Inhibitory mechanism of 10-hydroxy-trans-2-decenoic acid (royal jelly acid) against lipopolysaccharide- and interferon-β-induced nitric oxide production

Inflammation

Volumn 36, Issue 2, 2013, Pages 372-378

  Sugiyama, Tsuyoshi ^a   Takahashi, Keita ^a   Kuzumaki, Akihiro ^a   Tokoro, Shunji ^a   Neri, Paola ^a   Mori, Hiroshi ^a  

^a GIFU PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

fatty acid; lipopolysaccharide; nitric oxide; royal jelly

Indexed keywords

10 HYDROXY 2 DECENOIC ACID; BETA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERFERON REGULATORY FACTOR 1; LIPOPOLYSACCHARIDE; NITRIC OXIDE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; ENZYME INDUCTION; GENETIC TRANSCRIPTION; IMMUNOMODULATION; INDUCIBLE NITRIC OXIDE SYNTHASE GENE; INTERFERON PRODUCTION; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION;

ANIMALS; CELL LINE; FATTY ACIDS, MONOUNSATURATED; INTERFERON REGULATORY FACTOR-1; INTERFERON-BETA; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE; NF-KAPPA B; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; RESPONSE ELEMENTS; TRANSCRIPTION, GENETIC; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84879500946     PISSN: 03603997     EISSN: 15732576     Source Type: Journal    
DOI: 10.1007/s10753-012-9556-0     Document Type: Article

References (25)

1. Rembold, H. 1965. Biologically active substances in royal jelly. Vitamins and Hormones 23: 359-382.
2. Shuel, R.; and S. Dixon. 1960. The early establishment of dimorphism in the female honeybee, Apis mellifera L. Insectes Sociaux 7: 265-282.
3. Kohno, K.; I. Okamoto, O. Sano, N. Arai, K. Iwaki, M. Ikeda, and M. Kurimoto. 2004. Royal jelly inhibits the production of proinflammatory cytokines by activated macrophages. Bioscience, Biotechnology, and Biochemistry 68: 138-145.
4. Tamura, T.; A. Fujii, and N. Kuboyama. 1987. Antitumor effects of royal jelly (RJ). Folia Pharmacologica Japonica 89: 73-80.
5. Helleu, C. 1956. Antibacterial properties of royal jelly; bactericidal and antibiotic effects of neutralized royal jelly. Annals of Institute Pasteur (Paris) 91: 231-237.
6. Lercker, G.; P. Capella, L.S. Conte, F. Ruini, and G. Giordani. 1982. Components of royal jelly II. The lipid fraction, hydrocarbons and sterols. Journal of Apicultural Research 21: 178-184.
7. Townsend, G.F.; J.F. Morgan, and B. Hazlett. 1959. Activity of 10-hydroxydecenoic acid from royal jelly against experimental leukaemia and ascitic tumours. Nature 183: 1270-1271.
8. Townsend, G.F.; J.F. Morgan, S. Tolnai, B. Hazlett, H.J. Morton, and R.W. Shuel. 1960. Studies on the in vitro antitumor activity of fatty acids. I. 10-Hydroxy-2-decenoic acid from royal jelly. Cancer Research 20: 503-510.
9. Blum, M.S.; A.F. Novak, and S. Taber 3rd. 1959. 10-Hydroxy-δ 2-decenoic acid, an antibiotic found in royal jelly. Science 130: 452-453.
10. Sugiyama, T.; K. Takahashi, S. Tokoro, T. Gotou, P. Neri, and H. Mori. 2011. Inhibitory effect of 10-hydroxy-trans-2-decenoic acid on LPS-induced IL-6 production via reducing IκB-ζ expression. Innate Immunity 18: 429-437.
11. Takahashi, K.; T. Sugiyama, S. Tokoro, P. Neri, and H. Mori. 2012. Inhibition of interferon-γ-induced nitric oxide production by 10-hydroxy-trans-2-decenoic acid through inhibition of interferon regulatory factor-8 induction. Cellular Immunology 273: 73-78.
12. Vila-del Sol, V.; M.D. Diaz-Munoz, and M. Fresno. 2007. Requirement of tumor necrosis factor α and nuclear factor-κB in the induction by IFN-γ of inducible nitric oxide synthase in macrophages. Journal of Leukocyte Biology 81: 272-283.
13. Xie, Q.W.; R. Whisnant, and C. Nathan. 1993. Promoter of the mouse gene encoding calcium-independent nitric oxide synthase confers inducibility by interferon γ and bacterial lipopolysaccharide. The Journal of Experimental Medicine 177: 1779-1784.
14. Kamijo, R.; H. Harada, T. Matsuyama, M. Bosland, J. Gerecitano, D. Shapiro, J. Le, S.I. Koh, T. Kimura, S.J. Green, T.W. Mak, T. Taniguchi, and J. Vilcek. 1994. Requirement for transcription factor IRF-1 in NO synthase induction in macrophages. Science 263: 1612-1615.
15. Kim, Y.M.; B.S. Lee, K.Y. Yi, and S.G. Paik. 1997. Upstream NF-κB site is required for the maximal expression of mouse inducible nitric oxide synthase gene in interferon-γ plus lipopolysaccharide-induced RAW 264.7 macrophages. Biochemical and Biophysical Research Communications 236: 655-660.
16. Martin, E.; C. Nathan, and Q.W. Xie. 1994. Role of interferon regulatory factor 1 in induction of nitric oxide synthase. The Journal of Experimental Medicine 180: 977-984.
17. Ohmori, Y.; and T.A. Hamilton. 2001. Requirement for STAT1 in LPS-induced gene expression in macrophages. Journal of Leukocyte Biology 69: 598-604.
18. Sugiyama, T.; T. Gotou, K. Moriyama, N. Kajiura, T. Hasegawa, J. Tomida, K. Takahashi, T. Komatsu, H. Ueda, K. Sato, S. Tokoro, P. Neri, and H. Mori. 2012. Mechanism of inhibition of lipopolysaccharide-induced interferon-β production by 2-aminopurine. Molecular Immunology 52: 299-304.
19. Sugiyama, T.; M. Fujita, N. Koide, I. Mori, T. Yoshida, H. Mori, and T. Yokochi. 2004. 2-Aminopurine inhibits lipopolysaccharide-induced nitric oxide production by preventing IFN-β production. Microbiology and Immunology 48: 957-963.
20. Green, L.C.; D.A. Wagner, J. Glogowski, P.L. Skipper, J.S. Wishnok, and S.R. Tannenbaum. 1982. Analysis of nitrate, nitrite, and [15 N]nitrate in biological fluids. Analytical Biochemistry 126: 131-138.
21. McWhirter, S.M.; K.A. Fitzgerald, J. Rosains, D.C. Rowe, D.T. Golenbock, and T. Maniatis. 2004. IFN-regulatory factor 3-dependent gene expression is defective in Tbk1-deficient mouse embryonic fibroblasts. Proceedings of the National Academy of Sciences of the United States of America 101: 233-238.
22. Yang, C.H.; A. Murti, S.R. Pfeffer, J.G. Kim, D.B. Donner, and L.M. Pfeffer. 2001. Interferon α/β promotes cell survival by activating nuclear factor κB through phosphatidylinositol 3-kinase and Akt. The Journal of Biological Chemistry 276: 13756-13761.
23. Pahl, H.L. 1999. Activators and target genes of Rel/NF-κB transcription factors. Oncogene 18: 6853-6866.
24. Schafer, S.L.; R. Lin, P.A. Moore, J. Hiscott, and P.M. Pitha. 1998. Regulation of type I interferon gene expression by interferon regulatory factor-3. The Journal of Biological Chemistry 273: 2714-2720.
25. Yamamoto, M.; S. Yamazaki, S. Uematsu, S. Sato, H. Hemmi, K. Hoshino, T. Kaisho, H. Kuwata, O. Takeuchi, K. Takeshige, T. Saitoh, S. Yamaoka, N. Yamamoto, S. Yamamoto, T. Muta, K. Takeda, and S. Akira. 2004. Regulation of Toll/IL-1-receptor-mediated gene expression by the inducible nuclear protein IκBζ. Nature 430: 218-222.