Association between obsessive-compulsive disorder and polymorphisms of genes encoding components of the serotonergic and dopaminergic pathways

European Neuropsychopharmacology

Volumn 10, Issue 3, 2000, Pages 205-209

  Frisch, A ^a,d   Michaelovsky, E ^a,d   Rockah, R ^a,d   Amir, I ^b   Hermesh, H ^c,d   Laor, N ^b,d   Fuchs, C ^d   Zohar, J ^d,e   Lerer, B ^f   Buniak, S F ^g   Landa, S ^h   Poyurovsky, M ^h   Shapira, B ⁱ   Weizman, R ^b,d  

^a RABIN MEDICAL CENTER   (Israel)

^b SHALVATA MENTAL HEALTH CENTER   (Israel)

^c GEHA MENTAL HEALTH CENTER   (Israel)

^d TEL AVIV UNIVERSITY   (Israel)

^e SHEBA MEDICAL CENTER   (Israel)

^f HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

^g Mazra Medical Health Center   (Israel)

^h Hacarmel Medical Center   (Israel)

ⁱ HERZOG HOSPITAL   (Israel)

Author keywords

Dopamine D4 receptor (DRD4); Dopamine transporter (DAT1); Serotonin 2A receptor (HTR2A); Serotonin 2C receptor (HTR2C); Serotonin transporter (5 HTT); Tryptophan hydroxylase (TPH)

Indexed keywords

DNA; DOPAMINE 4 RECEPTOR; DOPAMINE TRANSPORTER; SEROTONIN 2A RECEPTOR; SEROTONIN 2C RECEPTOR; SEROTONIN TRANSPORTER; TRYPTOPHAN HYDROXYLASE;

ARTICLE; CONTROLLED STUDY; DNA DETERMINATION; DNA POLYMORPHISM; DOPAMINERGIC SYSTEM; GENE ISOLATION; GENETIC ASSOCIATION; GENETIC PREDISPOSITION; GENETIC VARIABILITY; GENOTYPE; HUMAN; JEW; MAJOR CLINICAL STUDY; OBSESSION; PATHOGENESIS; PRIORITY JOURNAL; SEROTONINERGIC SYSTEM;

EID: 0033995464     PISSN: 0924977X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0924-977X(00)00071-7     Document Type: Article

References (24)

1. Billett E.A., Richter M.A., King N., Heils A., Lesch K.P., Kennedy J.L. Obsessive compulsive disorder, response to serotonin reuptake inhibitors and the serotonin transporter gene. Mol. Psychiatry. 2:1997;403-406.
2. Billett E.A., Richter M.A., Sam F., Swinson R.P., Dai X.-Y., King N., Badri F., Sasaki T., Buchanan J.A., Kennedy J.L. Investigation of dopamine system genes in obsessive-compulsive disorder. Psychiatric Genetics. 8:1998;163-169.
3. Cavallini M.C., Di-Bella D., Pasquale L., Henin M., Bellodi L. 5HT2C CYS23/SER23 polymorphism is not associated with obsessive-compulsive disorder. Psychiatry Res. 77:1998;97-102.
4. Endicott J., Spitzer R.L. Use of research diagnostic criteria and the Schedule for Affective Disorders and Schizophrenia. Am. J. Psychiatry. 136:1984;266-267.
5. First B.M., Spitzer R.L., Gibbon M., Williams J.B.W. Structured Clinical Interview for Axis I DSM-IV Disorders - Patient Edition, SCID-P Version 2.0. 1995;Biometrics Research Department, New York State Psychiatric Institute. in Hebrew.
6. Grice D.E., Leckman J.F., Pauls D.L., Kurlan R., Kidd K.K., Pakstis A.J., Chang F.M., Buxbaum J.D., Cohen D.J., Gelernter J. Linkage disequilibrium between an allele at the dopamine D4 receptor locus and Tourette syndrome, by the transmission-disequilibrium test. Am. J. Hum. Genet. 59:1996;644-652.
7. Hollander E., Liebowitz M.R. Augmentation of antiobsessional treatment with fenfluramine. Am. J. Psychiatry. 145:1988;1314-1315.
8. Kaplan H.I., Sadock J.B., Grebb J.A. Obsessive-compulsive disorder. Retford D.C. Kaplan and Sadock's Synopsis of Psychiatry. 7th ed. 1994;598-606 William and Wilkins, Baltimore.
9. Lappalainen J., Zhang L., Dean M., Oz M., Ozaki N., Yu D.-H., Virkkunen M., Weight F., Linnoila M., Goldman D. Identification, expression, and pharmacology of a Cys23-Ser23 substitution in the human 5-HT2C receptor gene (HTR2C). Genomics. 27:1995;274-279.
10. Lesch K.P., Bengel D., Heils A., Sabol S.Z., Greenberg B.D., Petri S., Benjamin J., Muller C.R., Hamer D.H., Murphy D.L. Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science. 274:1996;1527.
11. 4 (DRD4) gene. Hum. Mol. Genet. 2:1993;767-773.
12. McDougle C.J., Gordman W.K., Price L.H. The pharmacotherapy of obsessive-compulsive disorder. Pharmacopsychiatry. 26:(Suppl.):1993;24-29.
13. McDougle C.J., Goodman W.K., Price L.H. Dopamine antagonist in tic-related and psychotic spectrum obsessive compulsive disorder. J. Clin. Psychiatry. 55:(Suppl. 3):1994;24-31.
14. McDougle C.J., Epperson C.N., Price L.H., Gelernter J. Evidence for linkage disequilibrium between serotonin transporter protein gene (SLC6A4) and obsessive compulsive disorder. Mol. Psychiatry. 3:1998;270-273.
15. Miller S.A., Dykes D.D., Polesky H.F. A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res. 16:1988;1215.
16. Nicolini H., Cruz C., Camarena B., Orozco B., Kennedy J.L., King N., Weissbecker K., de la Fuente J.R., Sidenberg D. DRD2, DRD3, and 5HT2A receptor gene polymorphisms in obsessive-compulsive disorder. Mol. Psychiatry. 1:1996;461-465.
17. Nielsen D.A., Dean M., Goldman D. Genetic mapping of the human tryptophan hydroxylase gene on chromosome 11, using an intronic conformational polymorphism. Am. J. Hum. Genet. 51:1992;1366-1371.
18. Pauls D.L., Alsobrook J.P. II. The inheritance of obsessive-compulsive disorder. Child Adolesc. Psychiatr. Clin. N. Am. 8:1999;481-496.
19. Rapoport J.L., Wise S.P. Obsessive-compulsive disorder: Evidence for basal ganglia dysfunction. Psychopharmacol. Bull. 24:1988;380-384.
20. Rasmussen S.A., Tsuang M.T. Clinical characteristics and family history in DSM-III obsessive-compulsive disorder. Am. J. Psychiatry. 143:1986;317-322.
21. Satel S.L., McDougle C.J. Obsessions and compulsions associated with cocaine abuse. Am. J. Psychiatry. 150:1993;155-156. letter.
22. Vandenbergh D.J., Perisco A.M., Hawkins A.L., Griffin C.A., Li X., Jabs E.W., Uhl G.R. Humane dopamine transporter gene (DAT1) maps to chromosome 5p15.3 and displays a VNTR. Genomics. 14:1992;1104-1106.
23. Warren J.T. Jr., Peacock M.L., Rodriguez L.C., Fink J.K. An MspI polymorphism in the human serotonin receptor gene (HTR2): Detection by DGGE and RFLP analysis. Hum. Mol. Genet. 2:1993;338.
24. Zohar J., Muller E.A., Insel T.R., Zohar-Kadouch R.C., Murphy D.L. Serotonergic responsivity in obsessive-compulsive disorder: Comparison of patient and healthy control. Arch. Gen. Psychiatry. 44:1987;946-951.