Mental rotation in intellectually gifted boys is affected by the androgen receptor CAG repeat polymorphism

Neuropsychologia

Volumn 51, Issue 9, 2013, Pages 1693-1698

  Durdiaková, Jaroslava ^a   Lakatošová, Silvia ^a   Kubranská, Aneta ^a   Laznibatová, Jolana ^b   Ficek, Andrej ^a   Ostatníková, Daniela ^a   Celec, Peter ^a  

^a Faculty of Natural Sciences   (Slovakia)

^b School for intellectually gifted children and Grammar School   (Slovakia)

Author keywords

Androgen receptor; Intellectual giftedness; Mental rotation; Testosterone

Indexed keywords

ANDROGEN RECEPTOR; TESTOSTERONE;

ADOLESCENT; ADULT; ANALYTICAL PARAMETERS; ARTICLE; BRAIN FUNCTION; CAG REPEAT; CAPILLARY ELECTROPHORESIS; CHILD; ENZYME LINKED IMMUNOSORBENT ASSAY; FINGER; FINGER LENGTH RATIO; GENETIC ASSOCIATION; HUMAN; HUMAN EXPERIMENT; INTELLIGENCE; INTELLIGENCE QUOTIENT; MALE; MENTAL FUNCTION; MENTAL ROTATION; MENTAL TEST; NORMAL HUMAN; POLYMERASE CHAIN REACTION; PRENATAL PERIOD; SALIVA ANALYSIS; SALIVA LEVEL; SCHOOL CHILD; SPATIAL MEMORY; TESTOSTERONE SALIVA LEVEL;

ANDROGEN RECEPTOR; INTELLECTUAL GIFTEDNESS; MENTAL ROTATION; TESTOSTERONE;

ADOLESCENT; CHILD; CHILD, GIFTED; HUMANS; IMAGINATION; INTELLIGENCE TESTS; MALE; POLYMORPHISM, GENETIC; RECEPTORS, ANDROGEN; ROTATION; SALIVA; TESTOSTERONE; TRINUCLEOTIDE REPEATS;

EID: 84879518884     PISSN: 00283932     EISSN: 18733514     Source Type: Journal    
DOI: 10.1016/j.neuropsychologia.2013.05.016     Document Type: Article

References (54)

1. Alexander G.M., Son T. Androgens and eye movements in women and men during a test of mental rotation ability. Hormones and Behavior 2007, 52:197-204.
2. Amthauer, R. (1993). The I-S-T test. Subtest no. 8: Psychodiagnostic and didactic tests 1968 (in Slovak).
3. Auyeung B., Lombardo M.V., Baron-Cohen S. Prenatal and postnatal hormone effects on the human brain and cognition. Pflugers Archives-European Journal of Physiology 2013, 10.1007/s00424-013-1268-2.
4. Beaton A.A., Rudling N., Kissling C., Taurines R., Thome J. Digit ratio (2D:4D), salivary testosterone, and handedness. Laterality 2011, 16:136-155.
5. Berenbaum S.A., Bryk K.K., Nowak N., Quigley C.A., Moffat S. Fingers as a marker of prenatal androgen exposure. Endocrinology 2009, 150:5119-5124.
6. Breedlove S.M. Minireview: Organizational hypothesis: Instances of the fingerpost. Endocrinology 2010, 151:4116-4122.
7. Brosnan M.J. Digit ratio and faculty membership: Implications for the relationship between prenatal testosterone and academia. British Journal of Psychology 2006, 97:455-466.
8. Burton L.A., Henninger D., Hafetz J. Gender differences in relations of mental rotation, verbal fluency, and SAT scores to finger length ratios as hormonal indexes. Developmental Neuropsychology 2005, 28:493-505.
9. Butovskaya M.L., Vasilyev V.A., Lazebny O.E., Burkova V.N., Kulikov A.M., Mabulla A., et al. Aggression, digit ratio, and variation in the androgen receptor, serotonin transporter, and dopamine D4 receptor genes in African foragers: The Hadza. Behavior Genetics 2012, 42:647-662.
10. Celec P., Ostatnikova D., Holesova Z., Minarik G., Ficek A., Kelemenova S., et al. Spatial abilities in prepubertal intellectually gifted boys and genetic polymorphisms related to testosterone metabolism. Journal of Psychophysiology 2009, 23.
11. Celec P., Tretinarova D., Minarik G., Ficek A., Szemes T., Lakatosova S., et al. Genetic polymorphisms related to testosterone metabolism in intellectually gifted boys. Plos One 2013, 8:e54751.
12. Christensen L.W., Gorski R.A. Independent masculinization of neuroendocrine systems by intracerebral implants of testosterone or estradiol in the neonatal female rat. Brain Research 1978, 146:325-340.
13. Chura L.R., Lombardo M.V., Ashwin E., Auyeung B., Chakrabarti B., Bullmore E.T., et al. Organizational effects of fetal testosterone on human corpus callosum size and asymmetry. Psychoneuroendocrinology 2010, 35:122-132.
14. Collaer M.L., Hines M. Human behavioral sex differences: A role for gonadal hormones during early development?. Psychological Bulletin 1995, 118:55-107.
15. Courvoisier D.S., Renaud O., Geiser C., Paschke K., Gaudy K., Jordan K. Sex hormones and mental rotation: An intensive longitudinal investigation. Hormones and Behavior 2013, 63:345-351.
16. Ding D., Xu L., Menon M., Reddy G.P., Barrack E.R. Effect of a short CAG (glutamine) repeat on human androgen receptor function. Prostate 2004, 58:23-32.
17. Falter C.M., Arroyo M., Davis G.J. Testosterone: Activation or organization of spatial cognition?. Biological Psychology 2006, 73:132-140.
18. Fink B., Neave N., Manning J.T. Second to fourth digit ratio, body mass index, waist-to-hip ratio, and waist-to-chest ratio: Their relationships in heterosexual men and women. Annals of Human Biology 2003, 30:728-738.
19. Geschwind N., Galaburda A.M. Cerebral lateralization: biological mechanisms, associations and pathology 1987, MIT Press, Cambridge, MA.
20. Greenland K.J., Beilin J., Castro J., Varghese P.N., Zajac J.D. Polymorphic CAG repeat length in the androgen receptor gene and association with neurodegeneration in a heterozygous female carrier of Kennedy's disease. Journal of Neurology 2004, 251:35-41.
21. Hampson E., Sankar J.S. Hand preference in humans is associated with testosterone levels and androgen receptor gene polymorphism. Neuropsychologia 2012, 50:2018-2025.
22. Hausmann M., Schoofs D., Rosenthal H.E., Jordan K. Interactive effects of sex hormones and gender stereotypes on cognitive sex differences-A psychobiosocial approach. Psychoneuroendocrinology 2009, 34:389-401.
23. Hines M. Brain gender 2004, Oxford University Press, New York.
24. Hurd P.L., Vaillancourt K.L., Dinsdale N.L. Aggression, digit ratio and variation in androgen receptor and monoamine oxidase a genes in men. Behavior Genetics 2011, 41:543-556.
25. Irvine R.A., Ma H., Yu M.C., Ross R.K., Stallcup M.R., Coetzee G.A. Inhibition of p160-mediated coactivation with increasing androgen receptor polyglutamine length. Human Molecular Genetics 2000, 9:267-274.
26. Kalmady S.V., Agarwal S.M., Shivakumar V., Jose D., Venkatasubramanian G., Reddy Y.C. Revisiting Geschwind's hypothesis on brain lateralisation: A functional MRI study of digit ratio (2D:4D) and sex interaction effects on spatial working memory. Laterality 2013.
27. Kelemenova S., Schmidtova E., Ficek A., Celec P., Kubranska A., Ostatnikova D. Polymorphisms of candidate genes in Slovak autistic patients. Psychiatric Genetics 2010, 20:137-139.
28. Kempel P., Gohlke B., Klempau J., Zinsberger P., Reuter M., Hennig J. Second-to-fourth digit length, testosterone and spatial ability. Intelligence 2005, 33:215-230.
29. Lee D.M., Ulubaev A., Tajar A., Pye S.R., Pendleton N., Purandare N., et al. Endogenous hormones, androgen receptor CAG repeat length and fluid cognition in middle-aged and older men: Results from the European Male Ageing Study. European Journal of Endocrinology 2010, 162:1155-1164.
30. Malas M.A., Dogan S., Evcil E.H., Desdicioglu K. Fetal development of the hand, digits and digit ratio (2D:4D). Early Human Development 2006, 82:469-475.
31. Manning J.T., Barley L., Walton J., Lewis-Jones D.I., Trivers R.L., Singh D., et al. The 2nd:4th digit ratio, sexual dimorphism, population differences, and reproductive success. evidence for sexually antagonistic genes?. Evolution and Human Behavior 2000, 21:163-183.
32. Manning J.T., Fink B. Digit ratio (2D:4D), dominance, reproductive success, asymmetry, and sociosexuality in the BBC Internet Study. American Journal of Human Biology 2008, 20:451-461.
33. Manning J.T., Robinson S.J. 2nd to 4th digit ratio and a universal mean for prenatal testosterone in homosexual men. Medical Hypotheses 2003, 61:303-306.
34. Manning J.T., Scutt D., Wilson J., Lewis-Jones D.I. The ratio of 2nd to 4th digit length: A predictor of sperm numbers and concentrations of testosterone, luteinizing hormone and oestrogen. Human Reproduction 1998, 13:3000-3004.
35. Milivojevic B., Hamm J.P., Corballis M.C. Hemispheric dominance for mental rotation: It is a matter of time. Neuroreport 2009, 20:1507-1512.
36. Mrazik M., Dombrowski S.C. The neurobiological foundations of giftedness. Roeper Review 2010, 32:224-234.
37. Nowak N.T., Moffat S.D. The relationship between second to fourth digit ratio, spatial cognition, and virtual navigation. Archives of Sexual Behavior 2011, 40:575-585.
38. O'Connor D.B., Archer J., Hair W.M., Wu F.C. Activational effects of testosterone on cognitive function in men. Neuropsychologia 2001, 39:1385-1394.
39. Ostatnikova D., Celec P., Putz Z., Hodosy J., Schmidt F., Laznibatova J., et al. Intelligence and salivary testosterone levels in prepubertal children. Neuropsychologia 2007, 45:1378-1385.
40. Ostatnikova D., Putz Z., Celec P., Hodosy J. May testosterone levels and their fluctuations influence cognitive performance in humans?. Scripta Medica 2002, 75:245-254.
41. Peters M., Manning J.T., Reimers S. The effects of sex, sexual orientation, and digit ratio (2D:4D) on mental rotation performance. Archives of Sexual Behavior 2007, 36:251-260.
42. Puts D.A., Cardenas R.A., Bailey D.H., Burriss R.P., Jordan C.L., Breedlove S.M. Salivary testosterone does not predict mental rotation performance in men or women. Hormones and Behavior 2010, 58:282-289.
43. Puts D.A., McDaniel M.A., Jordan C.L., Breedlove S.M. Spatial ability and prenatal androgens: Meta-analyses of congenital adrenal hyperplasia and digit ratio (2D:4D) studies. Archives of Sexual Behavior 2008, 37:100-111.
44. Romeo R.D., Richardson H.N., Sisk C.L. Puberty and the maturation of the male brain and sexual behavior: Recasting a behavioral potential. Neuroscience & Biobehavioral Reviews 2002, 26:381-391.
45. Sanders G., Bereczkei T., Csatho A., Manning J. The ratio of the 2nd to 4th finger length predicts spatial ability in men but not women. Cortex 2005, 41:789-795.
46. Schulz K.M., Zehr J.L., Salas-Ramirez K.Y., Sisk C.L. Testosterone programs adult social behavior before and during, but not after, adolescence. Endocrinology 2009, 150:3690-3698.
47. Trivers R., Manning J., Jacobson A. A longitudinal study of digit ratio (2D:4D) and other finger ratios in Jamaican children. Hormones and Behavior 2006, 49:150-156.
48. van Anders S.M., Hampson E. Testing the prenatal androgen hypothesis: Measuring digit ratios, sexual orientation, and spatial abilities in adults. Hormones and Behavior 2005, 47:92-98.
49. van Anders S.M., Vernon P.A., Wilbur C.J. Finger-length ratios show evidence of prenatal hormone-transfer between opposite-sex twins. Hormones and Behavior 2006, 49:315-319.
50. Verhovshek T., Buckley K.E., Sergent M.A., Sengelaub D.R. Testosterone metabolites differentially maintain adult morphology in a sexually dimorphic neuromuscular system. Developmental Neurobiology 2010, 70:206-221.
51. Vuoksimaa E., Kaprio J., Eriksson C.J., Rose R.J. Pubertal testosterone predicts mental rotation performance of young adult males. Psychoneuroendocrinology 2012, 37:1791-1800.
52. Witelson S.F., Nowakowski R.S. Left out axons make men right: A hypothesis for the origin of handedness and functional asymmetry. Neuropsychologia 1991, 29:327-333.
53. Ypsilanti A., Ganou M., Koidou I., Grouios G. Digit ratio (2D:4D) in individuals with intellectual disability: Investigating the role of testosterone in the establishment of cerebral lateralisation. Laterality 2008, 13:527-544.
54. Zacks J.M. Neuroimaging studies of mental rotation: A meta-analysis and review. Journal of Cognitive Neuroscience 2008, 20:1-19.