Thermal and spectroscopic analysis of inclusion complex of spironolactone prepared by evaporation and hot melt methods

Journal of Thermal Analysis and Calorimetry

Volumn 102, Issue 1, 2010, Pages 349-355

  Patyi, G ^a,b   Bodis A ^b   Antal, I ^c   Vajna, B ^a   Nagy, Zs ^a   Marosi, Gy ^a  

^a BUDAPEST UNIVERSITY OF TECHNOLOGY AND ECONOMICS   (Hungary)

^b GEDEON RICHTER LTD   (Hungary)

^c SEMMELWEIS UNIVERSITY   (Hungary)

Author keywords

Amorphous; Extrusion; Inclusion complex; Solid solution

Indexed keywords

ACTIVE INGREDIENTS; AMORPHOUS; DISSOLUTION RATES; DSC STUDIES; FINE DISPERSIONS; HOT MELT; HYDROPHILIC POLYMERS; INCLUSION COMPLEX; LATTICE ENERGIES; MELTING TEMPERATURES; MODEL DRUGS; MOLECULAR DISPERSIONS; SOLVENT FREE; TWIN SCREW EXTRUSION;

COMPLEXATION; DISPERSIONS; DISSOLUTION; SOLID SOLUTIONS; SOLIDIFICATION; SPECTROSCOPIC ANALYSIS; THERMAL EVAPORATION;

EXTRUSION;

EID: 78049486366     PISSN: 13886150     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10973-010-0936-0     Document Type: Article

References (22)

1. D Hörter JB Dressman 2001 Influence of physicochemical properties on dissolution of drugs in the gastrointestinal tract Adv. Drug Deliv. Rev 46 75 87 10.1016/S0169-409X(00)00130-7
2. Yu. Lian 2001 Amorphous pharmaceutical solids: preparation, characterization and stabilization Adv. Drug Deliv. Rev 48 27 42 10.1016/S0169-409X(01)00098-9
3. DQM Craig PG Royall VL Kett ML Hopton 1999 The relevance of the amorphous state to pharmaceutical dosage forms: glassy drugs and freeze dried systems Int. J. of Pharm 179 179 207 1:CAS:528:DyaK1MXhsVensb0%3D 10.1016/S0378-5173(98) 00338-X
4. C Leuner J Dressman 2000 Improving drug solubility for oral delivery using solid dispersions Eur J Pharm Biopharm 50 47 60 1:CAS:528: DC%2BD3cXjslyju7c%3D 10.1016/S0939-6411(00)00076-X
5. T Vasconcelos B Sarmento P Costa 2007 Solid dispersions as strategy to improve oral bioavailability of poor water soluble drugs Drug Discov. Today 12 1068 1075 1:CAS:528:DC%2BD2sXhsVSmurnF 10.1016/j.drudis.2007.09.005
6. Kaneto Uekama Fumitoshi Hirayama Tetsumi Irie 1998 Cyclodextrin drug carrier systems Chem. Rev 98 2045 2076 1:CAS:528:DyaK1cXksV2itr0%3D 10.1021/cr970025p
7. MD Veiga M Merino D Fernández R Lozano 2002 Characterization of some cyclodextrin derivatives by thermal analysis J. Therm. Anal. Cal 68 511 516 1:CAS:528:DC%2BD38XkvFegs78%3D 10.1023/A:1016091803317
8. R Laitinen E Suihko K Toukola M Björkqvist J Riikonen VP Lehto K Järvinen J Ketolainen 2009 Intraorally fast-dissolving particles of a poorly soluble drug: preparation and in vitro characterization Eur J Pharm Biopharm 71 271 281 1:CAS:528:DC%2BD1MXitVShsb0%3D 10.1016/j.ejpb.2008.09.001
9. ®) on the dissolution properties of a poorly soluble drug from extrudates prepared by hot-melt extrusion Int J Pharm 350 88 196 10.1016/j.ijpharm.2007.08.038
10. K Six Ch Leuner J Dressman G Verreck J Peeters N Blaton P Augustijns R Kinget G Van den Mooter 2002 Thermal properties of hot-stage extrudates of itraconazole and EUDRAGIT E100 J Therm Anal Calorim 68 591 601 1:CAS:528:DC%2BD38XkvFegsLg%3D 10.1023/A:1016056222881
11. SE Bartsch UJ Griesser 2004 Physicochemical properties of the binary system glibenclamide and polyethylene glycol 4000 J. Therm. Anal. Cal 77 555 569 1:CAS:528:DC%2BD2cXmvFSmtb0%3D 10.1023/B:JTAN.0000038994.07044.8c
12. V Berbenni A Marini G Bruni A Maggioni R Riccardi A Orlandi 1999 Physico-chemical characterisation of different solid forms of spironolactone Thermochim Acta 340-341 117 129 10.1016/S0040-6031(99)00258-0
13. A Marini V Berbenni G Bruni A Maggioni A Orlandi M Villa 2001 Thermodynamics of complex melting process: the case of spironolactone Thermochim Acta 374 171 184 1:CAS:528:DC%2BD3MXks1Wrurw%3D 10.1016/S0040-6031(01)00500-7
14. F Giordano C Novak JR Moyano 2001 Thermal analysis of cyclodextrins and their inclusion compounds Thermochim Acta 380 123 151 1:CAS:528: DC%2BD3MXos1ChsL0%3D 10.1016/S0040-6031(01)00665-7
15. de Araujo DR, Tsuneda SS, Cereda CMS, Del GF Carvalho F, Preté PSC, Fernandes SA, Yokaichiya F, Franco MKKD, Mazzaro I, Fraceto LF, de FA Braga A, de Paula E (2008) Development and pharmacological evaluation of ropivacaine-2-hydroxypropyl-β-cyclodextrin inclusion complex. Eur J Pharm Sci 33:60-71.
16. H Aki T Niiya Y Iwase M Yamamoto 2001 Calorimetry to evaluate inclusion mechanism in the complexation between 2-hydroxypropyl-β-cyclodextrin and barbiturates in aqueous solution J Therm Anal Calorim 64 713 719 1:CAS:528:DC%2BD3MXkslWluro%3D 10.1023/A:1011592327676
17. ME Brown BD Glass MS Worthington 2002 Binary systems of nifedipine and various cyclodextrins in the solid state J. Therm. Anal. Cal 68 631 646 1:CAS:528:DC%2BD38XkvFegsbo%3D 10.1023/A:1016012407860
18. OAE Soliman K Kimura F Hirayama K Uekama HM El-Sabbagh Abd El-Gawad H Abd El-Gawad FM Hashim 1997 Amorphous spironolactone-hydroxypropylated cyclodextrin complexes with superior dissolution and oral bioavailability Int J Pharm 149 73 83 1:CAS:528:DyaK2sXjsVGjsrs%3D 10.1016/S0378-5173(96)04862-4
19. O Rajabi F Tayyari R Salari SF Tayyari 2008 Study of interaction of spironolactone with hydroxypropyl-b-cyclodextrin in aqueous solution and in solid state J Mol Struct 878 78 83 1:CAS:528:DC%2BD1cXktlOksL8%3D 10.1016/j.molstruc.2007.07.043
20. N Morin A Chilouet J Millet J-C Rouland 2000 Bifonazole-β- cyclodextrin inclusion complexes J Therm Anal Calorim 62 187 201 1:CAS:528:DC%2BD3cXosF2lsrk%3D 10.1023/A:1010127231416
21. MR Caira DR Dodds LR Nassimbeni 2002 Polymorphism and cyclodextrin inclusion of salbutamol laurate J Therm Anal Calorim 68 647 655 1:CAS:528:DC%2BD38XkvFegsbs%3D 10.1023/A:1016064424699
22. Beatrice Nicolaï p Espeau R Céolin M-A Perrin L Zaskel J Giovannini F Leveiller 2007 Polymorph formation from solvate desolvation J Therm Anal Calorim 90 2 337 339 10.1007/s10973-007-8389-9