메뉴 건너뛰기




Volumn 54, Issue 4, 2013, Pages 688-698

The role of clofarabine in acute myeloid leukemia

Author keywords

Clofarabine; Hematologic malignancies; Nucleoside analog; Solid tumors

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; CLADRIBINE; CLOFARABINE; CYTARABINE; DAUNORUBICIN; FLUDARABINE; GRANULOCYTE COLONY STIMULATING FACTOR; IDARUBICIN; TEMSIROLIMUS;

EID: 84879363702     PISSN: 10428194     EISSN: 10292403     Source Type: Journal    
DOI: 10.3109/10428194.2012.726722     Document Type: Review
Times cited : (45)

References (50)
  • 1
    • 0037276433 scopus 로고    scopus 로고
    • Antitumor activity of 2-fluoro-2 ' -deoxyadenosine against tumors that express Escherichia coli purine nucleoside phosphorylase
    • Parker WB, Allan PW, Hassan AE, et al. Antitumor activity of 2-fluoro-2 ' -deoxyadenosine against tumors that express Escherichia coli purine nucleoside phosphorylase. Cancer Gene Ther 2003; 10: 23-29.
    • (2003) Cancer Gene Ther , vol.10 , pp. 23-29
    • Parker, W.B.1    Allan, P.W.2    Hassan, A.E.3
  • 2
    • 0026533461 scopus 로고
    • Oral antilymphocyte activity and induction of apoptosis by 2-chloro-2 ' -arabino-fluoro-2 ' -deoxyadenosine
    • Carson DA, Wasson DB, Esparza LM, et al. Oral antilymphocyte activity and induction of apoptosis by 2-chloro-2 ' -arabino-fluoro-2 ' -deoxyadenosine. Proc Natl Acad Sci USA 1992; 89: 2970-2974.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 2970-2974
    • Carson, D.A.1    Wasson, D.B.2    Esparza, L.M.3
  • 3
    • 0345466497 scopus 로고    scopus 로고
    • Biochemical pharmacology and resistance to 2-chloro-2'-arabino-fluoro-2'- deoxyadenosine, anovel analogue of cladribine in human leukemic cells
    • Lotfi K, Mansson E, Spasokoukotskaja T, et al. Biochemical pharmacology and resistance to 2-chloro-2'-arabino-fluoro-2'-deoxyadenosine, anovel analogue of cladribine in human leukemic cells. Clin Cancer Res 1999; 5: 2438-2444.
    • (1999) Clin Cancer Res , vol.5 , pp. 2438-2444
    • Lotfi, K.1    Mansson, E.2    Spasokoukotskaja, T.3
  • 4
    • 0029053894 scopus 로고
    • Metabolism and actions of 2-chloro-9-(2-deoxy-2-fluoro-beta-D- arabinofuranosyl)-adenine in human lymphoblastoid cells
    • Xie C, Plunkett W. Metabolism and actions of 2-chloro-9-(2-deoxy-2- fluoro-beta-D-arabinofuranosyl)-adenine in human lymphoblastoid cells. Cancer Res 1995; 55: 2847-2852.
    • (1995) Cancer Res , vol.55 , pp. 2847-2852
    • Xie, C.1    Plunkett, W.2
  • 6
    • 0025811415 scopus 로고
    • Effects of 2-chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)adenine on K562 cellular metabolism and the inhibition of human ribonucleotide reductase and DNA polymerases by its 5'-triphosphate
    • Parker WB, Shaddix SC, Chang CH, et al. Effects of 2-chloro-9-(2-deoxy-2- fluoro-beta-D-arabinofuranosyl)adenine on K562 cellular metabolism and the inhibition of human ribonucleotide reductase and DNA polymerases by its 5'-triphosphate. Cancer Res 1991; 51: 2386-2394.
    • (1991) Cancer Res , vol.51 , pp. 2386-2394
    • Parker, W.B.1    Shaddix, S.C.2    Chang, C.H.3
  • 7
    • 0029927229 scopus 로고    scopus 로고
    • Deoxynucleotide pool depletion and sustained inhibition of ribonucleotide reductase and DNA synthesis after treatment of human lymphoblastoid cells with 2-chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl) adenine
    • Xie KC, Plunkett W. Deoxynucleotide pool depletion and sustained inhibition of ribonucleotide reductase and DNA synthesis after treatment of human lymphoblastoid cells with 2-chloro-9-(2-deoxy-2-fluoro-beta-D- arabinofuranosyl) adenine. Cancer Res 1996; 56: 3030-3037.
    • (1996) Cancer Res , vol.56 , pp. 3030-3037
    • Xie, K.C.1    Plunkett, W.2
  • 8
    • 0034669944 scopus 로고    scopus 로고
    • Deoxyadenosine analogs induce programmed cell death in chronic lymphocytic leukemia cells by damaging the DNA and by directly aff ecting the mitochondria
    • Genini D, Adachi S, Chao Q, et al. Deoxyadenosine analogs induce programmed cell death in chronic lymphocytic leukemia cells by damaging the DNA and by directly aff ecting the mitochondria. Blood 2000; 96: 3537-3543.
    • (2000) Blood , vol.96 , pp. 3537-3543
    • Genini, D.1    Adachi, S.2    Chao, Q.3
  • 9
    • 0033063791 scopus 로고    scopus 로고
    • Comparison of the mechanism of cytotoxicity of 2-chloro-9-(2-deoxy-2- fluoro-beta-D-arabinofuranosyl) adenine, 2-chloro-9-(2-deoxy-2-fluoro-beta-D- ribofuranosyl)adenine, and 2-chloro-9-(2-deoxy-2,2-difluoro-beta-D- ribofuranosyl)adenine in CEM cells
    • Parker WB, Shaddix SC, Rose LM, et al. Comparison of the mechanism of cytotoxicity of 2-chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl) adenine, 2-chloro-9-(2-deoxy-2-fluoro-beta-D-ribofuranosyl)adenine, and 2-chloro-9-(2-deoxy-2,2-difluoro-beta-D-ribofuranosyl)adenine in CEM cells. Mol Pharmacol 1999; 55: 515-520.
    • (1999) Mol Pharmacol , vol.55 , pp. 515-520
    • Parker, W.B.1    Shaddix, S.C.2    Rose, L.M.3
  • 10
    • 0023733094 scopus 로고
    • Interaction of 2-halogenated dATP analogs (F, Cl, and Br) with human DNA polymerases, DNA primase, and ribonucleotide reductase
    • Parker WB, Bapat AR, Shen JX, et al. Interaction of 2-halogenated dATP analogs (F, Cl, and Br) with human DNA polymerases, DNA primase, and ribonucleotide reductase. Mol Pharmacol 1988; 34: 485-491.
    • (1988) Mol Pharmacol , vol.34 , pp. 485-491
    • Parker, W.B.1    Bapat, A.R.2    Shen, J.X.3
  • 11
    • 0032917771 scopus 로고    scopus 로고
    • Antitumor activity of 2-chloro-9-(2-deoxy-2-fluoro-beta-D- arabinofuranosyl) adenine, anovel deoxyadenosine analog, against human colon tumor xenografts by oral administration
    • Takahashi T, Kanazawa J, Akinaga S, et al. Antitumor activity of 2-chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl) adenine, anovel deoxyadenosine analog, against human colon tumor xenografts by oral administration. Cancer Chemother Pharmacol 1999; 43: 233-240.
    • (1999) Cancer Chemother Pharmacol , vol.43 , pp. 233-240
    • Takahashi, T.1    Kanazawa, J.2    Akinaga, S.3
  • 12
    • 0034057850 scopus 로고    scopus 로고
    • Preclinical antitumor activity of 2-chloro-9-(2-deoxy-2-fluoro-beta-D- arabinofuranosyl) adenine (Cl-F-ara-A)
    • Waud W R, Schmid S M, Montgomery J A, et al. Preclinical antitumor activity of 2-chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl) adenine (Cl-F-ara-A). Nucleosides Nucleotides Nucleic Acids 2000; 19: 447-460.
    • (2000) Nucleosides Nucleotides Nucleic Acids , vol.19 , pp. 447-460
    • Waud, W.R.1    Schmid, S.M.2    Montgomery, J.A.3
  • 13
    • 0020992379 scopus 로고
    • Metabolism of 9-beta-D-arabinosyl-2-fluoroadenine-5'-phosphate by mice bearing P388 leukemia
    • Avramis VI, Plunkett W. Metabolism of 9-beta-D-arabinosyl-2- fluoroadenine-5'-phosphate by mice bearing P388 leukemia. Cancer Drug Deliv 1983; 1: 1-10.
    • (1983) Cancer Drug Deliv , vol.1 , pp. 1-10
    • Avramis, V.I.1    Plunkett, W.2
  • 15
    • 77953434853 scopus 로고    scopus 로고
    • 6th ed. F inal report. San Antonio, TX: Genzyme Corp.
    • Clofarabine investigator' s brochure, 6th ed. F inal report. San Antonio, TX: Genzyme Corp.; 2007.
    • (2007) Clofarabine investigator' s brochure
  • 16
    • 0037445122 scopus 로고    scopus 로고
    • Phase I clinical and pharmacology study of clofarabine in patients with solid and hematologic cancers
    • Kantarjian HM, Gandhi V, Kozuch P, et al. Phase I clinical and pharmacology study of clofarabine in patients with solid and hematologic cancers. J Clin Oncol 2003; 21: 1167-1173.
    • (2003) J Clin Oncol , vol.21 , pp. 1167-1173
    • Kantarjian, H.M.1    Gandhi, V.2    Kozuch, P.3
  • 17
    • 0346963139 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of plasma clofarabine and cellular clofarabine triphosphate in patients with acute leukemias
    • Gandhi V, Kantarjian H, Faderl S, et al. Pharmacokinetics and pharmacodynamics of plasma clofarabine and cellular clofarabine triphosphate in patients with acute leukemias. Clin Cancer Res 2003; 9: 6335-6342.
    • (2003) Clin Cancer Res , vol.9 , pp. 6335-6342
    • Gandhi, V.1    Kantarjian, H.2    Faderl, S.3
  • 18
    • 0141482004 scopus 로고    scopus 로고
    • Phase 2 clinical and pharmacologic study of clofarabine in patients with refractory or relapsed acute leukemia
    • Kantarjian H, Gandhi V, Cortes J, et al. Phase 2 clinical and pharmacologic study of clofarabine in patients with refractory or relapsed acute leukemia. Blood 2003; 102: 2379-2386.
    • (2003) Blood , vol.102 , pp. 2379-2386
    • Kantarjian, H.1    Gandhi, V.2    Cortes, J.3
  • 19
    • 0023854422 scopus 로고
    • Modulation of arabinosylnucleoside metabolism by arabinosylnucleotides in human leukemia cells
    • Gandhi V, Plunkett W. Modulation of arabinosylnucleoside metabolism by arabinosylnucleotides in human leukemia cells. Cancer Res 1988; 48: 329-334.
    • (1988) Cancer Res , vol.48 , pp. 329-334
    • Gandhi, V.1    Plunkett, W.2
  • 20
    • 0021847172 scopus 로고
    • Pharmacologically directed ara-C therapy for refractory leukemia
    • Plunkett W, Iacoboni S, Estey E, et al. Pharmacologically directed ara-C therapy for refractory leukemia. Semin Oncol 1985; 12: 20-30.
    • (1985) Semin Oncol , vol.12 , pp. 20-30
    • Plunkett, W.1    Iacoboni, S.2    Estey, E.3
  • 21
    • 0023470734 scopus 로고
    • Variables predicting response to high dose cytosine arabinoside therapy in patients with refractory acute leukemia
    • Estey E, Plunkett W, Dixon D, et al. Variables predicting response to high dose cytosine arabinoside therapy in patients with refractory acute leukemia. Leukemia 1987; 1: 580-583.
    • (1987) Leukemia , vol.1 , pp. 580-583
    • Estey, E.1    Plunkett, W.2    Dixon, D.3
  • 22
    • 15044340106 scopus 로고    scopus 로고
    • Biochemical modulation of cytarabine triphosphate by clofarabine
    • Cooper T, Ayres M, Nowak B, et al. Biochemical modulation of cytarabine triphosphate by clofarabine. Cancer Chemother Pharmacol 2005; 55: 361-368.
    • (2005) Cancer Chemother Pharmacol , vol.55 , pp. 361-368
    • Cooper, T.1    Ayres, M.2    Nowak, B.3
  • 23
    • 33845501150 scopus 로고    scopus 로고
    • Fludarabine increases oxaliplatin cytotoxicity in normal and chronic lymphocytic leukemia lymphocytes by suppressing interstrand DNA crosslink removal
    • Moufarij MA, Sampath D, Keating MJ, et al. Fludarabine increases oxaliplatin cytotoxicity in normal and chronic lymphocytic leukemia lymphocytes by suppressing interstrand DNA crosslink removal. Blood 2006; 108: 4187-4193.
    • (2006) Blood , vol.108 , pp. 4187-4193
    • Moufarij, M.A.1    Sampath, D.2    Keating, M.J.3
  • 24
    • 1542322135 scopus 로고    scopus 로고
    • A phase II, open-label study of clofarabine in adult patients with refractory or relapsed acute myelogenous leukemia
    • Abstract 2360
    • Foran JM, Faderl S, Wetzler M, et al. A phase II, open-label study of clofarabine in adult patients with refractory or relapsed acute myelogenous leukemia. Proc Am Soc Clin Oncol 2003; 22: Abstract 2360.
    • (2003) Proc Am Soc Clin Oncol , vol.22
    • Foran, J.M.1    Faderl, S.2    Wetzler, M.3
  • 25
    • 84879530706 scopus 로고    scopus 로고
    • Treatment of molecular relapse in patients with acute myeloid leukemia using clofarabine monotherapy
    • Oct 12. [Epub ahead of print]
    • Racil Z, Toskova M, Dvorakova D, et al. Treatment of molecular relapse in patients with acute myeloid leukemia using clofarabine monotherapy. Am J Hematol 2011 Oct 12. [Epub ahead of print]
    • (2011) Am J Hematol
    • Racil, Z.1    Toskova, M.2    Dvorakova, D.3
  • 26
    • 77957315407 scopus 로고    scopus 로고
    • Clofarabine in the treatment of poor risk acute myeloid leukaemia
    • Krawczyk J, Ansar N, Swords R, et al. Clofarabine in the treatment of poor risk acute myeloid leukaemia. Hematol Oncol 2010; 28: 118-123.
    • (2010) Hematol Oncol , vol.28 , pp. 118-123
    • Krawczyk, J.1    Ansar, N.2    Swords, R.3
  • 27
    • 84856232797 scopus 로고    scopus 로고
    • A randomized study of 2 dose levels of intravenous clofarabine in the treatment of patients with higher-risk myelodysplastic syndrome
    • Faderl S, Garcia-Manero G, Jabbour E, et al. A randomized study of 2 dose levels of intravenous clofarabine in the treatment of patients with higher-risk myelodysplastic syndrome. Cancer 2012; 118: 722-728.
    • (2012) Cancer , vol.118 , pp. 722-728
    • Faderl, S.1    Garcia-Manero, G.2    Jabbour, E.3
  • 28
    • 77954911871 scopus 로고    scopus 로고
    • Oral clofarabine in the treatment of patients with higher-risk myelodysplastic syndrome
    • Faderl S, Garcia-Manero G, Estrov Z, et al. Oral clofarabine in the treatment of patients with higher-risk myelodysplastic syndrome. J Clin Oncol 2010; 28: 2755-2760.
    • (2010) J Clin Oncol , vol.28 , pp. 2755-2760
    • Faderl, S.1    Garcia-Manero, G.2    Estrov, Z.3
  • 29
    • 19944433802 scopus 로고    scopus 로고
    • Results of a phase 1-2 study of clofarabine in combination with cytarabine (ara-C) in relapsed and refractory acute leukemias
    • Faderl S, Gandhi V, O' B rien S, et al. Results of a phase 1-2 study of clofarabine in combination with cytarabine (ara-C) in relapsed and refractory acute leukemias. Blood 2005; 105: 940-947.
    • (2005) Blood , vol.105 , pp. 940-947
    • Faderl, S.1    Gandhi, V.2    O'brien, S.3
  • 30
    • 18044372314 scopus 로고    scopus 로고
    • Clofarabine plus cytarabine (ara-C) combination is active in newly diagnosed patients (pts)>= age 50 with acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS)
    • Abstract 875
    • Faderl S, Gandhi V, Verstovsek S, et al. Clofarabine plus cytarabine (ara-C) combination is active in newly diagnosed patients (pts) >= age 50 with acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS). Blood 2004; 104(Suppl. 1): Abstract 875.
    • (2004) Blood , vol.104 , Issue.SUPPL. 1
    • Faderl, S.1    Gandhi, V.2    Verstovsek, S.3
  • 31
    • 52649154001 scopus 로고    scopus 로고
    • A randomized study of clofarabine versus clofarabine plus low-dose cytarabine as front-line therapy for patients aged 60 years and older with acute myeloid leukemia and high-risk myelodysplastic syndrome
    • Faderl S, Ravandi F, Huang X, et al. A randomized study of clofarabine versus clofarabine plus low-dose cytarabine as front-line therapy for patients aged 60 years and older with acute myeloid leukemia and high-risk myelodysplastic syndrome. Blood 2008; 112: 1638-1645.
    • (2008) Blood , vol.112 , pp. 1638-1645
    • Faderl, S.1    Ravandi, F.2    Huang, X.3
  • 32
    • 79952609277 scopus 로고    scopus 로고
    • Report of a phase II study of clofarabine and cytarabine in de novo and relapsed and refractory AML patients and in selected elderly patients at high risk for anthracycline toxicity
    • Agura E, Cooper B, Holmes H, et al. Report of a phase II study of clofarabine and cytarabine in de novo and relapsed and refractory AML patients and in selected elderly patients at high risk for anthracycline toxicity. Oncologist 2011; 16: 197-206.
    • (2011) Oncologist , vol.16 , pp. 197-206
    • Agura, E.1    Cooper, B.2    Holmes, H.3
  • 33
    • 84864372484 scopus 로고    scopus 로고
    • Clofarabine plus low-dose cytarabine followed by clofarabine plus low-dose cytarabine alternating with decitabine in acute myeloid leukemia frontline therapy for older patients
    • Faderl S, Ravandi F, Huang X, et al. Clofarabine plus low-dose cytarabine followed by clofarabine plus low-dose cytarabine alternating with decitabine in acute myeloid leukemia frontline therapy for older patients. Cancer 2012; 118: 4471-4477.
    • (2012) Cancer , vol.118 , pp. 4471-4477
    • Faderl, S.1    Ravandi, F.2    Huang, X.3
  • 34
    • 80053561103 scopus 로고    scopus 로고
    • Clofarabine with high dose cytarabine and granulocyte colony-stimulating factor (G-CSF) priming for relapsed and refractory acute myeloid leukaemia
    • Becker P S, Kantarjian H M, Appelbaum F R, et al. Clofarabine with high dose cytarabine and granulocyte colony-stimulating factor (G-CSF) priming for relapsed and refractory acute myeloid leukaemia. Br J Haematol 2011; 155: 182-189.
    • (2011) Br J Haematol , vol.155 , pp. 182-189
    • Becker, P.S.1    Kantarjian, H.M.2    Appelbaum, F.R.3
  • 35
    • 0035179950 scopus 로고    scopus 로고
    • DNA repair initiated in chronic lymphocytic leukemia lymphocytes by 4-hydroperoxycyclophosphamide is inhibited by fludarabine and clofarabine
    • Yamauchi T, Nowak BJ, Keating MJ, et al. DNA repair initiated in chronic lymphocytic leukemia lymphocytes by 4-hydroperoxycyclophosphamide is inhibited by fludarabine and clofarabine. Clin Cancer Res 2001; 7: 3580-3589.
    • (2001) Clin Cancer Res , vol.7 , pp. 3580-3589
    • Yamauchi, T.1    Nowak, B.J.2    Keating, M.J.3
  • 36
    • 0036621027 scopus 로고    scopus 로고
    • Anthracyclines potentiate activity against murine leukemias L1210 and P388 in vivo and in vitro
    • Szmigielska-Kaplon A, Ciesielska E, Szmigiero L, et a l. Anthracyclines potentiate activity against murine leukemias L1210 and P388 in vivo and in vitro. Eur J Haematol 2002; 68: 370-375.
    • (2002) Eur J Haematol , vol.68 , pp. 370-375
    • Szmigielska-Kaplon, A.1    Ciesielska, E.2    Szmigiero, L.3
  • 37
    • 55749096752 scopus 로고    scopus 로고
    • Clofarabine combinations as acute myeloid leukemia salvage therapy
    • Faderl S, Ferrajoli A, Wierda W, et al. Clofarabine combinations as acute myeloid leukemia salvage therapy. Cancer 2008; 113: 2090-2096.
    • (2008) Cancer , vol.113 , pp. 2090-2096
    • Faderl, S.1    Ferrajoli, A.2    Wierda, W.3
  • 38
    • 84879524806 scopus 로고    scopus 로고
    • Clofarabine, idarubicin, and cytarabine (CIA) as frontline therapy for patients younger than 61 years with newly diagnosed acute myeloid leukemia (AML)
    • Abstract
    • Nazha A, Ravandi F, Kantarjian HM, et al. Clofarabine, idarubicin, and cytarabine (CIA) as frontline therapy for patients younger than 61 years with newly diagnosed acute myeloid leukemia (AML). Blood 2011; 118(Suppl. 1): Abstract 1550.
    • (2011) Blood , vol.118 , Issue.SUPPL. 1 , pp. 1550
    • Nazha, A.1    Ravandi, F.2    Kantarjian, H.M.3
  • 39
    • 84879510771 scopus 로고    scopus 로고
    • Interim results of a phase I/II randomized study of clofarabine, idarubicin, and cytarabine (CIA) versus fludarabine, idarubicin, and cytarabine (FIA) for newly diagnosed or relapsed patients (pts) with acute myeloid leukemia (AML)
    • (Suppl.): Abstract 6607
    • Mathisen M, Kantarjian H, Faderl S, et al. Interim results of a phase I/II randomized study of clofarabine, idarubicin, and cytarabine (CIA) versus fludarabine, idarubicin, and cytarabine (FIA) for newly diagnosed or relapsed patients (pts) with acute myeloid leukemia (AML). J Clin Oncol 2012; 30(Suppl.): Abstract 6607.
    • (2012) J Clin Oncol , vol.30
    • Mathisen, M.1    Kantarjian, H.2    Faderl, S.3
  • 40
    • 70349346203 scopus 로고    scopus 로고
    • The feasibility of combining daunorubicin, clofarabine and gemtuzumab ozogamicin is feasible and effective. A pilot study
    • (Suppl.): Abstract
    • Burnett AK, Kell WJ, Hills RK, et al. The feasibility of combining daunorubicin, clofarabine and gemtuzumab ozogamicin is feasible and effective. A pilot study. Blood 2006; 108(Suppl.): Abstract 1950.
    • (2006) Blood , vol.108 , pp. 1950
    • Burnett, A.K.1    Kell, W.J.2    Hills, R.K.3
  • 41
    • 84862727979 scopus 로고    scopus 로고
    • A phase I dose-escalation study of clofarabine in combination with fractionated gemtuzumab ozogamicin in patients with refractory or relapsed acute myeloid leukemia
    • Foster M C, Amin C, Voorhees P M, et al. A phase I dose-escalation study of clofarabine in combination with fractionated gemtuzumab ozogamicin in patients with refractory or relapsed acute myeloid leukemia. Leuk Lymphoma 2012; 53: 1331-1337.
    • (2012) Leuk Lymphoma , vol.53 , pp. 1331-1337
    • Foster, M.C.1    Amin, C.2    Voorhees, P.M.3
  • 42
    • 84155180788 scopus 로고    scopus 로고
    • Temsirolimus, an mTOR inhibitor, in combination with lower-dose clofarabine as salvage therapy for older patients with acute myeloid leukaemia: Results of a phase II GIMEMA study (AML-1107)
    • Amadori S, Stasi R, Martelli AM, et al. Temsirolimus, an mTOR inhibitor, in combination with lower-dose clofarabine as salvage therapy for older patients with acute myeloid leukaemia: Results of a phase II GIMEMA study (AML-1107). Br J Haematol 2012; 156: 205-212.
    • (2012) Br J Haematol , vol.156 , pp. 205-212
    • Amadori, S.1    Stasi, R.2    Martelli, A.M.3
  • 43
    • 78649486856 scopus 로고    scopus 로고
    • Intensive chemotherapy does not benefi t most older patients (age 70 years or older) with acute myeloid leukemia
    • Kantarjian H, Ravandi F, O' Brien S, et al: Intensive chemotherapy does not benefi t most older patients (age 70 years or older) with acute myeloid leukemia. Blood 2010; 116: 4422-4429.
    • (2010) Blood , vol.116 , pp. 4422-4429
    • Kantarjian, H.1    Ravandi, F.2    O'Brien, S.3
  • 44
    • 77952491723 scopus 로고    scopus 로고
    • European development of clofarabine as treatment for older patients with acute myeloid leukemia considered unsuitable for intensive chemotherapy
    • Burnett AK, Russell NH, Kell J, et al. European development of clofarabine as treatment for older patients with acute myeloid leukemia considered unsuitable for intensive chemotherapy. J Clin Oncol 2010; 28: 2389-2395.
    • (2010) J Clin Oncol , vol.28 , pp. 2389-2395
    • Burnett, A.K.1    Russell, N.H.2    Kell, J.3
  • 45
    • 77449159668 scopus 로고    scopus 로고
    • Phase II study of clofarabine monotherapy in previously untreated older adults with acute myeloid leukemia and unfavorable prognostic factors
    • Kantarjian H M, Erba H P, Claxton D, et al. Phase II study of clofarabine monotherapy in previously untreated older adults with acute myeloid leukemia and unfavorable prognostic factors. J Clin Oncol 2010; 28: 549-555.
    • (2010) J Clin Oncol , vol.28 , pp. 549-555
    • Kantarjian, H.M.1    Erba, H.P.2    Claxton, D.3
  • 46
    • 84864050584 scopus 로고    scopus 로고
    • Clofarabine plus cytarabine compared with cytarabine alone in older patients with relapsed or refractory acute myelogenous leukemia: Results from the CLASSIC I trial
    • Faderl S, Wetzler M, Rizzieri D, et al. Clofarabine plus cytarabine compared with cytarabine alone in older patients with relapsed or refractory acute myelogenous leukemia: Results from the CLASSIC I trial. J Clin Oncol 2012; 30: 2492-2499.
    • (2012) J Clin Oncol , vol.30 , pp. 2492-2499
    • Faderl, S.1    Wetzler, M.2    Rizzieri, D.3
  • 47
    • 67651102574 scopus 로고    scopus 로고
    • Allo-SCT conditioning for myelodysplastic syndrome and acute myeloid leukemia with clofarabine, cytarabine and ATG
    • Martin MG, Uy GL, Procknow E, et al. Allo-SCT conditioning for myelodysplastic syndrome and acute myeloid leukemia with clofarabine, cytarabine and ATG. Bone Marrow Transplant 2009; 44: 13-17.
    • (2009) Bone Marrow Transplant , vol.44 , pp. 13-17
    • Martin, M.G.1    Uy, G.L.2    Procknow, E.3
  • 48
    • 79958743702 scopus 로고    scopus 로고
    • Phase I trial and pharmacokinetic study of high-dose clofarabine and busulfan and allogeneic stem cell transplantation in adults with high-risk and refractory acute leukemia
    • Farag SS, Wood LL, Schwartz JE, et al. Phase I trial and pharmacokinetic study of high-dose clofarabine and busulfan and allogeneic stem cell transplantation in adults with high-risk and refractory acute leukemia. Leukemia 2011; 25: 599-605.
    • (2011) Leukemia , vol.25 , pp. 599-605
    • Farag, S.S.1    Wood, L.L.2    Schwartz, J.E.3
  • 49
    • 78650205593 scopus 로고    scopus 로고
    • Feasibility of clofarabine cytoreduction before allogeneic transplant conditioning for refractory AML
    • Locke FL, Artz A, Rich E, et al. Feasibility of clofarabine cytoreduction before allogeneic transplant conditioning for refractory AML. Bone Marrow Transplant 2010; 45: 1692-1698.
    • (2010) Bone Marrow Transplant , vol.45 , pp. 1692-1698
    • Locke, F.L.1    Artz, A.2    Rich, E.3
  • 50
    • 83655184694 scopus 로고    scopus 로고
    • Cytoreductive treatment with clofarabine/ara-C combined with reduced-intensity conditioning and allogeneic stem cell transplantation in patients with high-risk, relapsed, or refractory acute myeloid leukemia and advanced myelodysplastic syndrome
    • Buchholz S, Dammann E, Stadler M, et al. Cytoreductive treatment with clofarabine/ara-C combined with reduced-intensity conditioning and allogeneic stem cell transplantation in patients with high-risk, relapsed, or refractory acute myeloid leukemia and advanced myelodysplastic syndrome. Eur J Haematol 2012; 88: 52-60.
    • (2012) Eur J Haematol , vol.88 , pp. 52-60
    • Buchholz, S.1    Dammann, E.2    Stadler, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.