Improved neurocognitive functions correlate with reduced inflammatory burden in atrial fibrillation patients treated with intensive cholesterol lowering therapy

Journal of Neuroinflammation

Volumn 10, Issue , 2013, Pages

  Lappegård, Knut Tore ^a,b   Pop Purceleanu, Monica ^c   van Heerde, Waander ^c   Sexton, Joe ^d   Tendolkar, Indira ^c,e   Pop, Gheorghe ^c  

^a NORDLAND HOSPITAL   (Norway)

^b UNIVERSITY OF TROMSØ   (Norway)

^c RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^d UNIVERSITY OF OSLO   (Norway)

^e RADBOUD UNIVERSITY   (Netherlands)

Author keywords

Atrial Fibrillation; Cerebral MRI; Inflammation; Neurocognitive Function; Statins

Indexed keywords

ATORVASTATIN; C REACTIVE PROTEIN; EZETIMIBE; FIBROBLAST GROWTH FACTOR; GAMMA INTERFERON; GRANULOCYTE COLONY STIMULATING FACTOR; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 13; INTERLEUKIN 17; INTERLEUKIN 9; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; PLACEBO;

AMYGDALOID NUCLEUS; ARTICLE; BRAIN SIZE; CLINICAL ARTICLE; COGNITION; CONTROLLED STUDY; DETERIORATION; FEMALE; HEART ATRIUM FIBRILLATION; HIPPOCAMPUS; HUMAN; INFLAMMATION; MALE; MEMORY; NUCLEAR MAGNETIC RESONANCE IMAGING; PROTEIN BLOOD LEVEL; RANDOMIZED CONTROLLED TRIAL;

EID: 84879433672     PISSN: None     EISSN: 17422094     Source Type: Journal    
DOI: 10.1186/1742-2094-10-78     Document Type: Article

References (37)

1. Guo Y, Lip GY, Apostolakis S. Inflammation in atrial fibrillation. J Am CollCardiol 2012, 60:2263-2270.
2. Lappegård KT, Hovland A, Pop GAM, Mollnes TE. Atrial fibrillation - inflammation in disguise?. Scand J Immunol 2013,
3. Calò L, Bianconi L, Colivicchi F, Lamberti F, Loricchio ML, de Ruvo E, Meo A, Pandozi C, Staibano M, Santini M. N-3 Fatty acids for the prevention of atrial fibrillation after coronary artery bypass surgery: a randomized, controlled tria. J Am CollCardiol 2005, 45:1723-1728.
4. Fauchier L, Pierre B, de Labriolle A, Grimard C, Zannad N, Babuty D. Antiarrhythmic effect of statin therapy and atrial fibrillation a meta-analysis of randomized controlled trials. J Am CollCardiol 2008, 51:828-835.
5. Liakopoulos OJ, Choi YH, Haldenwang PL, Strauch J, Wittwer T, Dörge H, Stamm C, Wassmer G, Wahlers T. Impact of preoperative statin therapy on adverse postoperative outcomes in patients undergoing cardiac surgery: a meta-analysis of over 30,000 patients. Eur Heart J 2008, 29:1548-1559. 10.1093/eurheartj/ehn198, 18506053.
6. Rubens FD, Nathan H, Labow R, Williams KS, Wozny D, Karsh J, Ruel M, Mesana T. Effects of methylprednisolone and a biocompatible copolymer circuit on blood activation during cardiopulmonary bypass. Ann ThoracSurg 2005, 79:655-665.
7. Healey JS, Morillo CA, Connolly SJ. Role of the renin-angiotensin-aldosterone system in atrial fibrillation and cardiac remodeling. Current Opinion in Cardiology 2005, 20:31-37.
8. Wachtell K, Lehto M, Gerdts E, Olsen MH, Hornestam B, Dahlöf B, Ibsen H, Julius S, Kjeldsen SE, Lindholm LH, Nieminen MS, Devereux RB. Angiotensin II receptor blockade reduces new-onset atrial fibrillation and subsequent stroke compared to atenolol: the losartan intervention for End point reduction in hypertension (LIFE) study. J Am CollCardiol 2005, 45:712-719.
9. Zhang G, Li J, Purkayastha S, Tang Y, Zhang H, Yin Y, Li B, Liu G, Cai D. Hypothalamic programming of systemic ageing involving IKK-β, NF-κB and GnRH. Nature 2013, 497:211-216. 10.1038/nature12143, 23636330.
10. Gabuzda D, Yankner BA. Physiology: Inflammation links ageing to the brain. Nature 2013, 497:197-198. 10.1038/nature12100, 23636321.
11. Ball J, Carrington MJ, Stewart S, SAFETY investigators Mild cognitive impairment in high-risk patients with chronic atrial fibrillation: a forgotten component of clinical management?. Heart 2013, 99:542-547. 10.1136/heartjnl-2012-303182, 23315607, SAFETY investigators.
12. Kilander L, Andrén B, Nyman H, Lind L, Boberg M, Lithell H. Atrial fibrillation is an independent determinant of low cognitive function: a cross-sectional study in elderly men. Stroke 1998, 29:1816-1820. 10.1161/01.STR.29.9.1816, 9731601.
13. Miyasaka Y, Barnes ME, Petersen RC, Cha SS, Bailey KR, Gersh BJ, Casaclang-Verzosa G, Abhayaratna WP, Seward JB, Iwasaka T, Tsang TS. Risk of dementia in stroke-free patients diagnosed with atrial fibrillation: data from a community-based cohort. Eur Heart J 2007, 28:1962-1967. 10.1093/eurheartj/ehm012, 17459900.
14. O'Connell E, Gray S, French M, Robertson H. Atrial fibrillation and cognitive function: case-control study. J NeurolNeurosurg Psychiatry 1998, 65:386-389.
15. Ott A, Breteler M, de Bruyne MC, van Harskamp F, Grobbee DE, Hofman A. Atrial fibrillation and dementia in a population-based study: the Rotterdam Study. Stroke 1997, 28:316-321. 10.1161/01.STR.28.2.316, 9040682.
16. Sabatini T, Frisoni GB, Barbisoni P, Bellelli G, Rozzini R, Trabucchi M. Atrial fibrillation and cognitive disorders in older people. J Am Geriatr Soc 2000, 48:387-390.
17. Licastro F, Pedrini S, Caputo L, Annoni G, Davis LJ, Ferri C, Casadei V, Grimaldi LME. Increased plasma levels of interleukin-1, interleukin-6 and a-1-antichymotrypsin in patients with Alzheimer's disease: peripheral inflammation or signals from the brain?. Journal of Neuroimmunol 2000, 103:97-102.
18. Engelmann B, Massberg S. Thrombosis as an intravascular effector of innate immunity. Nat Rev Immunol 2013, 13:34-45.
19. Gao SP, Deng XT, Ge LJ, Luan H, Zheng JG, Chen C, Jiang MH, Pan M. Is inflammation linked to thrombogenesis in atrial fibrillation?. Int J Cardiol 2011, 149:260-261. 10.1016/j.ijcard.2011.02.046, 21402421.
20. Van Kuilenburg J, Lappegård KT, Sexton J, Plesiewicz I, Lap P, Bouwels L, Sprong T, Mollnes TE, Verheugt F, Van Heerde WL, Pop GA. Persisting thrombin activity in elderly patients with atrial fibrillation on oral anticoagulation is decreased by anti-inflammatory therapy with intensive cholesterol-lowering treatment. J ClinLipidol 2011, 5:273-280.
21. Tendolkar I, Enajat M, Zwiers MP, van Wingen G, de Leeuw FE, van Kuilenburg J, Bouwels L, Pop G, Pop-Purceleanu M. One-year cholesterol lowering treatment reduces medial temporal lobe atrophy and memory decline in stroke-free elderly with atrial fibrillation: evidence from a parallel group randomized trial. Int J Geriatr Psychiatry 2012, 27:49-58. 10.1002/gps.2688, 21308791.
22. Mollnes TE, Brekke OL, Fung M, Fure H, Christiansen D, Bergseth G, Videm V, Lappegard KT, Kohl J, Lambris JD. Essential role of the C5a receptor in E coli-induced oxidative burst and phagocytosis revealed by a novel lepirudin-based human whole blood model of inflammation. Blood 2002, 100:1869-1877.
23. van Geffen M, van Heerde WL. Global haemostasis assays, from bench to bedside. Thromb Res 2012, 129:681-687. 10.1016/j.thromres.2011.12.006, 22221936.
24. Loughin TM. A systematic comparison of methods for combining p-values from independent tests. Computational Statistics and Data Analysis 2004, 47:467-485.
25. Pesarin F. Multivariate Permutation Tests, with applications in biostatistics 2001, Chichester: John Wiley & Sons.
26. Kwok CS, Loke YK, Hale R, Potter JF, Myint PK. Atrial fibrillation and incidence of dementia: a systematic review and meta-analysis. Neurology 2011, 76:914-922. 10.1212/WNL.0b013e31820f2e38, 21383328.
27. Becker RC. Biomarkers in atrial fibrillation: investigating biologic plausibility, cause, and effect. J Thromb Thrombolysis 2005, 19:71-75. 10.1007/s11239-005-0943-3, 15976971.
28. Boos CJ, Anderson RA, Lip GY. Is atrial fibrillation an inflammatory disorder?. Eur Heart J 2006, 27:136-149.
29. Amar D, Zhang H, Heerdt PM, Park B, Fleisher M, Thaler HT. Statin use is associated with a reduction in atrial fibrillation after noncardiac thoracic surgery independent of C-reactive protein. Chest 2005, 128:3421-3427. 10.1378/chest.128.5.3421, 16304294.
30. Carnes A, Chung K, Nakayama T, Nakayama H, Baliga S, Piao S, Kanderian A, Pavia S, Hamlin L, McCarthy M, Bauer A, Van Wagoner R. Ascorbate attenuates atrial pacing-induced peroxynitrite formation and electrical remodeling and decreases the incidence of postoperative atrial fibrillation. Circ Res 2001, 89:e32-e38. 10.1161/hh1801.097644, 11557745.
31. Imazio M, Brucato A, Ferrazzi P, Rovere ME, Gandino A, Cemin R, Ferrua S, Belli R, Maestroni S, Simon C, Zingarelli E, Barosi A, Sansone F, Patrini D, Vitali E, Trinchero R, Spodick DH, Adler Y, COPPS Investigators Colchicine reduces postoperative atrial fibrillation: results of the Colchicine for the Prevention of the Postpericardiotomy Syndrome (COPPS) atrial fibrillation substudy. Circulation 2011, 124:2290-2295. 10.1161/CIRCULATIONAHA.111.026153, 22090167, COPPS Investigators.
32. Dernellis J, Panaretou M. Relationship between C-reactive protein concentrations during glucocorticoid therapy and recurrent atrial fibrillation. Eur Heart J 2004, 25:1100-1107. 10.1016/j.ehj.2004.04.025, 15231367.
33. Siu CW, Lau CP, Tse HF. Prevention of atrial fibrillation recurrence by statin therapy in patients with lone atrial fibrillation after successful cardioversion. Am J Cardiol 2003, 92:1343-1345. 10.1016/j.amjcard.2003.08.023, 14636918.
34. Kastelein JJ, Akdim F, Stroes ES, Zwinderman AH, Bots ML, Stalenhoef AF, Visseren FL, Sijbrands EJ, Trip MD, Stein EA, Gaudet D, Duivenvoorden R, Veltri EP, Marais AD, de Groot E;ENHANCE Investigators Simvastatin with or without ezetimibe in familial hypercholesterolemia. N Engl J Med 2008, 358:1431-1443. 10.1056/NEJMoa0800742, 18376000, de Groot E;ENHANCE Investigators.
35. Ridker PM, Danielson E, Fonseca FA, Genest J, Gotto AM, Kastelein JJ, Koenig W, Libby P, Lorenzatti AJ, MacFadyen JG, Nordestgaard BG, Shepherd J, Willerson JT, Glynn RJ, JUPITER Study Group Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein. N Engl J Med 2008, 359:2195-2207. 10.1056/NEJMoa0807646, 18997196, JUPITER Study Group.
36. Rizos I, Tsiodras S, Rigopoulos AG, Dragomanovits S, Kalogeropoulos AS, Papathanasiou S, Sakadakis EA, Kremastinos DT. Interleukin-2 serum levels variations in recent onset atrial fibrillation are related with cardioversion outcome. Cytokine 2007, 40:157-164. 10.1016/j.cyto.2007.08.013, 17923414.
37. Ribeiro LR, Della-Pace ID, de Ferreira APO, Funck VR, Pinton S, Bobinski F, de Oliveira CV, Fiorin FDS, Duarte MMMF, Furian AF. Chronic administration of methylmalonate on young rats alters neuroinflammatory markers and spatial memory: Methylmalonate induces neuroinflammation in rats. Immunobiology 2013,