An LC/MS/MS method for simultaneous quantitation of two homoisoflavones: Protosappanin B and brazilin with hypoglycemic activity in rat plasma and its application to a comparative pharmacokinetic study in normal and streptozotocin-treated rats

Journal of Ethnopharmacology

Volumn 148, Issue 2, 2013, Pages 682-690

  Tong, Xiao Zhe ^a   Zhu, Hui ^b   Shi, Yan ^b   Xu, Hai Tao ^c   Wang, Biao ^d   Zhao, Jiu Han ^d  

^a JINZHOU MEDICAL UNIVERSITY   (China)

^b LIAONING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

^c Jinzhou Central Hospital   (China)

^d CHINA MEDICAL UNIVERSITY   (China)

Author keywords

Protosappanin B Brazilin Hypoglycemic activity LC MS MS Comparative pharmacokinetic

Indexed keywords

BRAZILIN; HOMOISOFLAVONE DERIVATIVE; PROTOSAPPANIN B; STREPTOZOCIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANTIDIABETIC ACTIVITY; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG ELIMINATION; LIQUID CHROMATOGRAPHY; MALE; NONHUMAN; RAT; TANDEM MASS SPECTROMETRY;

ANIMALS; AREA UNDER CURVE; BENZOPYRANS; CAESALPINIA; CHROMATOGRAPHY, LIQUID; DIABETES MELLITUS, EXPERIMENTAL; DRUGS, CHINESE HERBAL; FABACEAE; HYPOGLYCEMIC AGENTS; ISOFLAVONES; MALE; PLANT EXTRACTS; RANDOM ALLOCATION; RATS; RATS, WISTAR; TANDEM MASS SPECTROMETRY;

CAESALPINIA SAPPAN; FABACEAE; RATTUS;

EID: 84879412793     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2013.05.029     Document Type: Article

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