Dishevelled-2 silencing reduces androgen-dependent prostate tumor cell proliferation and migration and expression of Wnt-3a and matrix metalloproteinases

Molecular Biology Reports

Volumn 40, Issue 7, 2013, Pages 4241-4250

  Yang, Yinhui ^a   Jiao, Li ^a   Hou, Jianguo ^a   Xu, Chuanliang ^a   Wang, Linhui ^a   Yu, Yongwei ^a   Li, Yun ^a   Yang, Chun ^a   Wang, Xia ^b   Sun, Yinghao ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Dishevelled 2; Matrix metalloproteinase; Prostate cancer; RNAi; Wnt

Indexed keywords

ANDROGEN; ANDROGEN RECEPTOR; CHOLECYSTOKININ OCTAPEPTIDE; DISHEVELLED 2; GELATINASE A; GELATINASE B; MATRIX METALLOPROTEINASE; MESSENGER RNA; WNT3A PROTEIN; DISHEVELLED PROTEINS; PHOSPHOPROTEIN; SIGNAL TRANSDUCING ADAPTOR PROTEIN;

ADULT; AGED; ARTICLE; CANCER CELL CULTURE; CANCER GROWTH; CANCER STAGING; CANCER TISSUE; CARCINOGENESIS; CELL ASSAY; CELL MIGRATION; CELL MOTILITY; CELL PROLIFERATION; CONTROLLED STUDY; GENE EXPRESSION; GENE SILENCING; GLEASON SCORE; HORMONE DEPENDENCE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; METASTASIS POTENTIAL; PROSTATE CANCER; PROSTATE HYPERTROPHY; PROTEIN ANALYSIS; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE; TUMOR INVASION; WESTERN BLOTTING; CELL MOTION; DISEASE COURSE; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MIDDLE AGED; PATHOLOGY; PROSTATE TUMOR; TUMOR CELL LINE; VERY ELDERLY;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; AGED; AGED, 80 AND OVER; ANDROGENS; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; DISEASE PROGRESSION; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE SILENCING; HUMANS; MALE; MATRIX METALLOPROTEINASES; MIDDLE AGED; NEOPLASM STAGING; PHOSPHOPROTEINS; PROSTATIC NEOPLASMS; RNA INTERFERENCE; RNA, MESSENGER; WNT3A PROTEIN;

EID: 84879358593     PISSN: 03014851     EISSN: 15734978     Source Type: Journal    
DOI: 10.1007/s11033-013-2506-6     Document Type: Article

References (31)

1. Jemal A, Siegel R, Ward E et al (2009) Cancer stastistics. CA Cancer J Clin 59:225-249
2. Feldman BJ, Feldman D (2001) The development of androgen-independent prostate cancer. Nat Rev Cancer 1:34-35
3. Emami KH, Corey E (2007) When prostate cancer meets bone: control by Wnts. Cancer Lett 253:170-179
4. Paul S, Dey A (2008) Wnt signaling and cancer development: therapeutic implication. Neoplasma 55:165-176
5. Wallingford JB, Habas R (2005) The developmental biology of Dishevelled: an enigmatic protein governing cell fate and cell polarity. Development 132:4421-4436
6. Uematsu K, He B, You L et al (2003) Activation of the Wnt pathway in non small cell lung cancer: evidence of disheveled overexpression. Oncogene 22:7218-7221
7. Uematsu K, Kanazawa S, You L et al (2003) Wnt pathway activation in mesothelioma: evidence of Dishevelled overexpression and transcriptional activity of β-catenin. Cancer Res 63:4547-4551
8. Mizutani K, Miyamoto S, Nagahata T et al (2005) Upregulation and overexpression of Dvl1, the human counterpart of the Drosophila Dishevelled gene, in prostate cancer. Tumor 91:546-551
9. Zhao Y, Yang Z, Wang Y et al (2010) Dishevelled-1 and Dishevelled-3 affect cell invasion mainly through canonical and noncanonical Wnt pathway, respectively, and associate with poor prognosis in nonsmall cell lung cancer. Mol Carcinog 49:760-770
10. Yee DS, Tang Y, Li X et al (2010) The Wnt inhibitory factor 1 restoration in prostate cancer cells was associated with reduced tumor growth, decreased capacity of cell migration and invasion and a reversal of epithelial to mesenchymal transition. Mol Cancer 9:162-175
11. Wang Q, Diao X, Sun J et al. (2011) Regulation of VEGF, and metastasis by CXCR4 in a prostate cancer cell line. Cell Biol Int. as manuscript CBI20100744
12. Horoszewicz JS, Leong SS, Chu TM et al (1980) The LNCaP cell line-a new model for studies on human prostatic carcinoma. Prog Clin Biol Res 37:115-132
13. Tso CL, McBride WH, Sun J et al (2000) Androgen deprivation induces selective outgrowth of aggressive hormonerefractory prostate cancer clones expressing distinct cellular and molecular properties not present in parental androgen-dependent cancer cells. Cancer J 6:220-233
14. Schweizer L, Rizzo CA, Spires TE, Gottardis MM, Attar RM et al. (2008) The androgen receptor can signal through Wnt/beta-catenin in prostate cancer cells as an adaptation mechanism to castration levels of androgens. BMC Cell Biol. 9:4. doi: 10.1186/1471-2121-9-4
15. Tada M, Smith JC (2000) Xwnt11 is a target of Xenopus Brachyury: regulation of gastrulation movements via Dishevelled, but not through the canonical Wnt pathway. Development 127:2227-2238
16. Wallingford JB, Rowning BA, Vogeli KM et al (2000) Dishevelled controls cell polarity during Xenopus gastrulation. Nature 405:81-85
17. Wallingford JB, Harland RM (2001) Xenopus Dishevelled signaling regulates both neural and mesodermal convergent extension: parallel forces elongating the body axis. Development 128:2581-2592
18. Endo Y, Wolf V, Muraiso K et al (2005) Wnt-3a-dependent cell motility involves RhoA activity and is specifically regulated by Dishevelled-2. J Biol Chem 280(1):777-786
19. Chesire DR, Isaacs WB (2003) Beta-catenin signaling in prostate cancer: an early perspective. Endocr Relat Cancer 10(4):537-560
20. De la Taille A, Rubin MA, Chen MVV et al (2003) Beta-catenin-related anomalies in apoptosis-resistant and hormone-refractory prostate cancer cells. Clin Cancer Res 9(5):1801-1807
21. Chen G, Shukeir N, Potti A et al (2004) Up-regulation of Wnt-1 and beta-catenin production in patients with advanced metastatic prostate carcinoma. Cancer 101(6):1345-1356
22. Zhu H, Mazor M, Kawano Y et al (2004) Analysis of Wnt gene expression in prostate cancer: mutual inhibition by wnt11 and the androgen receptor. Cancer Res 64(21):7918-7926
23. Verras M, Brown J, Li X et al (2004) Wnt3a growth factor induces androgen receptor-mediated transcription and enhances cell growth in human prostate cancer cells. Cancer Res 64(24):8860-8866
24. Salas TR, Kim J, Vakar-Lopez F et al (2004) Glycogen synthase kinase-3beta is involved in the phosphorylation and suppression of androgen receptor activity. J Biol Chem 279:19191-19200
25. Medunjanin S, Hermani A, De Servi B et al (2005) Glycogen synthase kinase-3 interacts with and phosphorylates estrogen receptor alpha and is involved in the regulation of receptor activity. J Biol Chem 280:33006-33014
26. Navarro D, Luzardo OP, Fernandez L et al (2002) Transition to androgen-independence in prostate cancer. J Steroid Biochem Mol Biol 81(3):191-201
27. Marchenko GN, Marchenko ND, Leng J et al (2002) Promoter characterization of the novel human matrix metalloproteinase-26 gene: regulation by the T-cell factor-4 implies specific expression of the gene in cancer cells of epithelial origin. Biochem J 363:253-262
28. Wu B, Crampton SP, Hughes CC et al (2007) Wnt signaling induces matrix metalloproteinase expression and regulates T cell transmigration. Immunity 26:227-239
29. Bisson I, Prowse DM (2009) WNT signaling regulates self-renewal and differentiation of prostate cancer cells with stem cell characteristics. Cell Res 19(6):683-697
30. Chang Z, Sun Y, Jiao L (2012) MiR-221 expression affects invasion potention of human prostate carcinoma cell lines by targeting DVL2. Med Oncol 29(2):815-822
31. Xunxian L, Julia TA, Marc RB (2010) Dehydroepiandrosterone administration or Gαq overexpression inducesβ-catenin/T-cell factor signaling and growth via increasing association of estrogen receptor-β/Dishevelled2 in androgen-independent prostate cancer cells. Endocrinology 151(4):1428-1440