Mda-7/IL-24 expression inhibits breast cancer through upregulation of growth arrest-specific gene 3 (gas3) and disruption of β1 integrin function

Molecular Cancer Research

Volumn 11, Issue 6, 2013, Pages 593-603

  Li, You Jun ^b,e   Liu, Guodong ^a   Li, Yanmei ^a,b   Vecchiarelli Federico, Laura M ^a,b   Liu, Jeff C ^c   Zacksenhaus, Eldad ^a,c   Shan, Sze W ^b   Yang, Burton B ^b   Li, Qi ^e   Dash, Rupesh ^d,f   Fisher, Paul B ^d   Archer, Michael C ^a   Ben David, Yaacov ^a,b  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY HEALTH NETWORK   (Canada)

^c UNIVERSITY HEALTH NETWORK   (Canada)

^d VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e Basic Medical College   (China)

^f INSTITUTE OF LIFE SCIENCES   (India)

Author keywords

[No Author keywords available]

Indexed keywords

BETA1 INTEGRIN; FIBRONECTIN; INTERLEUKIN 24; PERIPHERAL MYELIN PROTEIN 22; SMALL INTERFERING RNA; STAT3 PROTEIN;

ADENOVIRUS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BREAST CANCER; CANCER CELL; CANCER GROWTH; CARCINOGENESIS; CELL GROWTH; CELL PROLIFERATION; CONTROLLED STUDY; FEMALE; GENE DISRUPTION; IN VITRO STUDY; IN VIVO STUDY; METASTASIS FREE SURVIVAL; MICROARRAY ANALYSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SUSPENSION CELL CULTURE; UPREGULATION;

ADENOVIRIDAE; ANIMALS; ANTIGENS, CD29; BREAST NEOPLASMS; CARCINOGENESIS; CELL ADHESION; CELL LINE, TUMOR; CELL PROLIFERATION; FEMALE; FIBRONECTINS; GENE EXPRESSION REGULATION, NEOPLASTIC; GLYCOSYLATION; HUMANS; INTERLEUKINS; LIGANDS; MAMMARY NEOPLASMS, ANIMAL; MICE; MICE, NUDE; MUTATION; MYELIN PROTEINS; PROTEIN BINDING; RATS; RECEPTORS, INTERLEUKIN; TREATMENT OUTCOME; UP-REGULATION;

RATTUS;

EID: 84879288537     PISSN: 15417786     EISSN: 15573125     Source Type: Journal    
DOI: 10.1158/1541-7786.MCR-12-0496     Document Type: Article

References (34)

1. Perou CM, Sorlie T, Eisen MB, van de Rijn M, Jeffrey SS, Rees CA, et al. Molecular portraits of human breast tumours. Nature 2000;406:747-52.
2. Sørlie T, Perou CM, Tibshirani R, Aas T, Geisler S, Johnsen H, et al. Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications. Proc Natl Acad Sci U S A 2001;98:10869-74.
3. Dash R, Bhutia SK, Azab B, Su ZZ, Quinn BA, Kegelmen TP, et al. mda-7/IL-24: a unique member of the IL-10 gene family promoting cancer-targeted toxicity. Cytokine Growth Factor Rev 2010;21:381-91.
4. Jiang H, Su ZZ, Lin JJ, Goldstein NI, Young CS, Fisher PB. The melanoma differentiation associated gene mda-7 suppresses cancer cell growth. Proc Natl Acad Sci U S A 1996;93:9160-5.
5. Jiang H, Lin JJ, Su ZZ, Goldstein NI, Fisher PB. Subtraction hybridization identifies a novel melanoma differentiation associated gene, mda-7, modulated during human melanoma differentiation, growth and progression. Oncogene 1995;11:2477-86.
6. Su ZZ, Lebedeva IV, Sarkar D, Gopalkrishnan RV, Sauane M, Sigmon C, et al. Melanoma differentiation associated gene-7, mda-7/IL-24, selectively induces growth suppression, apoptosis and radiosensiti-zation in malignant gliomas in a p53-independent manner. Oncogene 2003;22:1164-80.
7. Cunningham CC, Chada S, Merritt JA, Tong A, Senzer N, Zhang Y, et al. Clinical and local biological effects of an intratumoral injection of mda-7 (IL24; INGN 241) in patients with advanced carcinoma: a phase I study. Mol Ther 2005;11:149-59.
8. Sauane M, Su ZZ, Gupta P, Lebedeva IV, Dent P, Sarkar D, et al. Autocrine regulation of mda-7/IL-24 mediates cancer-specific apo-ptosis. Proc Natl Acad Sci U S A 2008;105:9763-8.
9. Gupta P, Walter MR, Su ZZ, Lebedeva IV, Emdad L, Randolph A, et al. BiP/GRP78 is an intracellular target for MDA-7/IL-24 induction of cancer-specific apoptosis. Cancer Res 2006;66:8182-91.
10. Zheng M, Bocangel D, Doneske B, Mhashilkar A, Ramesh R, Hunt KK, et al. Human interleukin 24 (MDA-7/IL-24) protein kills breast cancer cells via the IL-20 receptor and is antagonized by IL-10. Cancer Immunol Immunother 2007;56:205-15.
11. Wood GA, Korkola JE, Archer MC. Tissue-specific resistance to cancer development in the rat: phenotypes of tumor-modifier genes. Carcinogenesis 2002;23:1-9.
12. Li YJ, Song R, Korkola JE, Archer MC, Ben-David Y. Cyclin D1 is necessary but not sufficient for anchorage-independent growth of rat mammary tumor cells and is associated with resistance of the Copenhagen rat to mammary carcinogenesis. Oncogene 2003;22: 3452-62.
13. Xuan W, Li YJ, Liu G, Ben-David Y, Archer MC. Interleukin-24 induces expression of beta4 integrin but suppresses anchorage-independent growth of rat mammary tumor cells by a mechanism that is independent of beta4. Mol Cancer Res 2009;7:433-42.
14. Pareek S, Notterpek L, Snipes GJ, Naef R, Sossin W, Laliberte J, et al. Neurons promote the translocation of peripheral myelin protein 22 into myelin. J Neurosci 1997;17:7754-62.
15. Shan SW, Lee DY, Deng Z, Shatseva T, Jeyapalan Z, Du WW, et al. MicroRNA MiR-17 retards tissue growth and represses fibronectin expression. Nat Cell Biol 2009;11:1031-8.
16. Liu JC, Voisin V, Bader GD, Deng T, Pusztai L, Symmans WF, et al. Seventeen-gene signature from enriched Her2/Neu mammary tumor-initiating cells predicts clinical outcome for human HER2+: ERalpha-breast cancer. Proc Natl Acad Sci U S A 2012;109: 5832-7.
17. Korkola JE, Archer MC. Resistance to mammary tumorigenesis in Copenhagen rats is associated with the loss of preneoplastic lesions. Carcinogenesis 1999;20:221-7.
18. Karlsson C, Afrakhte M, Westermark B, Paulsson Y. Elevated level of gas3 gene expression is correlated with G0 growth arrest in human fibroblasts. Cell Biol Int 1999;23:351-8.
19. Wadehra M, Iyer R, Goodglick L, Braun J. The tetraspan protein epithelial membrane protein-2 interacts with beta1 integrins and regulates adhesion. J Biol Chem 2002;277:41094-100.
20. Hynes RO. Integrins: bidirectional, allosteric signaling machines. Cell 2002;110:673-87.
21. Danen EH, Marcinkiewicz C, Cornelissen IM, van Kraats AA, Pachter JA, Ruiter DJ, et al. The disintegrin eristostatin interferes with integrin alpha 4 beta 1 function and with experimental metastasis of human melanoma cells. Exp Cell Res 1998;238:188-96.
22. Chambers AF. MDA-MB-435 and M14 cell lines: identical but not M14 melanoma? Cancer Res 2009;69:5292-3.
23. Lebedeva IV, Su ZZ, Chang Y, Kitada S, Reed JC, Fisher PB. The cancer growth suppressing gene mda-7 induces apoptosis selectively in human melanoma cells. Oncogene 2002;21: 708-18.
24. Lu SJ, Archer MC. Ha-ras oncogene activation in mammary glands of N-methyl-N-nitrosourea-treated rats genetically resistant to mammary adenocarcinogenesis. Proc Natl Acad Sci U S A 1992; 89:1001-5.
25. Sukumar S, Notario V, Martin-Zanca D, Barbacid M. Induction of mammary carcinomas in rats by nitroso-methylurea involves malignant activation of H-ras-1 locus by single point mutations. Nature 1983;306:658-61.
26. Ponder BA. Cancer genetics. Nature 2001;411:336-41.
27. Tong AW, Nemunaitis J, Su D, Zhang Y, Cunningham C, Senzer N, et al. Intratumoral injection of INGN 241, a nonreplicating adenovector expressing the melanoma-differentiation associated gene-7 (mda-7/IL24): biologic outcome in advanced cancer patients. Mol Ther 2005;11:160-72.
28. Suter U, Snipes GJ, Schoener-Scott R, Welcher AA, Pareek S, Lupski JR, et al. Regulation of tissue-specific expression of alternative peripheral myelin protein-22 (PMP22) gene transcripts by two promoters. J Biol Chem 1994;269:25795-808.
29. Hai M, Bidichandani SI, Patel PI. Identification of a positive regulatory element in the myelin-specific promoter of the PMP22 gene. J Neurosci Res 2001;65:508-19.
30. Garbay B, Boiron-Sargueil F, Cassagne C. Expression of the exon 1A-containing PMP22 transcript is altered in the trembler mouse. Neurosci Lett 1995;198:157-60.
31. Ohsawa Y, Murakami T, Miyazaki Y, Shirabe T, Sunada Y. Peripheral myelin protein 22 is expressed in human central nervous system. J Neurol Sci 2006;247:11-5.
32. Valentijn LJ, Bolhuis PA, Zorn I, Hoogendijk JE, van den Bosch N, Hensels GW, et al. The peripheral myelin gene PMP-22/GAS-3 is duplicated in Charcot-Marie-Tooth disease type 1A. Nat Genet 1992;1:166-70.
33. Zhang BF, Liu JJ, Pei DS, Yang ZX, Di JH, Chen FF, et al. Potent antitumor effect elicited by RGD-mda-7, an mda-7/IL-24 mutant, via targeting the integrin receptor of tumor cells. Cancer Biother Radio-pharm 2011;26:647-55.
34. Contessa JN, Bhojani MS, Freeze HH, Rehemtulla A, Lawrence TS. Inhibition of N-linked glycosylation disrupts receptor tyrosine kinase signaling in tumor cells. Cancer Res 2008;68:3803-9.