High microvessel density in pancreatic ductal adenocarcinoma is associated with high grade

Virchows Archiv

Volumn 462, Issue 5, 2013, Pages 541-546

  Barău, Anca ^a   Ruiz Sauri, Amparo ^b   Valencia, Gerardo ^b   Gómez Mateo, Maria Del Carmen ^b   Sabater, Luis ^b   Ferrandez, Antonio ^b   Llombart Bosch, Antonio ^b  

^a UNIVERSITY OF MEDICINE AND PHARMACY OF CRAIOVA   (Romania)

^b UNIVERSITY OF VALENCIA   (Spain)

Author keywords

Angiogenesis; CD 31 antibody; Microvessel density; Pancreatic ductal adenocarcinoma

Indexed keywords

AVIDIN; BIOTIN; CD31 ANTIGEN;

ADULT; ANGIOGENESIS; ARTICLE; BLOOD VESSEL; CANCER GRADING; CANCER SURGERY; CAPILLARY DENSITY; CONTROLLED STUDY; DENSITY; FEMALE; HUMAN; HUMAN TISSUE; IMAGE ANALYSIS; IMMUNOPEROXIDASE STAINING; MAJOR CLINICAL STUDY; MALE; MORPHOMETRICS; PANCREAS ADENOCARCINOMA; PANCREAS RESECTION; PANCREATICODUODENECTOMY; PRIORITY JOURNAL; SPLENOPANCREATECTOMY; AGED; COMPUTER ASSISTED DIAGNOSIS; MICROVASCULATURE; MIDDLE AGED; NEOVASCULARIZATION (PATHOLOGY); PANCREAS CARCINOMA; PANCREAS TUMOR; PATHOLOGY; VASCULARIZATION;

AGED; CARCINOMA, PANCREATIC DUCTAL; FEMALE; HUMANS; IMAGE INTERPRETATION, COMPUTER-ASSISTED; MALE; MICROVESSELS; MIDDLE AGED; NEOPLASM GRADING; NEOVASCULARIZATION, PATHOLOGIC; PANCREATIC NEOPLASMS;

MLCS; MLOWN;

EID: 84879323965     PISSN: 09456317     EISSN: 14322307     Source Type: Journal    
DOI: 10.1007/s00428-013-1409-1     Document Type: Article

References (35)

1. Jemal A, Siegel R, Ward E et al (2008) Cancer statistics. Cancer J Clin 58:71-96
2. Chu GC, Kimmelman AC, Hezel A, DePinho RA (2007) Stromal biology of pancreatic cancer. J Cell Biochem 101:887-907
3. Mahadevan D, Von Hoff DD (2007) Tumor stroma interactions in pancreatic ductal adenocarcinoma. Mol Cancer Ther 6:1186-1197
4. Whatcott CJ, Han H, Posner RG et al (2011) Targeting the tumor microenvironment in cancer: why hyaluronidase deserves a second look. Cancer Discov 1:291-296
5. Vasseur S, Tomasini R, Tournaire R et al (2010) Hypoxia induced tumor metabolic switch contributes to pancreatic cancer aggressiveness. Cancers 2:2138-2152
6. Masamune A, Shimosegawa T (2009) Signal transduction in pancreatic stellate cells. J Gastroenterol 44:249-260
7. Erkan M, Reiser-Erkan C, Michalski CW et al (2009) Cancer stellate-cells interactions perpetuate the hypoxia fibrosis cycle in pancreatic ductal adenocarcinoma. Neoplasia 11:497-508
8. Koong AC, Mehta VK, Le QT et al (2000) Pancreatic tumors show high levels of hypoxia. Int J Radiat Oncol Biol Phys 48:919-922
9. Apte MV, Park S, Phillips PA et al (2004) Desmoplastic reaction in pancreatic cancer: role of pancreatic stellate cells. Pancreas 29:179-187
10. Brizel DM, Scully SP, Harrelson JM et al (1996) Tumor oxygenation predicts for the likelihood of distant metastases in human soft tissue sarcoma. Cancer Res 56:941-943
11. Hockel M, Schlenger K, Aral B et al (1996) Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix. Cancer Res 56:4509-4515
12. Svagzdys S, Lesauskaite V, Pavalkis D et al (2009) Microvessel density as a new prognostic marker after radiotherapy in rectal cancer. BMC Cancer 9:95
13. Ravazoula P, Hatjikondi O, Maragoudakis M et al (1996) Angiogenesis and metastatic potential in breast carcinoma. Breast 5:418-421
14. Weidner N (1995) Current pathologic methods for measuring intratumoral microvessel density within breast carcinoma and other solid tumors. Breast Cancer Res Treat 36:169-180
15. Uzzan B, Nicolas P, Cucherat M et al (2004) Microvessel density as a prognostic factor in women with breast cancer: a systematic review of the literature and meta-analysis. Cancer Res 64:2941-2955
16. Zhao H-C, Qin R, Chen X-X et al (2006) Microvessel density is a prognostic marker of human gastric cancer. World J Gastroenterol 12:7598-7603
17. Han H, Silverman JF, Santucci TS et al (2001) Vascular endothelial growth factor expression in stage I non-small cell lung cancer correlates with neoangiogenesis and a poor prognosis. Ann Surg Oncol 8:72-79
18. Takagi K, Takada T, Amano H (2005) A high peripheral microvessel density count correlates with a poor prognosis in pancreatic cancer. J Gastroenterol 40:402-408
19. Ikeda N, Adachi M, Taki T et al (1999) Prognostic significance of angiogenesis in human pancreatic cancer. Br J Cancer 79:1553-1563
20. Ueda T, Oda T, Kinoshita T et al (2002) Neovascularization in pancreatic ductal adenocarcinoma: microvessel count analysis, comparison with non-cancerous regions and other types of carcinomas. Oncol Rep 9:239-245
21. Karademir S, Sokmen S, Terzi C et al (2000) Tumor angiogenesis as a prognostic predictor in pancreatic cancer. J Hepatobiliary Pancreat Surg 7:489-495
22. Van der Zee JA, Van Eijck CH, Hop WC et al (2011) Angiogenesis: a prognostic determinant in pancreatic cancer? Eur J Cancer 47:2576-2584
23. Hsu SM, Raine L, Fanger H (1981) Use of avidin-biotin peroxidase complex (ABC) in immunoperoxidase techniques. J Histochem Cytochem 29:577-580
24. Kloppel G, Luttges J (2001) WHO classification 2000: exocrine pancreas tumor. VerhandlugenderDeutschenGesellschaft fur Pathologie 85:219-228
25. Sobin LH, Wittekind C (eds) (2002) TNM classification of malignant tumours, 6th ed. Wiley-Liss, Baltimore
26. Edge SB, Byrd DR, Compton CC et al (2010) Exocrine and endocrine pancreas. AJCC cancer staging manual, 7th edn. Springer, New York, pp 241-249
27. Folkman J (1995) Angiogenesis in cancer, vascular, rheumatoid and other disease. Nat Med 1:27-31
28. Weidner N (2003) Angiogenesis as a predictor of clinical outcome in cancer patients. Hum Pathol 31:403-405
29. Weidner N (2001) Tumor vascularity: what does it tell us about the growth and spread of cancer? In: D'Amore PA, Voest E (eds) Tumor angiogenesis and microcirculation. Marcel Dekker, New York, pp 465-486
30. Pluda JM, Parkinson DR (1996) Clinical implications of tumor-associated neovascularisation and current antiangiogenic strategies of the treatment of malignancies of pancreas. Cancer 78:680-687
31. Linder S, Blasjo M, von Rosen A et al (2001) Pattern of distribution and prognostic value of angiogenesis in pancreatic duct carcinoma: a semiquantitative immunohistochemical study of 45 patients. Pancreas 22:240-247
32. Khan AW, Dhillon AP, Hutchins R et al (2002) Prognostic significance of intratumoral microvessel density (IMD) in resected pancreatic and ampullary cancers to standard histopathological variables and survival. Eur J Surg Oncol 28:637-644
33. Takagi K, Takada T, Amano H et al (2005) Analysis of microvessels in pancreatic cancer: by light microscopy, confocal laser scan microscopy, and electron microscopy. J Gastroenterol 40(4):402-408
34. Rzepko R, JaskiewiczK KM et al (2003) Microvascular density in chronic pancreatitis and pancreatic ductal adenocarcinoma. Folia Histochem Cytobyol 41:237-239
35. Vermeulen PB, Gasparini G, Fox SB et al (1996) Quantification of angiogenesis in solid human tumors: in international consensus on the methodology and criteria of evaluation. Eur J Cancer 32:2474-2484