G.2    Lassen, M.R.3
  • 20
    • 34147141000 scopus 로고    scopus 로고
    • A phase II study of the oral factor Xa inhibitor LY517717 for the prevention of venous thromboembolism after hip or knee replacement
    • Agnelli G, Haas S, Ginsberg JS, Krueger KA, Dmitrienko A, Brandt JT. A phase II study of the oral factor Xa inhibitor LY517717 for the prevention of venous thromboembolism after hip or knee replacement. J Thromb Haemost 2007 5 : 746 53.
    • (2007) J Thromb Haemost , vol.5 , pp. 746-753
    • Agnelli, G.1    Haas, S.2    Ginsberg, J.S.3    Krueger, K.A.4    Dmitrienko, A.5    Brandt, J.T.6
  • 21
    • 33745757105 scopus 로고    scopus 로고
    • A phase-1 study to assess the antithrombotic properties of DU-176b: An orally active direct factor-Xa inhibitor
    • (Abstract 908-161).
    • Zafar MU, Gaztanga J, Velez M et al. A phase-1 study to assess the antithrombotic properties of DU-176b: an orally active direct factor-Xa inhibitor (Abstract 908-161). J Am Coll Cardiol 2006 47 : 288A.
    • (2006) J Am Coll Cardiol , vol.47
    • Zafar, M.U.1    Gaztanga, J.2    Velez, M.3
  • 22
    • 4644349854 scopus 로고    scopus 로고
    • Oral direct thrombin inhibition: An effective and novel approach for venous thromboembolism
    • Haas S. Oral direct thrombin inhibition: an effective and novel approach for venous thromboembolism. Drugs 2004 64 : 7 16.
    • (2004) Drugs , vol.64 , pp. 7-16
    • Haas, S.1
  • 23
    • 16644396040 scopus 로고    scopus 로고
    • New blood thinner offers first potential alternative in 50 years: Ximelagatran
    • Nutescu EA, Helgason CM, Briller J, Schwertz DW. New blood thinner offers first potential alternative in 50 years: Ximelagatran. J Cardiovasc Nurs 2004 19 : 374 83.
    • (2004) J Cardiovasc Nurs , vol.19 , pp. 374-383
    • Nutescu, E.A.1    Helgason, C.M.2    Briller, J.3    Schwertz, D.W.4
  • 24
    • 13444278653 scopus 로고    scopus 로고
    • Ximelagatran vs low-molecular-weight heparin and warfarin for the treatment of deep vein thrombosis: A randomized trial
    • Fiessinger JN, Huisman MV, Davidson BL et al. Ximelagatran vs low-molecular-weight heparin and warfarin for the treatment of deep vein thrombosis: a randomized trial. JAMA 2005 293 : 681 9.
    • (2005) JAMA , vol.293 , pp. 681-689
    • Fiessinger, J.N.1    Huisman, M.V.2    Davidson, B.L.3
  • 25
    • 0038185371 scopus 로고    scopus 로고
    • Ximelagatran versus warfarin for stroke prevention in patients with nonvalvular atrial fibrillation. SPORTIF II: A dose-guiding, tolerability and safety study
    • SPORTIF II Investigators.
    • Petersen P, Grind M, Adler J, SPORTIF II Investigators. Ximelagatran versus warfarin for stroke prevention in patients with nonvalvular atrial fibrillation. SPORTIF II: a dose-guiding, tolerability and safety study. J Am Coll Cardiol 2003 41 : 1445 51.
    • (2003) J Am Coll Cardiol , vol.41 , pp. 1445-1451
    • Petersen, P.1    Grind, M.2    Adler, J.3
  • 26
    • 0345414673 scopus 로고    scopus 로고
    • Executive Steering Committee on behalf of the SPORTIF III Investigators. Stroke prevention with the oral direct thrombin inhibitor ximelagatran compared with warfarin in patients with non-valvular atrial fibrillation (SPORTIF III): Randomized controlled trial
    • Olsson S. Executive Steering Committee on behalf of the SPORTIF III Investigators. Stroke prevention with the oral direct thrombin inhibitor ximelagatran compared with warfarin in patients with non-valvular atrial fibrillation (SPORTIF III): randomized controlled trial. Lancet 2003 362 : 1691 8.
    • (2003) Lancet , vol.362 , pp. 1691-1698
    • Olsson, S.1
  • 27
    • 13444309949 scopus 로고    scopus 로고
    • Ximelagatran versus warfarin for stroke prevention in patients with nonvalvular atrial fibrillation
    • SPORTIF Executive Committee for the SPORTIF V Investigators.
    • SPORTIF Executive Committee for the SPORTIF V Investigators. Ximelagatran versus warfarin for stroke prevention in patients with nonvalvular atrial fibrillation. JAMA 2005 293 : 690 8.
    • (2005) JAMA , vol.293 , pp. 690-698
  • 28
    • 0041829444 scopus 로고    scopus 로고
    • ESTEEM Investigators Oral ximelagatran for secondary prophylaxis after myocardial infarction: The ESTEEM randomized controlled trial
    • Wallentin L, Wilcox RG, Weaver WD et al. ESTEEM Investigators Oral ximelagatran for secondary prophylaxis after myocardial infarction: the ESTEEM randomized controlled trial. Lancet 2003 362 : 789 97.
    • (2003) Lancet , vol.362 , pp. 789-797
    • Wallentin, L.1    Wilcox, R.G.2    Weaver, W.D.3
  • 30
    • 57849143295 scopus 로고    scopus 로고
    • Safety assessment of new antithrombotic agents: Lessons from the EXTEND study on ximelagatran
    • Agnelli G, Eriksson BI, Cohen AT et al. Safety assessment of new antithrombotic agents: lessons from the EXTEND study on ximelagatran. Thromb Res 2009 123 : 488 97.
    • (2009) Thromb Res , vol.123 , pp. 488-497
    • Agnelli, G.1    Eriksson, B.I.2    Cohen, A.T.3
  • 31
    • 62549123947 scopus 로고    scopus 로고
    • (accessed December 2008).
    • AstraZeneca provide update on Ximelagatran. http://www. astrazenecaclinicaltrials.com/article/528850.aspx (accessed December 2008).
    • AstraZeneca Provide Update on Ximelagatran
  • 32
    • 27144511749 scopus 로고    scopus 로고
    • Ximelagatran for the secondary prevention of venous thromboembolism: A complementary follow-up analysis of the THRIVE III Study
    • Schulman S, Lundstrom T, Walander K, Billing Clason S, Eriksson H. Ximelagatran for the secondary prevention of venous thromboembolism: a complementary follow-up analysis of the THRIVE III Study. Thromb Haemost 2005 94 : 820 4.
    • (2005) Thromb Haemost , vol.94 , pp. 820-824
    • Schulman, S.1    Lundstrom, T.2    Walander, K.3    Billing Clason, S.4    Eriksson, H.5
  • 33
    • 34548031359 scopus 로고    scopus 로고
    • The pharmacokinetics, pharmacodynamics and tolerability of dabigatran etexilate, a new oral direct thrombin inhibitor, in healthy male subjects
    • Stangier J, Rathgen K, Stahle H, Gansser D, Roth W. The pharmacokinetics, pharmacodynamics and tolerability of dabigatran etexilate, a new oral direct thrombin inhibitor, in healthy male subjects. Br J Clin Pharmacol 2007 64 : 292 303.
    • (2007) Br J Clin Pharmacol , vol.64 , pp. 292-303
    • Stangier, J.1    Rathgen, K.2    Stahle, H.3    Gansser, D.4    Roth, W.5
  • 34
    • 13244266944 scopus 로고    scopus 로고
    • Dose escalating safety study of a new oral direct thrombin inhibitor, dabigatran etexilate, in patients undergoing total hip replacement: BISTRO i
    • Eriksson BI, Dahl OE, Ahnfelt L et al. Dose escalating safety study of a new oral direct thrombin inhibitor, dabigatran etexilate, in patients undergoing total hip replacement: BISTRO I. J Thromb Haemost 2004 2 : 1573 80.
    • (2004) J Thromb Haemost , vol.2 , pp. 1573-1580
    • Eriksson, B.I.1    Dahl, O.E.2    Ahnfelt, L.3
  • 35
    • 0035133938 scopus 로고    scopus 로고
    • Sixth ACCP Consensus Conference on Antithrombotic therapy. Prevention of venous thromboembolism
    • Geerts WH, Heit JA, Clagett GP et al. Sixth ACCP Consensus Conference on Antithrombotic therapy. Prevention of venous thromboembolism. Chest 2001 119 : 132S 75S.
    • (2001) Chest , vol.119 , pp. 132-175
    • Geerts, W.H.1    Heit, J.A.2    Clagett, G.P.3
  • 36
    • 17644409026 scopus 로고    scopus 로고
    • A new oral direct thrombin inhibitor, dabigatran etexilate, compared with enoxaparin for prevention of thromboembolic events following total hip or knee replacement: The BISTRO II randomized trial
    • Erisksson BI, Dahl OE, Buller HR et al. A new oral direct thrombin inhibitor, dabigatran etexilate, compared with enoxaparin for prevention of thromboembolic events following total hip or knee replacement: the BISTRO II randomized trial. J Thromb Haemost 2005 3 : 103 11.
    • (2005) J Thromb Haemost , vol.3 , pp. 103-111
    • Erisksson, B.I.1    Dahl, O.E.2    Buller, H.R.3
  • 37
    • 35348879239 scopus 로고    scopus 로고
    • Dabigatran with or without concomitant aspirin compared with warfarin alone in patients with nonvalvular atrial fibrillation (PETRO Study)
    • Ezekowitz MD, Reilly PA, Nehmiz G et al. Dabigatran with or without concomitant aspirin compared with warfarin alone in patients with nonvalvular atrial fibrillation (PETRO Study). Am J Cardiol 2007 100 : 1419 26.
    • (2007) Am J Cardiol , vol.100 , pp. 1419-1426
    • Ezekowitz, M.D.1    Reilly, P.A.2    Nehmiz, G.3
  • 38
    • 34548575058 scopus 로고    scopus 로고
    • Dabigatran etexilate versus enoxaparin for prevention of venous thromboembolism after total hip replacement: A randomized, double-blind, non-inferiority trial
    • Eriksson BI, Dahl OE, Rosencher N et al. Dabigatran etexilate versus enoxaparin for prevention of venous thromboembolism after total hip replacement: a randomized, double-blind, non-inferiority trial. Lancet 2007 370 : 949 56.
    • (2007) Lancet , vol.370 , pp. 949-956
    • Eriksson, B.I.1    Dahl, O.E.2    Rosencher, N.3
  • 39
    • 35449007749 scopus 로고    scopus 로고
    • Oral dabigatran etexilate vs. subcutaneous enoxaparin for the prevention of venous thromboembolism after total knee replacement: The RE-MODEL randomized trial
    • Eriksson BI, Dahl OE, Rosencher N et al. Oral dabigatran etexilate vs. subcutaneous enoxaparin for the prevention of venous thromboembolism after total knee replacement: the RE-MODEL randomized trial. J Thromb Haemost 2007 5 : 2178 85.
    • (2007) J Thromb Haemost , vol.5 , pp. 2178-2185
    • Eriksson, B.I.1    Dahl, O.E.2    Rosencher, N.3
  • 40
    • 57649123692 scopus 로고    scopus 로고
    • The oral thrombin inhibitor dabigatran etexilate vs the North American enoxaparin regimen for the prevention of venous thromboembolism after knee arthroplasty surgery
    • The RE-MOBILIZE Writing Committee.
    • The RE-MOBILIZE Writing Committee. The oral thrombin inhibitor dabigatran etexilate vs the North American enoxaparin regimen for the prevention of venous thromboembolism after knee arthroplasty surgery. J Arthroplasty 2009 24 : 1 9.
    • (2009) J Arthroplasty , vol.24 , pp. 1-9
  • 41
    • 62549148456 scopus 로고    scopus 로고
    • ClinicalTrials.gov Identifier: NCT00808067. (accessed December 2008).
    • ClinicalTrials.gov Identifier: NCT00808067. http://clinicaltrials.gov/ ct2/show/NCT00808067 (accessed December 2008).


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.