A validated LC-MS/MS method for rapid determination of brazilin in rat plasma and its application to a pharmacokinetic study

Biomedical Chromatography

Volumn 27, Issue 6, 2013, Pages 802-806

  Deng, Zhipeng ^a   Wang, Xin ^a   Zhao, Huanxin ^a   Cui, Shuxiang ^a   Yao, Qingqiang ^a   Bai, Hong ^a  

^a SHANDONG PROVINCIAL HOSPITAL AFFILIATED TO SHANDONG FIRST MEDICAL UNIVERSITY   (China)

Author keywords

Brazilin; LC MS MS; Pharmacokinetic study; Sappan lignum

Indexed keywords

BODY FLUIDS; MEDICINE; PHARMACOKINETICS;

BRAZILIN; HOMOISOFLAVONOIDS; ITS APPLICATIONS; LC-MS-MS; LC.MS/MS; NATURAL RED; PHARMACOKINETIC STUDIES; RAT PLASMA; SAPPAN LIGNUM; TRADITIONAL CHINESE MEDICINE;

RATS;

ACETONITRILE; AMMONIUM ACETATE; BRAZILIN; CAESALPINIA SAPPAN EXTRACT; ISOFLAVONOID; METHANOL; PROTOSAPPANIN B; UNCLASSIFIED DRUG; WATER;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG ISOLATION; FLOW RATE; LIMIT OF QUANTITATION; LIQUID CHROMATOGRAPHY; MALE; MASS SPECTROMETER; NONHUMAN; PRECIPITATION; RAT; SENSITIVITY AND SPECIFICITY; TANDEM MASS SPECTROMETRY; VALIDATION PROCESS;

CAESALPINIA SAPPAN; RATTUS;

EID: 84876302068     PISSN: 02693879     EISSN: 10990801     Source Type: Journal    
DOI: 10.1002/bmc.2863     Document Type: Article

References (16)

1. Badami S, Moorkoth S, Rai SR, Kannan E and Bhojraj S. Antioxidant activity of Caesalpinia sappan heartwood. Biological and Pharmaceutical Bulletin 2003; 26: 1534-1537.
2. Chen YP, Bi D and Tu PF. Quality standard of Sappan Lignum. China Journal of Chinese Materia Medica 2010; 35: 2068-2071.
3. Choi SY, Yang KM, Jeon SD, Kim JH, Khil LY and Chang TS. Brazilin modulates immune function mainly by augmenting T cell activity in halothane administered mice. Planta Medica 1997; 63: 405-408.
4. Hu J, Yan XL, Wang W, Wu H, Hua L and Du LJ. Antioxidant activity in vitro of three constituents from Caesalpinia sappan L. Tsinghua Science and Technology 2008; 13: 474-479.
5. Moon CK, Chung JH, Lee YM, Lee SH, Hwang GS, Park KS, Mock MS, Kim SG, Ahn YS and Ann JH. Effects of brazilin on erythrocyte deformability and its related biochemical factors in streptozotocin induced diabetic rats. Archives of Pharmacal Research 1988; 11: 149-154.
6. Niranjan Reddy VL, Ravikanth V, Jansi Lakshmi VV, Suryanarayan Murty U and Venkateswarlu Y. Inhibitory activity of homoisoflavonoids from Caesalpinia sappan against Beauveria bassiana. Fitoterapia 2003; 74: 600-602.
7. Oliveira L, Edwards H, Velozo E and Nesbitt M. Vibrational spectroscopic study of brazilin and brazilein, the main constituents of brazilwood from Brazil. Vibrational Spectroscopy 2002; 28: 243-249.
8. Peng X and Gu LG. Research on the effect of Caesalpinia Sappan ethanol extract on the human lung cancer A549 cell. Chinese Journal of Basic Medicine in Traditional Chinese Medicine 2009; 15: 547-549.
9. The State Pharmacopoeia Commission of the P.R. China. Pharmacopoeia of the P.R. China. Chemical Industry Press: Beijing, 2010; 153.
10. US Food and Drug Administration. Guidance for Industry: Bioanalytical Method Validation. US Food and Drug Administration, Center for Drug Evaluation and Research: Rockville, MD, 2001.
11. Wang X, Zhao SL, Xu JG and Zhao YF. Study on the proliferative inhibition and apoptosis of human gastric cancer cells with treatment of Caesalpinia sappan L. extract. Chinese Remedies and Clinics 2007; 7: 843-845.
12. Wu SQ, Otero M, Unger FM, Goldring MB, Phrutivorapongkul A, Chiari C, Kolb A, Viernstein H and Toegel S. Anti-inflammatory activity of an ethanolic Caesalpinia sappan extract in human chondrocytes and macrophages. Journal of Ethnopharmacology 2011; 138: 364-372.
13. Yan X, Wang W, Xing D, Zhao Y and Du L. Development and optimization of a method for the analysis of brazilein by HPLC with electrochemical detection. Journal of Chromatography. A 2005; 1077: 44-48.
14. Ye M, Xie WD, Lei F, Meng Z, Zhao YN, Su H and Du LJ. Brazilein, an important immunosuppressive component from Caesalpinia sappan L. International Immunopharmacology 2006; 6: 426-432.
15. Zhang H, Zhang Z, Huang XB, Li H, Sun YH and Huang XW. The effects on blood glucose, renal function and renal pathology of diabetic nephropathyrats by Sumu decoction. Lishizhen Medicine and Materia Medica Research 2011; 22: 1255-1256.
16. Zhao HX, Bai H, Wang YS, Luan Y, Liu YJ. Determination of brazilin and protosappanin B in Caesalpinia sappan L. by HPLC. West China Journal of Pharmaceutical Sciences 2010; 25: 363-364.