D-2-hydroxyglutarate metabolism is linked to photorespiration in the shm1-1 mutant

Plant Biology

Volumn 15, Issue 4, 2013, Pages 776-784

  Kuhn, A ^a   Engqvist, M K M ^a,d   Jansen, E E W ^b   Weber, A P M ^c   Jakobs, C ^b   Maurino, V G ^a,c  

^a UNIVERSITY OF COLOGNE   (Germany)

^b VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^c HEINRICH HEINE UNIVERSITY   (Germany)

^d California Institute of Technology   (United States)

Author keywords

2 hydroxyglutarate (2HG); Photorespiration; Senescence; Serine hydroxymethyltransferase (SHMT)

Indexed keywords

2 HYDROXYGLUTARIC ACID; 2 OXOGLUTARIC ACID; ALPHA-HYDROXYGLUTARATE; ALPHA-KETOGLUTARIC ACID; ARABIDOPSIS PROTEIN; CARBON DIOXIDE; CYSTEINE PROTEINASE; GLUTARIC ACID DERIVATIVE; GLYCINE; GLYCINE HYDROXYMETHYLTRANSFERASE; LYSINE; RECOMBINANT PROTEIN; SAG12 PROTEIN, ARABIDOPSIS; SHM1 PROTEIN, ARABIDOPSIS;

AMBIENT AIR; CARBON DIOXIDE; CONCENTRATION (COMPOSITION); DICOTYLEDON; ENZYME ACTIVITY; INHIBITION; MITOCHONDRION; MUTATION; RESPIRATION; SENESCENCE;

ARABIDOPSIS; ARTICLE; CELL RESPIRATION; DRUG EFFECT; GENETICS; INTRON; LIGHT; METABOLISM; MITOCHONDRION; MUTATION; PHENOTYPE; PHOTOSYNTHESIS; PLANT LEAF; RNA SPLICING; TRANSGENIC PLANT;

ARABIDOPSIS; ARABIDOPSIS PROTEINS; CARBON DIOXIDE; CELL RESPIRATION; CYSTEINE ENDOPEPTIDASES; GLUTARATES; GLYCINE; GLYCINE HYDROXYMETHYLTRANSFERASE; INTRONS; KETOGLUTARIC ACIDS; LIGHT; LYSINE; MITOCHONDRIA; MUTATION; PHENOTYPE; PHOTOSYNTHESIS; PLANT LEAVES; PLANTS, GENETICALLY MODIFIED; RECOMBINANT PROTEINS; RNA SPLICE SITES;

ARABIDOPSIS;

EID: 84879500964     PISSN: 14358603     EISSN: 14388677     Source Type: Journal    
DOI: 10.1111/plb.12020     Document Type: Article

References (33)

1. Araújo W.L., Ishizaki K., Nunes-Nesi A., Larson T.R., Tohge T., Krahnert I., Witt S., Obata T., Schauer N., Graham I.A., Leaver C.J., Fernie A.R. (2010) Identification of the 2-hydroxyglutarate and isovaleryl-CoA dehydrogenases as alternative electron donors linking lysine catabolism to the electron transport chain of Arabidopsis mitochondria. Plant Cell, 22, 1549-1563.
2. Behal R.H., Oliver D.J. (1997) Biochemical and molecular characterization of fumarase from plants: purification and characterization of the enzyme - cloning, sequencing, and expression of the gene. Archives of Biochemistry and Biophysics, 348, 65-74.
3. Bradford M.M. (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Analytical Biochemistry, 72, 248-254.
4. Bykova N.V., Keerberg O., Pärnik T., Bauwe H., Gardeström P. (2005) Interaction between photorespiration and respiration in transgenic potato plants with antisense reduction in glycine decarboxylase. Planta, 222, 130-140.
5. Collakova E., Goyer A., Naponelli V., Krassovskaya I., Gregory J.F., Hanson A.D., Shachar-Hill Y. (2008) Arabidopsis 10-formyl tetrahydrofolate deformylases are essential for photorespiration. Plant Cell, 20, 1818-1832.
6. Diaz C., Purdy S., Christ A., Morot-Gaudry J.F., Wingler A., Masclaux-Daubresse C.L. (2005) Characterization of markers to determine the extent and variability of leaf senescence in Arabidopsis. A metabolic profiling approach. Plant Physiology, 138, 898-908.
7. Engel N., Ewald R., Gupta K.J., Zrenner R., Hagemann M., Bauwe H. (2011) The presequence of Arabidopsis serine hydroxymethyltransferase SHM2 selectively prevents import into mesophyll mitochondria. Plant Physiology, 157, 1711-1720.
8. Engqvist M., Drincovich M.F., Flügge U.I., Maurino V.G. (2009) Two D-2-hydroxy-acid dehydrogenases in Arabidopsis thaliana with catalytic capacities to participate in the last reactions of the methylglyoxal and β-oxidation pathways. Journal of Biological Chemistry, 284, 25026-25037.
9. Engqvist M.K.M., Kuhn A., Wienstroer J., Weber K., Jansen E.E.W., Jakobs C., Weber A.P.M., Maurino V.G. (2011) Plant D-2-hydroxyglutarate dehydrogenase participates in the catabolism of lysine especially during senescence. Journal of Biological Chemistry, 286, 11382-11390.
10. Färber A., Young A.J., Ruban A.V., Horton P., Jahns P. (1997) Dynamics of xanthophyll-cycle activity in different antenna subcomplexes in the photosynthetic membranes of higher plants: the relationship between zeaxanthin conversion and nonphotochemical fluorescence quenching. Plant Physiology, 115, 1609-1618.
11. Foyer C.H., Bloom A.J., Queval G., Noctor G. (2009) Photorespiratory metabolism: genes, mutants, energetics, and redox signaling. Annual Review of Plant Biology, 60, 455-484.
12. Hall N.P., Kendall A.C., Lea P.J., Turner J.C., Wallsgrove R.M. (1987) Characteristics of a photorespiratory mutant of barley (Hordeum vulgare) deficient in phosphoglycollate phosphatase. Photosynthesis Research, 11, 89-96.
13. Jamai A., Salomé P.A., Schilling S.H., Weber A.P.M., McClung C.R. (2009) Arabidopsis photorespiratory Serine Hydroxymethyltransferase (SHMT) activity requires the mitochondrial accumulation of Ferredoxin-Dependent Glutamate Synthase (Fd-GOGAT). Plant Cell, 21, 125-143.
14. Kakkar T., Boxenbaum H., Mayersohn M. (1999) Estimation of Ki in a competitive-enzyme inhibition model: comparisons among three methods of data analysis. Drug Metabolism and Disposition, 6, 756-762.
15. Lee D.Y., Fiehn O. (2008) High quality metabolomic data for Chlamydomonas reinhardtii. Plant Methods, 4, 7.
16. Lisec J., Schauer N., Kopka J., Willmitzer L., Fernie A.R. (2006) Gas chromatography mass spectrometry-based metabolite profiling in plants. Nature Protocols, 1, 387-396.
17. Logemann J., Schell J., Willmitzer L. (1987) Improved method for the isolation of RNA from plant tissues. Analytical Biochemistry, 163, 16-20.
18. Maurino V.G., Peterhänsel C. (2010) Photorespiration: current status and approaches for metabolic engineering. Current Opinion in Plant Biology, 13, 248-255.
19. Noctor G., Veljovic-Jovanovic S., Driscoll S.P., Novitskaya L., Foyer C.H. (2002) Drought and oxidative load in the leaves of C3 plants: a predominant role for photorespiration? Annals of Botany, 89, 841-850.
20. Porcelli A.M., Ghelli A., Zanna C., Pinton P., Rizzuto R., Rugolo M. (2005) pH difference across the outer mitochondrial membrane measured with a green fluorescent protein mutant. Biochemical and Biophysical Research Communications, 326, 799-804.
21. Schirch L. (1982) Serine hydroxymethyltransferase. Advances in Enzymology, 53, 83-112.
22. Schreiber U., Schliwa U., Bilger W. (1986) Continuous recording of photochemical and non-photochemical chlorophyll fluorescence quenching with a new type of modulation fluorometer. Photosynthesis Research, 10, 51-62.
23. Somerville C.R., Ogren W.L. (1980) Inhibition of photosynthesis in Arabidopsis mutants lacking leaf glutamate synthase activity. Nature, 286, 257-259.
24. Somerville C.R., Ogren W.L. (1981) Photorespiration-deficient mutants of Arabidopsis thaliana lacking mitochondrial serine transhydroxymethylase activity. Plant Physiology, 67, 666-671.
25. Somerville C.R., Ogren W.L. (1982) Mutants of the cruciferous plant Arabidopsis thaliana lacking glycine decarboxylase activity. Biochemical Journal, 202, 373-380.
26. Sommerville S., Somerville C.R. (1985) Mutant of Arabidopsis thaliana deficient in chloroplast dicarboxylate transport is missing an envelope protein. Plant Science Letters, 37, 217-220.
27. Struys E.A., Jansen E.E.W., Verhoeven N.M., Jakobs C. (2004) Measurement of urinary D- and L-2-hydroxyglutarate enantiomers by stable-isotope- dilution liquid chromatography-tandem mass spectrometry after derivatization with diacetyl-L-tartaric anhydride. Clinical Chemistry, 50, 1391-1395.
28. Sweetlove L.J., Lytovchenko A., Morgan M., Nunes-Nesi A., Taylor N.L., Baxter C.J., Eickmeier I., Fernie A.R. (2006) Mitochondrial uncoupling protein is required for efficient photosynthesis. Proceedings of the National Academy of Sciences USA, 103, 19587-19592.
29. Timm S., Nunes-Nesi A., Parnik T., Morgenthal K., Wienkoop S., Keerberg O., Weckwerth W., Kleczkowski L.A., Fernie A.R., Bauwe H. (2008) A cytosolic pathway for the conversion of hydroxypyruvate to glycerate during photorespiration in Arabidopsis. Plant Cell, 20, 2848-2859.
30. Voll L.M., Jamai A., Renné P., Voll H., McClung C.R., Weber A.P.M. (2006) The photorespiratory Arabidopsis thaliana mutant shm is deficient in SHM1. Plant Physiology, 140, 59-66.
31. Walker G.H., Oliver D.J., Sarojini G. (1982) Simultaneous oxidation of glycine and malate by pea leaf mitochondria. Plant Physiology, 70, 1465-1469.
32. Wingler A., Roitsch T. (2008) Metabolic regulation of leaf senescence: interactions of sugar signalling with biotic and abiotic stress responses. Plant Biology, 10, 50-62.
33. Zell M.B., Fahnenstich H., Maier A., Saigo M., Voznesenskaya E.V., Edwards G.E., Schleifenbaum F., Zell C., Andreo C., Drincovich M.F., Maurino V.G. (2010) Analysis of A. thaliana with highly reduced levels of malate and fumarate sheds light on the role of these organic acids as storage carbon molecules. Plant Physiology, 152, 1251-1262.