Coupling protein engineering with probe design to inhibit and image matrix metalloproteinases with controlled specificity

Journal of the American Chemical Society

Volumn 135, Issue 24, 2013, Pages 9139-9148

  Morell, Montse ^a   Nguyen Duc, Thinh ^a   Willis, Amanda L ^b   Syed, Salahuddin ^a   Lee, Jiyoun ^a,e   Deu, Edgar ^a,f   Deng, Yang ^c   Xiao, Junpeng ^a   Turk, Benjamin E ^c   Jessen, Jason R ^d   Weiss, Stephen J ^b   Bogyo, Matthew ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^c YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^e Sungshin Women's University   (South Korea)

^f NATIONAL INSTITUTE FOR MEDICAL RESEARCH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL FUNCTIONS; CYSTEINE RESIDUES; DIRECT COVALENT MODIFICATIONS; MATRIX METALLOPROTEINASES; MODIFIED PROTEASE; PATHOPHYSIOLOGICAL; PROTEIN ENGINEERING; SMALL MOLECULES;

AMINO ACIDS; BIOCHEMICAL ENGINEERING; ENZYME ACTIVITY; GENETIC ENGINEERING; MOLECULES;

PROBES;

CYSTEINE; ELECTROPHILE; MACROPHAGE ELASTASE; MATRIX METALLOPROTEINASE 14;

ANIMAL TISSUE; ARTICLE; CHEMICAL BINDING; CHEMICAL INTERACTION; CHEMICAL MODIFICATION; CONTROLLED STUDY; CROSS COUPLING REACTION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME SPECIFICITY; ENZYME STRUCTURE; MASS SPECTROMETRY; MOLECULAR IMAGING; NONHUMAN; PROTEIN ENGINEERING; PROTEIN EXPRESSION; RAT; ZEBRA FISH;

AMINO ACID SEQUENCE; ANIMALS; CELL LINE; CYSTEINE; HUMANS; MATRIX METALLOPROTEINASE 1; MATRIX METALLOPROTEINASE 12; MICE; MODELS, MOLECULAR; MOLECULAR PROBE TECHNIQUES; MOLECULAR SEQUENCE DATA; OPTICAL IMAGING; PROTEIN ENGINEERING; SEQUENCE ALIGNMENT; ZEBRAFISH;

EID: 84879325210     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja403523p     Document Type: Article

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