Matrix metalloproteinase-driven endochondral fracture union proceeds independently of osteoclast activity

Journal of Bone and Mineral Research

Volumn 28, Issue 7, 2013, Pages 1550-1560

  McDonald, Michelle M ^a,b   Morse, Alyson ^a   Mikulec, Kathy ^a   Peacock, Lauren ^a   Baldock, Paul A ^b   Kostenuik, Paul J ^c   Little, David G ^a  

^a CHILDREN S HOSPITAL AT WESTMEAD   (Australia)

^b GARVAN INSTITUTE OF MEDICAL RESEARCH   (Australia)

^c AMGEN INC   (United States)

Author keywords

ENDOCHONDRAL OSSIFICATION; FRACTURE REPAIR; MATRIX METALLOPROTEINASES; OSTEOCLAST; REMODELING

Indexed keywords

2 [N (4 METHOXYSULFONYL)(3 PYRIDINYLMETHYL)AMINO] 3 METHYLBUTYROHYDROXAMIC ACID; CLODRONIC ACID; MATRIX METALLOPROTEINASE; RECOMBINANT OSTEOGENIC PROTEIN 1; ZOLEDRONIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; ENCHONDRAL OSSIFICATION; ENDOCHONDRAL FRACTURE; ENZYME ACTIVITY; ENZYME INHIBITION; FRACTURE; FRACTURE HEALING; MALE; NONHUMAN; OSTEOCLAST ACTIVITY; OSTEOCLASTOGENESIS; RAT;

ANIMALS; BONE DENSITY CONSERVATION AGENTS; CLODRONIC ACID; COLLAGENASES; DIPHOSPHONATES; FEMORAL FRACTURES; FRACTURE HEALING; HUMANS; HYDROXAMIC ACIDS; IMIDAZOLES; MALE; MATRIX METALLOPROTEINASE INHIBITORS; OSTEOCLASTS; OSTEOPROTEGERIN; PYRAZINES; RATS; RATS, WISTAR; RECOMBINANT PROTEINS; SULFONAMIDES; TIME FACTORS;

EID: 84879230322     PISSN: 08840431     EISSN: 15234681     Source Type: Journal    
DOI: 10.1002/jbmr.1889     Document Type: Article

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