Pre-clinical toxicological evaluation of tea from the leaves of Morus nigra l. (Moraceae);Avaliação toxicológica pré-clínica do chá das folhas de Morus nigra l. (Moraceae)

Revista Brasileira de Plantas Medicinais

Volumn 15, Issue 2, 2013, Pages 244-249

  Oliveira, A C B ^a   Oliveira, A P ^a   Guimaraes A L ^a   Oliveira, R A ^a   Silva, F S ^a   Reis, S A G B ^a   Ribeiro, L A A ^a   Almeida, J R G S ^a  

^a UNIVERSIDADE FEDERAL DO VALE DO SÃO FRANCISCO   (Brazil)

Author keywords

Moraceae; Morus nigra L.; Subchronic toxicity

Indexed keywords

MULBERRY EXTRACT;

ARTICLE; BIOCHEMISTRY; CONTROLLED STUDY; HEMATOLOGICAL PARAMETERS; MORUS NIGRA; NONHUMAN; PLANT LEAF; RAT; TEA; TOXICITY TESTING;

ANIMALIA; MORACEAE; MORUS NIGRA; RATTUS;

EID: 84879319890     PISSN: 15160572     EISSN: 1983084X     Source Type: Journal    
DOI: 10.1590/S1516-05722013000200012     Document Type: Article

References (20)

1. ALMEIDA, J.R.G.S.; GUIMARÃES, A.L.; OLIVEIRA, A.P.; ARAÚJO, E.C.C.; SILVA, F.S.; NEVES, L.F.; OLIVEIRA, R.A.; SÁ, P.G.S.; Quintans-Júnior, L.J. Evaluation of hypoglycemic potential and pre-clinical toxicology of Morus nigra L. (Moraceae). Latin American Journal of Pharmacy, v.30, p.96-100, 2011.
2. BRASIL. Agência Nacional de Vigilância Sanitária. Formulário de Fitoterápicos da Farmacopéia Brasileira/Agência Nacional de Vigilância Sanitária. Brasília: Anvisa, 2011, 126p.
3. CHEN, F.J.; NAKASHIMA, N.; KIMURA, I.; KIMURA, M. Hypoglicemic activity and mechanisms of extracts from mulberry leaves (folium mori) and cortex mori radicis in streptozotocin-induced diabetic mice. Yakugaku Zasshi, v.115, p.476-482, 1995.
4. ERCISLI, S.; ORHAN, E. Chemical composition of white (Morus alba), red (Morus rubra) and black (Morus nigra) mulberry fruits. Food Chemistry, v.103, p.1380-1384, 2007.
5. FUKAI, T.; SATOH, K.; NOMURA, T.; SAKAGAMI, H. Antinephritis and radical scavenging activities of prenylflavonoids. Fitoterapia, v.74, p.720-724, 2003.
6. HEMMATI, A.A.; JALAI, M.H.; RASSHIDI, I.; HORMOZI, T.K. Effects of aqueous extract of black mulberry (Morus nigra) on liver and kidney of diabetic mice. Toxicology Letters, v.180, p.S48-S49, 2008.
7. KIM, E.S.; PARK, S.J.; LEE, E.J.; KIM, B.K.; HUH, H.; LEE, B.J. Purification and characterization of Moran 20K from Morus alba. Archives of Pharmaceutical Research, v.22, p.9-12, 1999.
8. KIM, J.W.; KIM, S.U.; LEE, H.S.; KIM, I.; AHN, M.Y.; RYU, K.S. Determination of 1-deoxynojirimycin in Morus alba L. leaves by derivatization with 9-fluorenylmethyl chloroformate followed by reversed-phase highperformance liquid chromatography. Journal of Chromatography A, v.1002, p.93-99, 2003.
9. MUKINDA, J.T.; EAGLES, P.F.K. Acute and subchronic oral toxicity profiles of the aqueous extract of Polygala fruticosa in female mice and rats. Journal of Ethnopharmacology, v. 128, p. 236-240, 2010.
10. NADERI, G.A.; ASGARY, S.; Sarraf-Zadegan, N.; OROOJY, H.; Afshin-Nya, F. Antioxidant activity of three extracts of Morus nigra. Phytotherapy Research, v.18, p.365-369, 2004.
11. NOMURA, T. Phenolic compounds of the mulberry tree and related plants. Progress in the Chemistry of Organic Natural Products, v. 53, p. 87-201, 1988.
12. NOMURA, T.; HANO, Y. Isoprenoid-substituted phenolic compounds of moraceous plants. Natural Products Reports, v.11, p.205-218, 1994.
13. OZGEN, M.; SERÇE, S.; KAYA, C. Phytochemical and antioxidant properties of anthocyanin-rich Morus nigra and Morus rubra fruits. Scientia Horticulturae, v.119, p.275-279, 2009.
14. PADILHA, M.M.; VILELA, F.C.; SILVA, M.J.D.; SANTOS, M.H.; Alves-Da-Silva, G.; Giusti-Paiva, A. Antinociceptive effect of Morus nigra leaves in mice. Journal of Medicinal Food, v.12, n.6, p.1381-1385, 2009.
15. PADILHA, M.M.; VILELA, F.C.; ROCHA, C.Q.; DIAS, M.J.; SONCINI, R.; SANTOS, M.H.; Alves-Da-Silva, G.; Giusti-Paiva, A. Antiinflammatory properties of Morus nigra leaves. Phytotherapy Research, 2010. DOI: 10.1002/ptr.3134.
16. SOUZA, M.M.; BITTAR, M.; Cechinel-Filho, V.; YUNES, R.A.; MESSANA, I.; Delle-Monache, F.; FERRARI, F. Antinociceptive properties of morusin, a prenylflavonoid isolated from Morus nigra root bark. Zeitschrift für Naturforschung, v. 55c, p. 256-260, 2000.
17. SUBRAMANION, L.J., ZURAINI, Z.; YENG, C.; YEE, L.L.; LACHIMANAN, Y.L.; SREENIVASAN, S. Acute oral toxicity of methanolic seed extract of Cassia fistula in mice. Molecules, v. 16, p. 5268-5282, 2011.
18. SYAH, Y.M.; ACHMAD, S.A.; GHISALBERTI, E.L.; HAKIM, E.H.; IMAN, M.Z.N.; MAKMUR, L.; MUJAHIDDIN, D. Andalasin A, a new stilbene dimmer from Morus macroura. Fitoterapia, v.71, p.630-635, 2000.
19. VASCONCELOS, T.H.C.; Modesto-Filho, J.; DINIZ, M.F.F.M.; SANTOS, H.B.; AGUIAR, F.B.; MOREIRA, P.V.L. Estudo toxicológico pré-clínico agudo com o extrato hidroalcoólco das folhas de Cissus sicyoides L. (Vitaceae). Brazilian Journal of Pharmacognosy, v.17, p.583-591, 2007.
20. WANG, L.; GONG, T.; CHEN, R.Y. Two new prenylflavonoids from Morus nigra L. Chinese Chemical Letters, v.20, p.1469-1471, 2009.