Genetic Polymorphisms Related to Testosterone Metabolism in Intellectually Gifted Boys

PLoS ONE

Volumn 8, Issue 1, 2013, Pages

  Celec, Peter ^a   Tretinárová, Denisa ^a   Minárik, Gabriel ^a,b   Ficek, Andrej ^a,b   Szemes, Tomáš ^a   Lakatošová, Silvia ^a   Schmidtová, Eva ^a   Turňa, Ján ^a   Kádaši, Ľudevít ^a,b   Ostatníková, Daniela ^a  

^a Faculty of Natural Sciences   (Slovakia)

^b INSTITUTE OF MOLECULAR PHYSIOLOGY AND GENETICS   (Slovakia)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN RECEPTOR; AROMATASE; ESTROGEN RECEPTOR; SEX HORMONE BINDING GLOBULIN; STEROID 5ALPHA REDUCTASE; TESTOSTERONE;

5 ALPHA REDUCTASE GENE; ADOLESCENT; ANDROGEN RECEPTOR GENE; AROMATASE GENE; ARTICLE; CAG REPEAT; CHILD; CONTROLLED STUDY; ESTROGEN RECEPTOR GENE; GENE; GENE FREQUENCY; GENE IDENTIFICATION; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE; GIFTED CHILD; HUMAN; INTELLIGENCE; MALE; SCHOOL CHILD; SEX HORMONE BINDING GLOBULIN GENE; SINGLE NUCLEOTIDE POLYMORPHISM; TESTOSTERONE METABOLISM;

ADOLESCENT; ALLELES; GENE FREQUENCY; GENOTYPE; HUMANS; INTELLIGENCE; MALE; POLYMORPHISM, GENETIC; POLYMORPHISM, SINGLE NUCLEOTIDE; QUANTITATIVE TRAIT, HERITABLE; RECEPTORS, ANDROGEN; TESTOSTERONE;

EID: 84873810369     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0054751     Document Type: Article

References (33)

1. Bartels M, Rietveld MJH, Van Baal GCM, Boomsma DI, (2002) Genetic and environmental influences on the development of intelligence. Behavior Genetics 32: 237-249.
2. van Leeuwen M, van den Berg SM, Boomsma DI, (2008) A twin-family study of general IQ. Learning and Individual Differences 18: 76-88.
3. Bouchard TJ, (1998) Genetic and environmental influences on adult intelligence and special mental abilities. Human Biology 70: 257-279.
4. Turkheimer E, Haley A, Waldron M, D'Onofrio B, Gottesman II, (2003) Socioeconomic status modifies heritability of IQ in young children. Psychological Science 14: 623-628.
5. Buyske S, Bates ME, Gharani N, Matise TC, Tischfield JA, et al. (2006) Cognitive traits link to human chromosomal regions. Behavior Genetics 36: 65-76.
6. Plomin R, Hill L, Craig IW, McGuffin P, Purcell S, et al. (2001) A genome-wide scan of 1842 DNA markers for allelic associations with general cognitive ability: A five-stage design using DNA pooling and extreme selected groups. Behavior Genetics 31: 497-509.
7. Luciano M, Wright MJ, Duffy DL, Wainwright MA, Zhu G, et al. (2006) Genome-wide scan of IQ finds significant linkage to a quantitative trait locus on 2q. Behavior Genetics 36: 45-55.
8. Dick DM, Aliev F, Kramer J, Wang JC, Hinrichs A, et al. (2007) Association of CHRM2 with IQ: Converging evidence for a gene influencing intelligence. Behavior Genetics 37: 265-272.
9. Butcher LM, Davis OSP, Craig IW, Plomin R, (2008) Genome-wide quantitative trait locus association scan of general cognitive ability using pooled DNA and 500K single nucleotide polymorphism microarrays. Genes Brain and Behavior 7: 435-446.
10. Seshadri S, DeStefano AL, Au R, Massaro JM, Beiser AS, et al. (2007) Genetic correlates of brain aging on MRI and cognitive test measures: a genome-wide association and linkage analysis in the Framingham study. Bmc Medical Genetics 8: 14.
11. Hedges LV, Nowell A, (1995) Sex-differences in mental test-scores, variability, and numbers of high-scoring individuals. Science 269: 41-45.
12. Irwing P, Lynn R, (2005) Sex differences in means and variability on the progressive matrices in university students: a meta-analysis. Br J Psychol 96: 505-524.
13. Benbow CP, (1988) Sex-Differences in Mathematical Reasoning Ability in Intellectually Talented Preadolescents- Their Nature, Effects, and Possible Causes. Behavioral and Brain Sciences 11: 169-183.
14. Barrett-Connor E, Goodman-Gruen D, Patay B, (1999) Endogenous sex hormones and cognitive function in older men. Journal of Clinical Endocrinology and Metabolism 84: 3681-3685.
15. Muller M, Aleman A, Grobbee DE, de Haan EHF, van der Schouw YT, (2005) Endogenous sex hormone levels and cognitive function in aging men- Is there an optimal level? Neurology 64: 866-871.
16. Azurmendi A, Braza F, Sorozabal A, Garcia A, Braza P, et al. (2005) Cognitive abilities, androgen levels, and body mass index in 5-year-old children. Hormones and Behavior 48: 187-195.
17. Kutlu N, Ekerbicer N, Ari Z, Uyanik BS, Zeren T, et al. (2001) Testosterone and nonverbal intelligence in right-handed men with successful and unsuccessful educational levels. International Journal of Neuroscience 111: 1-9.
18. Azurmendi A, Braza F, Garcia A, Braza P, Munoz JM, et al. (2006) Aggression, dominance, and affiliation: Their relationships with androgen levels and intelligence in 5-year-old children. Hormones and Behavior 50: 132-140.
19. Ostatnikova D, Celec P, Putz Z, Hodosy J, Schmidt F, et al. (2007) Intelligence and salivary testosterone levels in prepubertal children. Neuropsychologia 45: 1378-1385.
20. Celec P, Ostatnikova D, Holesova Z, Minarik G, Ficek A, et al. (2009) Spatial Abilities in Prepubertal Intellectually Gifted Boys and Genetic Polymorphisms Related to Testosterone Metabolism. Journal of Psychophysiology 23: 1-6.
21. Chakrabarti B, Dudbridge F, Kent L, Wheelwright S, Hill-Cawthorne G, et al. (2009) Genes related to sex steroids, neural growth, and social-emotional behavior are associated with autistic traits, empathy, and Asperger syndrome. Autism Res 2: 157-177.
22. Matsumoto Y, Suzuki A, Shibuya N, Sadahiro R, Kamata M, et al. (2009) Effect of the cytochrome P450 19 (aromatase) gene polymorphism on personality traits in healthy subjects. Behavioural Brain Research 205: 234-237.
23. Henningsson S, Jonsson L, Ljunggren E, Westberg L, Gillberg C, et al. (2009) Possible association between the androgen receptor gene and autism spectrum disorder. Psychoneuroendocrinology 34: 752-761.
24. Weickert CS, Miranda-Angulo AL, Wong J, Perlman WR, Ward SE, et al. (2008) Variants in the estrogen receptor alpha gene and its mRNA contribute to risk for schizophrenia. Hum Mol Genet 17: 2293-2309.
25. Giton F, Fiet J, Guechot J, Ibrahim F, Bronsard F, et al. (2006) Serum bioavailable testosterone: assayed or calculated? Clin Chem 52: 474-481.
26. Thakur MK, Sharma PK, (2007) Transcription of estrogen receptor alpha and beta in mouse cerebral cortex: effect of age, sex, 17beta-estradiol and testosterone. Neurochem Int 50: 314-321.
27. Paus T, Nawaz-Khan I, Leonard G, Perron M, Pike GB, et al. (2010) Sexual dimorphism in the adolescent brain: Role of testosterone and androgen receptor in global and local volumes of grey and white matter. Hormones and Behavior 57: 63-75.
28. Ding DC, Xu LH, Menon M, Reddy GPV, Barrack ER, (2004) Effect of a short CAG (glutamine) repeat on human androgen receptor functin. Prostate 58: 23-32.
29. Beilin J, Ball EM, Favaloro JM, Zajac JD, (2000) Effect of the androgen receptor CAG repeat polymorphism on transcriptional activity: specificity in prostate and non-prostate cell lines. J Mol Endocrinol 25: 85-96.
30. Irvine RA, Yu MC, Ross RK, Coetzee GA, (1995) The CAG and GGC microsatellites of the androgen receptor gene are in linkage disequilibrium in men with prostate cancer. Cancer Res 55: 1937-1940.
31. Hardy DO, Scher HI, Bogenreider T, Sabbatini P, Zhang ZF, et al. (1996) Androgen receptor CAG repeat lengths in prostate cancer: correlation with age of onset. J Clin Endocrinol Metab 81: 4400-4405.
32. Giovannucci E, Stampfer MJ, Krithivas K, Brown M, Dahl D, et al. (1997) The CAG repeat within the androgen receptor gene and its relationship to prostate cancer. Proc Natl Acad Sci U S A 94: 3320-3323.
33. Quintans B, Alvarez-Iglesias V, Salas A, Phillips C, Lareu MV, et al. (2004) Typing of mitochondrial DNA coding region SNPs of forensic and anthropological interest using SNaPshot minisequencing. Forensic Science International 140: 251-257.