Importance of His192 in the human thyroid hormone transporter MCT8 for substrate recognition

Endocrinology

Volumn 154, Issue 7, 2013, Pages 2525-2532

  Groeneweg, Stefan ^a   Lima De Souza, Elaine C ^a   Visser, W Edward ^a   Peeters, Robin P ^a   Visser, Theo J ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; DIETHYL PYROCARBONATE; EXTRACELLULAR LOOP 1; HISTIDINE; LIOTHYRONINE; MEMBRANE PROTEIN; MONOCARBOXYLATE TRANSPORTER 8; THYROID HORMONE; THYROXINE; TRANSMEMBRANE DOMAIN 1; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ARTICLE; CONTROLLED STUDY; DRUG INHIBITION; DRUG SENSITIVITY; ENZYME SPECIFICITY; HORMONE TRANSPORT; HUMAN; HUMAN CELL; LIOTHYRONINE BLOOD LEVEL; MOLECULAR RECOGNITION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN MODIFICATION; PROTEIN TRANSPORT; SITE DIRECTED MUTAGENESIS; THYROXINE BLOOD LEVEL; WILD TYPE;

BIOLOGICAL TRANSPORT; CELL LINE; HUMANS; IMMUNOBLOTTING; MONOCARBOXYLIC ACID TRANSPORTERS; MUTATION; THYROID HORMONES;

EID: 84879305749     PISSN: 00137227     EISSN: 19457170     Source Type: Journal    
DOI: 10.1210/en.2012-2225     Document Type: Article

References (31)

1. Hennemann G, Docter R, Friesema EC, de Jong M, Krenning EP, Visser TJ. Plasma membrane transport of thyroid hormones and its role in thyroid hormone metabolism and bioavailability. Endocr Rev. 2001;22:451-476. (Pubitemid 32762323)
2. Visser WE, Friesema EC, Jansen J, Visser TJ. Thyroid hormone transport in and out of cells. Am J Physiol. 2008;19:50-56. (Pubitemid 351317898)
3. Yen PM, Ando S, Feng X, Liu Y, Maruvada P, Xia X. Thyroid hormone action at the cellular, genomic and target gene levels. Mol Cell Endocrinol. 2006;246:121-127. (Pubitemid 43238405)
4. Price NT, Jackson VN, Halestrap AP. Cloning and sequencing of four new mammalian monocarboxylate transporter (MCT) homologues confirms the existence of a transporter family with an ancient past. Biochem J. 1998;329:321-328. (Pubitemid 28040795)
5. Chan SY, Franklyn JA, Pemberton HN, et al. Monocarboxylate transporter 8 expression in the human placenta: the effects of severe intrauterine growth restriction. J Endocrinol. 2006;189:465-471.
6. Alkemade A, Friesema EC, Unmehopa UA, et al. Neuroanatomical pathways for thyroid hormone feedback in the human hypothalamus. J Clin Endocrinol Metab. 2005;90:4322-4334. (Pubitemid 41058215)
7. Alkemade A, Friesema EC, Kuiper GG, et al. Novel neuroanatomical pathways for thyroid hormone action in the human anterior pituitary. Eur J Endocrinol. 2006;154:491-500.
8. Friesema EC, Grueters A, Biebermann H, et al. Association between mutations in a thyroid hormone transporter and severe X-linked psychomotor retardation. Lancet. 2004;364:1435-1437. (Pubitemid 39370719)
9. Dumitrescu AM, Liao XH, Best TB, Brockmann K, Refetoff S. A novel syndrome combining thyroid and neurological abnormalities is associated with mutations in a monocarboxylate transporter gene. Am J Hum Genet. 2004;74:168-175. (Pubitemid 38085248)
10. Friesema EC, Visser WE, Visser TJ. Genetics and phenomics of thyroid hormone transport by MCT8. Mol Cell Endocrinol. 2010;322(1-2):107-113.
11. Kinne A, Kleinau G, Hoefig CS, et al. Essential molecular determinants for thyroid hormone transport and first structural implications for monocarboxylate transporter 8. J Biol Chem. 2010;285(36):28054-28063.
12. Kinne A, Roth S, Biebermann H, Koehrle J, Gruters A, Schweizer U. Surface translocation and tri-iodothyronine uptake of mutant MCT8 proteins are cell type-dependent. J Mol Endocrinol. 2009;43(6):263-271.
13. 3 levels caused by mutations in monocarboxylate transporter 8. Nat Clin Pract Endocrinol Metab. 2006;2:512-523.
14. Jansen J, Friesema EC, Kester MH, et al. Functional analysis of monocarboxylate transporter 8 mutations identified in patients with X-linked psychomotor retardation and elevated serum triiodothyronine. J Clin Endocrinol Metab. 2007;92:2378-2381. (Pubitemid 46997150)
15. Jansen J, Friesema EC, Kester MH, Schwartz CE, Visser TJ. Genotype-phenotype relationship in patients with mutations in thyroid hormone transporter MCT8. Endocrinology. 2008;149:2184-2190. (Pubitemid 351574539)
16. Lu JM, Bush DR. His-65 in the proton-sucrose symporter is an essential amino acid whose modification with site-directed mutagenesis increases transport activity. Proc Natl Acad Sci U S A. 1998;95:9025-9030. (Pubitemid 28350608)
17. Fujisawa Y, Tateoka R, Nara T, Kamo N, Taira T, Miyauchi S. The extracellular pH dependency of transport activity by human oligopeptide transporter 1 (hPEPT1) expressed stably in Chinese hamster ovary (CHO) cells: a reason for the bell-shaped activity versus pH. Biol Pharm Bull. 2006;29(5) 997-1005.
18. Kuze K, Graves P, Leahy A, Wilson P, Stuhlmann H, You G. Heterologous expression and functional characterization of a mouse renal organic anion transporter in mammalian cells. J Biol Chem. 1999;274(3):1519-1524.
19. Izuhara K, Okubo K, Hamasaki N. Conformational change of band 3 protein induced by diethyl pyrocarbonate modification in human erythrocyte ghosts. Biochemistry. 1989;28:4725-4728. (Pubitemid 19151050)
20. Hamasaki N, Izuhara K, Okubo K, Kanazawa Y, Omachi A, Kleps RA. Inhibition of chloride binding to the anion transport site by diethylpyrocarbonate modification of Band 3. J Membr Biol. 1990;116:87-91. (Pubitemid 20182432)
21. Takazaki S, Abe Y, Yamaguchi T, et al. Mutation of His 834 in human anion exchanger 1 affects substrate binding. Biochim Biophys Acta. 2010;1798:903-908.
22. Asaka J, Terada T, Tsuda M, Katsura T, Inui K. Identification of essential histidine and cysteine residues of the H+/organic cation antiporter multidrug and toxin extrusion (MATE). Mol Pharmacol. 2007;71(6):1487-1493. (Pubitemid 47010901)
23. Miles EW. Modification of histidyl residues in proteins by diethylpyrocarbonate. Methods Enzymol. 1977;47:431-442.
24. Cheng KC, Nowak T. A histidine residue at the active site of avian liver phosphoenolpyruvate carboxykinase. J Biol Chem. 1989;264:19666-19676. (Pubitemid 20008073)
25. Friesema EC, Kuiper GG, Jansen J, Visser TJ, Kester MH. Thyroid hormone transport by the human monocarboxylate transporter 8 and its rate-limiting role in intracellular metabolism. Mol Endocrinol. 2006;20:2761-2772. (Pubitemid 44833533)
26. Mol JA, Visser TJ. Synthesis and some properties of sulfate esters and sulfamates of iodothyronines. Endocrinology. 1985;117(1):1-7. (Pubitemid 15019839)
27. Friesema EC, Jansen J, Jachtenberg JW, Visser WE, Kester MH, Visser TJ. Effective cellular uptake and efflux of thyroid hormone by human monocarboxylate transporter 10. Mol Endocrinol. 2008;22(6):1357-1369. (Pubitemid 351786996)
28. Kaback HR. Use of site-directed mutagenesis to study the mechanism of a membrane transport protein. Biochemistry. 1987;26:2071-2076.
29. Poolman B, Royer TJ, Mainzer SE, Schmidt BF. Lactose transport system of Streptococcus thermophilus: a hybrid protein with homology to the melibiose carrier and enzyme III of phosphoenolpyruvate-dependent phosphotransferase systems. J Bacteriol. 1989;171:244-253.
30. Vaurs-Barriere C, Deville M, Sarret C, et al. Pelizaeus-Merzbacherlike disease presentation of MCT8 mutated male subjects. Ann Neurol. 2009;65:114-118.
31. Capri Y, Friesema EC, Kersseboom S, et al. Relevance of different cellular models to determine the effects of mutations in the MCT8 thyroid hormone transporter and genotype-phenotype correlation [published online April 8, 2013]. Hum Mutat. doi:10.1002/humu.22331.