Lumican Accelerates Wound Healing by Enhancing α2β1 Integrin-Mediated Fibroblast Contractility

PLoS ONE

Volumn 8, Issue 6, 2013, Pages

  Liu, Xiao Jin ^a,b   Kong, Fan Zhi ^b,c   Wang, Ya Hui ^b   Zheng, Jiang Hong ^a   Wan, Wei Dong ^a   Deng, Chen Liang ^a   Mao, Guang Yu ^a   Li, Jun ^b   Yang, Xiao Mei ^b   Zhang, Yan Li ^b   Zhang, Xue li ^c   Yang, Song lin ^a   Zhang, Zhi Gang ^b  

^a SHANGHAI JIAO TONG UNIVERSITY AFFILIATED SIXTH PEOPLE S HOSPITAL   (China)

^b SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^c Central Hospital of Fengxian District   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; ALPHA2 INTEGRIN; LUMICAN; VERY LATE ACTIVATION ANTIGEN 2; RECOMBINANT PROTEIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL ACTIVATION; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; DEGLYCOSYLATION; FEMALE; FIBROBLAST; GENE SILENCING; IN VITRO STUDY; KERATINOCYTE; MOUSE; MUSCLE FIBER CONTRACTION; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PURIFICATION; WOUND HEALING; ANIMAL; BAGG ALBINO MOUSE; CELL MOTION; CYTOLOGY; DEFICIENCY; DRUG EFFECTS; GENETICS; HEK293 CELL LINE; HUMAN; MALE; METABOLISM; SKIN;

MUS;

ANIMALS; CELL MOVEMENT; CELL PROLIFERATION; FIBROBLASTS; GENE SILENCING; HEK293 CELLS; HUMANS; INTEGRIN ALPHA2BETA1; LUMICAN; MALE; MICE; MICE, INBRED BALB C; RECOMBINANT PROTEINS; SKIN; WOUND HEALING;

EID: 84879490417     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0067124     Document Type: Article

References (42)

1. Schultz GS, Davidson JM, Kirsner RS, Bornstein P, Herman IM, (2011) Dynamic reciprocity in the wound microenvironment. Wound repair and regeneration: official publication of the Wound Healing Society [and] the European Tissue Repair Society 19: 134-148.
2. Junker JP, Caterson EJ, Eriksson E, (2013) The microenvironment of wound healing. The Journal of craniofacial surgery 24: 12-16.
3. Mori R, Shaw TJ, Martin P, (2008) Molecular mechanisms linking wound inflammation and fibrosis: knockdown of osteopontin leads to rapid repair and reduced scarring. The Journal of experimental medicine 205: 43-51.
4. Echtermeyer F, Streit M, Wilcox-Adelman S, Saoncella S, Denhez F, et al. (2001) Delayed wound repair and impaired angiogenesis in mice lacking syndecan-4. The Journal of clinical investigation 107: R9-R14.
5. Okamoto O, Fujiwara S, (2006) Dermatopontin, a novel player in the biology of the extracellular matrix. Connective Tissue Research 47: 177-189.
6. Nikitovic D, Katonis P, Tsatsakis A, Karamanos NK, Tzanakakis GN, (2008) Lumican, a Small Leucine-rich Proteoglycan. IUBMB Life 60: 818-823.
7. Yeh JT, Yeh LK, Jung SM, Chang TJ, Wu HH, et al. (2010) Impaired skin wound healing in lumican-null mice. The British journal of dermatology 163: 1174-1180.
8. Lee S, Bowrin K, Hamad AR, Chakravarti S, (2009) Extracellular matrix lumican deposited on the surface of neutrophils promotes migration by binding to beta2 integrin. Journal of Biological Chemistry 284: 23662-23669.
9. Lohr K, Sardana H, Lee S, Wu F, Huso DL, et al. (2012) Extracellular matrix protein lumican regulates inflammation in a mouse model of colitis. Inflammatory Bowel Diseases 18: 143-151.
10. Yeh LK, Chen WL, Li W, Espana EM, Ouyang J, et al. (2005) Soluble lumican glycoprotein purified from human amniotic membrane promotes corneal epithelial wound healing. Investigative Ophthalmology & Visual Science 46: 479-486.
11. Saika S, Shiraishi A, Liu CY, Funderburgh JL, Kao CW, et al. (2000) Role of lumican in the corneal epithelium during wound healing. The Journal of biological chemistry 275: 2607-2612.
12. Vuillermoz B, Khoruzhenko A, D'Onofrio MF, Ramont L, Venteo L, et al. (2004) The small leucine-rich proteoglycan lumican inhibits melanoma progression. Experimental Cell Research 296: 294-306.
13. Boukamp P, Petrussevska RT, Breitkreutz D, Hornung J, Markham A, et al. (1988) Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell line. The Journal of cell biology 106: 761-771.
14. Liu X-J, Xu M-J, Fan S-T, Wu Z, Li J, et al. (2013) Xiamenmycin Attenuates Hypertrophic Scars by Suppressing Local Inflammation and the Effects of Mechanical Stress. Journal of Investigative Dermatology.
15. Singer AJ, Clark RA, (1999) Cutaneous wound healing. The New England journal of medicine 341: 738-746.
16. Shaw TJ, Martin P, (2009) Wound repair at a glance. Journal of Cell Science 122: 3209-3213.
17. Freedberg IM, Tomic-Canic M, Komine M, Blumenberg M, (2001) Keratins and the keratinocyte activation cycle. The Journal of investigative dermatology 116: 633-640.
18. Grinnell F, (1992) Wound repair, keratinocyte activation and integrin modulation. Journal of Cell Science 101 (Pt 1): 1-5.
19. Hinz B, Celetta G, Tomasek JJ, Gabbiani G, Chaponnier C, (2001) Alpha-smooth muscle actin expression upregulates fibroblast contractile activity. Molecular Biology of the Cell 12: 2730-2741.
20. Wong VW, Longaker MT, Gurtner GC, (2012) Soft tissue mechanotransduction in wound healing and fibrosis. Seminars in cell & developmental biology 23: 981-986.
21. Wehrle-Haller B, (2012) Structure and function of focal adhesions. Current Opinion in Cell Biology 24: 116-124.
22. Geiger B, Yamada KM (2011) Molecular architecture and function of matrix adhesions. Cold Spring Harbor perspectives in biology 3.
23. Li J, Chen J, Kirsner R, (2007) Pathophysiology of acute wound healing. Clinics in dermatology 25: 9-18.
24. Niewiarowska J, Brezillon S, Sacewicz-Hofman I, Bednarek R, Maquart F-X, et al. (2011) Lumican inhibits angiogenesis by interfering with alpha 2 beta 1 receptor activity and downregulating MMP-14 expression. Thrombosis research 128: 452-457.
25. Zeltz C, Brezillon S, Kapyla J, Eble JA, Bobichon H, et al. (2010) Lumican inhibits cell migration through alpha2beta1 integrin. Experimental Cell Research 316: 2922-2931.
26. Tomasek JJ, Gabbiani G, Hinz B, Chaponnier C, Brown RA, (2002) Myofibroblasts and mechano-regulation of connective tissue remodelling. Nature Reviews Molecular Cell Biology 3: 349-363.
27. Hinz B, (2007) Formation and function of the myofibroblast during tissue repair. Journal of Investigative Dermatology 127: 526-537.
28. Grinnell F, (1994) Fibroblasts, myofibroblasts, and wound contraction. Journal of Cell Biology 124: 401-404.
29. Martin P, (1997) Wound healing- Aiming for perfect skin regeneration. Science 276: 75-81.
30. Carlson MA, Longaker MT, (2004) The fibroblast-populated collagen matrix as a model of wound healing: a review of the evidence. Wound Repair and Regeneration 12: 134-147.
31. Brezillon S, Radwanska A, Zeltz C, Malkowski A, Ploton D, et al. (2009) Lumican core protein inhibits melanoma cell migration via alterations of focal adhesion complexes. Cancer Letters 283: 92-100.
32. D'Onofrio MF, Brezillon S, Baranek T, Perreau C, Roughley PJ, et al. (2008) Identification of beta1 integrin as mediator of melanoma cell adhesion to lumican. Biochem Biophys Res Commun 365: 266-272.
33. Schedin P, Keely PJ (2011) Mammary Gland ECM Remodeling, Stiffness, and Mechanosignaling in Normal Development and Tumor Progression. Cold Spring Harbor perspectives in biology 3.
34. Agha R, Ogawa R, Pietramaggiori G, Orgill DP, (2011) A Review of the Role of Mechanical Forces in Cutaneous Wound Healing. Journal of Surgical Research 171: 700-708.
35. Huang C, Ogawa R, (2012) Fibroproliferative Disorders and Their Mechanobiology. Connective Tissue Research 53: 187-196.
36. Ingber DE, (2008) Tensegrity-based mechanosensing from macro to micro. Progress in biophysics and molecular biology 97: 163-179.
37. Langevin HM, Bouffard NA, Fox JR, Palmer BM, Wu J, et al. (2011) Fibroblast cytoskeletal remodeling contributes to connective tissue tension. Journal of Cellular Physiology 226: 1166-1175.
38. Kalamajski S, Oldberg A, (2009) Homologous sequence in lumican and fibromodulin leucine-rich repeat 5-7 competes for collagen binding. The Journal of biological chemistry 284: 534-539.
39. Brown RD, Ambler SK, Mitchell MD, Long CS (2005) The cardiac fibroblast: Therapeutic target in myocardial remodeling and failure. Annual Review of Pharmacology and Toxicology. 657-687.
40. Kalluri R, Zeisberg M, (2006) Fibroblasts in cancer. Nature Reviews Cancer 6: 392-401.
41. Sen CK, Gordillo GM, Roy S, Kirsner R, Lambert L, et al. (2009) Human skin wounds: A major and snowballing threat to public health and the economy. Wound Repair and Regeneration 17: 763-771.
42. Gunter CI, Machens HG, (2012) New Strategies in Clinical Care of Skin Wound Healing. European Surgical Research 49: 16-23.