Effect of n-3 polyunsaturated fatty acid supplementation in patients with rheumatoid arthritis: A 16-week randomized, double-blind, placebo-controlled, parallel-design multicenter study in Korea

Journal of Nutritional Biochemistry

Volumn 24, Issue 7, 2013, Pages 1367-1372

  Park, Yongsoon ^a   Lee, AeRi ^a   Shim, Seung Cheol ^b   Lee, Ji Hyun ^c   Choe, Jung Yoon ^d   Ahn, Hongyup ^e   Choi, Chan Bum ^f   Sung, Yoon Kyoung ^f   Bae, Sang Cheol ^f  

^a Hanyang University   (South Korea)

^b Eulji University School of Medicine   (South Korea)

^c Maryknoll Hospital   (South Korea)

^d Catholic University of Daegu   (South Korea)

^e Dongguk University   (South Korea)

^f Hanyang University Hospital for Rheumatic Diseases   (South Korea)

Author keywords

Bone turnover; Inflammation; Multicenter clinical trial; N 3 polyunsaturated fatty acids; Rheumatoid arthritis

Indexed keywords

ANTIRHEUMATIC AGENT; DOCOSAHEXAENOIC ACID; EICOSAPENTAENOIC ACID PLUS DOCOSAHEXAENOIC ACID; ICOSANOID; ICOSAPENTAENOIC ACID; LEUKOTRIENE B4; OLEIC ACID; OMEGA 3 FATTY ACID; ROPUFA; SUNFLOWER OIL; UNCLASSIFIED DRUG; PLACEBO;

ADULT; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOUBLE BLIND PROCEDURE; DRUG EFFECT; ERYTHROCYTE; FEMALE; HUMAN; KOREA; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; PAIN ASSESSMENT; RANDOMIZED CONTROLLED TRIAL; RHEUMATOID ARTHRITIS; SUPPLEMENTATION; SYMPTOM; ARTHRITIS, RHEUMATOID; CLINICAL TRIAL; DIET SUPPLEMENTATION; MIDDLE AGED;

HELIANTHUS;

ADULT; ARTHRITIS, RHEUMATOID; DIETARY SUPPLEMENTS; DOUBLE-BLIND METHOD; FATTY ACIDS, OMEGA-3; FEMALE; HUMANS; MALE; MIDDLE AGED; PLACEBOS;

EID: 84879316673     PISSN: 09552863     EISSN: 18734847     Source Type: Journal    
DOI: 10.1016/j.jnutbio.2012.11.004     Document Type: Article

References (36)

1. Firestein G.S. Evolving concepts of rheumatoid arthritis. Nature 2003, 423:356-361.
2. Choy E.H., Smith C., Doré C.J., Scott D.L. A meta-analysis of the efficacy and toxicity of combining disease-modifying anti-rheumatic drugs in rheumatoid arthritis based on patient withdrawal. Rheumatology (Oxford) 2005, 44:1414-1421.
3. Lo V., Meadows S.E., Saseen J. When should COX-2 selective NSAIDs be used for osteoarthritis and rheumatoid arthritis?. J Fam Pract 2006, 55:260-262.
4. Kromann N., Green A. Epidemiological studies in the Upernavik district, Greenland. Incidence of some chronic diseases 1950-1974. Acta Med Scand 1980, 208:401-406.
5. Kremer J.M., Jubiz W., Michalek A., Rynes R.I., Bartholomew L.E., Bigaouette J., et al. Fish-oil fatty acid supplementation in active rheumatoid arthritis. A double-blinded, controlled crossover study. Ann Intern Med 1987, 106:497-503.
6. Kremer J.M., Lawrence D.A., Jubiz W., DiGiacomo R., Rynes R., Bartholomew L.E., et al. Dietary fish oil and olive oil supplementation in patients with rheumatoid arthritis. Clinical and immunologic effects. Arthritis Rheum 1990, 33:810-820.
7. Kremer J.M., Lawrence D.A., Petrillo G.F., Litts L.L., Mullaly P.M., Rynes R.I., et al. Effects of high-dose fish oil on rheumatoid arthritis after stopping nonsteroidalantiinflammatory drugs. Clinical and immune correlates. Arthritis Rheum 1995, 38:1107-1114.
8. Cleland L.G., French J.K., Betts W.H., Murphy G.A., Elliott M.J. Clinical and biochemical effects of dietary fish oil supplements in rheumatoid arthritis. J Rheumatol 1988, 15:1471-1475.
9. van der Temple H., Tulleken J.E., Limburg P.C., Muskiet F.A., van Rijswijk M.H. Defects of fish oil supplementation in rheumatoid arthritis. Ann Rheum Dis 1990, 49:76-80.
10. Sköldstam L., Börjesson O., Kjällman A., Seiving B., Akesson B. Effect of six months of fish oil supplementation in stable rheumatoid arthritis. A double blind, controlled study. Scand J Rheumatol 1992, 21:178-185.
11. Kjeldsen-Kragh J., Lund J.A., Riise T., Finnanger B., Haaland K., Finstad R., et al. Dietary omega-3 fatty acid supplementation and naproxen treatment in patients with rheumatoid arthritis. J Rheumatol 1992, 19:1531-1536.
12. Nielsen G.L., Faarvang K.L., Thomsen B.S., Teglbjaerg K.L., Jensen L.T., Hansen T.M., et al. The effects of dietary supplementation with n-3 polyunsaturated fatty acids in patients with rheumatoid arthritis: a randomized, double blind trial. Eur J Clin Invest 1992, 22:687-691.
13. Espersen G.T., Grunnet N., Lervang H.H., Nielsen G.L., Thomsen B.S., Faarvang K.L., et al. Decreased interleukin-1beta levels in plasma from rheumatoid arthritis patients after dietary supplementation with n-3 polyunsaturated fatty acids. Clin Rheumatol 1992, 11:393-395.
14. Berbert A.A., Kondo C.R., Almendra C.L., Matsuo T., Dichi I. Supplementation of fish oil and olive oil in patients with rheumatoid arthritis. Nutrition 2005, 21:131-136.
15. Geusens P., Wouters C., Nijs J., Jiang Y., Dequeker J. Long-term effect of omega-3 fatty acid supplementation in active rheumatoid arthritis. A 12-month, double blind, controlled study. Arthritis Rheum 1994, 37:824-829.
16. Lau C.S., Morley K.D., Belch J.J. Effects of fish oil supplementation on non-steroidal anti-inflammatory drug requirement in patients with mild rheumatoid arthritis-a double-blind placebo controlled study. Br J Rheumatol 1993, 32:982-989.
17. Galarraga B., Ho M., Youssef H.M., Hill A., McMahon H., Hall C., et al. Cod liver oil (n-3 fatty acids) as a non-steroidal anti-inflammatory drug sparing agent in rheumatoid arthritis. Rheumatology (Oxford) 2008, 47:665-669.
18. Goldberg R.J., Katz J. A meta-analysis of the analgesic effects of omega-3 polyunsaturated fatty acid supplementation for inflammatory joint pain. Pain 2007, 129:210-223.
19. Korea Institute for Health and Social Affairs, Ministry of Health and Welfare Korean National Health and Nutrition Examination Survey: KNAINES IV report on 2007 2009, Korea Government Printing Office, Seoul, Korea.
20. Farina E.K., Kiel D.P., Roubenoff R., Schaefer E.J., Cupples L.A., Tucker K.L. Protective effects of fish intake and interactive effects of long-chain polyunsaturated fatty acid intakes on hip bone mineral density in older adults: the Framingham Osteoporosis Study. Am J Clin Nutr 2011, 93:1142-1151.
21. Dawczynski C., Schubert R., Hein G., Müller A., Eidner T., Vogelsang H., et al. Long-term moderate intervention with n-3 long-chain PUFA-supplemented dairy products: effects on pathophysiological biomarkers in patients with rheumatoid arthritis. Br J Nutr 2009, 101:1517-1526.
22. Kolahi S., Ghorbanihaghjo A., Alizadeh S., Rashtchizadeh N., Argani H., Khabazzi A.R., et al. Fish oil supplementation decreases serum soluble receptor activator of nuclear factor-kappa B ligand/osteoprotegerin ratio in female patients with rheumatoid arthritis. Clin Biochem 2010, 43:576-580.
23. Aletaha D., Neogi T., Silman A.J., Funovits J., Felson D.T., Bingham C.O., et al. 2010 Rheumatoid arthritis classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative. Arthritis Rheum 2010, 62:2569-2581.
24. Harris W.S., Von Schacky C. The Omega-3 Index: a new risk factor for death from coronary heart disease?. Prev Med 2004, 39:212-220.
25. Adam O., Beringer C., Kless T., Lemmen C., Adam A., Wiseman M., et al. Anti-inflammatory effects of a low arachidonic acid diet and fish oil in patients with rheumatoid arthritis. RheumatolInt 2003, 23:27-36.
26. Remans P.H., Sont J.K., Wagenaar L.W., Wouters-Wesseling W., Zuijderduin W.M., Jongma A., et al. Nutrient supplementation with polyunsaturated fatty acids and micronutrients in rheumatoid arthritis: clinical and biochemical effects. Eur J Clin Nutr 2004, 58:839-845.
27. Sundrarjun T., Komindr S., Archararit N., Dahlan W., Puchaiwatananon O., Angthararak S., et al. Effects of n-3 fatty acids on serum interleukin-6, tumour necrosis factor-alpha and soluble tumour necrosis factor receptor p55 in active rheumatoid arthritis. J Int Med Res 2004, 32:443-454.
28. Schuchardt J.P., Schneider I., Meyer H., Neubronner J., von Schacky C., Hahn A. Incorporation of EPA and DHA into plasma phospholipids in response to different omega-3 fatty acid formulations-a comparative bioavailability study of fish oil vs. krill oil. Lipids Health Dis 2011, 10:145.
29. Schuchardt J.P., Neubronner J., Kressel G., Merkel M., von Schacky C., Hahn A. Moderate doses of EPA and DHA from re-esterified triacylglycerols but not from ethyl-esters lower fasting serum triacylglycerols in statin-treated dyslipidemic subjects: results from a six month randomized controlled trial. Prostaglandins Leukot Essent Fatty Acids 2011, 85:381-386.
30. Song C., Phillips A.G., Leonard B.E., Horrobin D.F. Ethyl-eicosapentaenoic acid ingestion prevents corticosterone-mediated memory impairment induced by central administration of interleukin-1beta in rats. Mol Psychiatry 2004, 9:630-638.
31. Vallette G., Sumida C., Thobie N., Nunez E.A. Unsaturated fatty acids synergistically enhance glucocorticoid-induced gene expression. Cell Signal 1995, 7:319-323.
32. Stavropoulos-Kalinoglou A., Metsios G.S., Koutedakis Y., Kitas G.D. Obesity in rheumatoid arthritis. Rheumatology (Oxford) 2011, 50:450-462.
33. Wolfe F., Michaud K. The effect of body mass index on mortality and clinical status in rheumatoid arthritis. Arthritis Care Res 2012, 64:1471-1479.
34. Salari Sharif P., Asalforoush M., Ameri F., Larijani B., Abdollahi M. The effect of n-3 fattyacids on bone biomarkers in Iranian postmenopausal osteoporotic women: a randomized clinical trial. Age (Dordr) 2010, 32:179-186.
35. Dodin S., Lemay A., Jacques H., Légaré F., Forest J.C., Mâsse B. The effects of flaxseed dietary supplement on lipid profile, bone mineral density, and symptoms in menopausal women: a randomized, double-blind, wheat germ placebo-controlled clinical trial. J Clin Endocrinol Metab 2005, 90:1390-1397.
36. Appleton K.M., Fraser W.D., Rogers P.J., Ness A.R., Tobias J.H. Supplementation with a low-moderate dose of n-3 long-chain PUFA has no short-term effect on bone resorption in human adults. Br J Nutr 2011, 105:1145-1149.