Synthesis and structure-activity relationship of 2-arylamino-4-aryl- pyrimidines as potent PAK1 inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 14, 2013, Pages 4072-4075

  Xu, Yong ^a   Foulks, Jason M ^a   Clifford, Adrianne ^a   Brenning, Benjamin ^a   Lai, Shuping ^a   Luo, Bai ^a   Parnell, K Mark ^a   Merx, Shannon ^a   McCullar, Michael V ^a   Kanner, Steven B ^a   Ho, Koc Kan ^a  

^a ASTEX PHARMACEUTICALS   (United Kingdom)

Author keywords

2 Arylamino 4 aryl pyrimidines; Bioisostere; Colon cancer; Pak1 inhibitor; PAK1 kinase

Indexed keywords

2 ARYLAMINO 4 ARYL PYRIMIDINE DERIVATIVE; ANTINEOPLASTIC AGENT; BROMIDE; P21 ACTIVATED KINASE 1; PROTEIN SERINE THREONINE KINASE INHIBITOR; PYRIMIDINE; UNCLASSIFIED DRUG;

AMINATION; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CANCER CELL CULTURE; COLON CANCER; CRYSTAL STRUCTURE; DRUG CYTOTOXICITY; DRUG SYNTHESIS; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; HUMAN TISSUE; HYDROGEN BOND; IC 50; MALE; STRUCTURE ACTIVITY RELATION; SUZUKI REACTION;

ANILINE COMPOUNDS; CELL LINE, TUMOR; CELL PROLIFERATION; HUMANS; P21-ACTIVATED KINASES; PROTEIN BINDING; PROTEIN KINASE INHIBITORS; PYRIMIDINONES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84879422749     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.05.059     Document Type: Article

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