Aspirin enhances IFN-α-induced growth inhibition and apoptosis of hepatocellular carcinoma via JAK1/STAT1 pathway

Cancer Gene Therapy

Volumn 20, Issue 6, 2013, Pages 366-374

  Li, T ^a   Dong, Z R ^b   Guo, Z Y ^a   Wang, C H ^a   Tang, Z Y ^b   Qu, S F ^a   Chen, Z T ^a   Li, X W ^a   Zhi, X T ^a  

^a SHANDONG UNIVERSITY   (China)

^b FUDAN UNIVERSITY   (China)

Author keywords

apoptosis; aspirin; hepatocellular carcinoma; interferon ; STAT1

Indexed keywords

ACETYLSALICYLIC ACID; ALPHA INTERFERON; CASPASE 3; CASPASE 8; CASPASE 9; JANUS KINASE 1; PROTEIN BAX; STAT1 PROTEIN; STAT3 PROTEIN; X LINKED INHIBITOR OF APOPTOSIS;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CANCER THERAPY; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVATION; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; LIVER CELL CARCINOMA; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TUMOR RESISTANCE; TUMOR XENOGRAFT; WESTERN BLOTTING;

ANIMALS; APOPTOSIS; ASPIRIN; CARCINOMA, HEPATOCELLULAR; CELL PROLIFERATION; DRUG RESISTANCE, NEOPLASM; DRUG SYNERGISM; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; INTERFERON-ALPHA; JANUS KINASE 1; LIVER NEOPLASMS; MICE; SIGNAL TRANSDUCTION; STAT1 TRANSCRIPTION FACTOR;

MUS MUSCULUS;

EID: 84879412768     PISSN: 09291903     EISSN: 14765500     Source Type: Journal    
DOI: 10.1038/cgt.2013.29     Document Type: Article

References (40)

1. Gish RG. Hepatocellular carcinoma: overcoming challenges in disease management. Clin Gastroenterol Hepatol 2006; 4: 252-261. (Pubitemid 43343879)
2. Kudo M. Early detection and curative treatment of early-stage hepatocellular carcinoma. Clin Gastroenterol Hepatol 2005; 3: S144-S148. (Pubitemid 41427748)
3. Omori R, Eguchi J, Hiroishi K, Ishii S, Hiraide A, Sakaki M et al. Effects of interferon-alpha-transduced tumor cell vaccines and blockade of programmed cell death-1 on the growth of established tumors. Cancer Gene Ther 2012; 19: 637-643.
4. Lai CL, Lau JY, Wu PC, Ngan H, Chung HT, Mitchell SJ et al. Recombinant inter-feron-alpha in inoperable hepatocellular carcinoma: a randomized controlled trial. Hepatology 1993; 17: 389-394. (Pubitemid 23072812)
5. Toyoda H, Kumada T, Nakano S, Takeda I, Sugiyama K, Kiriyama S et al. The effect of retreatment with interferon-alpha on the incidence of hepatocellular carcinoma in patients with chronic hepatitis C. Cancer 2000; 88: 58-65. (Pubitemid 30027679)
6. Lin SM, Lin CJ, Hsu CW, Tai DI, Sheen IS, Lin DY et al. Prospective randomized controlled study of interferon-alpha in preventing hepatocellular carcinoma recurrence after medical ablation therapy for primary tumors. Cancer 2004; 100: 376-382.
7. Sun HC, Tang ZY, Wang L, Qin LX, Ma ZC, Ye QH et al. Postoperative interferon alpha treatment postponed recurrence and improved overall survival in patients after curative resection of HBV-related hepatocellular carcinoma: a randomized clinical trial. J Cancer Res Clin Oncol 2006; 132: 458-465.
8. Rozera C, Mecchia M, Gresser I, Bandu MT, Proietti E, Venditti M et al. Murine interferon-alpha1 gene-transduced ESb tumor cells are rejected by host-mediated mechanisms despite resistance of the parental tumor to interferon-alpha/beta therapy. Cancer Gene Ther 1999; 6: 246-253. (Pubitemid 129667796)
9. Zhang X, Yang Z, Dong L, Papageorgiou A, McConkey DJ, Benedict WF. Adeno-viral-mediated interferon alpha overcomes resistance to the interferon protein in various cancer types and has marked bystander effects. Cancer Gene Ther 2007; 14: 241-250.
10. Sun WH, Pabon C, Alsayed Y, Huang PP, Jandeska S, Uddin S et al. Interferon-alpha resistance in a cutaneous T-cell lymphoma cell line is associated with lack of STAT1 expression. Blood 1998; 91: 570-576. (Pubitemid 28053380)
11. Khodarev NN, Roizman B, Weichselbaum RR. Molecular pathways: interferon/stat1 pathway: role in the tumor resistance to genotoxic stress and aggressive growth. Clin Cancer Res 2012; 18: 3015-3021.
12. Sironi JJ, Ouchi T. STAT1-induced apoptosis is mediated by caspases 2, 3, and 7. J Biol Chem 2004; 279: 4066-4074. (Pubitemid 38198990)
13. Gerolami R, Uch R, Brechot C, Mannoni P, Bagnis C. Gene therapy of hepato-carcinoma: a long way from the concept to the therapeutical impact. Cancer Gene Ther 2003; 10: 649-660. (Pubitemid 37129453)
14. Liu JF, Jamieson GG, Wu TC, Zhu GJ, Drew PA. A preliminary study on the postoperative survival of patients given aspirin after resection for squamous cell carcinoma of the esophagus or adenocarcinoma of the cardia. Ann Surg Oncol 2009; 16: 1397-1402.
15. Tuvdendorj D, Oketani M, Ikeda R, Kohara K, Komorizono Y, Ishibashi K et al. Aspirin induces hepatoma-derived cell apoptosis via a hydrogen peroxide-dependent pathway. Hepatol Res 2003; 26: 47-54. (Pubitemid 36939931)
16. Chen LC, Kepka-Lenhart D, Wright TM, Morris Jr. SM. Salicylate-enhanced activation of transcription factors induced by interferon-gamma. Biochem J 1999; 342: 503-507. (Pubitemid 29452633)
17. Li T, Zeng ZC, Wang L, Qiu SJ, Zhou JW, Zhi XT et al. Radiation enhances long-term metastasis potential of residual hepatocellular carcinoma in nude mice through TMPRSS4-induced epithelial-mesenchymal transition. Cancer Gene Ther 2011; 18: 617-626.
18. Omata M, Yoshida H, Shiratori Y. Prevention of hepatocellular carcinoma and its recurrence in chronic hepatitis C patients by interferon therapy. Clin Gastroenterol Hepatol 2005; 3: S141-S143. (Pubitemid 41427747)
19. Okanoue T, Minami M, Makiyama A, Sumida Y, Yasui K, Itoh Y. Natural course of asymptomatic hepatitis C virus-infected patients and hepatocellular carcinoma after interferon therapy. Clin Gastroenterol Hepatol 2005; 3: S89-S91. (Pubitemid 41427736)
20. Agarwala SS, Kirkwood JM. Potential uses of interferon alpha 2 as adjuvant therapy in cancer. Ann Surg Oncol 1995; 2: 365-371.
21. Iqbal Ahmed CM, Johnson DE, Demers GW, Engler H, Howe JA, Wills KN et al. Interferon alpha2b gene delivery using adenoviral vector causes inhibition of tumor growth in xenograft models from a variety of cancers. Cancer Gene Ther 2001; 8: 788-795. (Pubitemid 32983135)
22. Streck CJ, Zhang Y, Miyamoto R, Zhou J, Ng CY, Nathwani AC et al. Restriction of neuroblastoma angiogenesis and growth by interferon-alpha/beta. Surgery 2004; 136: 183-189. (Pubitemid 39037652)
23. Herzer K, Hofmann TG, Teufel A, Schimanski CC, Moehler M, Kanzler S et al. IFN-alpha-induced apoptosis in hepatocellular carcinoma involves promyelocytic leukemia protein and TRAIL independently of p53. Cancer Res 2009; 69: 855-862.
24. Saile B, Eisenbach C, El-Armouche H, Neubauer K, Ramadori G. Antiapoptotic effect of interferon-alpha on hepatic stellate cells (HSC): a novel pathway of IFN-alpha signal transduction via Janus kinase 2 (JAK2) and caspase-8. Eur J Cell Biol 2003; 82: 31-41. (Pubitemid 36181862)
25. Arulampalam V, Kolosenko I, Hjortsberg L, Bjorklund AC, Grander D, Tamm KP. Activation of STAT1 is required for interferon-alpha-mediated cell death. Exp Cell Res 2011; 317: 9-19.
26. Regis G, Pensa S, Boselli D, Novelli F, Poli V. Ups and downs: the STAT1:STAT3 seesaw of Interferon and gp130 receptor signalling. Semin Cell Dev Biol 2008; 19: 351-359.
27. Urban TJ, Thompson AJ, Bradrick SS, Fellay J, Schuppan D, Cronin KD et al. IL28B genotype is associated with differential expression of intrahepatic inter-feron-stimulated genes in patients with chronic hepatitis C. Hepatology 2010; 52: 1888-1896.
28. Chawla-Sarkar M, Lindner DJ, Liu YF, Williams BR, Sen GC, Silverman RH et al. Apoptosis and interferons: role of interferon-stimulated genes as mediators of apoptosis. Apoptosis 2003; 8: 237-249. (Pubitemid 36749609)
29. Gomez-Benito M, Balsas P, Bosque A, Anel A, Marzo I, Naval J. Apo2L/TRAIL is an indirect mediator of apoptosis induced by interferon-alpha in human myeloma cells. FEBS Lett 2005; 579: 6217-6222. (Pubitemid 41546271)
30. Cheriyath V, Glaser KB, Waring JF, Baz R, Hussein MA, Borden EC. G1P3, an IFN-induced survival factor, antagonizes TRAIL-induced apoptosis in human myeloma cells. J Clin Invest 2007; 117: 3107-3117. (Pubitemid 47529640)
31. Qi R, Gu J, Zhang Z, Yang K, Li B, Fan J et al. Potent antitumor efficacy of XAF1 delivered by conditionally replicative adenovirus vector via caspase-independent apoptosis. Cancer Gene Ther 2007; 14: 82-90. (Pubitemid 44952237)
32. Shibata T, Noguchi T, Takeno S, Gabbert HE, Ramp U, Kawahara K. Disturbed XIAP and XAF1 expression balance is an independent prognostic factor in gastric adenocarcinomas. Ann Surg Oncol 2008; 15: 3579-3587.
33. Sun Y, Qiao L, Xia HH, Lin MC, Zou B, Yuan Y et al. Regulation of XAF1 expression in human colon cancer cell by interferon beta: activation by the transcription regulator STAT1. Cancer Lett 2008; 260: 62-71.
34. Nishikawa T, Tsuno NH, Tsuchiya T, Yoneyama S, Yamada J, Shuno Y et al. Sulforaphane stimulates activation of proapoptotic protein bax leading to apoptosis of endothelial progenitor cells. Ann Surg Oncol 2009; 16: 534-543.
35. Tu SP, Sun YW, Cui JT, Zou B, Lin MC, Gu Q et al. Tumor suppressor XIAP-Associated factor 1 (XAF1) cooperates with tumor necrosis factor-related apop-tosis-inducing ligand to suppress colon cancer growth and trigger tumor regression. Cancer 2010; 116: 1252-1263.
36. Straszewski-Chavez SL, Visintin IP, Karassina N, Los G, Liston P, Halaban R et al. XAF1 mediates tumor necrosis factor-alpha-induced apoptosis and X-linked inhibitor of apoptosis cleavage by acting through the mitochondrial pathway. J Biol Chem 2007; 282: 13059-13072. (Pubitemid 47100639)
37. Yu LF, Wang J, Zou B, Lin MC, Wu YL, Xia HH et al. XAF1 mediates apoptosis through an extracellular signal-regulated kinase pathway in colon cancer. Cancer 2007; 109: 1996-2003. (Pubitemid 46744193)
38. Tong QS, Zheng LD, Wang L, Zeng FQ, Chen FM, Dong JH et al. Downregulation of XIAP expression induces apoptosis and enhances chemotherapeutic sensitivity in human gastric cancer cells. Cancer Gene Ther 2005; 12: 509-514. (Pubitemid 40629341)
39. Tahara Jr E, Tahara H, Kanno M, Naka K, Takeda Y, Matsuzaki T et al. G1P3, an interferon inducible gene 6-16, is expressed in gastric cancers and inhibits mitochondrial-mediated apoptosis in gastric cancer cell line TMK-1 cell. Cancer Immunol Immunother 2005; 54: 729-740. (Pubitemid 40977141)
40. Laimer K, Spizzo G, Obrist P, Gastl G, Brunhuber T, Schäfer G et al. STAT1 activation in squamous cell cancer of the oral cavity: a potential predictive marker of response to adjuvant chemotherapy. Cancer 2007; 110: 326-333. (Pubitemid 47121892)