Synthesis and antibacterial activities of N-substituted-glycinyl 1H-1,2,3-triazolyl oxazolidinones

European Journal of Medicinal Chemistry

Volumn 66, Issue , 2013, Pages 246-257

  Phillips, Oludotun A ^a   Udo, Edet E ^a   Abdel Hamid, Mohammed E ^a   Varghese, Reny ^a  

^a KUWAIT UNIVERSITY   (Kuwait)

Author keywords

Antibacterial activity; Gram positive bacteria; Linezolid; Substituted glycinyl oxazolidinone; Triazolyl oxazolidinone

Indexed keywords

ANTIINFECTIVE AGENT; LINEZOLID; N (2 (4 (2 FLUORO 4 (5 ((4 METHYL 1H 1,2,3 TRIAZOL 1YL) METHYL) 2 OXO OXAZOLIDIN 3 YL) PHENYL)PIPERAZIN 1 YL) 2 OXOETHYL) 5 NITROFURAN 2 CARBOXAMIDE; N (2 (4 (2 FLUORO 4 (5 ((4 METHYL 1H 1,2,3 TRIAZOL 1YL)METHYL) 2 OXO OXAZOLIDIN 3 YL)PHENYL)PIPERAZIN 1 YL) 2 OXOETHYL) 3,5 DINITROBENZAMIDE; N (2 (4 (4 (5 ((1H 1,2,3 TRIAZOL 1 YL)METHYL) 2 OXOOXAZOLIDIN 3 YL) 2 FLUOROPHENYL)PIPERAZIN 1 Y) 2 OXOETHYL) 5 NITROFURAN 2 CARBOXAMIDE; N (2 (4 (4 (5 ((1H 1,2,3 TRIAZOL 1 YL)METHYL) 2 OXOOXAZOLIDIN 3 YL) 2 FLUOROPHENYL)PIPERAZIN 1 YL) 2 OXOETHYL) 3,5 DINITROBENZAMIDE; N SUBSTITUTED GLYCINYL 1H 1,2,3 TRIAZOLYL OXAZOLIDINONE DERIVATIVE; OXAZOLIDINONE DERIVATIVE; UNCLASSIFIED DRUG; 2,2 DICHLORO N (2 (4 (2 FLUORO 4 (5 ((4 METHYL 1H 1,2,3 TRIAZOL 1 YL)METHYL) 2 OXOOXAZOLIDIN 3 YL)PHENYL)PIPERAZIN 1 YL) 2 OXOETHYL)ACETAMIDE; 2,2,2 TRIFLUORO N (2 (4 (2 FLUORO 4 (5 ((4 METHYL 1H 1,2,3 TRIAZOL 1 YL)METHYL) 2 OXOOXAZOLIDIN 3 YL)PHENYL)PIPERAZIN 1 YL) 2 OXOETHYL)ACETAMIDE; ANTIBIOTIC AGENT; ETHYL 3 ((2 (4 (2 FLUORO 4 (5 ((4 METHYL 1H 1,2,3 TRIAZOL 1 YL)METHYL) 2 OXO OXAZOLIDIN 3 YL)PHENYL)PIPERAZIN 1 YL) 2 OXOETHYL)AMINO) 3 OXOPROPANOATE; ETHYL 3 ((2 (4 (4(5 ((1H 1,2,3 TRIAZOL 1 YL)METHYL) 2 OXOOXAZOLIDIN 3 YL) 2 FLUOROPHENYL)PIPERAZIN 1 YL) 2 OXOETHYL)AMINO) 3 OXOPROPANOATE; GLYCINYL 1H 1,2,3 TRIAZOLYL OXAZOLIDINONE DERIVATIVE; N (2 (4 (2 FLUORO 4 (5 ((4 METHYL 1H 1,2,3 TRIAZOL 1 YL)METHYL) 2 OXO OXAZOLIDIN 3 YL)PHENYL)PIPERAZIN 1 YL) 2 OXOETHYL) 3,5 DINITROBENZAMIDE; N (2 (4 (2 FLUORO 4 (5 ((4 METHYL 1H 1,2,3 TRIAZOL 1 YL)METHYL) 2 OXO OXAZOLIDIN 3 YL)PHENYL)PIPERAZIN 1 YL) 2 OXOETHYL) ACETAMIDE; N (2 (4 (2 FLUORO 4 (5 ((4 METHYL 1H 1,2,3 TRIAZOL 1 YL)METHYL) 2 OXO OXAZOLIDIN 3 YL)PHENYL)PIPERAZIN 1 YL) 2 OXOETHYL)BENZAMIDE; N (2 (4 (2 FLUORO 4 (5 ((4 METHYL 1H 1,2,3 TRIAZOL 1 YL)METHYL) 2 OXO OXAZOLIDIN 3 YL)PHENYL)PIPERAZIN 1 YL) 2 OXOETHYL)NICOTINAMIDE; N (2 (4 (2 FLUORO 4 (5 ((4 METHYL 1H 1,2,3 TRIAZOL 1 YL)METHYL) 2 OXO OXAZOLIDIN 3 YL)PHENYL)PIPERAZIN 1 YL) 2 OXOETHYL)TETRAHYDROFURAN 2 CARBOXAMIDE; N (2 (4 (2 FLUORO 4 (5 ((4 METHYL 1H 1,2,3 TRIAZOL 1 YL)METHYL) 2 OXO OXAZOLIDIN 3 YL)PHENYL)PIPERAZIN 1 YL) 2 OXOETHYL)THIOPHENE 2 SULFONAMIDE; N (2 (4 (2 FLUORO 4 (5 ((4 METHYL 1H 1,2,3 TRIAZOL 1 YL)METHYL) 2 OXOOXAZOLIDIN 3 YL)PHENYL)PIPERAZIN 1 YL) 2 OXOETHYL) THIOPHENE 2 CARBOXAMIDE; N (2 (4 (2 FLUORO 4 (5 ((4 METHYL 1H 1,2,3 TRIAZOL 1 YL)METHYL) 2 OXOOXAZOLIDIN 3 YL)PHENYL)PIPERAZIN 1 YL) 2 OXOETHYL)FURAN 2 CARBOXAMIDE; N (2 (4 (2 FLUORO 4 (5 ((4 METHYL 1H 1,2,3 TRIAZOL 1YL)METHYL) 2 OXO OXAZOLIDIN 3 YL)PHENYL)PIPERAZIN 1 YL) 2 OXOETHYL) 5 NITROFURAN 2 CARBOXAMIDE; N (2 (4 (4 (5 ((1H 1,2,3 TRIAZOL 1 YL)METHYL) 2 OXOOXAZO LIDIN 3 YL)) 2 FLUORO PHENYL PIPERAZIN 1 YL) 2 OXOETHYL)ACETAMIDE; N (2 (4 (4 (5 ((1H 1,2,3 TRIAZOL 1 YL)METHYL) 2 OXOOXAZOLIDIN 3 YL) 2 FLUORO PHENYL)PIPERAZIN 1 YL) 2 OXOETHYL) TETRAHYDROFURAN 2 CARBOXAMIDE; N (2 (4 (4 (5 ((1H 1,2,3 TRIAZOL 1 YL)METHYL) 2 OXOOXAZOLIDIN 3 YL) 2 FLUOROPHENYL)PIPERAZIN 1 YL) 2 OXOETHYL) 5 NITROFURAN 2 CARBOXAMIDE; N (2 (4 (4 (5 ((1H 1,2,3 TRIAZOL 1 YL)METHYL) 2 OXOOXAZOLIDIN 3 YL) 2 FLUOROPHENYL)PIPERAZIN 1 YL) 2 OXOETHYL) FURAN 2 CARBOXAMIDE; N (2 (4 (4 (5 ((1H 1,2,3 TRIAZOL 1 YL)METHYL) 2 OXOOXAZOLIDIN 3 YL) 2 FLUOROPHENYL)PIPERAZIN 1 YL) 2 OXOETHYL)BENZAMIDE; N (2 (4 (4 (5 ((1H 1,2,3 TRIAZOL 1 YL)METHYL) 2 OXOOXAZOLIDIN 3 YL) 2 FLUOROPHENYL)PIPERAZIN 1 YL) 2 OXOETHYL)NICOTINAMIDE; N (2 (4 (4 (5 ((1H 1,2,3 TRIAZOL 1 YL)METHYL) 2 OXOOXAZOLIDIN 3 YL) 2 FLUOROPHENYL)PIPERAZIN 1 YL) 2 OXOETHYL)THIOPHENE 2 CARBOXAMIDE; N (2 (4 (4 (5 ((1H 1,2,3 TRIAZOL 1 YL)METHYL) 2 OXOOXAZOLIDIN 3 YL) 2 FLUOROPHENYL)PIPERAZIN 1 YL) 2 OXOETHYL)THIOPHENE 2 SULFONAMIDE;

ANTIBACTERIAL ACTIVITY; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIUM ISOLATE; DRUG SYNTHESIS; ESCHERICHIA COLI; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; HAEMOPHILUS INFLUENZAE; IN VITRO STUDY; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; METHICILLIN SUSCEPTIBLE STAPHYLOCOCCUS AUREUS; MINIMUM INHIBITORY CONCENTRATION; MORAXELLA CATARRHALIS; NONHUMAN; PLASMA PROTEIN BINDING; STREPTOCOCCUS PNEUMONIAE; VANCOMYCIN RESISTANT ENTEROCOCCUS; BINDING AFFINITY; COAGULASE NEGATIVE STAPHYLOCOCCUS; DRUG POTENCY; DRUG STRUCTURE; ENTEROCOCCUS; OBSERVATIONAL STUDY;

EID: 84879474796     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2013.05.041     Document Type: Article

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