Mineralization kinetics in murine trabecular bone quantified by time-lapsed in vivo micro-computed tomography

Bone

Volumn 56, Issue 1, 2013, Pages 55-60

  Lukas, Carolin ^a,b   Ruffoni, Davide ^a   Lambers, Floor M ^a   Schulte, Friederike A ^a   Kuhn, Gisela ^a   Kollmannsberger, Philip ^b   Weinkamer, Richard ^b   Müller, Ralph ^a  

^a ETH ZURICH   (Switzerland)

^b MAX PLANCK INSTITUTE OF COLLOIDS AND INTERFACES   (Germany)

Author keywords

Bone formation; Bone resorption; Mechanical loading; Mineralization kinetics; Time lapsed micro CT

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ARTIFACT; BONE DEMINERALIZATION; BONE DENSITY; BONE MATRIX; BONE MINERALIZATION; BONE STRUCTURE; CONTROLLED STUDY; FEMALE; IN VIVO STUDY; MICRO-COMPUTED TOMOGRAPHY; MOUSE; NONHUMAN; OSSIFICATION; OSTEOLYSIS; QUANTITATIVE STUDY; SURFACE PROPERTY; TRABECULAR BONE;

BONE FORMATION; BONE RESORPTION; MECHANICAL LOADING; MINERALIZATION KINETICS; TIME-LAPSED MICRO-CT;

ANIMALS; BONE AND BONES; BONE DENSITY; CALCIFICATION, PHYSIOLOGIC; FEMALE; IMAGE PROCESSING, COMPUTER-ASSISTED; KINETICS; MICE; MICE, INBRED C57BL; OSTEOGENESIS; REPRODUCIBILITY OF RESULTS; TIME FACTORS; TIME-LAPSE IMAGING; X-RAY MICROTOMOGRAPHY;

EID: 84879285852     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bone.2013.05.005     Document Type: Article

References (34)

1. Seeman E., Delmas P.D. Mechanisms of disease - bone quality - the material and structural basis of bone strength and fragility. New Engl J Med 2006, 354:2250-2261.
2. Ruffoni D., Fratzl P., Roschger P., Klaushofer K., Weinkamer R. The bone mineralization density distribution as a fingerprint of the mineralization process. Bone 2007, 40:1308-1319.
3. Boivin G., Meunier P. Methodological considerations in measurement of bone mineral content. Osteoporosis Int 2003, 14:22-28.
4. Blair H.C., Kahn A.J., Crouch E.C., Jeffrey J.J., Teitelbaum S.L. Isolated osteoclasts resorb the organic and inorganic components of bone. J. Cell Biol. 1986, 102:1164-1172.
5. Teitelbaum S.L. Bone resorption by osteoclasts. Science 2000, 289:1504-1508.
6. Teitelbaum S.L., Ross F.P. Genetic regulation of osteoclast development and function. Nat. Rev. Genet. 2003, 4:638-649.
7. Fajardo R.J., Cory E., Patel N.D., Nazarian A., Laib A., Manoharan R.K., Schmitz J.E., DeSilva J.M., MacLatchy L.M., Snyder B.D., Bouxsein M.L. Specimen size and porosity can introduce error into mu CT-based tissue mineral density measurements. Bone 2009, 44:176-184.
8. Kristensen E., Hallgrimsson B., Morck D.W., Boyd S.K. Timing of growth hormone treatment affects trabecular bone microarchitecture and mineralization in growth hormone deficient mice. Bone 2010, 47:295-300.
9. Waarsing J.H., Day J.S., Weinans H. An improved segmentation method for in vivo mu CT Imaging. J. Bone Miner. Res. 2004, 19:1640-1650.
10. Roschger P., Fratzl P., Eschberger J., Klaushofer K. Validation of quantitative backscattered electron imaging for the measurement of mineral density distribution in human bone biopsies. Bone 1998, 23:319-326.
11. Roschger P., Paschalis E.P., Fratzl P., Klaushofer K. Bone mineralization density distribution in health and disease. Bone 2008, 42:456-466.
12. Ruffoni D., Fratzl P., Roschger P., Phipps R., Klaushofer K., Weinkamer R. Effect of temporal changes in bone turnover on the bone mineralization density distribution: a computer simulation study. J. Bone Miner. Res. 2008, 23:1905-1914.
13. Roschger P., Gupta H.S., Berzanovich A., Ittner G., Dempster D.W., Fratzl P., Cosman F., Parisien M., Lindsay R., Nieves J.W., Klaushofer K. Constant mineralization density distribution in cancellous human bone. Bone 2003, 32:316-323.
14. Lukas C., Kollmannsberger P., Ruffoni D., Roschger P., Fratzl P., Weinkamer R. The heterogeneous mineral content of bone-using stochastic arguments and simulations to overcome experimental limitations. J Stat Phys 2011, 144:316-331.
15. Bouxsein M.L., Boyd S.K., Christiansen B.A., Guldberg R.E., Jepsen K.J., Müller R. Guidelines for assessment of bone microstructure in rodents using micro-computed tomography. J. Bone Miner. Res. 2010, 25:1468-1486.
16. Lambers F.M., Schulte F.A., Kuhn G., Webster D.J., Müller R. Mouse tail vertebrae adapt to cyclic mechanical loading by increasing bone formation rate and decreasing bone resorption rate as shown by time-lapsed in vivo imaging of dynamic bone morphometry. Bone 2011, 49:1340-1350.
17. Schulte F.A., Lambers F.M., Kuhn G., Müller R. In vivo micro-computed tomography allows direct three-dimensional quantification of both bone formation and bone resorption parameters using time-lapsed imaging. Bone 2011, 48:433-442.
18. Webster D., Wasserman E., Ehrbar M., Weber F., Bab I., Müller R. Mechanical loading of mouse caudal vertebrae increases trabecular and cortical bone mass-dependence on dose and genotype. Biomech Model Mechan 2010, 9:737-747.
19. Webster D.J., Morley P.L., van Lenthe G.H., Müller R. A novel in vivo mouse model for mechanically stimulated bone adaptation - a combined experimental and computational validation study. Comput Method Biomec 2008, 11:435-441.
20. Schulte F.A., Lambers F.M., Mueller T.L., Stauber M., Müller R. Image interpolation allows accurate quantitative bone morphometry in registered micro-computed tomography scans. Comput Method Biomec 2012, 1-10.
21. Kohler T., Stauber M., Donahue L.R., Müller R. Automated compartmental analysis for high-throughput skeletal phenotyping in femora of genetic mouse models. Bone 2007, 41:659-667.
22. Barrett J.F., Keat N. Artifacts in CT: recognition and avoidance. Radiographics 2004, 24:1679-1691.
23. Burghardt A.J., Kazakia G.J., Laib A., Majumdar S. Quantitative assessment of bone tissue mineralization with polychromatic micro-computed tomography. Calcified Tissue Int 2008, 83:129-138.
24. Glüer C.C., Blake G., Lu Y., Blunt B.A., Jergas M., Genant H.K. Accurate assessment of precision errors: how to measure the reproducibility of bone densitometry techniques. Osteoporosis Int 1995, 5:262-270.
25. Kohler T., Beyeler M., Webster D., Müller R. Compartmental bone morphometry in the mouse femur: reproducibility and resolution dependence of microtomographic measurements. Calcified Tissue Int 2005, 77:281-290.
26. Vargha P. Letter to the Editor A critical discussion of intraclass correlation coefficients by R. Müller and P. Büttner, Statistics in Medicine, 13, 2465-2476 (1995). Stat. Med. 1997, 16:821-822.
27. Entezari V., Vartanians V., Zurakowski D., Patel N., Fajardo R.J., Müller R., Snyder B.D., Nazarian A. Further improvements on the factors affecting bone mineral density measured by quantitative micro-computed tomography. Bone 2012, 50:611-618.
28. Nazarian A., Snyder B.D., Zurakowski D., Müller R. Quantitative micro-computed tomography: a non-invasive method to assess equivalent bone mineral density. Bone 2008, 43:302-311.
29. Mulder L., Koolstra J.H., Weijs W.A., Van Eijden T.M.G.J. Architecture and mineralization of developing trabecular bone in the pig mandibular condyle. Anat Rec Part A 2005, 285A:659-667.
30. Novack D.V., Teitelbaum S.L. The osteoclast: friend or foe?. Annual Review of Pathology: Mechanisms of Disease 2008, 3:457-484.
31. Gowen M., Lazner F., Dodds R., Kapadia R., Feild J., Tavaria M., Bertoncello I., Drake F., Zavarselk S., Tellis I., Hertzog P., Debouck C., Kola I. Cathepsin K knockout mice develop osteopetrosis due to a deficit in matrix degradation but not demineralization. J. Bone Miner. Res. 1999, 14:1654-1663.
32. Lee T.C., Staines A., Taylor D. Bone adaptation to load: microdamage as a stimulus for bone remodelling. J. Anat. 2002, 201:437-446.
33. Dunlop J., Hartmann M., Bréchet Y., Fratzl P., Weinkamer R. New suggestions for the mechanical control of bone remodeling. Calcified Tissue Int 2009, 85:45-54.
34. Hartmann M.A., Dunlop J.W.C., Bréchet Y.J.M., Fratzl P., Weinkamer R. Trabecular bone remodelling simulated by a stochastic exchange of discrete bone packets from the surface. J Mech Behav Biomed 2011, 4:879-887.