메뉴 건너뛰기




Volumn 28, Issue 3, 2013, Pages 260-264

Comparison of serotonin glucuronidation activity of UDP-glucuronosyltransferase 1a6a (Ugt1a6a) and Ugt1a6b: Evidence for the preferential expression of Ugt1a6a in the mouse brain

Author keywords

Serotonin; UDP glucuronosyl transferase (Ugt); Ugt1a6a; Ugt1a6b

Indexed keywords

GLUCURONOSYLTRANSFERASE 1A6; GLUCURONOSYLTRANSFERASE 1A6A; GLUCURONOSYLTRANSFERASE 1A6B; SEROTONIN; UNCLASSIFIED DRUG;

EID: 84879376658     PISSN: 13474367     EISSN: 18800920     Source Type: Journal    
DOI: 10.2133/dmpk.DMPK-12-NT-091     Document Type: Article
Times cited : (10)

References (30)
  • 2
    • 84879373053 scopus 로고    scopus 로고
    • The critical role of amino acid residue at position 117 of mouse UDP-glucuronosyltransfererase 1a6a and 1a6b in resveratrol glucuronidation
    • in press
    • Uchihashi, S., Nishikawa, M., Sakaki, T. and Ikushiro, S.: The critical role of amino acid residue at position 117 of mouse UDP-glucuronosyltransfererase 1a6a and 1a6b in resveratrol glucuronidation. J. Biochem., in press.
    • J. Biochem.
    • Uchihashi, S.1    Nishikawa, M.2    Sakaki, T.3    Ikushiro, S.4
  • 3
    • 0028037803 scopus 로고
    • Cloning and characterization of cDNAs encoding mouse Ugt1.6 and rabbit UGT1.6: Differential induction by 2,3,7,8-tetrachlorodibenzo-p-dioxin
    • Lamb, J. G., Straub, P. and Tukey, R. H.: Cloning and characterization of cDNAs encoding mouse Ugt1.6 and rabbit UGT1.6: differential induction by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Biochemistry, 33: 10513-10520 (1994).
    • (1994) Biochemistry , vol.33 , pp. 10513-10520
    • Lamb, J.G.1    Straub, P.2    Tukey, R.H.3
  • 4
    • 33845929797 scopus 로고    scopus 로고
    • Tissue-and gender-specific mRNA expression of UDP-glucuronosyltransferases (UGTs) in mice
    • Buckley, D. B. and Klaassen, C. D.: Tissue-and gender-specific mRNA expression of UDP-glucuronosyltransferases (UGTs) in mice. Drug Metab. Dispos., 35: 121-127 (2007).
    • (2007) Drug Metab. Dispos. , vol.35 , pp. 121-127
    • Buckley, D.B.1    Klaassen, C.D.2
  • 5
    • 74549165687 scopus 로고    scopus 로고
    • UDP-glucuronosyltransferases (UGTs) in neuroolfactory tissues: Expression, regulation, and function
    • Heydel, J. M., Holsztynska, E. J., Legendre, A., Thiebaud, N., Artur, Y. and Le Bon, A. M.: UDP-glucuronosyltransferases (UGTs) in neuroolfactory tissues: expression, regulation, and function. Drug Metab. Rev., 42: 74-97 (2010).
    • (2010) Drug Metab. Rev. , vol.42 , pp. 74-97
    • Heydel, J.M.1    Holsztynska, E.J.2    Legendre, A.3    Thiebaud, N.4    Artur, Y.5    Le Bon, A.M.6
  • 6
    • 0031755214 scopus 로고    scopus 로고
    • Immunohistochemical localization of UDP-glucuronosyltransferases in rat brain during early development
    • Martinasevic, M. K., King, C. D., Rios, G. R. and Tephly, T. R.: Immunohistochemical localization of UDP-glucuronosyltransferases in rat brain during early development. Drug Metab. Dispos., 26: 1039-1041 (1998).
    • (1998) Drug Metab. Dispos. , vol.26 , pp. 1039-1041
    • Martinasevic, M.K.1    King, C.D.2    Rios, G.R.3    Tephly, T.R.4
  • 8
    • 18744406973 scopus 로고    scopus 로고
    • Glucuronidation of odorant molecules in the rat olfactory system: Activity, expression and age-linked modifications of UDP-glucuronosyltransferase isoforms, UGT1A6 and UGT2A1, and relation to mitral cell activity
    • Leclerc, S., Heydel, J. M., Amossé, V., Gradinaru, D., Cattarelli, M., Artur, Y., Goudonnet, H., Magdalou, J., Netter, P., Pelczar, H. and Minn, A.: Glucuronidation of odorant molecules in the rat olfactory system: activity, expression and age-linked modifications of UDP-glucuronosyltransferase isoforms, UGT1A6 and UGT2A1, and relation to mitral cell activity. Brain Res. Mol. Brain Res., 107: 201-213 (2002).
    • (2002) Brain Res. Mol. Brain Res. , vol.107 , pp. 201-213
    • Leclerc, S.1    Heydel, J.M.2    Amossé, V.3    Gradinaru, D.4    Cattarelli, M.5    Artur, Y.6    Goudonnet, H.7    Magdalou, J.8    Netter, P.9    Pelczar, H.10    Minn, A.11
  • 9
    • 66749124915 scopus 로고    scopus 로고
    • Serotonergic modulation of odor input to the mammalian olfactory bulb
    • Petzold, G. C., Hagiwara, A. and Murthy, V. N.: Serotonergic modulation of odor input to the mammalian olfactory bulb. Nat. Neurosci., 12: 784-791 (2009).
    • (2009) Nat. Neurosci. , vol.12 , pp. 784-791
    • Petzold, G.C.1    Hagiwara, A.2    Murthy, V.N.3
  • 10
    • 0034667643 scopus 로고    scopus 로고
    • Serotonin depletion in vivo inhibits the branching of olfactory projection neurons in the lobster deutocerebrum
    • Sullivan, J. M., Benton, J. L. and Beltz, B. S.: Serotonin depletion in vivo inhibits the branching of olfactory projection neurons in the lobster deutocerebrum. J. Neurosci., 20: 7716-7721 (2000).
    • (2000) J. Neurosci. , vol.20 , pp. 7716-7721
    • Sullivan, J.M.1    Benton, J.L.2    Beltz, B.S.3
  • 11
    • 0033134122 scopus 로고    scopus 로고
    • Expression of UDP-glucuronosyltransferases (UGTs) 2B7 and 1A6 in the human brain and identification of 5-hydroxytryptamine as a substrate
    • King, C. D., Rios, G. R., Assouline, J. A. and Tephly, T. R.: Expression of UDP-glucuronosyltransferases (UGTs) 2B7 and 1A6 in the human brain and identification of 5-hydroxytryptamine as a substrate. Arch. Biochem. Biophys., 365: 156-162 (1999).
    • (1999) Arch. Biochem. Biophys. , vol.365 , pp. 156-162
    • King, C.D.1    Rios, G.R.2    Assouline, J.A.3    Tephly, T.R.4
  • 12
    • 30144431738 scopus 로고    scopus 로고
    • UDP-glucuronosyltransferase 1A6: Structural, functional, and regulatory aspects
    • Bock, K. W. and Köhle, C.: UDP-glucuronosyltransferase 1A6: structural, functional, and regulatory aspects. Methods Enzymol., 400: 57-75 (2005).
    • (2005) Methods Enzymol. , vol.400 , pp. 57-75
    • Bock, K.W.1    Köhle, C.2
  • 13
    • 17044430349 scopus 로고
    • In vivo metabolism of serotonin and tryptamine: Effect of monoamine oxidase inhibition
    • Weissbach, H., Lovenberg, W., Redfield, B. G. and Udenfriend, S.: In vivo metabolism of serotonin and tryptamine: effect of monoamine oxidase inhibition. J. Pharmacol. Exp. Ther., 131: 26-30 (1961).
    • (1961) J. Pharmacol. Exp. Ther. , vol.131 , pp. 26-30
    • Weissbach, H.1    Lovenberg, W.2    Redfield, B.G.3    Udenfriend, S.4
  • 14
    • 58149475265 scopus 로고    scopus 로고
    • Discovery of dopamine glucuronide in rat and mouse brain microdialysis samples using liquid chromatography tandem mass spectrometry
    • Uutela, P., Karhu, L., Piepponen, P., Käenmäki, M., Ketola, R. A. and Kostiainen, R.: Discovery of dopamine glucuronide in rat and mouse brain microdialysis samples using liquid chromatography tandem mass spectrometry. Anal. Chem., 81: 427-434 (2009).
    • (2009) Anal. Chem. , vol.81 , pp. 427-434
    • Uutela, P.1    Karhu, L.2    Piepponen, P.3    Käenmäki, M.4    Ketola, R.A.5    Kostiainen, R.6
  • 15
    • 3242710218 scopus 로고    scopus 로고
    • Sequential metabolism of 2,3,7-trichlorodibenzo-p-dioxin (2,3,7-triCDD) by cytochrome P450 and UDPglucuronosyltransferase in human liver microsomes
    • Kasai, N., Sakaki, T., Shinkyo, R., Ikushiro, S., Iyanagi, T., Kamao, M., Okano, T., Ohta, M. and Inouye, K.: Sequential metabolism of 2,3,7-trichlorodibenzo-p-dioxin (2,3,7-triCDD) by cytochrome P450 and UDPglucuronosyltransferase in human liver microsomes. Drug Metab. Dispos., 32: 870-875 (2004).
    • (2004) Drug Metab. Dispos. , vol.32 , pp. 870-875
    • Kasai, N.1    Sakaki, T.2    Shinkyo, R.3    Ikushiro, S.4    Iyanagi, T.5    Kamao, M.6    Okano, T.7    Ohta, M.8    Inouye, K.9
  • 16
    • 33645995117 scopus 로고    scopus 로고
    • Monospecific antipeptide antibodies against human hepatic UDP-glucuronosyltransferase 1A subfamily (UGT1A) isoforms
    • Ikushiro, S., Emi, Y., Kato, Y., Yamada, S. and Sakaki, T.: Monospecific antipeptide antibodies against human hepatic UDP-glucuronosyltransferase 1A subfamily (UGT1A) isoforms. Drug Metab. Pharmacokinet., 21: 70-74 (2006).
    • (2006) Drug Metab. Pharmacokinet. , vol.21 , pp. 70-74
    • Ikushiro, S.1    Emi, Y.2    Kato, Y.3    Yamada, S.4    Sakaki, T.5
  • 17
    • 79954988600 scopus 로고    scopus 로고
    • Metabolism of the c-Fos/activator protein-1 inhibitor T-5224 by multiple human UGT isoforms
    • Uchihashi, S., Fukumoto, H., Onoda, M., Hayakawa, H., Ikushiro, S. and Sakaki, T.: Metabolism of the c-Fos/activator protein-1 inhibitor T-5224 by multiple human UGT isoforms. Drug Metab. Dispos., 39: 803-813 (2011).
    • (2011) Drug Metab. Dispos. , vol.39 , pp. 803-813
    • Uchihashi, S.1    Fukumoto, H.2    Onoda, M.3    Hayakawa, H.4    Ikushiro, S.5    Sakaki, T.6
  • 18
    • 0036499212 scopus 로고    scopus 로고
    • Increased serotonin release in mice frontal cortex and hippocampus induced by acute physiological stressors
    • Fujino, K., Yoshitake, T., Inoue, O., Ibii, N., Kehr, J., Ishida, J., Nohta, H. and Yamaguchi, M.: Increased serotonin release in mice frontal cortex and hippocampus induced by acute physiological stressors. Neurosci. Lett., 320: 91-95 (2002).
    • (2002) Neurosci. Lett. , vol.320 , pp. 91-95
    • Fujino, K.1    Yoshitake, T.2    Inoue, O.3    Ibii, N.4    Kehr, J.5    Ishida, J.6    Nohta, H.7    Yamaguchi, M.8
  • 19
    • 0037324354 scopus 로고    scopus 로고
    • Serotonin (5-hydroxytryptamine) glucuronidation in vitro: Assay development, human liver microsome activities and species differences
    • Krishnaswamy, S., Duan, S. X., Von Moltke, L. L., Greenblatt, D. J., Sudmeier, J. L., Bachovchin, W. W. and Court, M. H.: Serotonin (5-hydroxytryptamine) glucuronidation in vitro: assay development, human liver microsome activities and species differences. Xenobiotica, 33: 169-180 (2003).
    • (2003) Xenobiotica , vol.33 , pp. 169-180
    • Krishnaswamy, S.1    Duan, S.X.2    von Moltke, L.L.3    Greenblatt, D.J.4    Sudmeier, J.L.5    Bachovchin, W.W.6    Court, M.H.7
  • 20
    • 3242685873 scopus 로고    scopus 로고
    • Evaluation of 5-hydroxytryptophol and other endogenous serotonin (5-hydroxytryptamine) analogs as substrates for UDP-glucuronosyltransferase 1A6
    • Krishnaswamy, S., Hao, Q., Von Moltke, L. L., Greenblatt, D. J. and Court, M. H.: Evaluation of 5-hydroxytryptophol and other endogenous serotonin (5-hydroxytryptamine) analogs as substrates for UDP-glucuronosyltransferase 1A6. Drug Metab. Dispos., 32: 862-869 (2004).
    • (2004) Drug Metab. Dispos. , vol.32 , pp. 862-869
    • Krishnaswamy, S.1    Hao, Q.2    von Moltke, L.L.3    Greenblatt, D.J.4    Court, M.H.5
  • 21
    • 0343963108 scopus 로고    scopus 로고
    • In situ hybridization studies of UDP-glucuronosyltransferase UGT1A6 expression in rat testis and brain
    • Brands, A., Münzel, P. A. and Bock, K. W.: In situ hybridization studies of UDP-glucuronosyltransferase UGT1A6 expression in rat testis and brain. Biochem. Pharmacol., 59: 1441-1444 (2000).
    • (2000) Biochem. Pharmacol. , vol.59 , pp. 1441-1444
    • Brands, A.1    Münzel, P.A.2    Bock, K.W.3
  • 22
    • 0035397402 scopus 로고    scopus 로고
    • An alternative promoter contributes to tissue-and inducer-specific expression of the rat UDPglucuronosyltransferase 1A6 gene
    • Auyeung, D. J., Kessler, F. K. and Ritter, J. K.: An alternative promoter contributes to tissue-and inducer-specific expression of the rat UDPglucuronosyltransferase 1A6 gene. Toxicol. Appl. Pharmacol., 174: 60-68 (2001).
    • (2001) Toxicol. Appl. Pharmacol. , vol.174 , pp. 60-68
    • Auyeung, D.J.1    Kessler, F.K.2    Ritter, J.K.3
  • 23
    • 0043236180 scopus 로고    scopus 로고
    • Differential regulation of alternate UDP-glucuronosyltransferase 1A6 gene promoters by hepatic nuclear factor-1
    • Auyeung, D. J., Kessler, F. K. and Ritter, J. K.: Differential regulation of alternate UDP-glucuronosyltransferase 1A6 gene promoters by hepatic nuclear factor-1. Toxicol. Appl. Pharmacol., 191: 156-166 (2003).
    • (2003) Toxicol. Appl. Pharmacol. , vol.191 , pp. 156-166
    • Auyeung, D.J.1    Kessler, F.K.2    Ritter, J.K.3
  • 26
    • 13044304201 scopus 로고    scopus 로고
    • Nrf2 is essential for protection against acute pulmonary injury in mice
    • Chan, K. and Kan, Y. W.: Nrf2 is essential for protection against acute pulmonary injury in mice. Proc. Natl. Acad. Sci. USA, 96: 12731-12736 (1999).
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 12731-12736
    • Chan, K.1    Kan, Y.W.2
  • 27
    • 0035153227 scopus 로고    scopus 로고
    • High sensitivity of Nrf2 knockout mice to acetaminophen hepatotoxicity associated with decreased expression of ARE-regulated drug metabolizing enzymes and antioxidant genes
    • Enomoto, A., Itoh, K., Nagayoshi, E., Haruta, J., Kimura, T., O'Connor, T., Harada, T. and Yamamoto, M.: High sensitivity of Nrf2 knockout mice to acetaminophen hepatotoxicity associated with decreased expression of ARE-regulated drug metabolizing enzymes and antioxidant genes. Toxicol. Sci., 59: 169-177 (2001).
    • (2001) Toxicol. Sci. , vol.59 , pp. 169-177
    • Enomoto, A.1    Itoh, K.2    Nagayoshi, E.3    Haruta, J.4    Kimura, T.5    O'Connor, T.6    Harada, T.7    Yamamoto, M.8
  • 28
    • 63849258680 scopus 로고    scopus 로고
    • Induction of mouse UDPglucuronosyltransferase mRNA expression in liver and intestine by activators of aryl-hydrocarbon receptor, constitutive androstane receptor, pregnane X receptor, peroxisome proliferator-activated receptor alpha, and nuclear factor erythroid 2-related factor 2
    • Buckley, D. B. and Klaassen, C. D.: Induction of mouse UDPglucuronosyltransferase mRNA expression in liver and intestine by activators of aryl-hydrocarbon receptor, constitutive androstane receptor, pregnane X receptor, peroxisome proliferator-activated receptor alpha, and nuclear factor erythroid 2-related factor 2. Drug Metab. Dispos., 37: 847-856 (2009).
    • (2009) Drug Metab. Dispos. , vol.37 , pp. 847-856
    • Buckley, D.B.1    Klaassen, C.D.2
  • 29
    • 84862936370 scopus 로고    scopus 로고
    • UDP-glucuronosyltransferase expression in mouse liver is increased in obesity-and fastinginduced steatosis
    • Xu, J., Kulkarni, S. R., Li, L. and Slitt, A. L.: UDP-glucuronosyltransferase expression in mouse liver is increased in obesity-and fastinginduced steatosis. Drug Metab. Dispos., 40: 259-266 (2012).
    • (2012) Drug Metab. Dispos. , vol.40 , pp. 259-266
    • Xu, J.1    Kulkarni, S.R.2    Li, L.3    Slitt, A.L.4
  • 30
    • 84862689443 scopus 로고    scopus 로고
    • Coordinated Regulation of Hepatic Phase I and II Drug-Metabolizing Genes and Transporters using AhR-, CAR-, PXR-, PPARα-, and Nrf2-Null Mice
    • Aleksunes, L. M. and Klaassen, C. D.: Coordinated Regulation of Hepatic Phase I and II Drug-Metabolizing Genes and Transporters using AhR-, CAR-, PXR-, PPARα-, and Nrf2-Null Mice. Drug Metab. Dispos., 40: 1366-1379 (2012).
    • (2012) Drug Metab. Dispos. , vol.40 , pp. 1366-1379
    • Aleksunes, L.M.1    Klaassen, C.D.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.