Divergent effects of D2/3 receptor activation in the nucleus accumbens core and shell on impulsivity and locomotor activity in high and low impulsive rats

Psychopharmacology

Volumn 228, Issue 1, 2013, Pages 19-30

  Moreno, M ^a   Economidou, D ^b,c   Mar, A C ^b,c   Lopez Granero C ^a   Caprioli, D ^b,c   Theobald, D E ^b,c   Fernando, A ^b,c   Newman, A H ^d   Robbins, T W ^b,c   Dalley, Jeffrey W ^b,c  

^a UNIVERSITY OF ALMERÍA   (Spain)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^d NATIONAL INSTITUTE ON DRUG ABUSE   (United States)

Author keywords

Dopamine; Impulsivity; Locomotion; Nafadotride; Nucleus accumbens; Quinpirole

Indexed keywords

DOPAMINE 2 RECEPTOR; DOPAMINE 3 RECEPTOR; NAFADOTRIDE; QUINPIROLE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATTENTION DEFICIT DISORDER; BRAIN FUNCTION; CONTROLLED STUDY; DOPAMINE RECEPTOR BLOCKING; HYPERACTIVITY; IMPULSIVENESS; LOCOMOTION; MALE; MOTOR PERFORMANCE; NONHUMAN; NUCLEUS ACCUMBENS; OPEN FIELD BEHAVIOR; PRIORITY JOURNAL; PROTEIN DEFECT; PROTEIN LOCALIZATION; RAT;

ANIMALS; ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY; DOPAMINE AGONISTS; DOPAMINE ANTAGONISTS; DOSE-RESPONSE RELATIONSHIP, DRUG; HYPERKINESIS; IMPULSIVE BEHAVIOR; MALE; MOTOR ACTIVITY; NAPHTHALENES; NUCLEUS ACCUMBENS; PYRROLIDINES; QUINPIROLE; RATS; REACTION TIME; RECEPTORS, DOPAMINE D2; RECEPTORS, DOPAMINE D3;

EID: 84879231980     PISSN: 00333158     EISSN: 14322072     Source Type: Journal    
DOI: 10.1007/s00213-013-3010-3     Document Type: Article

References (55)

1. American Psychiatric Association (2000) Diagnostic and statistical manual of mental disorders, 4th edn. American Psychiatric Press, Washington, DC
2. Bardo MT (1998) Neuropharmacological mechanisms of drug reward: beyond dopamine in the nucleus accumbens. Crit Rev Neurobiol 12:37-67
3. 2 receptors in rat nucleus accumbens: resistance to differential rearing conditions. Neuroscience 45:281-290
4. Bari A, Dalley JW, Robbins TW (2008) The application of the 5-choice serial reaction time task for the assessment of visual attentional processes and impulse control in rats. Nat Protoc 3:759-767
5. 3 receptors in the cerebellum. Brain Res 737:347-350
6. Basar K, Sesia T, Groenewegen H, Steinbusch HW, Visser-Vandewalle V, Temel Y (2010) Nucleus accumbens and impulsivity. Prog Neurobiol 92:533-557
7. Belin D, Mar AC, Dalley JW, Robbins TW, Everitt BJ (2008) High impulsivity predicts the switch to compulsive cocaine-taking. Science 320:1352-1355
8. 2/3 receptors in the core and shell subregions of the nucleus accumbens. Neuropsychopharmacology 35:560-569
9. Canales JJ, Iversen SD (2000) Psychomotor-activating effects mediated by dopamine D(2) and D(3) receptors in the nucleus accumbens. Pharmacol Biochem Behav 67:161-168
10. Cardinal RN, Pennicott DR, Sugathapala CL, Robbins TW, Everitt BJ (2001) Impulsive choice induced in rats by lesions of the nucleus accumbens core. Science 292:2499-2501
11. Cole BJ, Robbins TW (1989) Effects of 6-hydroxydopamine lesions of the nucleus accumbens septi on performance of a 5-choice serial reaction time task in rats: implications for theories of selective attention and arousal. Behav Brain Res 33:165-179
12. 2/3 receptors predict trait impulsivity and cocaine reinforcement. Science 315:1267-1270
13. Dalley JW, Everitt BJ, Robbins TW (2011) Impulsivity, compulsivity, and top-down cognitive control. Neuron 69:680-694
14. Di Chiara G (2002) Nucleus accumbens shell and core dopamine: differential role in behavior and addiction. Behav Brain Res 137:75-114
15. 3 receptor in the rat brain. Neuroscience 65:731-745
16. 3 receptors expressed by all mesencephalic dopamine neurons. J Neurosci 20:8677-8684
17. Diergaarde L, Pattij T, Poortvliet I, Hogenboom F, de Vries W, Schoffelmeer AN, De Vries TJ (2008) Impulsive choice and impulsive action predict vulnerability to distinct stages of nicotine seeking in rats. Biol Psychiatry 63:301-308
18. 2 dopamine receptors in mediating locomotor activity elicited from the nucleus accumbens of rats. Brain Res 487:267-277
19. Economidou D, Pelloux Y, Robbins TW, Dalley JW, Everitt BJ (2009) High impulsivity predicts relapse to cocaine-seeking after punishment-induced abstinence. Biol Psychiatry 65:851-856
20. Economidou D, Theobald DE, Robbins TW, Everitt BJ, Dalley JW (2012) Norepinephrine and dopamine modulate impulsivity on the five-choice serial reaction time task through opponent actions in the shell and core sub-regions of the nucleus accumbens. Neuropsychopharmacology; e-pub ahead of print 18 April 2012. doi: 10.1038/npp.2012.53
21. Fattore L, Piras G, Corda MG, Giorgi O (2009) The Roman high- and low-avoidance rat lines differ in the acquisition, maintenance, extinction, and reinstatement of intravenous cocaine self-administration. Neuropsychopharmacology 34:1091-1101
22. Fernando AB, Economidou D, Theobald DE, Zou MF, Newman AH, Spoelder M, Caprioli D, Moreno M, Hipólito L, Aspinall AT, Robbins TW, Dalley JW (2012) Modulation of high impulsivity and attentional performance in rats by selective direct and indirect dopaminergic and noradrenergic receptor agonists. Psychopharmacology (Berl) 219:341-352
23. Fineberg NA, Potenza MN, Chamberlain SR, Berlin HA, Menzies L, Bechara A, Sahakian BJ, Robbins TW, Bullmore ET, Hollander E (2010) Probing compulsive and impulsive behaviors, from animal models to endophenotypes: a narrative review. Neuropsychopharmacology 35:591-604
24. 3 dopamine receptor affinity of dopaminergic compounds in rat brain. Life Sci 62:1825-1831
25. Giorgi O, Piras G, Corda MG (2007) The psychogenetically selected Roman high- and low-avoidance rat lines: a model to study the individual vulnerability to drug addiction. Neurosci Biobehav Rev 31:148-163
26. 2 agonists injected into nucleus accumbens and ventral pallidum differentially affect locomotor activity depending on site. Neuroscience 93:1349-1358
27. Goto Y, Grace AA (2005) Dopaminergic modulation of limbic and cortical drive of nucleus accumbens in goal-directed behavior. Nat Neurosci 8:805-812
28. Heidbreder C, Feldon J (1998) Amphetamine-induced neurochemical and locomotor responses are expressed differentially across the anteroposterior axis of the core and shell subterritories of the nucleus accumbens. Synapse 29:310-322
29. 3 receptors in drug addiction: a review of pharmacological evidence. Brain Res Brain Res Rev 49:77-105
30. Jupp B, Saigal N, Caprioli D, Reverté Soler I, Shrestha S, Cumming P, Everitt BJ, Robbins TW, Dalley JW (2013) Dopaminergic and GABA-ergic markers of impulsivity in rats: evidence for anatomical localization in ventral striatum and prefrontal cortex. Eur J Neurosci. doi: 10.1111/ejn.12146
31. Lecca D, Piras G, Driscoll P, Giorgi O, Corda MG (2004) A differential activation of dopamine output in the shell and core of the nucleus accumbens is associated with the motor responses to addictive drugs: a brain dialysis study in Roman high- and low-avoidance rats. Neurochopharmacology 46:688-699
32. Millan MJ, Dekeyne A, Rivet JM, Dubuffet T, Lavielle G, Brocco M (2000) S33084, a novel, potent, selective, and competitive antagonist at dopamine D(3)-receptors: II. Functional and behavioral profile compared with GR218, 231 and L741, 626. J Pharmacol Exp Ther 293:1063-1073
33. 2 receptors in the control of locomotor activity: a combined behavioural and neurochemical analysis with novel, selective antagonists in rats. Psychopharmacology (Berl) 174:341-357
34. Mizuno T, Schmauss C, Rayport S (2007) Distinct roles of presynaptic dopamine receptors in the differential modulation of the intrinsic synapses of medium-spiny neurons in the nucleus accumbens. BMC Neurosci 8:8
35. Molander AC, Mar A, Norbury A, Steventon S, Moreno M, Caprioli D, Theobald DE, Belin D, Everitt BJ, Robbins TW, Dalley JW (2011) High impulsivity predicting vulnerability to cocaine addiction in rats: some relationship with novelty preference but not novelty reactivity, anxiety or stress. Psychopharmacology (Berl) 215:721-731
36. Moreno M, Cardona D, Gómez M, Sánchez-santed F, Tobeña A, Fernández-teruel A, Campa L, Suñol C, Escarabajal M, Torres C, Flores P (2010) Impulsivity characterization in the Roman high- and low-avoidance rat strains: behavioral and neurochemical differences. Neuropsychopharmacology 35:1198-1208
37. Murphy ER, Robinson ES, Theobald DE, Dalley JW, Robbins TW (2008) Contrasting effects of selective lesions of nucleus accumbens core or shell on inhibitory control and amphetamine-induced impulsive behaviour. Eur J Neurosci 28:353-363
38. Natesan S, Reckless GE, Barlow BL, Nobrega JN, Kapur S (2011) Partial agonists in schizophrenia - why some work and others do not: insights from preclinical animal models. Int J Neuropsychopharm 14:1165-1178
39. 2 receptors in the nucleus accumbens core and shell in inhibitory response control. Psychopharmacology (Berl) 191:587-598
40. Paxinos G, Watson C (1998) The rat brain in stereotaxic coordinates. Academic, Orlando
41. 2 receptors in the nucleus accumbens in attentional performance on the five-choice serial reaction time task. Neuropsychopharmacology 32:273-283
42. 2/3 receptor antagonist sulpiride. Psychopharmacology (Berl) 202:307-313
43. Phillips GD, Howes SR, Whitelaw RB, Robbins TW, Everitt BJ (1995) Analysis of the effects of intra-accumbens SKF-38393 and LY-171555 upon the behavioral satiety sequence. Psychopharmacology (Berl) 117:82-90
44. Plaznik A, Stefanski R, Kostowski W (1989) Interaction between accumbens D-1 and D-2 receptors regulating rat locomotor activity. Psychopharmacology (Berl) 99:558-562
45. 3 receptor antagonist, SB-277011-A. J Pharmacol Exp Ther 294:1154-1165
46. Reynolds SM, Berridge KC (2008) Emotional environments retune the valence of appetitive versus fearful functions in nucleus accumbens. Nat Neurosci 11:423-425
47. Robbins TW (2002) The 5-choice serial reaction time task: behavioural pharmacology and functional neurochemistry. Psychopharmacology (Berl) 163:362-380
48. Robinson ES, Eagle DM, Economidou D, Theobald DE, Mar AC, Murphy ER, Robbins TW, Dalley JW (2009) Behavioural characterisation of high impulsivity on the 5-choice serial reaction time task: specific deficits in 'waiting' versus 'stopping'. Behav Brain Res 196:310-316
49. 3 receptor antagonist, activates locomotion in rodents. J Pharmacol Exp Ther 275:1239-1246
50. Sesia T, Temel Y, Lim LW, Blokland A, Steinbusch HW, Visser-Vandewalle V (2008) Deep brain stimulation of the nucleus accumbens core and shell: opposite effects on impulsive action. Exp Neurol 214:135-139
51. Swanson CJ, Heath S, Stratford TR, Kelley AE (1997) Differential behavioral responses to dopaminergic stimulation of nucleus accumbens subregions in the rat. Pharmacol Biochem Behav 58:933-945
52. 3, receptors. Behav Pharmacol 20:484-491
53. Volkow ND, Wang GJ, Kollins SH, Wigal TL, Newcorn JH, Telang F, Fowler JS, Zhu W, Logan J, Ma Y, Pradhan K, Wong C, Swanson JM (2009) Evaluating dopamine reward pathway in ADHD: clinical implications. JAMA 302:1084-1091
54. Winstanley CA, Zeeb FD, Bedard A, Fu K, Lai B, Steele C, Wong AC (2010) Dopaminergic modulation of the orbitofrontal cortex affects attention, motivation and impulsive responding in rats performing the five-choice serial reaction time task. Behav Brain Res 210:263-272
55. Wise RA (1998) Drug-activation of brain reward pathways. Drug Alcohol Depend 51:13-22