Alterations of Neuromuscular Function after the World's Most Challenging Mountain Ultra-Marathon

PLoS ONE

Volumn 8, Issue 6, 2013, Pages

  Saugy, Jonas ^a   Place, Nicolas ^b   Millet, Guillaume Y ^c   Degache, Francis ^a   Schena, Federico ^d   Millet, Grégoire P ^a  

^a UNIVERSITY OF LAUSANNE   (Switzerland)

^b UNIVERSITY OF GENEVA   (Switzerland)

^c UNIVERSITÉ JEAN MONNET   (France)

^d UNIVERSITY OF VERONA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

C REACTIVE PROTEIN; CREATINE KINASE; LACTATE DEHYDROGENASE; MYOGLOBIN;

ARTICLE; CONTROLLED STUDY; ENZYME BLOOD LEVEL; EXTENSOR MUSCLE; FLEXOR MUSCLE; HUMAN; HUMAN EXPERIMENT; MALE; MARATHON RUNNER; MOUNTAIN ULTRA MARATHON; MUSCLE CONTRACTION; MUSCLE INJURY; MUSCLE STRENGTH; MUSCLE WEAKNESS; MYOSITIS; NEUROMUSCULAR FUNCTION; PROTEIN BLOOD LEVEL; RUNNING; SLEEP DEPRIVATION; SPORT; VOLUNTARY MOVEMENT; ADULT; ALTITUDE; ENDURANCE; FATIGUE; MIDDLE AGED; MUSCLE FATIGUE; PAIN; PATHOPHYSIOLOGY; PHYSIOLOGY;

ELAGATIS;

ADULT; ALTITUDE; FATIGUE; HUMANS; MALE; MIDDLE AGED; MUSCLE FATIGUE; PAIN; PHYSICAL ENDURANCE; RUNNING;

EID: 84879470316     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0065596     Document Type: Article

References (51)

1. Millet GP, Millet GY, (2012) Ultramarathon is an outstanding model for the study of adaptive responses to extreme load and stress. BMC medicine 10: 77.
2. Hoffman MD, Ingwerson JL, Rogers IR, Hew-Butler T, Stuempfle KJ, (2012) Increasing creatine kinase concentrations at the 161-km Western States Endurance Run. Wilderness & environmental medicine 23: 56-60.
3. Millet GY, Tomazin K, Verges S, Vincent C, Bonnefoy R, et al. (2011) Neuromuscular consequences of an extreme mountain ultra-marathon. PLoS ONE 6: e17059.
4. Millet GY, Lepers R, Maffiuletti NA, Babault N, Martin V, et al. (2002) Alterations of neuromuscular function after an ultramarathon. Journal of applied physiology 92: 486-492.
5. Robach P, Boisson RC, Vincent L, Lundby C, Moutereau S, et al. (2012) Hemolysis induced by an extreme mountain ultra-marathon is not associated with a decrease in total red blood cell volume. Scandinavian journal of medicine & science in sports.
6. Martin V, Kerherve H, Messonnier LA, Banfi JC, Geyssant A, et al. (2010) Central and peripheral contributions to neuromuscular fatigue induced by a 24-h treadmill run. Journal of applied physiology 108: 1224-1233.
7. Millet GY, (2011) Can neuromuscular fatigue explain running strategies and performance in ultra-marathons?: the flush model. Sports Medicine 41: 489-506.
8. Skenderi KP, Kavouras SA, Anastasiou CA, Yiannakouris N, Matalas AL, (2006) Exertional Rhabdomyolysis during a 246-km continuous running race. Med Sci Sports Exerc 38: 1054-1057.
9. Blumert PA, Crum AJ, Ernsting M, Volek JS, Hollander DB, et al. (2007) The acute effects of twenty-four hours of sleep loss on the performance of national-caliber male collegiate weightlifters. Journal of strength and conditioning research/National Strength & Conditioning Association 21: 1146-1154.
10. Bulbulian R, Heaney JH, Leake CN, Sucec AA, Sjoholm NT, (1996) The effect of sleep deprivation and exercise load on isokinetic leg strength and endurance. European journal of applied physiology and occupational physiology 73: 273-277.
11. Symons JD, Bell DG, Pope J, VanHelder T, Myles WS, (1988) Electro-mechanical response times and muscle strength after sleep deprivation. Can J Sport Sci 13: 225-230.
12. Symons JD, VanHelder T, Myles WS, (1988) Physical performance and physiological responses following 60 hours of sleep deprivation. Medicine and science in sports and exercise 20: 374-380.
13. Schütz UHW, Schmidt-Trucksäss A, Knechtle B, Machann J, Wiedelbach H, et al. (2012) The Transeurope Footrace Project: Longitudinal data acquisition in a cluster randomized mobile MRI observational cohort study on 44 endurance runners at a 64-stage 4,486km transcontinental ultramarathon. BMC Medicine.
14. Burnley M, Vanhatalo A, Jones AM, (2012) Distinct profiles of neuromuscular fatigue during muscle contractions below and above the critical torque in humans. Journal of applied physiology 113: 215-223.
15. Place N, Maffiuletti NA, Martin A, Lepers R, (2007) Assessment of the reliability of central and peripheral fatigue after sustained maximal voluntary contraction of the quadriceps muscle. Muscle & nerve 35: 486-495.
16. Loscher WN, Cresswell AG, Thorstensson A, (1994) Electromyographic responses of the human triceps surae and force tremor during sustained submaximal isometric plantar flexion. Acta physiologica Scandinavica 152: 73-82.
17. Hermens HJ, Freriks B, Disselhorst-Klug C, Rau G, (2000) Development of recommendations for SEMG sensors and sensor placement procedures. J Electromyogr Kinesiol 10: 361-374.
18. Place N, Martin A, Ballay Y, Lepers R, (2007) Neuromuscular fatigue differs with biofeedback type when performing a submaximal contraction. Journal of electromyography and kinesiology: official journal of the International Society of Electrophysiological Kinesiology 17: 253-263.
19. Lippi G, Schena F, Salvagno GL, Montagnana M, Gelati M, et al. (2008) Acute variation of biochemical markers of muscle damage following a 21-km, half-marathon run. Scand J Clin Lab Invest 68: 667-672.
20. Lippi G, Schena F, Salvagno GL, Aloe R, Banfi G, et al. (2012) Foot-strike haemolysis after a 60-km ultramarathon. Blood Transfus 10: 377-383.
21. Verges S, Maffiuletti NA, Kerherve H, Decorte N, Wuyam B, et al. (2009) Comparison of electrical and magnetic stimulations to assess quadriceps muscle function. Journal of applied physiology 106: 701-710.
22. Kent-Braun JA, Le Blanc R, (1996) Quantitation of central activation failure during maximal voluntary contractions in humans. Muscle & nerve 19: 861-869.
23. Millet GY, Lepers R, (2004) Alterations of neuromuscular function after prolonged running, cycling and skiing exercises. Sports Medicine 34: 105-116.
24. Tucker R, (2009) The anticipatory regulation of performance: the physiological basis for pacing strategies and the development of a perception-based model for exercise performance. British Journal of Sports Medicine 43: 392-400.
25. Millet GY, Banfi JC, Kerherve H, Morin JB, Vincent L, et al. (2011) Physiological and biological factors associated with a 24 h treadmill ultra-marathon performance. Scandinavian journal of medicine & science in sports 21: 54-61.
26. Noakes TD, (2007) The central governor model of exercise regulation applied to the marathon. Sports medicine 37: 374-377.
27. Bigland-Ritchie B, Woods JJ, (1984) Changes in muscle contractile properties and neural control during human muscular fatigue. Muscle & nerve 7: 691-699.
28. Place N, Yamada T, Bruton JD, Westerblad H, (2010) Muscle fatigue: from observations in humans to underlying mechanisms studied in intact single muscle fibres. European journal of applied physiology 110: 1-15.
29. Place N, Bruton JD, Westerblad H, (2009) Mechanisms of fatigue induced by isometric contractions in exercising humans and in mouse isolated single muscle fibres. Clinical and experimental pharmacology & physiology 36: 334-339.
30. Bellinger AM, Reiken S, Dura M, Murphy PW, Deng SX, et al. (2008) Remodeling of ryanodine receptor complex causes "aky"channels: a molecular mechanism for decreased exercise capacity. Proceedings of the National Academy of Sciences of the United States of America 105: 2198-2202.
31. Noakes TD, (2012) Fatigue is a Brain-Derived Emotion that Regulates the Exercise Behavior to Ensure the Protection of Whole Body Homeostasis. Frontiers in physiology 3: 82.
32. Sasaki K, Neptune RR, (2006) Differences in muscle function during walking and running at the same speed. Journal of biomechanics 39: 2005-2013.
33. Snyder KL, Kram R, Gottschall JS, (2012) The role of elastic energy storage and recovery in downhill and uphill running. The Journal of experimental biology 215: 2283-2287.
34. Braun WA, Paulson S, (2012) The effects of a downhill running bout on running economy. Research in sports medicine 20: 274-285.
35. Chapman D, Newton M, Sacco P, Nosaka K, (2006) Greater muscle damage induced by fast versus slow velocity eccentric exercise. International journal of sports medicine 27: 591-598.
36. Minetti AE, Moia C, Roi GS, Susta D, Ferretti G, (2002) Energy cost of walking and running at extreme uphill and downhill slopes. Journal of applied physiology 93: 1039-1046.
37. Millet GP, (2012) Economy is not sacrificed in ultramarathon runners. Journal of Applied Physiology 113: 686.
38. Millet GY, Hoffman MD, Morin JB, (2012) Sacrificing economy to improve running performance - a reality in the ultramarathon? Journal of Applied Physiology 113: 507-509.
39. Martin BJ, (1981) Effect of sleep deprivation on tolerance of prolonged exercise. European journal of applied physiology and occupational physiology 47: 345-354.
40. Oliver SJ, Costa RJ, Laing SJ, Bilzon JL, Walsh NP, (2009) One night of sleep deprivation decreases treadmill endurance performance. European journal of applied physiology 107: 155-161.
41. Myles WS, (1985) Sleep deprivation, physical fatigue, and the perception of exercise intensity. Medicine and science in sports and exercise 17: 580-584.
42. Malm C, Sjodin TL, Sjoberg B, Lenkei R, Renstrom P, et al. (2004) Leukocytes, cytokines, growth factors and hormones in human skeletal muscle and blood after uphill or downhill running. The Journal of physiology 556: 983-1000.
43. Eston RG, Mickleborough J, Baltzopoulos V, (1995) Eccentric activation and muscle damage: biomechanical and physiological considerations during downhill running. British Journal of Sports Medicine 29: 89-94.
44. Fallon KE, Sivyer G, Sivyer K, Dare A, (1999) The biochemistry of runners in a 1600 km ultramarathon. British Journal of Sports Medicine 33: 264-269.
45. Mischler I, Boirie Y, Gachon P, Pialoux V, Mounier R, et al. (2003) Human albumin synthesis is increased by an ultra-endurance trial. Medicine and science in sports and exercise 35: 75-81.
46. Lucas SJ, Anglem N, Roberts WS, Anson JG, Palmer CD, et al. (2008) Intensity and physiological strain of competitive ultra-endurance exercise in humans. Journal of sports sciences 26: 477-489.
47. Warren GL, Hayes DA, Lowe DA, Armstrong RB, (1993) Mechanical factors in the initiation of eccentric contraction-induced injury in rat soleus muscle. The Journal of physiology 464: 457-475.
48. Tsatalas T, Giakas G, Spyropoulos G, Sideris V, Lazaridis S, et al. (2013) The effects of eccentric exercise-induced muscle damage on running kinematics at different speeds. Journal of sports sciences 31: 288-298.
49. Blazevich AJ, Cannavan D, Coleman DR, Horne S, (2007) Influence of concentric and eccentric resistance training on architectural adaptation in human quadriceps muscles. J Appl Physiol 103: 1565-1575.
50. Guilhem G, Cornu C, Guevel A, (2011) Muscle architecture and EMG activity changes during isotonic and isokinetic eccentric exercises. Eur J Appl Physiol 111: 2723-2733.
51. Nosaka K, Sakamoto K, Newton M, Sacco P, (2001) The repeated bout effect of reduced-load eccentric exercise on elbow flexor muscle damage. Eur J Appl Physiol 85: 34-40.