Optimization of the electrophile of chloronitrobenzamide leads active against Trypanosoma brucei

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 14, 2013, Pages 4127-4131

  Hwang, Jong Yeon ^a   Smithson, David C ^a   Holbrook, Gloria ^a   Zhu, Fangyi ^a   Connelly, Michele C ^a   Kaiser, Marcel ^b   Brun, Reto ^b   Kiplin Guy, R ^a  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^b SWISS TROPICAL AND PUBLIC HEALTH INSTITUTE   (Switzerland)

Author keywords

Drug discovery; Parasitology; Trypanosomes

Indexed keywords

ANTIPROTOZOAL AGENT; BENZAMIDE DERIVATIVE; PHENYLCHLORONITROBENZAMIDE; UNCLASSIFIED DRUG;

ANTIPROTOZOAL ACTIVITY; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DRUG SYNTHESIS; ELECTROPHILICITY; HUMAN; HUMAN CELL; NONHUMAN; PROCESS OPTIMIZATION; TRYPANOSOMA BRUCEI;

ANIMALS; BENZAMIDES; CELL LINE; HEP G2 CELLS; HUMANS; MICE; MICROSOMES; SOLUBILITY; TRYPANOCIDAL AGENTS; TRYPANOSOMA BRUCEI BRUCEI;

MAMMALIA; TRYPANOSOMA; TRYPANOSOMA BRUCEI;

EID: 84879416472     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.05.049     Document Type: Article

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