Mass spectrometric imaging of red fluorescent protein in breast tumor xenografts

Journal of the American Society for Mass Spectrometry

Volumn 24, Issue 5, 2013, Pages 711-717

  Chughtai, Kamila ^a   Jiang, Lu ^b   Post, Harm ^c   Winnard, Paul T ^b   Greenwood, Tiffany R ^b   Raman, Venu ^b,d   Bhujwalla, Zaver M ^b,d   Heeren, Ron M A ^a,c   Glunde, Kristine ^b,d  

^a FOM INSTITUTE AMOLF   (Netherlands)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c NETHERLANDS PROTEOMICS CENTRE   (Netherlands)

^d JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

Breast cancer; MALDI; Tryptic peptides

Indexed keywords

DIMERS; FLUORESCENCE; MASS SPECTROMETERS; MASS SPECTROMETRY; MEDICAL IMAGING; MOLECULAR BIOLOGY; PROTEINS; TUMORS;

BREAST CANCER; BREAST TUMOUR; ELECTROSPRAY MASS SPECTROMETRY; FLUORESCENT PROTEIN; MALDI; MASS SPECTROMETRIC IMAGING; RED FLUORESCENT PROTEINS; TISSUE SECTIONS; TRYPTIC PEPTIDES; TUMOUR XENOGRAFTS;

VISUALIZATION;

RED FLUORESCENT PROTEIN;

AMINO ACID SEQUENCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BREAST TUMOR; CONTROLLED STUDY; ELECTROSPRAY MASS SPECTROMETRY; HUMAN; HUMAN TISSUE; HYPOXIA; IMAGE ANALYSIS; IMAGE QUALITY; MASS SPECTROMETRY; MICROSCOPY; MOLECULAR IMAGING; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN ISOLATION; SEQUENCE ANALYSIS; TUMOR XENOGRAFT;

LYCOPERSICON ESCULENTUM;

EID: 84879465169     PISSN: 10440305     EISSN: 18791123     Source Type: Journal    
DOI: 10.1007/s13361-012-0503-y     Document Type: Article

References (19)

1. Chughtai, K.; Heeren, R.M.: Mass spectrometric imaging for biomedical tissue analysis. Chem. Rev. 110, 3237-3277 (2010)
2. Campbell, R.E.; Tour, O.; Palmer, A.E.; Steinbach, P.A.; Baird, G.S.; Zacharias, D.A.; Tsien, R.Y.: A monomeric red fluorescent protein. Proc. Natl. Acad. Sci. U. S. A. 99, 7877-7882 (2002)
3. Matz, M.V.; Fradkov, A.F.; Labas, Y.A.; Savitsky, A.P.; Zaraisky, A.G.; Markelov, M.L.; Lukyanov, S.A.: Fluorescent proteins from nonbioluminescent Anthozoa species. Nat. Biotechnol. 17, 969-973 (1999)
4. Gross, L.A.; Baird, G.S.; Hoffman, R.C.; Baldridge, K.K.; Tsien, R.Y.: The structure of the chromophore within DsRed, a red fluorescent protein from coral. Proc. Natl. Acad. Sci. U. S. A. 97, 11990-11995 (2000)
5. Baird, G.S.; Zacharias, D.A.; Tsien, R.Y.: Biochemistry, mutagenesis, and oligomerization of DsRed, a red fluorescent protein from coral. Proc. Natl. Acad. Sci. U. S. A. 97, 11984-11989 (2000)
6. Shaner, N.C.; Campbell, R.E.; Steinbach, P.A.; Giepmans, B.N.; Palmer, A.E.; Tsien, R.Y.: Improved monomeric red, orange and yellow fluorescent proteins derived from Discosoma sp. red fluorescent protein. Nat. Biotechnol. 22, 1567-1572 (2004)
7. Morris, L.M.; Klanke, C.A.; Lang, S.A.; Lim, F.Y.; Crombleholme, T.M.: TdTomato and EGFP identification in histological sections: insight and alternatives. Biotech. Histochem. 85, 379-387 (2010)
8. Winnard Jr.; P.T.; Kluth, J.B.; Raman, V.: Noninvasive optical tracking of red fluorescent protein-expressing cancer cells in a model of metastatic breast cancer. Neoplasia 8, 796-806 (2006)
9. Deliolanis, N.C.; Kasmieh, R.; Wurdinger, T.; Tannous, B.A.; Shah, K.; Ntziachristos, V.: Performance of the red-shifted fluorescent proteins in deep-tissue molecular imaging applications. J. Biomed. Opt. 13, 044008 (2008)
10. Raman, V.; Artemov, D.; Pathak, A.P.; Winnard Jr.; P.T.; McNutt, S.; Yudina, A.; Bogdanov Jr.; A.; Bhujwalla, Z.M.: Characterizing vascular parameters in hypoxic regions: a combined magnetic resonance and optical imaging study of a human prostate cancer model. Cancer Res. 66, 9929-9936 (2006)
11. Krishnamachary, B.; Penet, M.F.; Nimmagadda, S.; Mironchik, Y.; Raman, V.; Solaiyappan, M.; Semenza, G.L.; Pomper, M.G.; Bhujwalla, Z.M.: Hypoxia regulates CD44 and its variant isoforms through HIF-1α in triple negative breast cancer. PLoS ONE 7(8): e44078 (2012)
12. Chughtai, K.; Jiang, L.; Greenwood, T.R.; Klinkert, I.; Amstalden van Hove, E.R.; Heeren, R.M.; Glunde, K.: Fiducial markers for combined 3-dimensional mass spectrometric and optical tissue imaging. Anal. Chem. 84, 1817-1823 (2012)
13. Jiang, L.; Greenwood, T.R.; Artemov, D.; Raman, V.; Winnard, Jr.; P.T.; Heeren, R.M.; Bhujwalla, Z.M.; Glunde, K.: Localized hypoxia results in spatially heterogeneous metabolic signatures in breast tumor models. Neoplasia 14, 732-741 (2012)
14. Jiang, L.; Greenwood, T.R.; Amstalden van Hove, E.R.; Chughtai, K.; Raman, V.; Winnard, Jr.; P.T.; Heeren, R.M.A.; Artemov, D.; Glunde, K.: Combined magnetic resonance, fluorescence, and histology imaging strategy in a human breast tumor xenograft model. NMR Biomed. doi: 10.1002/nbm.2846(2012)
15. Stoeckli, M.; Staab, D.; Schweitzer, A.: Compound and metabolite distribution measured by MALDI mass spectrometric imaging in whole-body tissue sections. Int. J. Mass Spectrom. 260, 195-202 (2007)
16. Surrey, T.; Jahnig, F.: Refolding and oriented insertion of a membrane protein into a lipid bilayer. Proc. Natl. Acad. Sci. U. S. A. 89, 7457-7461 (1992)
17. Cheley, S.; Malghani, M.S.; Song, L.; Hobaugh, M.; Gouaux, J.E.; Yang, J.; Bayley, H.: Spontaneous oligomerization of a staphylococcal alpha-hemolysin conformationally constrained by removal of residues that form the transmembrane beta-barrel. Protein Eng. 10, 1433-1443 (1997)
18. Chiang, C.F.; Okou, D.T.; Griffin, T.B.; Verret, C.R.; Williams, M.N.: Green fluorescent protein rendered susceptible to proteolysis: positions for protease-sensitive insertions. Arch. Biochem. Biophys. 394, 229-235 (2001)
19. Alvarez, L.A.; Merola, F.; Erard, M.; Rusconi, F.: Mass spectrometry-based structural dissection of fluorescent proteins. Biochemistry 48, 3810-3812 (2009)