Tetrandrine ameliorates cognitive impairment via inhibiting astrocyte-derived S100B activation in a rat model of chronic cerebral hypoperfusion

Neurological Research

Volumn 35, Issue 6, 2013, Pages 614-621

  Chen, Lianlian ^a   Chen, Lixue ^a   Yanling, Lv ^a   Cui, Zhiwei ^a   Bei, Gui ^a   Qin, Guangcheng ^a   Zhou, Jiying ^a   Ge, Tan ^a  

^a THE FIRST AFFILIATED HOSPITAL OF CHONGQING MEDICAL UNIVERSITY   (China)

Author keywords

Chronic cerebral hypoperfusion; Cognitive impairment; Neuroinflammation; S100B; Tetrandrine

Indexed keywords

INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; PROTEIN S100B; TETRANDRINE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; ASSOCIATION; ASTROCYTE; BRAIN PERFUSION; COGNITION; COGNITIVE DEFECT; CONTROLLED STUDY; HIPPOCAMPAL CA1 REGION; HISTOPATHOLOGY; IMMUNOFLUORESCENCE; MALE; MAZE TEST; MEMORY; NONHUMAN; PROTEIN EXPRESSION; RAT; REAL TIME POLYMERASE CHAIN REACTION; SPATIAL LEARNING; TASK PERFORMANCE; WESTERN BLOTTING;

ANIMALS; ASTROCYTES; BENZYLISOQUINOLINES; CEREBROVASCULAR DISORDERS; CHRONIC DISEASE; COGNITION DISORDERS; DISEASE MODELS, ANIMAL; DRUGS, CHINESE HERBAL; MALE; MAZE LEARNING; RATS; S100 CALCIUM BINDING PROTEIN BETA SUBUNIT;

EID: 84879494684     PISSN: 01616412     EISSN: 17431328     Source Type: Journal    
DOI: 10.1179/1743132813Y.0000000175     Document Type: Article

References (34)

1. Dubois MF, Hébert R. The incidence of vascular dementia in Canada: a comparison with Europe and East Asia. Neuroepidemiology. 2001;20:179-87.
2. Farkas E, Luiten PG, Bari F. Permanent bilateral common carotid artery occlusion in the rat: a model for chronic cerebral hypoperfusion-related neurodegenerative diseases. Brain Res Rev. 2007;54:162-80.
3. Vicente E, Degerone D, Bohn L, Scornavaca F, Pimentel A, Leite MC, et al. Astroglial and cognitive effects of chronic cerebral hypoperfusion in the rat. Brain Res. 2009;1251:204-12.
4. Bruce-Keller AJ. Microglial-neuronal interactions in synaptic damage and recovery. J Neurosci Res. 1999;58:191-201.
5. Tuppo EE, Arias HR. The role of inflammation in Alzheimer's disease. Int J Biochem Cell Biol. 2005;37:289-305.
6. Mrak RE, Griffin WS. The role of activated astrocytes and of the neurotrophic cytokine S100B in the pathogenesis of Alzheimer's disease. Neurobiol Aging. 2001;22:915-22.
7. Hu J, Van Eldik LJ. Glial-derived proteins activate cultured astrocytes and enhance b amyloid-induced glial activation. Brain Res. 1999;842:46-54.
8. Ponath G, Schettler C, Kaestner F, Voigt B, Wentker D, Arolt V, et al. Autocrine S100B effects on astrocytes are mediated via RAGE. J Neuroimmunol. 2007;184:214-22.
9. Kim SH, Smith CJ, Van Eldik LJ. Importance of MAPK pathways for microglial pro-inflammatory cytokine IL-1b production. Neurobiol Aging. 2004;25:431-9.
10. Hu J, Ferreira A, Van Eldik LJ. S100beta induces neuronal cell death through nitric oxide release from astrocytes. J Neurochem. 1997;69:2294-301.
11. Lam AG, Koppal T, Akama KT, Guo L, Craft JM, Samy B, et al. Mechanism of glial activation by S100B: involvement of the transcription factor NFkappaB. Neurobiol Aging. 2001; 22:765-72.
12. Yao WX, Jiang MX. Effects of tetrandrine on cardiovascular electrophysiologic properties. Acta Pharmacol Sin. 2002;23: 1069-74.
13. Wu SJ, Ng LT. Tetrandrine inhibits proinflammatory cytokines, iNOS and COX-2 expression in human monocytic cells. Biol Pharm Bull. 2007;30:59-62.
14. Lin ST, Wang Y, Xue Y, Feng DC, Xu Y, Xu LY. Tetrandrine suppresses LPS-induced astrocyte activation via modulating IKKs-IkappaBalpha-NF-kappaB signaling pathway. Mol Cell Biochem. 2008;315:41-9.
15. Lin TY, Tseng SH, Li SJ, Chen JC, Shieh JS, Chen Y. Tetrandrine increased the survival rate of mice with lipopolysaccharide- induced endotoxemia. J Trauma. 2009;66:411-7.
16. He FQ, Qiu BY, Zhang XH, Li TK, Xie Q, Cui DJ, et al. Tetrandrine attenuates spatial memory impairment and hippocampal neuroinflammation via inhibiting NF-kB activation in a rat model of Alzheimer's disease induced by amyliod-b (1-42). Brain Res. 2011;1384:89-96.
17. Pappas BA, de la Torre JC, Davidson CM, Keyes MT, Fortin T. Chronic reduction of cerebral blood flow in the adult rat: late-emerging CA1 cell loss and memory dysfunction. Brain Res. 1996;708:50-8.
18. Zhu LX, Dong Z, Liao H, He BC, Xiao YL. An experimental study on rats brain protection of tetrandrine from dementia (in Chinese). Chin Pharmacol Bull. 2004;20:959-60.
19. Morris, R.G. Developments of a water maze procedure for studying spatial learning in the rat. J Neurosci Methods. 1984;11:47-60.
20. Zarow C, Vinters HV, Ellis WG, Weiner MW, Mungas D, White L, et al. Correlates of hippocampal neuron number in Alzheimer's disease and ischemic vascular dementia. Ann Neurol. 2005;57:896-903.
21. Zhu LX, Dong Z, Liao H. The experimental study on protective effect of tetrandrine on rat's dementia induced by QA (in Chinese). Chin J Gerontol. 2005;25:78-80.
22. Takano T, Tian GF, Peng W, Lou N, Libionka W, Han X, et al. Astrocyte-mediated control of cerebral blood flow. Nat Neurosci. 2006;9:260-7.
23. Engelhart MJ, Geerlings MI, Meijer J, Kiliaan A, Ruitenberg A, van Swieten JC, et al. Inflammatory proteins in plasma and the risk of dementia: the Rotterdam study. Arch Neurol. 2004;61:668-72.
24. Yamasaki Y, Matsuura N, Shozuhara H, Onodera H, Itoyama Y, Kogure K. Interleukin-1 as a pathogenetic mediator of ischemic brain injury in rats. Stroke. 1995;26:676-81.
25. Barone FC, Arvin B, White RF, Miller A, Webb CL, Willette RN, et al. Tumor necrosis factor-alpha. A mediator of focal ischemic brain injury. Stroke. 1997;28:1233-44.
26. Mori T, Town T, Kobayashi M, Tan J, Fujita SC, Asano T, et al. Augmented delayed infarct expansion and reactive astrocytosis after permanent focal ischemia in apolipoprotein E4 knock-in mice. J Cereb Blood Flow Metab. 2004;24:646-56.
27. Mori T, Tan J, Arendash GW, Koyama N, Nojima Y, Town T. Overexpression of human S100B exacerbates brain damage and periinfarct gliosis after permanent focal ischemia. Stroke. 2008;39:2114-21.
28. Mori T, Koyama N, Arendash GW, Horikoshi-Sakuraba Y, Tan J, Town T. Overexpression of human S100B exacerbates cerebral amyloidosis and gliosis in the Tg2576 mouse model of Alzheimer's disease. Glia. 2010;58:300-14.
29. Asano T, Mori T, Shimoda T, Shinagawa R, Satoh S, Yada N, et al. Arundic acid (ONO-2506) ameliorates delayed ischemic brain damage by preventing astrocytic overproduction of S100B. Curr Drug Targets CNS Neurol Disord. 2005;4:127-42.
30. Mori T, Town T, Tan J, Yada N, Horikoshi Y, Yamamoto J, et al. Arundic Acid ameliorates cerebral amyloidosis and gliosis in Alzheimer transgenic mice. J Pharmacol Exp Ther. 2006; 318:571-8.
31. Donato R. RAGE: a single receptor for several ligands and different cellular responses: the case of certain S100 proteins. Curr Mol Med. 1997;7:711-24.
32. Hofmann MA, Drury S, Fu C, Qu W, Taguchi A, Lu Y, et al. RAGE mediates a novel proinflammatory axis: a central cell surface receptor for S100/calgranulin polypeptides. Cell. 1999;97: 889-901.
33. Bianchi R, Giambanco I, Donato R. S100B/RAGE dependent activation of microglia via NF-kappaB and AP-1 Coregulation of COX-2 expression by S100B, IL-1beta and TNF-alpha. Neurobiol Aging. 2010;31:665-77.
34. Hu J, Castets F, Guevara JL, Van Eldik LJ. S100beta stimulates inducible nitric oxide synthase activity and mRNA levels in rat cortical astrocytes. J Biol Chem. 1996;271:2543-7.