-
2
-
-
79957920754
-
Inflammatory links between obesity and metabolic disease
-
Lumeng, C. N. and Saltiel, A. R. (2011) Inflammatory links between obesity and metabolic disease. J. Clin. Invest. 121, 2111-2117.
-
(2011)
J. Clin. Invest.
, vol.121
, pp. 2111-2117
-
-
Lumeng, C.N.1
Saltiel, A.R.2
-
3
-
-
79151484704
-
Adipokines in inflammation and metabolic disease
-
Ouchi, N., Parker, J. L., Lugus, J. J., and Walsh, K. (2011) Adipokines in inflammation and metabolic disease. Nat. Rev. Immunol. 11, 85-97.
-
(2011)
Nat. Rev. Immunol.
, vol.11
, pp. 85-97
-
-
Ouchi, N.1
Parker, J.L.2
Lugus, J.J.3
Walsh, K.4
-
4
-
-
0348230958
-
Obesity is associated with macrophage accumulation in adipose tissue
-
Weisberg, S. P., McCann, D., Desai, M., Rosenbaum, M., Leibel, R. L., et al. (2003) Obesity is associated with macrophage accumulation in adipose tissue. J. Clin. Invest. 112, 1796-1808.
-
(2003)
J. Clin. Invest.
, vol.112
, pp. 1796-1808
-
-
Weisberg, S.P.1
McCann, D.2
Desai, M.3
Rosenbaum, M.4
Leibel, R.L.5
-
5
-
-
9144223683
-
Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance
-
Xu, H., Barnes, G. T., Yang, Q., Tan, G., Yang, D., et al. (2003) Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J. Clin. Invest. 112, 1821-1830.
-
(2003)
J. Clin. Invest.
, vol.112
, pp. 1821-1830
-
-
Xu, H.1
Barnes, G.T.2
Yang, Q.3
Tan, G.4
Yang, D.5
-
6
-
-
2342537773
-
From blood monocytes to adipose tissue-resident macrophages: induction of diapedesis by human mature adipocytes
-
Curat, C. A., Miranville, A., Sengenes, C., Diehl, M., Tonus, C., et al. (2004) From blood monocytes to adipose tissue-resident macrophages: induction of diapedesis by human mature adipocytes. Diabetes 53, 1285-1292.
-
(2004)
Diabetes
, vol.53
, pp. 1285-1292
-
-
Curat, C.A.1
Miranville, A.2
Sengenes, C.3
Diehl, M.4
Tonus, C.5
-
7
-
-
80355133234
-
Macrophage-mediated inflammation in metabolic disease
-
Chawla, A., Nguyen, K. D., and Goh, Y. P. (2011) Macrophage-mediated inflammation in metabolic disease. Nat. Rev. Immunol. 11, 738-749.
-
(2011)
Nat. Rev. Immunol.
, vol.11
, pp. 738-749
-
-
Chawla, A.1
Nguyen, K.D.2
Goh, Y.P.3
-
8
-
-
41249098290
-
Aging up-regulates expression of inflammatory mediators in mouse adipose tissue
-
Wu, D., Ren, Z., Pae, M., Guo, W., Cui, X., et al. (2007) Aging up-regulates expression of inflammatory mediators in mouse adipose tissue. J. Immunol. 179, 4829-4839.
-
(2007)
J. Immunol.
, vol.179
, pp. 4829-4839
-
-
Wu, D.1
Ren, Z.2
Pae, M.3
Guo, W.4
Cui, X.5
-
9
-
-
83755178932
-
Aging is associated with an increase in T cells and inflammatory macrophages in visceral adipose tissue
-
Lumeng, C. N., Liu, J., Geletka, L., Delaney, C., Delproposto, J., et al. (2011) Aging is associated with an increase in T cells and inflammatory macrophages in visceral adipose tissue. J. Immunol. 187, 6208-6216.
-
(2011)
J. Immunol.
, vol.187
, pp. 6208-6216
-
-
Lumeng, C.N.1
Liu, J.2
Geletka, L.3
Delaney, C.4
Delproposto, J.5
-
10
-
-
0018646905
-
Pretreatment of plastic Petri dishes with fetal calf serum. A simple method for macrophage isolation
-
Kumagai, K., Itoh, K., Hinuma, S., and Tada, M. (1979) Pretreatment of plastic Petri dishes with fetal calf serum. A simple method for macrophage isolation. J. Immunol. Methods 29, 17-25.
-
(1979)
J. Immunol. Methods
, vol.29
, pp. 17-25
-
-
Kumagai, K.1
Itoh, K.2
Hinuma, S.3
Tada, M.4
-
11
-
-
0035140821
-
Interleukin-6 production does not increase with age
-
Beharka, A. A., Meydani, M., Wu, D., Leka, L. S., Meydani, A., et al. (2001) Interleukin-6 production does not increase with age. J. Gerontol. A Biol. Sci. Med. Sci. 56, B81-B88.
-
(2001)
J. Gerontol. A Biol. Sci. Med. Sci.
, vol.56
-
-
Beharka, A.A.1
Meydani, M.2
Wu, D.3
Leka, L.S.4
Meydani, A.5
-
12
-
-
0031227764
-
Enhanced expression of inducible cyclooxygenase with age in murine macrophages
-
Hayek, M. G., Mura, C., Wu, D., Beharka, A. A., Han, S. N., et al. (1997) Enhanced expression of inducible cyclooxygenase with age in murine macrophages. J. Immunol. 159, 2445-2451.
-
(1997)
J. Immunol.
, vol.159
, pp. 2445-2451
-
-
Hayek, M.G.1
Mura, C.2
Wu, D.3
Beharka, A.A.4
Han, S.N.5
-
14
-
-
0037838859
-
Ceramide-induced and age-associated increase in macrophage COX-2 expression is mediated through up-regulation of NF-kappa B activity
-
Wu, D., Marko, M., Claycombe, K., Paulson, K. E., and Meydani, S. N. (2003) Ceramide-induced and age-associated increase in macrophage COX-2 expression is mediated through up-regulation of NF-kappa B activity. J. Biol. Chem. 278, 10983-10992.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 10983-10992
-
-
Wu, D.1
Marko, M.2
Claycombe, K.3
Paulson, K.E.4
Meydani, S.N.5
-
15
-
-
0027503291
-
Interleukin-6: a cytokine for gerontologists
-
Ershler, W. B. (1993) Interleukin-6: a cytokine for gerontologists. J. Am. Geriatr. Soc. 41, 176-181.
-
(1993)
J. Am. Geriatr. Soc.
, vol.41
, pp. 176-181
-
-
Ershler, W.B.1
-
16
-
-
0033911488
-
Inflamm-aging. An evolutionary perspective on immunosenescence
-
Franceschi, C., Bonafe, M., Valensin, S., Olivieri, F., De Luca, M., et al. (2000) Inflamm-aging. An evolutionary perspective on immunosenescence. Ann. N Y Acad. Sci. 908, 244-254.
-
(2000)
Ann. N Y Acad. Sci.
, vol.908
, pp. 244-254
-
-
Franceschi, C.1
Bonafe, M.2
Valensin, S.3
Olivieri, F.4
De Luca, M.5
-
17
-
-
0035047271
-
Aging and proinflammatory cytokines
-
Bruunsgaard, H., Pedersen, M., and Pedersen, B. K. (2001) Aging and proinflammatory cytokines. Curr. Opin. Hematol. 8, 131-136.
-
(2001)
Curr. Opin. Hematol.
, vol.8
, pp. 131-136
-
-
Bruunsgaard, H.1
Pedersen, M.2
Pedersen, B.K.3
-
18
-
-
69949187615
-
Connecting obesity, aging and diabetes
-
Ahima, R. S. (2009) Connecting obesity, aging and diabetes. Nat. Med. 15, 996-997.
-
(2009)
Nat. Med.
, vol.15
, pp. 996-997
-
-
Ahima, R.S.1
-
19
-
-
69949150673
-
A crucial role for adipose tissue p53 in the regulation of insulin resistance
-
Minamino, T., Orimo, M., Shimizu, I., Kunieda, T., Yokoyama, M., et al. (2009) A crucial role for adipose tissue p53 in the regulation of insulin resistance. Nat. Med. 15, 1082-1087.
-
(2009)
Nat. Med.
, vol.15
, pp. 1082-1087
-
-
Minamino, T.1
Orimo, M.2
Shimizu, I.3
Kunieda, T.4
Yokoyama, M.5
-
20
-
-
85030434746
-
Increased oxidative stress in obesity and its impact on metabolic syndrome
-
Furukawa, S., Fujita, T., Shimabukuro, M., Iwaki, M., Yamada, Y., et al. (2004) Increased oxidative stress in obesity and its impact on metabolic syndrome. J. Clin. Invest. 114, 1752-1761.
-
(2004)
J. Clin. Invest.
, vol.114
, pp. 1752-1761
-
-
Furukawa, S.1
Fujita, T.2
Shimabukuro, M.3
Iwaki, M.4
Yamada, Y.5
-
21
-
-
34548419344
-
Thematic review series: adipocyte biology. Adipocyte stress: the endoplasmic reticulum and metabolic disease
-
Gregor, M. F. and Hotamisligil, G. S. (2007) Thematic review series: adipocyte biology. Adipocyte stress: the endoplasmic reticulum and metabolic disease. J. Lipid Res. 48, 1905-1914.
-
(2007)
J. Lipid Res.
, vol.48
, pp. 1905-1914
-
-
Gregor, M.F.1
Hotamisligil, G.S.2
-
22
-
-
84871309275
-
Oxidative stress and inflammation interactions in human obesity
-
Bondia-Pons, I., Ryan, L., and Martinez, J. A. (2012) Oxidative stress and inflammation interactions in human obesity. J. Physiol. Biochem. 68, 701-711.
-
(2012)
J. Physiol. Biochem
, vol.68
, pp. 701-711
-
-
Bondia-Pons, I.1
Ryan, L.2
Martinez, J.A.3
-
23
-
-
0030754240
-
Preadipocyte function and aging: links between age-related changes in cell dynamics and altered fat tissue function
-
Kirkland, J. L. and Dobson, D. E. (1997) Preadipocyte function and aging: links between age-related changes in cell dynamics and altered fat tissue function. J. Am. Geriatr. Soc. 45, 959-967.
-
(1997)
J. Am. Geriatr. Soc.
, vol.45
, pp. 959-967
-
-
Kirkland, J.L.1
Dobson, D.E.2
-
24
-
-
0036604165
-
Adipogenesis and aging: does aging make fat go MAD?
-
Kirkland, J. L., Tchkonia, T., Pirtskhalava, T., Han, J., and Karagiannides, I. (2002) Adipogenesis and aging: does aging make fat go MAD? Exp. Gerontol. 37, 757-767.
-
(2002)
Exp. Gerontol.
, vol.37
, pp. 757-767
-
-
Kirkland, J.L.1
Tchkonia, T.2
Pirtskhalava, T.3
Han, J.4
Karagiannides, I.5
-
25
-
-
33646806826
-
Lipotoxicity, overnutrition and energy metabolism in aging
-
Slawik, M. and Vidal-Puig, A. J. (2006) Lipotoxicity, overnutrition and energy metabolism in aging. Ageing Res. Rev. 5, 144-164.
-
(2006)
Ageing Res. Rev.
, vol.5
, pp. 144-164
-
-
Slawik, M.1
Vidal-Puig, A.J.2
-
26
-
-
78349299099
-
Fat tissue, aging, and cellular senescence
-
Tchkonia, T., Morbeck, D. E., Von Zglinicki, T., Van Deursen, J., Lustgarten, J., et al. (2010) Fat tissue, aging, and cellular senescence. Aging Cell 9, 667-684.
-
(2010)
Aging Cell
, vol.9
, pp. 667-684
-
-
Tchkonia, T.1
Morbeck, D.E.2
Von Zglinicki, T.3
Van Deursen, J.4
Lustgarten, J.5
-
27
-
-
0034972714
-
Altered expression of C/EBP family members results in decreased adipogenesis with aging
-
Karagiannides, I., Tchkonia, T., Dobson, D. E., Steppan, C. M., Cummins, P., et al. (2001) Altered expression of C/EBP family members results in decreased adipogenesis with aging. Am. J. Physiol. Regul. Integr. Comp. Physiol. 280, R1772-R1780.
-
(2001)
Am. J. Physiol. Regul. Integr. Comp. Physiol.
, vol.280
-
-
Karagiannides, I.1
Tchkonia, T.2
Dobson, D.E.3
Steppan, C.M.4
Cummins, P.5
-
28
-
-
67651148136
-
Aging alters PPARgamma in rodent and human adipose tissue by modulating the balance in steroid receptor coactivator-1
-
Miard, S., Dombrowski, L., Carter, S., Boivin, L., and Picard, F. (2009) Aging alters PPARgamma in rodent and human adipose tissue by modulating the balance in steroid receptor coactivator-1. Aging Cell 8, 449-459.
-
(2009)
Aging Cell
, vol.8
, pp. 449-459
-
-
Miard, S.1
Dombrowski, L.2
Carter, S.3
Boivin, L.4
Picard, F.5
-
29
-
-
79954996879
-
Oxidative stress accumulates in adipose tissue during aging and inhibits adipogenesis
-
Findeisen, H. M., Pearson, K. J., Gizard, F., Zhao, Y., Qing, H., et al. (2011) Oxidative stress accumulates in adipose tissue during aging and inhibits adipogenesis. PLoS One 6, e18532.
-
(2011)
PLoS One
, vol.6
-
-
Findeisen, H.M.1
Pearson, K.J.2
Gizard, F.3
Zhao, Y.4
Qing, H.5
-
30
-
-
0036182137
-
Lipotoxic diseases
-
Unger, R. H. (2002) Lipotoxic diseases. Annu. Rev. Med. 53, 319-336.
-
(2002)
Annu. Rev. Med.
, vol.53
, pp. 319-336
-
-
Unger, R.H.1
-
31
-
-
0038509036
-
Lipotoxicity: when tissues overeat
-
Schaffer, J. E. (2003) Lipotoxicity: when tissues overeat. Curr. Opin. Lipidol. 14, 281-287.
-
(2003)
Curr. Opin. Lipidol.
, vol.14
, pp. 281-287
-
-
Schaffer, J.E.1
-
33
-
-
31644443192
-
Ceramides in insulin resistance and lipotoxicity
-
Summers, S. A. (2006) Ceramides in insulin resistance and lipotoxicity. Prog. Lipid Res. 45, 42-72.
-
(2006)
Prog. Lipid Res.
, vol.45
, pp. 42-72
-
-
Summers, S.A.1
-
34
-
-
76049095119
-
Lipid oversupply, selective insulin resistance, and lipotoxicity: molecular mechanisms
-
Chavez, J. A. and Summers, S. A. (2010) Lipid oversupply, selective insulin resistance, and lipotoxicity: molecular mechanisms. Biochim. Biophys. Acta 1801, 252-265.
-
(2010)
Biochim. Biophys. Acta
, vol.1801
, pp. 252-265
-
-
Chavez, J.A.1
Summers, S.A.2
-
35
-
-
0037163119
-
Ceramide mediates age-associated increase in macrophage cyclooxygenase-2 expression
-
Claycombe, K. J., Wu, D., Nikolova-Karakashian, M., Palmer, H., Beharka, A., et al. (2002) Ceramide mediates age-associated increase in macrophage cyclooxygenase-2 expression. J. Biol. Chem. 277, 30784-30791.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 30784-30791
-
-
Claycombe, K.J.1
Wu, D.2
Nikolova-Karakashian, M.3
Palmer, H.4
Beharka, A.5
-
36
-
-
0030066399
-
Elaboration of type-1 plasminogen activator inhibitor from adipocytes. A potential pathogenetic link between obesity and cardiovascular disease
-
Lundgren, C. H., Brown, S. L., Nordt, T. K., Sobel, B. E., and Fujii, S. (1996) Elaboration of type-1 plasminogen activator inhibitor from adipocytes. A potential pathogenetic link between obesity and cardiovascular disease. Circulation 93, 106-110.
-
(1996)
Circulation
, vol.93
, pp. 106-110
-
-
Lundgren, C.H.1
Brown, S.L.2
Nordt, T.K.3
Sobel, B.E.4
Fujii, S.5
-
37
-
-
0032943709
-
C-reactive protein in healthy subjects: associations with obesity, insulin resistance, and endothelial dysfunction: a potential role for cytokines originating from adipose tissue?
-
Yudkin, J. S., Stehouwer, C. D., Emeis, J. J., and Coppack, S. W. (1999) C-reactive protein in healthy subjects: associations with obesity, insulin resistance, and endothelial dysfunction: a potential role for cytokines originating from adipose tissue?. Arterioscler. Thromb. Vasc. Biol. 19, 972-978.
-
(1999)
Arterioscler. Thromb. Vasc. Biol.
, vol.19
, pp. 972-978
-
-
Yudkin, J.S.1
Stehouwer, C.D.2
Emeis, J.J.3
Coppack, S.W.4
-
38
-
-
0034577768
-
Raised interleukin-6 levels in obese patients
-
Roytblat, L., Rachinsky, M., Fisher, A., Greemberg, L., Shapira, Y., et al. (2000) Raised interleukin-6 levels in obese patients. Obes. Res. 8, 673-675.
-
(2000)
Obes. Res.
, vol.8
, pp. 673-675
-
-
Roytblat, L.1
Rachinsky, M.2
Fisher, A.3
Greemberg, L.4
Shapira, Y.5
-
39
-
-
0035403205
-
Circulating interleukin-6 in relation to adiposity, insulin action, and insulin secretion
-
Vozarova, B., Weyer, C., Hanson, K., Tataranni, P. A., Bogardus, C., et al. (2001) Circulating interleukin-6 in relation to adiposity, insulin action, and insulin secretion. Obes. Res. 9, 414-417.
-
(2001)
Obes. Res.
, vol.9
, pp. 414-417
-
-
Vozarova, B.1
Weyer, C.2
Hanson, K.3
Tataranni, P.A.4
Bogardus, C.5
-
40
-
-
1442352212
-
Serum interleukin-18 concentrations are increased in the polycystic ovary syndrome: relationship to insulin resistance and to obesity
-
Escobar-Morreale, H. F., Botella-Carretero, J. I., Villuendas, G., Sancho, J., and San Millan, J. L. (2004) Serum interleukin-18 concentrations are increased in the polycystic ovary syndrome: relationship to insulin resistance and to obesity. J. Clin. Endocrinol. Metab. 89, 806-811.
-
(2004)
J. Clin. Endocrinol. Metab.
, vol.89
, pp. 806-811
-
-
Escobar-Morreale, H.F.1
Botella-Carretero, J.I.2
Villuendas, G.3
Sancho, J.4
San Millan, J.L.5
-
41
-
-
4644338458
-
Circulating mononuclear cells in the obese are in a proinflammatory state
-
Ghanim, H., Aljada, A., Hofmeyer, D., Syed, T., Mohanty, P., et al. (2004) Circulating mononuclear cells in the obese are in a proinflammatory state. Circulation 110, 1564-1571.
-
(2004)
Circulation
, vol.110
, pp. 1564-1571
-
-
Ghanim, H.1
Aljada, A.2
Hofmeyer, D.3
Syed, T.4
Mohanty, P.5
-
42
-
-
34948813665
-
Osteopontin mediates obesity-induced adipose tissue macrophage infiltration and insulin resistance in mice
-
Nomiyama, T., Perez-Tilve, D., Ogawa, D., Gizard, F., Zhao, Y., et al. (2007) Osteopontin mediates obesity-induced adipose tissue macrophage infiltration and insulin resistance in mice. J. Clin. Invest. 117, 2877-2888.
-
(2007)
J. Clin. Invest.
, vol.117
, pp. 2877-2888
-
-
Nomiyama, T.1
Perez-Tilve, D.2
Ogawa, D.3
Gizard, F.4
Zhao, Y.5
-
43
-
-
49249116067
-
CC chemokine and CC chemokine receptor profiles in visceral and subcutaneous adipose tissue are altered in human obesity
-
Huber, J., Kiefer, F. W., Zeyda, M., Ludvik, B., Silberhumer, G. R., et al. (2008) CC chemokine and CC chemokine receptor profiles in visceral and subcutaneous adipose tissue are altered in human obesity. J. Clin. Endocrinol. Metab. 93, 3215-3221.
-
(2008)
J. Clin. Endocrinol. Metab.
, vol.93
, pp. 3215-3221
-
-
Huber, J.1
Kiefer, F.W.2
Zeyda, M.3
Ludvik, B.4
Silberhumer, G.R.5
-
44
-
-
77951918926
-
Macrophages, inflammation, and insulin resistance
-
Olefsky, J. M. and Glass, C. K. (2010) Macrophages, inflammation, and insulin resistance. Annu. Rev. Physiol. 72, 219-246.
-
(2010)
Annu. Rev. Physiol.
, vol.72
, pp. 219-246
-
-
Olefsky, J.M.1
Glass, C.K.2
-
45
-
-
33846026712
-
Obesity induces a phenotypic switch in adipose tissue macrophage polarization
-
Lumeng, C. N., Bodzin, J. L., and Saltiel, A. R. (2007) Obesity induces a phenotypic switch in adipose tissue macrophage polarization. J. Clin. Invest. 117, 175-184.
-
(2007)
J. Clin. Invest.
, vol.117
, pp. 175-184
-
-
Lumeng, C.N.1
Bodzin, J.L.2
Saltiel, A.R.3
-
46
-
-
70449113184
-
Human adipose tissue macrophages: m1 and m2 cell surface markers in subcutaneous and omental depots and after weight loss
-
Aron-Wisnewsky, J., Tordjman, J., Poitou, C., Darakhshan, F., Hugol, D., et al. (2009) Human adipose tissue macrophages: m1 and m2 cell surface markers in subcutaneous and omental depots and after weight loss. J. Clin. Endocrinol. Metab. 94, 4619-4623.
-
(2009)
J. Clin. Endocrinol. Metab.
, vol.94
, pp. 4619-4623
-
-
Aron-Wisnewsky, J.1
Tordjman, J.2
Poitou, C.3
Darakhshan, F.4
Hugol, D.5
-
47
-
-
70350560546
-
Regulatory mechanisms for adipose tissue M1 and M2 macrophages in diet-induced obese mice
-
Fujisaka, S., Usui, I., Bukhari, A., Ikutani, M., Oya, T., et al. (2009) Regulatory mechanisms for adipose tissue M1 and M2 macrophages in diet-induced obese mice. Diabetes 58, 2574-2582.
-
(2009)
Diabetes
, vol.58
, pp. 2574-2582
-
-
Fujisaka, S.1
Usui, I.2
Bukhari, A.3
Ikutani, M.4
Oya, T.5
|