Immunomodulatory effect of mangiferin in experimental animals with Benzo(a)pyrene-induced lung carcinogenesis

International Journal of Biomedical Science

Volumn 9, Issue 2, 2013, Pages 68-74

  Rajendran, Peramaiyan ^a   Jayakumar, Thangavel ^a   Nishigaki, Ikuo ^b   Ekambaram, Ganapathy ^a   Nishigaki, Yutaka ^b   Vetriselvi, Jayabal ^c   Sakthisekaran, Dhanapal ^a  

^a UNIVERSITY OF MADRAS   (India)

^b NPO International Laboratory of Biochemistry   (Japan)

^c A V V M SRI PUSHPAM COLLEGE   (India)

Author keywords

Benzo(a)Pyrene; Immunomodulation; Mangiferin; Polyaromatic hydrocarbon

Indexed keywords

BENZO[A]PYRENE; CATALASE; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; LIPID PEROXIDASE; MALONALDEHYDE; MANGIFERIN; SUPEROXIDE DISMUTASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN ANTIBODY COMPLEX; ANTINEOPLASTIC ACTIVITY; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVITY; IMMUNOCOMPETENCE; IMMUNOMODULATION; LIPID PEROXIDATION; LUNG CANCER; LUNG CARCINOGENESIS; LYMPHOCYTE; MACROPHAGE; MALE; MOUSE; NEUTROPHIL; NONHUMAN; OXIDATIVE STRESS; POLYMORPHONUCLEAR CELL; UPREGULATION;

ANIMALIA; MUS;

EID: 84879304204     PISSN: 15509702     EISSN: 15552810     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. Sanchez GM. Re L, Giuliani A, Nuońez-Selles AJ, et al. Protective effects of Mangifera indica L. Extract, mangiferin and selected antioxidants against TPA induced biomolecules oxidation and peritoneal macrophage activation in mice. Pharmacol. Res. 2000; 42: 565-573.
2. Rajendran P, Ekambaram G, Magesh V, Sakthisekaran D. Chemopreventive efficacy of mangiferin against benzo(a)pyrene induced lung carcinogenesis in experimental animals. Environ. Toxicol. Pharmacol. 2008; 26 (3): 278-282.
3. Rajendran P, Ekambaram G, Sakthisekaran D. Cytoprotective effect of mangiferin on benzo(a)pyrene-induced lung carcinogenesis in swiss albino mice. Basic. Clin. Pharmacol. Toxicol. 2008; 3 (2): 137-142.
4. Rajendran P, Ekambaram G, Sakthisekaran D. Protective role of mangiferin against benzo(a)pyrene induced lung carcinogenesis in experimental animals. Biol. Pharm. Bull. 2008; 31 (6):1053-1058.
5. Rajendran P, Ekambaram G, Sakthisekaran D. Effect of mangiferin on benzo(a)pyrene induced lung carcinogenesis in experimental Swiss albino mice. Nat. Pro. Res. 2008; 22 (8): 672-680.
6. Guha S, Ghosal S, Chattopadhyay U. Antitumor, immunomodulatory and anti-HIV effect of mangiferin, a naturally occurring glucosylxanthone. Chemothe. 1996; 42: 443-445.
7. Zheng MS, Lu ZY. Antiviral effect of mangiferin and isomangiferin on herpes simplex virus. Chi. Med. J. 1990; 103: 160-165.
8. Zhu XM, Song JX, Huang ZZ, Wu YM, et al. Antiviral activity of mangiferin against herpes simplex virus type 2 in vitro. Zhongguo Yao Li XueBao. 1993; 4: 452-454.
9. Yoosook C, Bunyapraphatsara N, Boonyakiat Y, Kantasuk C. Antiherpes simplex virus activities of crude water extracts of Thai medicinal plants. Phytomed. 2000; 6: 411-419.
10. Makare N, Bodhankar S, Rangari V. Immunomodulatory activity of alcoholic extract of Mangifera indica L. in mice. J. Eth. Pharmacol. 2001; 78: 133-137.
11. Leiro J, Arranz JA, Yanez M, Ubeira FM, et al. Expression profiles of genes involved in the mouse nuclear factor-kappa B signal transduction pathway are modulated by mangiferin. Int. Immunopharmacol. 2004; 4: 763-778.
12. Jagetia GC, Baliga MS. Radioprotection by mangiferin in DBAx-C57BL mice: a preliminary study. Phytomed. 2005; 2: 209-215.
13. John MB. Laboratory Medicine Haematology: fourth ed. St Louis: CV Mosby Co. 1972; pp1198-1204.
14. Seth P, Srinivas RV. Circulating immune complexes in cervical cancer: simple method for detection and characterization. Ind. J. Med. Res. 1981; 73: 926-929.
15. Gifford RH, Malawista SE. A simple rapid micro method for detecting chronic granulomatus diseases of childhood. J. Lab. Cli. Med. 1970; 108: 18-21.
16. Tennant B, Baldwin BH, Braunn RK, Norcross NL, et al. Use of the glutaraldehyde coagulation test for the detection of hypogamma globulinemia in neonatal calves. Am. J. V. Med. 1979; 174: 848-853.
17. Satpathy PK, Dutta NK, Mishra PR, Kar B. Glutaraldehyde coagulation test standard curve and its applications to detect gammaglobulin level in kids. Ind. V. J. 1996; 73: 257-260.
18. Vray B, Plasman N. Separation of murine peritoneal macrophages using Percoll density gradients. J. Immunol. Met. 1994; 174: 53-59.
19. Lowry OH, Rosenbrough NJ, Farrn AI, Randall R. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 1951; 193: 265-275.
20. Madesh M, Balasubramanian KA. Microtiter plate assay for superoxide dismutase using MTT reduction by superoxide. Ind. J. Biochem. Biophy. 1998; 35: 184-188.
21. Madesh M, Balasubramanian KA. Microtiter plate assay for superoxide dismutase using MTT reduction by superoxide. Ind. J. Biochem. Biophys. 1998; 35 (3): 184-188.
22. Maehly AC Chance. In: Glick Jr., D. (Ed.), Methods of Biochemical Analysis, vol. 1. New York: Interscience. 1954; pp357.
23. Ohkawa H, Ohishi N, Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Ana. Biochem. 1979; 95: 351-358.
24. Neff JM. Polycyclic aromatic hydrocarbons in the aquatic environment. London: Applied Sciences. 1979; pp3-12.
25. White KL, Kawabata TT, Ladics GS. Mechanisms of polycyclic aro matic hydrocarbon immunotoxicity. In Immunotoxicology and immunopharmacology, eds. J. H. Dean, M. I. Luster, A. E. Munson, and Kimber, 2nd ed. New York: Raven Press. 1994; pp3-12.
26. White KL, JrLysy HH, Holsapple MP. Immunosuppression by polycyclic aromatic hydrocarbons: A structure activity relationship in B6C3F1 and DBA/2 mice. Immunopharmacol. 1985; 9: 155-164.
27. IARC. Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Humans, Polynuclear Aromatic Compounds. Part I. Chemical and Environmental Data, IARC, Lyon, France. 1983; 32: 105-121.
28. Malmgren RA, Bennison BE. Mckinley TW. Reduced antibody titers in mice treated with carcinogenic and cancer chemotherapeutic agents. Proce. Soc. Exp. Biol. Med. 1952; 79: 484-488.
29. Sver L, Orsolic N, Tadic Z, Njari B, et al. A royal jelly as a new potential immunomodulator in rats and mice. Comp. Immunol. Microbiol. Infec. Dis. 1996; 19: 31-38.
30. Ravichandiran1 V, Nazeer ahamed H, Nirmala S. Natural Flavonoids and Lung Cancer. Pharmacie Globale© (IJCP). 2011; 2 (6): 1-9.
31. Iio W, Strober S, Broder Polmar SH. The metabolism of IgE in patients with immunodeficiency states and neoplastic conditions. J. Clini. Inves. 1977; 59: 743-755.
32. Sianyi NI, Namytor MM. Changes in immunology indices in patients with brain tumors. Zh. Vopr. Neivorhir. 1985; 19: 615-619.
33. Chandy KG, Huebscher SG, Elias E, Berg J, et al. Dual role of the liver in regulating polymeric IgA in man: studies on patients with liver diseases. Clini. Emp. Immunol. 1983; 52: 207-218.
34. Verbitskaya LV, Tenditnik MV, Michurina SV, Shurlygina AV, et al. Effect of benzo[a]pyrene on the immune status of mice with anxiousdepressive syndrome. Bull. Exp. Bio. Med. 2005; 140: 70-73.
35. Garci{dotless}a D, Delgado R, Ubeira FM, Leiro J. Modulation of rat macrophage function by the Mangifera indica L. extracts and mangiferin. Int. Immunopharmacol. 2002; 2: 797-806.
36. Jung JH, kim M, Kim HK. Green tea polyphenols suppress nitric oxide-induced apoptosis and acetylcholinesterase activity in human neuroblastoma cells. Nutr. Res. 2005; 25 (5): 477-483.
37. Sato T, Kawamoto A, Tamura A, Tatsumi Y, et al. Mechanism of antioxidant action of pueraria glycoside (PG)-1 (an isoflavonoid) and mangiferin (a xanthonoid). Chem. Pharmacolo. Bull. 1992; 40: 721-724.
38. Tang SY, Whiteman M, Peng ZF, Jenner A, et al. Characterization of antioxidant and antiglycation properties and isolation of active ingredients from traditional Chinese medicines. Free. Radi. Biol. Med. 2004; 15: 1575-1587.
39. Neyfah EA, Alimbekova AI, Ivanenko GF. Radiation-induced lipoperoxidation stress in children coupled with deficit of essential antioxidants. Biochem (Mosc). 1998; 63: 977-987.
40. Marnett LJ. Oxy radicals, lipid peroxidation and DNA damage. Toxicol. 2002; 27: 219-222.