Bacterial Cytolysin during Meningitis Disrupts the Regulation of Glutamate in the Brain, Leading to Synaptic Damage

PLoS Pathogens

Volumn 9, Issue 6, 2013, Pages

  Wippel, Carolin ^a   Maurer, Jana ^a   Förtsch, Christina ^a   Hupp, Sabrina ^a   Bohl, Alexandra ^a   Ma, Jiangtao ^b   Mitchell, Timothy J ^b,c   Bunkowski, Stephanie ^d   Brück, Wolfgang ^d   Nau, Roland ^d,e   Iliev, Asparouh I ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b UNIVERSITY OF GLASGOW   (United Kingdom)

^c UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^d UNIVERSITY OF GÖTTINGEN   (Germany)

^e Sleep Laboratory   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINO 5 PHOSPHONOVALERIC ACID; DIZOCILPINE; GLUTAMIC ACID; PNEUMOLYSIN; POSTSYNAPTIC DENSITY PROTEIN 95; SYNAPSIN I;

ADULT; AGED; ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; AUTOPSY; BIOCHEMISTRY; CLINICAL ARTICLE; CONTROLLED STUDY; DEATH; DENDRITIC SPINE; EXCITOTOXICITY; FEMALE; HUMAN; HUMAN TISSUE; IMAGING; IMMUNOHISTOCHEMISTRY; MALE; MOUSE; NONHUMAN; PNEUMOCOCCAL MENINGITIS; SYNAPTIC INHIBITION;

ADULT; AGED; AGED, 80 AND OVER; ANIMALS; ASTROCYTES; BACTERIAL PROTEINS; DENDRITES; DIZOCILPINE MALEATE; FRONTAL LOBE; GLUTAMIC ACID; HUMANS; MENINGITIS, PNEUMOCOCCAL; MICE; MIDDLE AGED; RECEPTORS, N-METHYL-D-ASPARTATE; STREPTOCOCCUS PNEUMONIAE; STREPTOLYSINS; SYNAPSES;

BACTERIA (MICROORGANISMS); MUS; STREPTOCOCCUS PNEUMONIAE;

EID: 84879524778     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1003380     Document Type: Article

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