Aberrant Regulation of the BST2 (Tetherin) Promoter Enhances Cell Proliferation and Apoptosis Evasion in High Grade Breast Cancer Cells

PLoS ONE

Volumn 8, Issue 6, 2013, Pages

  Sayeed, Aejaz ^a,b   Luciani Torres, Gloria ^a,c   Meng, Zhenhang ^a   Bennington, James L ^a   Moore, Dan H ^a   Dairkee, Shanaz H ^a  

^a CALIFORNIA PACIFIC MEDICAL CENTER   (United States)

^b THOMAS JEFFERSON UNIVERSITY   (United States)

^c KAISER PERMANENTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL ANTIGEN; CELL SURFACE PROTEIN; PHYTOALEXIN; RESVERATROL; STAUROSPORINE; TAMOXIFEN; TETHERIN PROTEIN; TRANSCRIPTION FACTOR AP 2; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; BREAST CANCER; BREAST CARCINOMA; BREAST EPITHELIUM; BST2 GENE; CANCER CELL; CANCER CELL CULTURE; CANCER GRADING; CANCER GROWTH; CANCER HORMONE THERAPY; CANCER INHIBITION; CELL CYCLE S PHASE; CELL DEATH; CELL PROLIFERATION; CONTROLLED STUDY; EPITHELIUM CELL; GENE; GENE CONTROL; GENE EXPRESSION; GENE FUNCTION; GENE SILENCING; GENETIC CORRELATION; GENETIC MANIPULATION; HISTOPATHOLOGY; HUMAN; HUMAN CELL; IMMUNE EVASION; IMMUNOCOMPETENT CELL; INTRACELLULAR SIGNALING; MOLECULARLY TARGETED THERAPY; PHENOTYPE; PRIMARY TUMOR; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN FUNCTION; TREATMENT OUTCOME; TUMOR INVASION; VIRUS INHIBITION; VIRUS RELEASE;

ANTIGENS, CD; ANTINEOPLASTIC AGENTS, HORMONAL; APOPTOSIS; BASE SEQUENCE; BINDING SITES; BREAST NEOPLASMS; CARCINOMA, DUCTAL, BREAST; CELL LINE, TUMOR; CELL PROLIFERATION; DRUG SYNERGISM; FATTY ACID-BINDING PROTEINS; FEMALE; GENE EXPRESSION; GENE EXPRESSION REGULATION, NEOPLASTIC; GPI-LINKED PROTEINS; HUMANS; KAPLAN-MEIER ESTIMATE; MOLECULAR SEQUENCE DATA; PROMOTER REGIONS, GENETIC; PROPORTIONAL HAZARDS MODELS; PROTEIN BINDING; STILBENES; TAMOXIFEN; TRANSFORMING GROWTH FACTOR BETA;

EID: 84879273408     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0067191     Document Type: Article

References (34)

1. Bieniasz PD, (2004) Intrinsic immunity: A front-line defense against viral attack. Nat Immunol 5: 1109-1115.
2. Bartee E, McCormack A, Früh K, (2006) Quantitative membrane proteomics reveals new cellular targets of viral immune modulators. PLoS Pathog 2: e107.
3. Neil SJ, Zang T, Bieniasz PD, (2008) Tetherin inhibits retrovirus release and is antagonized by HIV-1 Vpu. Nature 451: 425-430.
4. Perez-Caballero D, Zang T, Ebrahimi A, McNatt MW, Gregory DA, et al. (2009) Tetherin inhibits HIV-1 release by directly tethering virions to cells. Cell 139: 499-511.
5. Cao W, Bover L, (2010) Signaling and ligand interaction of ILT7: receptor-mediated regulatory mechanisms for plasmacytoid dendritic cells. Immunol Rev 234: 163-176.
6. Bego MG, Mercier J, Cohen EA, (2012) Virus-activated interferon regulatory factor 7 upregulates expression of the interferon-regulated BST2 gene independently of interferon signaling. J Virol 86: 3513-3527.
7. Van Damme N, Goff D, Katsura C, Jorgenson RL, Mitchell R, et al. (2008) The interferon induced protein BST-2 restricts HIV-1 release and is downregulated from the cell surface by the viral Vpu protein. Cell Host Microbe 3: 245-252.
8. Kupzig S, Korolchuk V, Rollason R, Sugden A, Wilde A, et al. (2003) Bst-2/HM1.24 is a raft-associated apical membrane protein with an unusual topology. Traffic 4: 694-709.
9. Andrew AJ, Kao S, Strebel K, (2011) C-terminal hydrophobic region in human bone marrow stromal cell antigen 2 (BST-2)/tetherin protein functions as second transmembrane motif. J Biol Chem 286: 39967-39981.
10. Blasius AL, Giurisato E, Cella M, Schreiber RD, Shaw AS, et al. (2006) Bone marrow stromal cell antigen 2 is a specific marker of type I IFN-producing cells in the naive mouse, but a promiscuous cell surface antigen following IFN stimulation. J Immunol 177: 3260-3265.
11. Ohtomo T, Sugamata Y, Ozaki Y, Ono K, Yoshimura Y, et al. (1999) Molecular cloning and characterization of a surface antigen preferentially overexpressed on multiple myeloma cells. Biochem Biophys Res Commun 258: 583-591.
12. Cai D, Cao J, Li Z, Zheng X, Yao Y, et al. (2009) Up-regulation of bone marrow stromal protein 2 (BST2) in breast cancer with bone metastasis. BMC Cancer 9: 102.
13. Wirapati P, Sotiriou C, Kunkel S, Farmer P, Pradervand S, et al. (2008) Meta-analysis of gene expression profiles in breast cancer: toward a unified understanding of breast cancer subtyping and prognosis signatures. Breast Cancer Res 10: R65.
14. Dairkee SH, Ji Y, Ben Y, Moore DH, Meng Z, et al. (2004) A molecular 'signature' of primary breast cancer cultures; patterns resembling tumor tissue. BMC Genomics 5: 47.
15. Dairkee SH, Nicolau M, Sayeed A, Champion S, Ji Y, et al. (2007) Oxidative stress pathways highlighted in tumor cell immortalization: association with breast cancer outcome. Oncogene 26: 6269-6279.
16. Dairkee SH, Sayeed A, Luciani G, Champion S, Meng Z, et al. (2009) Immutable functional attributes of histologic grade revealed by context-independent gene expression in primary breast cancer cells. Cancer Res 69: 7826-7834.
17. Sayeed A, Meng Z, Luciani G, Chen LC, Bennington JL, et al. (2010) Negative regulation of UCP2 by TGFβ signaling characterizes low and intermediate-grade primary breast cancer. Cell Death Dis 1: e53.
18. Dairkee SH, Paulo EC, Traquina P, Moore DH, Ljung BM, et al. (1997) Partial enzymatic degradation of stroma allows enrichment and expansion of primary breast tumor cells. Cancer Res 57: 1590-1596.
19. Ivshina AV, George J, Senko O, Mow B, Putti TC, et al. (2006) Genetic reclassification of histologic grade delineates new clinical subtypes of breast cancer. Cancer Res 66: 10292-102301.
20. Gota C, Calabrese L, (2003) Induction of clinical autoimmune disease by therapeutic interferon-alpha. Autoimmunity 36: 511-518.
21. Cao W, Bover L, Cho M, Wen X, Hanabuchi S, et al. (2009) Regulation of TLR7/9 responses in plasmacytoid dendritic cells by BST2 and ILT7 receptor interaction. J. Exp. Med 206: 1603-1614.
22. Luciani MG, Seok J, Sayeed A, Champion S, Goodson WH, et al. (2011) Distinctive responsiveness to stromal signaling accompanies histologic grade programming of cancer cells. PLoS One 6: e20016.
23. McMillin DW, Delmore J, Weisberg E, Negri JM, Geer DC, et al. (2010) Tumor cell-specific bioluminescence platform to identify stroma-induced changes to anticancer drug activity. Nat Med 16: 483-489.
24. Ikushima H, Miyazono K, (2010) TGFbeta signalling: a complex web in cancer progression. Nat Rev Cancer 10: 415-424.
25. Koinuma D, Tsutsumi S, Kamimura N, Taniguchi H, Miyazawa K, et al. (2009) Chromatin immunoprecipitation on microarray analysis of Smad2/3 binding sites reveals roles of ETS1 and TFAP2A in transforming growth factor beta signaling. Mol Cell Biol 29: 172-186.
26. Perissi V, Menini N, Cottone E, Capello D, Sacco M, et al. (2000) AP-2 transcription factors in the regulation of ERBB2 gene transcription by oestrogen. Oncogene 19: 280-288.
27. Gee JM, Robertson JF, Ellis IO, Nicholson RI, Hurst HC, (1999) Immunohistochemical analysis reveals a tumour suppressor-like role for the transcription factor AP-2 in invasive breast cancer. J. Pathol 189: 514-520.
28. Schliemann C, Roesli C, Kamada H, Borgia B, Fugmann T, et al. (2010) In vivo biotinylation of the vasculature in B-cell lymphoma identifies BST-2 as a target for antibody-based therapy. Blood 115: 736-744.
29. Buck MB, Pfizenmaier K, Knabbe C, (2004) Antiestrogens induce growth inhibition by sequential activation of p38 mitogen-activated protein kinase and transforming growth factor-beta pathways in human breast cancer cells. Mol Endocrinol 18: 1643-1657.
30. Schild-Hay LJ, Leil TA, Divi RL, Olivero OA, Weston A, et al. (2009) Tamoxifen induces expression of immune response-related genes in cultured normal human mammary epithelial cells. Cancer Res 69: 1150-1155.
31. Athar M, Back JH, Tang X, Kim KH, Kopelovich L, et al. (2007) Resveratrol: a review of preclinical studies for human cancer prevention. Toxicol Appl Pharmacol 224: 274-283.
32. Serrero G, Lu R, (2001) Effect of resveratrol on the expression of autocrine growth modulators in human breast cancer cells. Antioxid Redox Signal 3: 969-979.
33. Jhumka Z, Pervaiz S, Clément MV, (2009) Resveratrol regulates the expression of NHE-1 by repressing its promoter activity: critical involvement of intracellular H2O2 and caspases 3 and 6 in the absence of cell death. Int J Biochem Cell Biol 41: 945-956.
34. Wang D, Kanuma T, Mizunuma H, Takama F, Ibuki Y, et al. (2000) Analysis of specific gene mutations in the transforming growth factor-beta signal transduction pathway in human ovarian cancer. Cancer Res 60: 4507-4512.