No associations between 5-HTT, 5-HT2A gene polymorphisms and obsessive-compulsive disorder in a Korean population

Psychiatry Investigation

Volumn 3, Issue 1, 2006, Pages 78-86

  Jung, Hye Ryung ^a   Cho, Joo Youn ^a   Chung, Jae Yong ^a   Kim, Jung Ryul ^a   Yu, Kyung Sang ^a   Jang, In Jin ^a,b   Shin, Sang Goo ^a   Lee, Kyung Jin ^a   Yoo, So Young ^a   Kim, Euitae ^a   Kwon, Jun Soo ^a  

^a Seoul National University College of Medicine   (South Korea)

^b Seoul National University   (South Korea)

Author keywords

5 HT2A; 5 HTT; DRD; OCD; Single nucleotide polymorhism

Indexed keywords

5 HT2A GENE; 5HTT GENE; ADULT; ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; DEPRESSION; ENVIRONMENTAL FACTOR; FEMALE; GENE; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC SUSCEPTIBILITY; HUMAN; KOREA; MAJOR CLINICAL STUDY; MALE; NUCLEOTIDE SEQUENCE; OBSESSIVE COMPULSIVE DISORDER; POLYMERASE CHAIN REACTION; RECURRENCE RISK; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; SCHIZOPHRENIA; TWO DIMENSIONAL GENE SCANNING; VARIABLE NUMBER OF TANDEM REPEAT;

EID: 33645688159     PISSN: 17383684     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (46)

1. Weissman MM, Bland RC, Canino GJ. The cross national epidemiology of obsessive compulsive disorder. J Clin Psychiatry 1994; 55:5-10.
2. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders (4th ed.). Washington, DC. American Psychiatric Press, 1994.
3. Pauls DL, Alsobrook JP, Phil M. A family study of obsessive-compulsive disorder. Am J Psychiatry 1995; 152:76-84.
4. Barr LC, Goodman WK, Price LH. 1993. The serotonin hypothesis of obsessive compulsive disorder. Int Clin Psychopharmacol 1993; 2:79-82.
5. Murphy DL, Greenberg B, Altemus M. The neuropharmacology and neurobiology of obsessive compulsive disorder: An update on the serotonin hypothesis. In: Advance in the Neurobiology of Anxiety Disorders. Ed. by Westenberg HGM, Murphy DL, and Boer JAD, 1995, pp278-298.
6. McDougle CJ, Epperson CN, Price LH, Gelernter J. Evidence for linkage disequilibrium between serotonin transporter protein gene (SLC6A4) and obsessive-ompulsive disorder. Mol Psychiatry 1998; 3:270-273.
7. Lesch KP, Mossner R. Genetically driven variation in serotonin uptake: Is there a link to affective spectrum, neurodevelopmental, and neurodegenerative disorders?. Biol Psychiatry 1998; 44:179-192.
8. Rammamoorthy S, Bauman AL, Moore KR, Han H, Yang-Feng T, Chang AS. Antidepressant- and cocaine-sensitive human serotonin transporter: Molecular cloning, expression, and chromosomal localization. Proc Natl Acad Sci USA 1993; 90:2542-2546.
9. Heils A, Teufel A, Petri S, Stober G, Riederer P, Bengel D, Lesch KP. Allelic variation of human serotonin transporter gene expression. J Neurochem 1996; 66:1-4.
10. Lesch KP, Balling U, Gross J, Strauss K, Wolozin BL, Murphy DL, Riederer P. Organization of the human serotonin transporter gene. J Neural Trans Gen Sect 1994; 95: 157-162.
11. Lesch KP, Bengel D, Heils A, Sabol SZ, Greenberg BD, Petri S. Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 1996; 274:1527-1531.
12. Nobile M, Begni B, Giorda R, Frigerio A, Marino C, Molteni M. Effects of serotonin transporter promoter genotype on platelet serotonin transporter functionality in depressed children and adolescents. J Am Acad Child Adolesc Psychiatry 1999; 38:1396-1402.
13. Stoltenberg SF, Twitchell GR, Hanna GL, Cook EH, Fitzgerald HE, Zucker RA, Little KY. Serotonin transporter promoter polymorphism, peripheral indexes of serotonin function, and personality measures in families with alcoholism. Am J Med Genet 2002; 114:230-234.
14. Hanna GL, Himle JA, Curtis GC, Koram DQ, Weele JVV, Leventhal BL, Cook EH. Serotonin transporter and seasonal variation in blood serotonin in families with obsessive-compulsive disorder. Neuropsychopharmacol 1998; 18: 102-111.
15. Mortensen OV, Thomassen M, Larsen MB, Whittemore SR, Wiborg O. Functional analysis of a novel human serotonin transporter gene promoter in immortalized raphe cells. Brain Res Mol Brain Res 1999; 68:141-148.
16. Heinz A, Jones DW, Mazzanti C, Goldman D, Ragan P, Hommer D. A relationship between serotonin transporter genotype and in vivo protein expression and alcohol neurotoxicity. Biol Psychiatry 2000; 47:643-649.
17. Hariri AR, Mattay VS, Tessitore A, Kolachana B, Fera F, Goldman D. Serotonin transporter genetic variation and the response of the human amygdala. Science 2002; 297: 400-403.
18. Willeit M, Stastny J, Pirker W, Praschak-Rieder N, Neumeister A, Asenbaum S. No evidence for in vivo regulation of midbrain serotonin transporter availability by serotonin transporter promoter gene polymorphism. Biol Psychiatry 2001; 50:8-12.
19. Sakai K, Nakamura M, Ueno S, Sano A, Sakai N, Shirai Y, Saito N. The silencer activity of the novel human serotonin transporter linked polymorphic regions. Neurosci Lett 2002; 327:13-16.
20. Shioe K, Nakamura M, Ueno S, Sano A, Sakai N, Shirai Y, Saito N. No association between genotype of the promoter region of serotonin transporter gene and serotonin transporter binding in human brain measured by PET. Synapse 2003; 48:184-188.
21. Fiskerstrand CE, Lovejoy EA, Quinn JP. An intronic polymorphic domain often associated with susceptibility to affective disorders has allele dependent differential enhancer activity in embryonic stem cells. FEBS Lett 1999; 458:171-174.
22. MacKenzie A, Quinn J. A serotonin transporter gene intron 2 polymorphic region, correlated with affective disorders, has allele-dependent differential enhancer-like properties in the mouse embryo. Proc Natl Acad Sci USA 1999; 96: 15251-15255.
23. Lovejoy EA, Scott AC, Fiskerstrand CE, Bubb VJ, Quinn JP. The serotonin transporter intronic VNTR enhancer correlated with a predisposition to affective disorders has distinct regulatory elements within the domain based on the primary DNA sequence of the repeat unit. Eur J Neuroscience 2003; 17:417-420.
24. Kaiser R, Muller-Oerlinghausen B, Filler D, Tremblay PB, Berghofer A, Roots I, Brockmoller J. Correlation between serotonin uptake in human blood platelets with the 44-bp polymorphism and the 17-bp variable number of tandem repeat of the serotonin transporter. Am J Med Genet 2002; 114:323-328.
25. Jonsson EG, Nothen MM, Gustavsson JP, Neidt H, Bunzel R, Propping P, Sedvall GC. Polymorphisms in the dopamine, serotonin, and norepinephrine transporter genes and their relationships to monoamine metabolite concentrations in CSF of healthy volunteers. Psychiatry Res 1998; 79:1-9.
26. Goodman WK, McDougle CJ, Price LH, Riddle MA, Pauls DL, Leckman JF. Beyond the serotonin hypothesis: A role for dopamine in some forms of obsessive compulsive disorder? J Clin Psychiatry 1990; 51:36-43.
27. Randrup A, Munkvad I. Stereotyped activities produced by amphetamine in several animal species and man. Psychopharmacologia 1967; 11:300-310.
28. Tizabi Y, Louis VA, Taylor CT, Waxman D, Culver KE, Szechtman H. Effect of nicotine on quinpirole-induced checking behavior in rats: Implications for obsessive-compulsive disorder. Biol Psychiatry 2002; 51:164-171.
29. Carmin CN, Wiegartz PS, Yunus U, Gillock KL. Treatment of late-onset OCD following basal ganglia infarct. Depress Anxiety 2002; 15:87-90.
30. Jenike MA, Baer L, Summergrad P, Minichiello WE. Holland A, Seymour R. Sertraline in obsessive-compulsive disorder: A double-blind comparison with placebo. Am J Psychiatry 1990; 147:923-928.
31. Saxena S, Brody AL, Schwartz JM, Baxter LR. Neuroimaging and frontal-subcortical circuitry in obsessive-compulsive disorder. Br J Psychiatry 1998; 35:26-37.
32. Alexander GE, Crutcher MD. Functional architecture of basal ganglia circuits: Neural substrates of parallel processing. Trends Neurosci 1990; 13:266-271.
33. Lee JH, Choi JH, Namkung W, Hanrahan JW, Chang J, Song SY, Park SW, Kim DS, Yoon JH, Suh Y, Jang IJ, Nam JH, Kim SJ, Cho MO, Lee JE, Kim KH, Lee MG. A haplotype-based molecular analysis of CFTR mutations associated with respiratory and pancreatic diseases. Hum Mol Genet 2003; 12:2321-2332.
34. Han HS, Hong JP. Korean Version of Statistical Clinical Interview Schedule for DSM-IV Axis I. Seoul, Hana Medical Publishing, 2000
35. Han HS, Hong JP. Korean Version of Statistical Clinical Interview Schedule for DSM-IV Axis I. Seoul, Hana Medical Publishing, 2000
36. Goodman WK. Pharmacotherapy of obsessive-compulsive disorder. In: Zwangsstorungen, Duphar Medical Communication, Band 5, Ed. by Hand I, Goodman WK. and Evers U, Berlin, Springer-Verlag 1992, pp 141-151
37. Billett EA, Richter MA, King N, Heils A, Lesch KP, Kennedy JL. Obsessive compulsive disorder, response to serotonin reuptake inhibitors and the serotonin transporter gene. Mol Psychiatry 1997; 2:403-406.
38. Frisch A, Michaelovsky E, Rockah R, Amir I, Hermesh H, Laor N, Fuchs C, Zohar J, Lerer B, Buniak SF, Landa S, Poyurovsky M, Shapira B, Weizman R. Association between obsessive-compulsive disorder and polymorphisms of genes encoding components of the serotonergic and dopaminergic pathways. Eur Neuropsychopharmacol 2000; 10(3):205-209.
39. Nicolini H, Cruz C, Camarena B, Orozco B, Kennedy JL. King N, Weissbecker K, de la Fuente JR, Sidenberg D. DRD2, DRD3 and 5HT2A receptor genes polymorphisms in obsessive-compulsive disorder. Mol Psychiatry 1996; 1 (6):461-465.
40. Tot S, Erdal ME, Yazici K, Yazici AE, Metin O. T102C and -1438 G/A polymorphisms of the 5-HT2A receptor gene in Turkish patients with obsessive-compulsive disorder. Eur Psychiatry 2003; 18 (5):249-254.
41. Bebbington PE. Epidemiology of obsessive-compulsive disorder. Br J Psychiatry (Suppl) 1998; (35):2-6.
42. Zohar AH. The epidemiology of obsessive-compulsive disorder in children and adolescents. Child Adolesc Psychiatr Clin N Am 1999; 8 (3):445-460.
43. Nestadt G, Lan T, Samuels J, Riddle M, Bienvenu OJ 3rd, Liang KY, Hoehn-Saric R, Cullen B, Grados M, Beaty TH, Shugart YY. Complex segregation analysis provides compelling evidence for a major gene underlying obsessive-compulsive disorder and for heterogeneity by sex. Am J Hum Genet 2000; 67 (6): 1611-1616.
44. Castle DJ, Deale A, Marks IM. Gender differences in obsessive compulsive disorder. Austr N Z J Psychiatry 1995; 29:114-117.
45. Rubinsztein DC, Leggo J, Goodburn S. Genetic association between monoamine oxidase A microsatellite and RFLP alleles and bipolar affective disorder: analysis and meta-analysis. Hum Mol Genet 1996; 5:779-782.
46. Karayiorgou M, Altemus M, Galke BL. Genotype determining low catechol-O-methyltransferase activity as a risk factor for obsessive-compulsive disorder. Proc Natl Acad Sci USA 1997; 94:4572-4575.