Effects of antihypertensive and triglyceride lowering agents on splenocyte apoptosis in rats with fatty liver

Basic and Clinical Pharmacology and Toxicology

Volumn 113, Issue 1, 2013, Pages 37-42

  Ackerman, Zvi ^a   Grozovski, Maria ^b   Oron Herman, Mor ^c,d   Rosenthal, Talma ^c   Sela, Ben Ami ^d   Amir, Gail ^a  

^a HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

^b ORT BRAUDE COLLEGE   (Israel)

^c TEL AVIV UNIVERSITY   (Israel)

^d SHEBA MEDICAL CENTER   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

AMLODIPINE; BEZAFIBRATE; CAPTOPRIL; CASPASE 3; FRUCTOSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; B LYMPHOCYTE; CONTROLLED STUDY; HISTOPATHOLOGY; LIPID COMPOSITION; MALE; METABOLIC SYNDROME X; NONALCOHOLIC FATTY LIVER; NONHUMAN; OXIDATION; PRIORITY JOURNAL; RAT; SPLEEN CELL; T LYMPHOCYTE;

AMLODIPINE; ANIMALS; ANTIHYPERTENSIVE AGENTS; APOPTOSIS; BEZAFIBRATE; BLOOD PRESSURE; CAPTOPRIL; CASPASE 3; FATTY LIVER; HYPOLIPIDEMIC AGENTS; LIPIDS; MALE; METABOLIC SYNDROME X; RATS; RATS, SPRAGUE-DAWLEY; SPLEEN; TRIGLYCERIDES;

RATTUS;

EID: 84879241233     PISSN: 17427835     EISSN: 17427843     Source Type: Journal    
DOI: 10.1111/bcpt.12067     Document Type: Article

References (33)

1. Vernon G, Baranova A, Younossi ZM. Systematic review: the epidemiology and natural history of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis in adults. Aliment Pharmacol Ther 2011;34:274-85.
2. Vanni E, Bugianesi E, Kotronen A, De Minicis S, Yki-Järvinen H, Svegliati-Baroni G. From the metabolic syndrome to NAFLD or vice versa? Dig Liver Dis 2010;42:320-30.
3. Falagas ME, Kompoti M. Obesity and infection. Lancet Infect Dis 2006;6:438-46.
4. Falguera M, Pifarre R, Martin A, Sheikh A, Moreno A. Etiology and outcome of community-acquired pneumonia in patients with diabetes mellitus. Chest 2005;128:3233-9.
5. Benfield T, Jensen JS, Nordestgaard BG. Influence of diabetes and hyperglycaemia on infectious disease hospitalisation and outcome. Diabetologia 2007;50:549-54.
6. Schuetz P, Castro P, Shapiro NI. Diabetes and sepsis: preclinical findings and clinical relevance. Diabetes Care 2011;34:771-8.
7. Nseir W, Taha H, Khateeb J, Grosovski M, Assy N. Fatty liver is associated with recurrent bacterial infections independent of metabolic syndrome. Dig Dis Sci 2011;56:3328-34.
8. Kremer M, Thomas E, Milton RJ, Perry AW, van Rooijen N, Wheeler MD et al. Kupffer cell and interleukin-12-dependent loss of natural killer T cells in hepatosteatosis. Hepatology 2010;51:130-41.
9. Hotchkiss RS, Strasser A, McDunn JE, Swanson PE. Cell death. N Engl J Med 2009;361:1570-83.
10. Hotchkiss RS, Chang KC, Grayson MH, Tinsley KW, Dunne BS, Davis CG et al. Adoptive transfer of apoptotic splenocytes worsens survival, whereas adoptive transfer of necrotic splenocytes improves survival in sepsis. Proc Natl Acad Sci USA 2003;100:6724-9.
11. Doi K, Leelahavanichkul A, Hu X, Sidransky KL, Zhou H, Qin Y et al. Pre-existing renal disease promotes sepsis-induced acute kidney injury and worsens outcome. Kidney Int 2008;74:1017-25.
12. Wang J, Wang YQ, Yu J, Cao XD, Wu GC. Electroacupuncture suppresses surgical trauma stress-induced lymphocyte apoptosis in rats. Neurosci Lett 2005;383:68-72.
13. Ackerman Z, Oron-Herman M, Grozovski M, Rosenthal T, Pappo O, Link G et al. Fructose-induced fatty liver disease: hepatic effects of blood pressure and plasma triglyceride reduction. Hypertension 2005;45:1012-8.
14. Ackerman Z, Oron-Herman M, Rosenthal T, Pappo O, Link G, Sela BA et al. Effects of amlodipine, captopril, and bezafibrate on oxidative milieu in rats with fatty liver. Dig Dis Sci 2008;53:777-84.
15. Oron-Herman M, Sela BA, Rosenthal T. Risk reduction therapy for syndrome X: comparison of several treatments. Am J Hypertens 2005;18:372-8.
16. Matot I, Cohen K, Pappo O, Barash H, Abramovitch R. Liver response to hemorrhagic shock and subsequent resuscitation: MRI analysis. Shock 2008;29:16-24.
17. Samuel VT. Fructose induced lipogenesis: from sugar to fat to insulin resistance. Trends Endocrinol Metab 2011;22:60-5.
18. Cohly H, Jenkins J, Skelton T, Meydrech E, Markov AK. Fructose-1, 6-diphosphate suppresses T-lymphocyte proliferation, promotes apoptosis and inhibits interleukins-1, 6, beta-actin mRNAs, and transcription factors expression. Immunol Invest 2004;33:407-21.
19. Kossoy G, Stark A, Tendler Y, Ben-Hur H, Beniashvili D, Madar Z et al. Transplacental effects of high fat diets on functional activity of the spleen and lymph nodes, cell kinetics and apoptosis in mammary gland tumors in female rat offspring. Int J Mol Med 2002;10:773-8.
20. Avula CP, Zaman AK, Lawrence R, Fernandes G. Induction of apoptosis and apoptotic mediators in Balb/C splenic lymphocytes by dietary n-3 and n-6 fatty acids. Lipids 1999;34:921-7.
21. Eid NA, Ito Y, Li Z, Abe H, Kusakabe K, Shibata MA et al. The relationship between apoptosis and splenocyte depletion in rats following ethanol treatment. Med Electron Microsc 2000;33:89-95.
22. Buemi M, Allegra A, Marino D, Marino MT, Medici MA, De Pasquale G et al. Does captopril have a direct pro-apoptotic effect? Nephron 1999;81:99-101.
23. Odaka C, Mizuochi T. Angiotensin-converting enzyme inhibitor captopril prevents activation-induced apoptosis by interfering with T cell activation signals. Clin Exp Immunol 2000;121:515-22.
24. De Albuquerque DA, Saxena V, Adams DE, Boivin GP, Brunner HI, Witte DP et al. An ACE inhibitor reduces Th2 cytokines and TGF-beta1 and TGF-beta2 isoforms in murine lupus nephritis. Kidney Int 2004;65:846-59.
25. Albuquerque D, Nihei J, Cardillo F, Singh R. The ACE inhibitors enalapril and captopril modulate cytokine responses in Balb/c and C57Bl/6 normal mice and increase CD4 (+) CD103 (+) CD25 (negative) splenic T cell numbers. Cell Immunol 2010;260:92-7.
26. Johnson P, Wei Y, Huentelman MJ, Peters CM, Boldyrev AA. Hydralazine, but not captopril, decreases free radical production and apoptosis in neurons and thymocytes. Free Radic Res 1998;28:393-402.
27. Saga D, Sakatsume M, Ogawa A, Tsubata Y, Kaneko Y, Kuroda T et al. Bezafibrate suppresses rat antiglomerular basement membrane crescentic glomerulonephritis. Kidney Int 2005;67:1821-9.
28. Hayden RE, Pratt G, Davies NJ, Khanim FL, Birtwistle J, Delgado J et al. Treatment of primary CLL cells with bezafibrate and medroxyprogesterone acetate induces apoptosis and represses the pro-proliferative signal of CD40-ligand, in part through increased 15dDelta12, 14, PGJ2. Leukemia 2009;23:292-304.
29. Tomiyama N, Yasuda N, Iwano C, Matzno S, Matsuyama K. Flow cytometric evaluation of synergistic pro-apoptotic effects of statins and clofibrates in IM-9 human lymphoblasts. Clin Exp Pharmacol Physiol 2007;34:876-80.
30. Mason RP, Mak IT, Trumbore MW, Mason PE. Antioxidant properties of calcium antagonists related to membrane biophysical interactions. Am J Cardiol 1999;84:16L-22L.
31. Yamanaka S, Tatsumi T, Shiraishi J, Mano A, Keira N, Matoba S et al. Amlodipine inhibits doxorubicin-induced apoptosis in neonatal rat cardiac myocytes. J Am Coll Cardiol 2003;41:870-8.
32. Ogino A, Takemura G, Kanamori H, Okada H, Maruyama R, Miyata S et al. Amlodipine inhibits granulation tissue cell apoptosis through reducing calcineurin activity to attenuate post infarction cardiac remodelling. Am J Physiol Heart Circ Physiol 2007;293:H2271-80.
33. Balakumaran A, Campbell GA, Moslen MT. Calcium channel blockers induce thymic apoptosis in vivo in rats. Toxicol Appl Pharmacol 1996;139:122-7.