The absence of myocardial calcium-independent phospholipase a2γ results in impaired prostaglandin e2 production and decreased survival in mice with acute trypanosoma cruzi infection

Infection and Immunity

Volumn 81, Issue 7, 2013, Pages 2278-2287

  Sharma, Janhavi ^a   Eickhoff, Christopher S ^a   Hoft, Daniel F ^a   Ford, David A ^a   Gross, Richard W ^b   McHowat, Jane ^a  

^a SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARACHIDONIC ACID; BROMOENOL LACTONE; CALCIUM INDEPENDENT PHOSPHOLIPASE A2; ICOSANOID; PROSTAGLANDIN E2; THROMBIN;

ANIMAL CELL; ANIMAL CELL CULTURE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CARDIOMYOPATHY; CELL STIMULATION; CHAGAS DISEASE; ENZYME ACTIVITY; HEART MUSCLE CELL; HEART PROTECTION; INFECTION SENSITIVITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; RABBIT; SURVIVAL RATE; TISSUE CULTURE;

ANIMALS; ARACHIDONIC ACID; CALCIUM; CELL ADHESION; CHAGAS DISEASE; DINOPROSTONE; ENZYME ACTIVATION; GROUP VI PHOSPHOLIPASES A2; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MYOCYTES, CARDIAC; NAPHTHALENES; NIH 3T3 CELLS; PHENOTYPE; PYRONES; SURVIVAL ANALYSIS; THROMBIN; TRYPANOSOMA CRUZI;

EID: 84879433268     PISSN: 00199567     EISSN: 10985522     Source Type: Journal    
DOI: 10.1128/IAI.00497-12     Document Type: Article

References (39)

1. WHO. 2012.WHOfactsheet for Chagas' disease. WHO, Geneva, Switzerland
2. Bern C, Montgomery SP. 2009. An estimate of the burden of Chagas disease in the United States. Clin. Infect. Dis. 49:e52- e54
3. Tanowitz HB, Machado FS, Jelicks LA, Shirani J, de Carvalho AC, Spray DC, Factor SM, Kirchhoff LV, Weiss LM. 2009. Perspectives on Trypanosoma cruzi-induced heart disease (Chagas disease). Prog. Cardiovasc. Dis. 51:524 -539
4. Rassi A, Jr, Rassi A, Marin-Neto JA. 2010. Chagas disease. Lancet 375: 1388-1402
5. Rossi MA, Tanowitz HB, Malvestio LM, Celes MR, Campos EC, Blefari V, Prado CM. 2010. Coronary microvascular disease in chronic Chagas cardiomyopathy including an overview on history, pathology, and other proposed pathogenic mechanisms. PLoS Negl. Trop. Dis. 4:e674
6. Huang H, Calderon TM, Berman JW, Braunstein VL, Weiss LM, Wittner M, Tanowitz HB. 1999. Infection of endothelial cells with Trypanosoma cruzi activates NF-kappaB and induces vascular adhesion molecule expression. Infect. Immun. 67:5434 -5440
7. Talvani ARC, Aliberti JC, Michailowsky V, Santos PV, Murta SM, Romanha AJ, Almeida IC, Farber J, Lannes-Vieira J, Silva JS, Gazzinelli RT. 2000. Kinetics of cytokine gene expression in experimental chagasic cardiomyopathy: tissue parasitism and endogenous IFN-gamma as important determinants of chemokine mRNA expression during infection with Trypanosoma cruzi. Microbes Infect. 2:851- 866
8. Machado FS, Souto JT, Rossi MA, Esper L, Tanowitz HB, Aliberti J, Silva JS. 2008. Nitric oxide synthase-2 modulates chemokine production by Trypanosoma cruzi-infected cardiac myocytes. Microbes Infect. 10: 1558-1566
9. Mukherjee S, Machado FS, Huang H, Oz HS, Jelicks LA, Prado CM, Koba W, Fine EJ, Zhao D, Factor SM, Collado JE, Weiss LM, Tanowitz HB, Ashton AW. 2011. Aspirin treatment of mice infected with Trypanosoma cruzi and implications for the pathogenesis of Chagas disease. PLoS One 6:e16959
10. Novaes RD, Penitente AR, Goncalves RV, Talvani A, Neves CA, Maldonado IR, Natali AJ. 2011. Effects of Trypanosoma cruzi infection on myocardial morphology, single cardiomyocyte contractile function and exercise tolerance in rats. Int. J. Exp. Pathol. 92:299 -307
11. Machado FS, Martins GA, Aliberti JC, Mestriner FL, Cunha FQ, Silva JS. 2000. Trypanosoma cruzi-infected cardiomyocytes produce chemokines and cytokines that trigger potent nitric oxide-dependent trypanocidal activity. Circulation 102:3003-3008
12. Tanowitz HB, Burns ER, Sinha AK, Kahn NN, Morris SA, Factor SM, Hatcher VB, Bilezikian JP, Baum SG, Wittner M. 1990. Enhanced platelet adherence and aggregation in Chagas' disease: a potential pathogenic mechanism for cardiomyopathy. Am. J. Trop. Med. Hyg. 43:274-281
13. McHowat J, Creer MH. 1998. Thrombin activates a membraneassociated calcium-independent PLA2 in ventricular myocytes. Am. J. Physiol. 274:C447-C454
14. McHowat J, Creer MH. 1998. Calcium-independent phospholipase A2 in isolated rabbit ventricular myocytes. Lipids 33:1203-1212
15. Beckett CS, McHowat J. 2008. Calcium-independent phospholipase A2 in rabbit ventricular myocytes. Lipids 43:775-782
16. Sharma J, McHowat J. 2011. PGE2 release from tryptase-stimulated rabbit ventricular myocytes is mediated by calcium-independent phospholipase A2γ. Lipids 46:391-397
17. Claycomb WC, Lanson NA, Jr, Stallworth BS, Egeland DB, Delcarpio JB, Bahinski A, Izzo NJ, Jr. 1998. HL-1 cells: a cardiac muscle cell line that contracts and retains phenotypic characteristics of the adult cardiomyocyte. Proc. Natl. Acad. Sci. U. S. A. 95:2979 -2984
18. Mancuso DJ, Kotzbauer P, Wozniak DF, Sims HF, Jenkins CM, Guan S, Han X, Yang K, Sun G, Malik I, Conyers S, Green KG, Schmidt RE, Gross RW. 2009. Genetic ablation of calcium-independent phospholipase A2{gamma} leads to alterations in hippocampal cardiolipin content and molecular species distribution, mitochondrial degeneration, autophagy, and cognitive dysfunction. J. Biol. Chem. 284:35632-35644
19. Degousee N, Fazel S, Angoulvant D, Stefanski E, Pawelzik SC, Korotkova M, Arab S, Liu P, Lindsay TF, Zhuo S, Butany J, Li RK, Audoly L, Schmidt R, Angioni C, Geisslinger G, Jakobsson PJ, Rubin BB. 2008. Microsomal prostaglandin E2 synthase-1 deletion leads to adverse left ventricular remodeling after myocardial infarction. Circulation 117: 1701-1710
20. Bligh EG, Dyer WJ. 1959. A rapid method of total lipid extraction and purification. Can. J. Biochem. Physiol. 37:911-917
21. Schnapp AR, Eickhoff CS, Sizemore D, Curtiss R, III, Hoft DF. 2002. Cruzipain induces both mucosal and systemic protection against Trypanosoma cruzi in mice. Infect. Immun. 70:5065-5074
22. Jenkins CM, Han X, Mancuso DJ, Gross RW. 2002. Identification of calcium-independent phospholipase A2 (iPLA2) beta, and not iPLA2gamma, as the mediator of arginine vasopressin-induced arachidonic acid release in A-10 smooth muscle cells. Enantioselective mechanism-based discrimination of mammalian iPLA2s. J. Biol. Chem. 277: 32807-32814
23. Le Loup G, Pialoux G, Lescure FX. 2011. Update in treatment of Chagas disease. Curr. Opin. Infect. Dis. 24:428-434
24. Apt W. 2010. Current and developing therapeutic agents in the treatment of Chagas disease. Drug Des. Devel. Ther. 4:243-253
25. Machado FS, Tyler KM, Brant F, Esper L, Teixeira MM, Tanowitz HB. 2012. Pathogenesis of Chagas disease: time to move on. Front. Biosci. 4:1743-1758
26. Michelin MA, Silva JS, Cunha FQ. 2005. Inducible cyclooxygenase released prostaglandin mediates immunosuppression in acute phase of experimental Trypanosoma cruzi infection. Exp. Parasitol. 111:71-79
27. Abdalla GK, Faria GE, Silva KT, Castro EC, Reis MA, Michelin MA. 2008. Trypanosoma cruzi: the role of PGE2 in immune response during the acute phase of experimental infection. Exp. Parasitol. 118:514 -521
28. Ashton AW, Mukherjee S, Nagajyothi FN, Huang H, Braunstein VL, Desruisseaux MS, Factor SM, Lopez L, Berman JW, Wittner M, Scherer PE, Capra V, Coffman TM, Serhan CN, Gotlinger K, Wu KK, Weiss LM, Tanowitz HB. 2007. Thromboxane A2 is a key regulator of pathogenesis during Trypanosoma cruzi infection. J. Exp. Med. 204:929 -940
29. Sterin-Borda L, Gorelik G, Goren N, Cappa SG, Celentano AM, Borda E. 1996. Lymphocyte muscarinic cholinergic activity and PGE2 involvement in experimental Trypanosoma cruzi infection. Clin. Immunol. Immunopathol. 81:122-128
30. Hazen SL, Zupan LA, Weiss RH, Getman DP, Gross RW. 1991. Suicide inhibition of canine myocardial cytosolic calciumindependent phospholipase A2. Mechanism-based discrimination between calcium-dependent and -independent phospholipases A2. J. Biol. Chem. 266:7227-7232
31. McHowat J, Creer MH. 2001. Comparative roles of phospholipase A2 isoforms in cardiovascular pathophysiology. Cardiovasc. Toxicol. 1:253-265
32. Kerkela R, Boucher M, Zaka R, Gao E, Harris D, Piuhola J, Song J, Serpi R, Woulfe KC, Cheung JY, O'Leary E, Bonventre JV, Force T. 2011 Cytosolic phospholipase A(2)alpha protects against ischemia/reperfusion injury in the heart. Clin. Transl Sci. 4:236 -242
33. Haq S, Kilter H, Michael A, Tao J, O'Leary E, Sun XM, Walters B, Bhattacharya K, Chen X, Cui L, Andreucci M, Rosenzweig A, Guerrero JL, Patten R, Liao R, Molkentin J, Picard M, Bonventre JV, Force T. 2003. Deletion of cytosolic phospholipase A2 promotes striated muscle growth. Nat. Med. 9:944 -951
34. Reddy ST, Herschman HR. 1994. Ligand-induced prostaglandin synthesis requires expression of the TIS10/PGS-2 prostaglandin synthase gene in murine fibroblasts and macrophages. J. Biol. Chem. 269:15473-15480
35. McHowat J, Kell PJ, O'Neill HB, Creer MH. 2001. Endothelial cell PAF synthesis following thrombin stimulation utilizes Ca(2 )-independent phospholipase A(2). Biochemistry 40:14921-14931
36. Aliberti JC, Machado FS, Gazzinelli RT, Teixeira MM, Silva JS. 1999. Platelet-activating factor induces nitric oxide synthesis in Trypanosoma cruzi-infected macrophages and mediates resistance to parasite infection in mice. Infect. Immun. 67:2810 -2814
37. Talvani A, Santana G, Barcelos LS, Ishii S, Shimizu T, Romanha AJ, Silva JS, Soares MB, Teixeira MM. 2003. Experimental Trypanosoma cruzi infection in platelet-activating factor receptor-deficient mice. Microbes Infect. 5:789 -796
38. Tanowitz HB, Kaul DK, Chen B, Morris SA, Factor SM, Weiss LM, Wittner M. 1996. Compromised microcirculation in acute murine Trypanosoma cruzi infection. J. Parasitol. 82:124 -130
39. Pinazo MJ, Tassies D, Munoz J, Fisa R, Posada Ede J, Monteagudo J, Ayala E, Gallego M, Reverter JC, Gascon J. 2011. Hypercoagulability biomarkers in Trypanosoma cruzi-infected patients. Thromb. Haemost. 106:617- 623.