Peripheral blood derived gene panels predict response to infliximab in rheumatoid arthritis and Crohn's disease

Genome Medicine

Volumn 5, Issue 6, 2013, Pages

  Mesko, Bertalan ^a   Poliska, Szilard ^a,c   Váncsa, Andrea ^a   Szekanecz, Zoltan ^a   Palatka, Karoly ^a   Hollo, Zsolt ^b   Horvath, Attila ^a   Steiner, Laszlo ^a   Zahuczky, Gabor ^c   Podani, Janos ^d   Nagy, Laszlo ^a  

^a UNIVERSITY OF DEBRECEN   (Hungary)

^b EGIS PHARMACEUTICALS LTD   (Hungary)

^c UD GenoMed Ltd   (Hungary)

^d EÖTVÖS LORÁND UNIVERSITY   (Hungary)

Author keywords

[No Author keywords available]

Indexed keywords

INFLIXIMAB; METHOTREXATE; PREDNISOLONE; B LYMPHOCYTE INDUCED MATURATION PROTEIN 1; BONE MORPHOGENETIC PROTEIN 6; CELL ADHESION MOLECULE; CELL ADHESION MOLECULE 2; G PROTEIN COUPLED RECEPTOR; G PROTEIN COUPLED RECEPTOR 34; INTERLEUKIN 1 RECEPTOR LIKE 1 PROTEIN; INTERLEUKIN RECEPTOR; MULTIDRUG RESISTANCE ASSOCIATED PROTEIN 4; PROTEIN; RAD23A PROTEIN; SLC7A5 PROTEIN; THIOESTERASE SUPERFAMILY MEMBER 5 PROTEIN; THIOL ESTER HYDROLASE; UNCLASSIFIED DRUG;

ADULT; ARTICLE; BLOOD; CLINICAL ARTICLE; CROHN DISEASE; FEMALE; FILTER; GENE; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENOME; HUMAN; MALE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS; BIOLOGICAL THERAPY; BIOSTATISTICS; CAUCASIAN; COHORT ANALYSIS; DISEASE COURSE; GENETIC ANALYSIS; HUMAN GENOME; MICROARRAY ANALYSIS; PERIPHERAL BLOOD MONONUCLEAR CELL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA ISOLATION; TREATMENT RESPONSE;

EID: 84879434458     PISSN: None     EISSN: 1756994X     Source Type: Journal    
DOI: 10.1186/gm463     Document Type: Article

References (26)

1. Karampetsou MP, Liossis SN, Sfikakis PP. TNF-alpha antagonists beyond approved indications: stories of success and prospects for the future. QJM 2010, 103:917-928. 10.1093/qjmed/hcq152, 20802008.
2. Smolen JS, Aletaha D, Koeller M, Weisman MH, Emery P. New therapies for treatment of rheumatoid arthritis. Lancet 2007, 370:1861-1874. 10.1016/S0140-6736(07)60784-3, 17570481.
3. Cohen RD, Tsang JF, Hanauer SB. Infliximab in Crohn's disease: first anniversary clinical experience. Am J Gastroenterol 2000, 95:3469-3477. 10.1111/j.1572-0241.2000.03363.x, 11151879.
4. Mesko B, Poliska S, Szegedi A, Szekanecz Z, Palatka K, Papp M, Nagy L. Peripheral blood gene expression patterns discriminate among chronic inflammatory diseases and healthy controls and identify novel targets. BMC Med Genomics 2010, 3:15. 10.1186/1755-8794-3-15, 2874757, 20444268.
5. Van't Veer LJ, Dai H, van de Vijver MJ, He YD, Hart AA, Mao M, Peterse HL, van der Kooy K, Marton MJ, Witteveen AT, Schreiber GJ, Kerkhoven RM, Roberts C, Linsley PS, Bernards R, Friend SH. Gene expression profiling predicts clinical outcome of breast cancer. Nature 2002, 415:530-536. 10.1038/415530a, 11823860.
6. Hakonarson H, Bjornsdottir US, Halapi E, Bradfield J, Zink F, Mouy M, Helgadottir H, Gudmundsdottir AS, Andrason H, Adalsteinsdottir AE, Kristjansson K, Birkisson I, Arnason T, Andresdottir M, Gislason D, Gislason T, Gulcher JR, Stefansson K. Profiling of genes expressed in peripheral blood mononuclear cells predicts glucocorticoid sensitivity in asthma patients. Proc Natl Acad Sci USA 2005, 102:14789-14794. 10.1073/pnas.0409904102, 1253826, 16203992.
7. Aziz H, Zaas A, Ginsburg GS. Peripheral blood gene expression profiling for cardiovascular disease assessment. Genomic Med 2007, 1:105-112. 10.1007/s11568-008-9017-x, 2269039, 18923935.
8. Targan SR, Hanauer SB, van Deventer SJ, Mayer L, Present DH, Braakman T, DeWoody KL, Schaible TF, Rutgeerts PJ. A short-term study of chimeric monoclonal antibody cA2 to tumor necrosis factor alpha for Crohn's disease. Crohn's Disease cA2 Study Group. N Engl J Med 1997, 337:1029-1035. 10.1056/NEJM199710093371502, 9321530.
9. Strand V, Kimberly R, Isaacs JD. Biologic therapies in rheumatology: lessons learned, future directions. Nat Rev Drug Discov 2007, 6:75-92. 10.1038/nrd2196, 17195034.
10. Van Baarsen LG, Wijbrandts CA, Gerlag DM, Rustenburg F, van der Pouw Kraan TC, Dijkmans BA, Tak PP, Verweij CL. Pharmacogenomics of infliximab treatment using peripheral blood cells of patients with rheumatoid arthritis. Genes Immun 2010, 11:622-629. 10.1038/gene.2010.34, 20555356.
11. Rubbert-Roth A, Finckh A. Treatment options in patients with rheumatoid arthritis failing initial TNF inhibitor therapy: a critical review. Arthritis Res Ther 2009, 11(Suppl 1):S1. 10.1186/ar2666, 2669237, 19368701.
12. Toonen EJ, Gilissen C, Franke B, Kievit W, Eijsbouts AM, den Broeder AA, van Reijmersdal SV, Veltman JA, Scheffer H, Radstake TR, van Riel PL, Barrera P, Coenen MJ. Validation study of existing gene expression signatures for anti-TNF treatment in patients with rheumatoid arthritis. PLoS One 2012, 7:e33199. 10.1371/journal.pone.0033199, 3310059, 22457743.
13. Agnholt J, Kaltoft K. Infliximab downregulates interferon-gamma production in activated gut T-lymphocytes from patients with Crohn's disease. Cytokine 2001, 15:212-222. 10.1006/cyto.2001.0919, 11563881.
14. Julia A, Erra A, Palacio C, Tomas C, Sans X, Barcelo P, Marsal S. An eight-gene blood expression profile predicts the response to infliximab in rheumatoid arthritis. PLoS One 2009, 4:e7556. 10.1371/journal.pone.0007556, 2762038, 19847310.
15. Bansard C, Lequerre T, Derambure C, Vittecoq O, Hiron M, Daragon A, Pouplin S, Daveau M, Boyer O, Tron F, Le Loët X, Salier JP. Gene profiling predicts rheumatoid arthritis responsiveness to IL-1Ra (anakinra). Rheumatology (Oxford) 2011, 50:283-292.
16. Lindberg J, af Klint E, Catrina AI, Nilsson P, Klareskog L, Ulfgren AK, Lundeberg J. Effect of infliximab on mRNA expression profiles in synovial tissue of rheumatoid arthritis patients. Arthritis Res Ther 2006, 8:R179. 10.1186/ar2090, 1794525, 17134501.
17. Aletaha D, Neogi T, Silman AJ, Funovits J, Felson DT, Bingham CO, Birnbaum NS, Burmester GR, Bykerk VP, Cohen MD, Combe B, Costenbader KH, Dougados M, Emery P, Ferraccioli G, Hazes JM, Hobbs K, Huizinga TW, Kavanaugh A, Kay J, Kvien TK, Laing T, Mease P, Ménard HA, Moreland LW, Naden RL, Pincus T, Smolen JS, Stanislawska-Biernat E, Symmons D, et al. 2010 Rheumatoid arthritis classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative. Arthritis Rheum 2010, 62:2569-2581. 10.1002/art.27584, 20872595.
18. Hamadeh HK, Bushel PR, Jayadev S, DiSorbo O, Bennett L, Li L, Tennant R, Stoll R, Barrett JC, Paules RS, Blanchard K, Afshari CA. Prediction of compound signature using high density gene expression profiling. Toxicol Sci 2002, 67:232-240. 10.1093/toxsci/67.2.232, 12011482.
19. R Development Core Team (2008) R: A language and environment for statistical computing. 2008, Vienna, Austria, R Development Core Team (2008)., http://www.r-project.org
20. Venables WN, Ripley BD. Modern Applied Statistics with S 2002, New York: Springer, Fourth.
21. Sing T, Sander O, Beerenwinkel N, Lengauer T. ROCR: visualizing classifier performance in R. Bioinformatics 2005, 21(20):3940-3941. 10.1093/bioinformatics/bti623, 16096348.
22. Bovin LF, Brynskov J, Hegedus L, Jess T, Nielsen CH, Bendtzen K. Gene expression profiling in autoimmune diseases: chronic inflammation or disease specific patterns?. Autoimmunity 2007, 40:191-201. 10.1080/08916930701233813, 17453718.
23. Chae SC, Yu JI, Oh GJ, Choi CS, Choi SC, Yang YS, Yun KJ. Identification of single nucleotide polymorphisms in the TNFRSF17 gene and their association with gastrointestinal disorders. Mol Cells 2010, 29:21-28. 10.1007/s10059-010-0002-6, 20016944.
24. Wang K, Zhang H, Kugathasan S, Annese V, Bradfield JP, Russell RK, Sleiman PM, Imielinski M, Glessner J, Hou C, Wilson DC, Walters T, Kim C, Frackelton EC, Lionetti P, Barabino A, van Limbergen J, Guthery S, Denson L, Piccoli D, Li M, Dubinsky M, Silverberg M, Griffiths A, Grant SF, Satsangi J, Baldassano R, Hakonarson H. Diverse genome-wide association studies associate the IL12/IL23 pathway with Crohn Disease. Am J Hum Genet 2009, 84:399-405. 10.1016/j.ajhg.2009.01.026, 2668006, 19249008.
25. Törkvist L, Halfvarson J, Ong RT, Lördal M, Sjöqvist U, Bresso F, Björk J, Befrits R, Löfberg R, Blom J, Carlson M, Padyukov L, D'Amato M, Seielstad M, Pettersson S. Analysis of 39 Crohn's disease risk loci in Swedish inflammatory bowel disease patients. flamm Bowel Dis 2010, 16:907-909.
26. Bohanec Grabar P, Logar D, Lestan B, Dolzan V. Genetic determinants of methotrexate toxicity in rheumatoid arthritis patients: a study of polymorphisms affecting methotrexate transport and folate metabolism. Eur J Clin Pharmacol 2008, 64:1057-1068. 10.1007/s00228-008-0521-7, 18607581.